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journal of Pharmaceutical Analysis 2020年第3期10卷 233-239页

作者： Max Sauter Philipp Uhl jürgen burhenne Walter E.Haefeli Department of Clinical Pharmacology and Pharmacoepidemiology Heidelberg University HospitalIm Neuenheimer Feld 41069120HeidelbergGermany

Exenatide is the first approved glucagon-like peptide 1 receptor agonist subcutaneously or intramuscularly injected for the treatment of type 2 diabetes *** therapeutic plasma concentrations are in the low pg/mL range,therefore requiring ultra-sensitive *** enable the accurate evaluation of pharmacokinetic studies,we established a UPLC-MS/MS assay with a lower limit of quantification(LLOQ)of 5 pg/mL(1.2 pM)using 200μL of plasma,validated acco rding to FDA's and EMA's pertinent *** was isolated from plasma with solid phase extraction utilizing anionexchange *** was performed with positive electrospray ionization tandem mass spectrometry in the selected reaction monitoring *** calibrated concentration range of 5-10,000 pg/mL was linear showing co rrelation coefficients>*** and intraday accuracy ranged from 97.5%to 105.4%with corre sponding precision of<10.9%.Accuracy at the LLOQ ranged from 93.0%to 102.5%with corresponding precision of<15.9%.Because of the validity of a 10-fold dilution QC(accuracy 111.2%),the assay is suitable for exenatide quantification up to 100,000 pg/*** ultra-sensitive assay's applicability was demonstrated by the quantification of exenatide plasma concentrations and pharmacokinetics after intravenous and nasal administration to beagle dogs.

关键词： Exenatide Nasal Intravenous UPLC Tandem mass spectrometry Pharmacokinetics

Supervision of two fundamental problems in modern fluid dynamics for sparing energy

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journal of Thermal Science 2009年第2期18卷 97-98页

作者： jürgen Zierep Institut für Strmungslehre Universitt Karlsruhe

The normal shock at a curved surface in transonic flow leads to a superdetermined boundary value problem. A bump behind the shock decreases the drag of the airfoil and reduces the necessary energy. Flows of non-Newtonian media lead in the contrary to subdetermined boundary initial problems. The energy balance for these fluids is of great interest for chemical engineering.

关键词： Transonic flow Shock at a curved wall Superdetermined problem Non- Newtonian media Subdeermined problem Energy balance.

Dust growth in protoplanetary disks-a comprehensive experimental / theoretical approach

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Research in Astronomy and Astrophysics 2010年第12期10卷 1199-1214页

作者： jürgen Blum Institut für Geophysik und extraterrestrische Physik University of Braunschweig

More than a decade of dedicated experimental work on the collisional physics of protoplanetary dust has brought us to a point at which the growth of dust aggregates can - for the first time - be self-consistently and reliably modeled. In this article, the emergent collision model for protoplanetery dust aggregates, as well as the numerical model for the evolution of dust aggregates in protoplanetary disks, is reviewed. It turns out that, after a brief period of rapid collisional growth of fluffy dust aggregates to sizes of a few centimeters, the protoplanetary dust particles are subject to bouncing collisions, in which their porosity is considerably decreased. The model results also show that low-velocity fragmentation can reduce the final mass of the dust aggregates but that it does not trigger a new growth mode as discussed previously. According to the current stage of our model, the direct formation of kilometer-sized planetesimals by collisional sticking seems unlikely, implying that collective effects, such as the streaming instability and the gravitational instability in dust-enhanced regions of the protoplanetary disk, are the best candidates for the processes leading to planetesimals.

关键词： planetary systems: protoplanetary disks -- planetary systems: formation-- methods: laboratory -- methods: numerical

Exaptation at the molecular genetic level

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Science China(Life Sciences) 2019年第4期62卷 437-452页

作者： jürgen Brosius Institute of Experimental Pathology (ZMBE) Centre for Molecular Biology of Inflammation University of Münster Brandenburg Medical School (MHB)

The realization that body parts of animals and plants can be recruited or coopted for novel functions dates back to, or even predates the observations of Darwin. S.j. Gould and E.S. Vrba recognized a mode of evolution of characters that differs from adaptation. The umbrella term aptation was supplemented with the concept of exaptation. Unlike adaptations, which are restricted to features built by selection for their current role, exaptations are features that currently enhance fitness, even though their present role was not a result of natural selection. Exaptations can also arise from nonaptations; these are characters which had previously been evolving neutrally. All nonaptations are potential exaptations. The concept of exaptation was expanded to the molecular genetic level which aided greatly in understanding the enormous potential of neutrally evolving repetitive DNA—including transposed elements, formerly considered junk DNA—for the evolution of genes and genomes. The distinction between adaptations and exaptations is outlined in this review and examples are given. Also elaborated on is the fact that such distinctions are sometimes more difficult to determine; this is a widespread phenomenon in biology, where continua abound and clear borders between states and definitions are rare.

