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Proximity-dependent protein (de)stabilization: scr.ening the human OrFeome for protein degraders and stabilizers

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3161-3162页

作者： Thomas Hermanns Kay hofmann Institute for Genetics University of CologneCologneGermany

In a recent study published in Nature,Poirson et *** an unbiased scr.en for proteins that can either bring about-or prevent-the destruction of proteinaceous model substrates in a proximity-dependent *** of such protein degraders and stabilizers will be instrumental in the development of new drug classes that specifically regulate the abundance of their target proteins.

关键词： al. stabilization stabilizers

Mapping the clinical practice of traditional,complementary and integrative medicine in oncology in Western countries:A multinational cross-sectional survey

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journal of Integrative Medicine 2024年第1期22卷 64-71页

作者： Matthias Huemer Sandro Graca Sarah Bitsche Guenter hofmann Mike Armour Martin Pichler Palliative Care Unit Division of OncologyDepartment of Internal MedicineMedical University of Graz8036 GrazAustria Northern College of Acupuncture York YO16LJUnited Kingdom School of Health and Society Faculty of EducationHealth and WellbeingUniversity of WolverhamptonWolverhampton WV11LYUnited Kingdom National Institute of Complementary Medicine Health research Institute Western Sydney UniversityPenrith NSW 2751Australia Translational Health research Institute Western Sydney UniversityPenrith NSW 2751Australia Medical research Institute of New Zealand Wellington 6021New Zealand Translational Oncology University Hospital of Augsburg86156 AugsburgGermany

Background Many cancer patients seek adjunctive therapies to biomedical cancer treatments at some point of their disease *** acupuncture is increasingly recommended by leading oncological associations,limited evidence exists concerning the evidence-informed practice and adherence to cur.ent guidelines of traditional complementary and integrative medicine(TCIM)practitioners treating cancer *** An international online-survey assessed the demographical data,clinical practice,and sources of information used by TCIM practitioners in Austria,Germany,United States of America,Australia,and New *** In total,404 respondents completed the survey,of which 254(62.9%)treated cancer *** practitioners were acupuncturists and herbalists(57.1%),had(16.8±9.9)years of clinical exper.ence and see a median of 2(1,4)cancer patients per *** cancer(61.8%)is the most common cancer type seen in TCIM *** TCIM treatments are frequently concur.ent with the patient’s cancer specific treatment(39.9%),which is also reflected by the main goal of a TCIM treatment to alleviate side effects(52.4%).However,only 28.0%of the respondents are in contact with the treating *** to the respondents,pain is most effectively treated using acupuncture,while herbal medicine is best for cancer-related *** practitioners mostly use certified courses(33.1%)or online databases(28.3%)but often believe that experts are more reliable to inform their practice(37.0%)than research publications(32.7%).Conclusion Acupuncturists and herbalists commonly treat cancer *** practitioners use TCIM as an adjunct to biomedicine as supportive care and use it largely in accordance with cur.ent oncological guidelines.

关键词： Integrative medicine Acupuncture Oncology Evidence-informed practice International survey

Transfer learning from synthetic data for open-circuit voltage curve reconstruction and state of health estimation of lithium-ion batteries from partial charging segments

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energy and AI 2024年第3期17卷 80-97页

作者： Tobias hofmann jacob Hamar Bastian Mager Simon Erhard jan Philipp Schmidt Chair of Systems engineering for Electrical energy Storage University of BayreuthWeiherstraße 26Bayreuth95448BavariaGermany BMW Group Petuelring 130Munich80809BavariaGermany

Data-driven models for battery state estimation require extensive experimental training data,which may not be available or suitable for specific tasks like open-circuit voltage(OCV)reconstruction and subsequent state of health(SOH)*** study addresses this issue by developing a transfer-learning-based OCV reconstruction model using a temporal convolutional long short-term memory(TCN-LSTM)network trained on synthetic data from an automotive nickel cobalt aluminium oxide(NCA)cell generated through a mechanistic model *** data consists of voltage curves at constant temperature,C-rates between C/30 to 1C,and a SOH-range from 70%to 100%.The model is refined via Bayesian optimization and then applied to four use cases with reduced experimental nickel manganese cobalt oxide(NMC)cell training data for higher use *** TL models’performances are compared with models trained solely on experimental data,focusing on different C-rates and voltage *** results demonstrate that the OCV reconstruction mean absolute error(MAE)within the average battery electric vehicle(BEV)home charging window(30%to 85%state of charge(SOC))is less than 22 mV for the first three use cases across all *** SOH estimated from the reconstructed OCV exhibits an mean absolute per.entage error(MAPE)below 2.2%for these *** study further investigates the impact of the source domain on TL by incorporating two additional synthetic datasets,a lithium iron phosphate(LFP)cell and an entirely artificial,non-existing,cell,showing that solely the shifting and scaling of gradient changes in the charging curve suffice to transfer knowledge,even between different cell chemistries.A key limitation with respect to extrapolation capability is identified and evidenced in our fourth use case,where the absence of such comprehensive data hindered the TL process.

关键词： Lithium-ion battery State of health estimation Transfer learning OCV curve Partial charging Synthetic data

Are school uniforms associated with gender inequalities in physical activity? A pooled analysis of population-level data from 135 countries/regions

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journal of Sport and Health Science 2024年第4期13卷 590-598页

作者： Mairead ryan Luiza I.C.ricardo Nicole Nathan riikka hofmann Esther van Sluijs Medical research Council Epidemiology Unit University of CambridgeCambridge CB20QQUK Faculty of Education University of CambridgeCambridge CB28PQUK Hunter New england Population Health WallsendNSW 2287Australia School of Medicine and Public Health College of HealthMedicine and WellbeingUniversity of NewcastleCallaghanNSW 2308Australia Hunter Medical research Institute New Lambton HeightsNSW 2305Australia National Centre of Implementation Science University of NewcastleCallaghanNSW 2308Australia

Purpose:It is aimed to assess whether school uniforms are associated with population-level gender inequalities in physical activity,and whether associations differ by school level,country/region income,and assessment ***:An ecological study design was *** collected data about global uniform practices using an online *** searched for country/region-level estimates of school-aged youth meeting physical activity guidelines from international surveillance *** selection was conducted in duplicate using a systematic process,and a random sample of