关键词： exaptation adaptation aptation neofunctionalization subfunctionalization non-protein coding RNA cooptation recruitment novel functional gene modules de novo genes retrogenes

Taguchi Analysis for Improving Optimization of Integrated Forward/Reverse Logistics

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journal of the Operations Research Society of China 2023年第3期11卷 529-552页

作者： Elham Behmanesh jürgen Pannek International Graduate School for Dynamics in Logistics University of BremenBremenGermany Faculty of Production Engineering University of BremenBremenGermany BIBA Bremer Institut für Produktion und Logistik GmbH BremenGermany

The distribution–allocation problem is known as one of the most comprehensive strategic *** real-world cases,it is impossible to solve a distribution–allocation problem completely in acceptable *** forces the researchers to develop efficient heuristic techniques for the large-term operation of the whole supply *** techniques provide near optimal solution and are comparably fast particularly for large-scale test *** paper presents an integrated supply chain model which is flexible in the delivery *** solution methodology,we apply a memetic algorithm with a novelty in population *** identify the optimum operating condition of the proposed memetic algorithm,Taguchi method is *** this study,four factors,namely population size,crossover rate,local search iteration and number of iteration,are *** the best level of the considered parameters is the outlook of this research.

关键词： Integrated logistics network Flexible path Memetic algorithm Taguchi analysis

Multi-Product Expansion with Suzuki’s Method: Generalization

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Numerical Mathematics(Theory,Methods and Applications) 2011年第1期4卷 68-91页

作者： jürgen Geiser Department of Mathematics Humboldt University of BerlinUnter den Linden 6D-10099 BerlinGermany

In this paper we discuss the extension to exponential splitting methods withrespect to time-dependent operators. We concentrate on the Suzuki’s method, whichincorporates ideas to the time-ordered exponential of [3, 11, 12, 34]. We formulate themethods with respect to higher order by using kernels for an extrapolation scheme. Theadvantages include more accurate and less computational intensive schemes to specialtime-dependent harmonic oscillator problems. The benefits of the higher order kernelsare given on different numerical examples.

关键词： Suzuki’s method multiproduct expansion multiplicate and additive splitting schemes exponential splitting

Solid-state batteries:from 'all-solid' to 'almost-solid'

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National Science Review 2023年第6期10卷 57-59页

作者： Hanyu Huo jürgen janek Institute of Physical Chemistry Justus Liebig University Giessen Center for Materials Research (ZfM) Justus Liebig University Giessen

Lithium-ion batteries (LIBs) have been the undisputed leading technology in electrochemical energy storage since they were commercialized in *** then,the mass manufacturing of LIBs has reached maturity,and we have also seen the realization of high energy density,long cycling stability and low *** technology enabled the huge success of mobile consumer electronics,with its usage in electric vehicles and other advanced *** to the use of organic solvents for the ele ctrolytes,LIBs are sensitive to high temperatures,lose performance at low temperatures and show inherent safety risks with increasing energy density (Fig.1a).As the performance of current LIBs is also limited,next-generation battery technologies are being intensively investigated,especially given the ever-increasing demand for high energy density as well as high power density.

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A noninteracting control strategy for the robust output synchronization of linear heterogeneous networks

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Control Theory and Technology 2014年第3期12卷 234-249页

作者： Saman KHODAVERDIAN jürgen ADAMY Institute of Automatic Control and Mechatronics Control Methods and Robotics Lab Technische Universitt DarmstadtLandgraf-Georg-Str.464283 Darmstadt Germany

This paper deals with the problem of robust output synchronization for heterogeneous multi-agent systems. First, a new synchronization approach is presented to synchronize the outputs of heterogeneous agents. Based on noninteracting control techniques, a method is derived for homogenizing the input-output behavior of every agent. Hence, applying the same reference input signal to every agent leads to synchronization. Furthermore, a strategy for increasing the robustness of the synchronization process against exogenous disturbances is presented, which leads to a structurally constrained optimization problem. However, by a convenient reformulation of the problem, well established tools from robust control theory can be used. Moreover, it is shown that this procedure allows to separate the robustness issue from the synchronization task. The effectiveness of the approach is illustrated by a robust output synchronization example for a heterogeneous aircraft fleet.

关键词： Heterogeneous networks Multi-agent systems Decentralized control Robust synchronization Disturbance rejection Controller constraints and structure

Floer Homology:From Generalized Morse–Smale Dynamical Systems to Forman’s Combinatorial Vector Fields

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Communications in Mathematics and Statistics 2024年第4期12卷 695-720页

作者： Marzieh Eidi jürgen jost Max-Planck Institute for Mathematics in the Sciences LeipzigGermany Santa Fe Institute Santa FeNMUSA

We construct a Floer type boundary operator for generalised Morse–Smale dynamical systems on compact smooth manifolds by counting the number of suitable flow lines between closed(both homoclinic and periodic)orbits and isolated critical *** same principle works for the discrete situation of general combinatorial vector fields,defined by Forman,on CW *** can thus recover the Z2 homology of both smooth and discrete structures directly from the flow lines(V-paths)of our vector field.

关键词： field. Morse flow

The Projective Cover of the Trivial Representation for a Finite Group of Lie Type in Defining Characteristic

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Algebra Colloquium 2017年第3期24卷 439-452页

作者： Shigeo Koshitani jürgen Müller Department of Mathematics Graduate School of Science Chiba University 1-33 Yayoi-cho Inage-ku Chiba 263-8522 Japan Fakult t für Mathematik und Naturwissenschaften Bergische Universit t Wuppertal GauBstr. 20 D-42119 Wuppertal Germany

We give a lower bound of the Loewy length of the projective cover of the trivial module for the group algebra kG of a finite group G of Lie type defined over a finite field of odd characteristic p, where k is an arbit... 详细信息

关键词： modular representations projective cover of trivial module finite groups ofLie type in defining characteristic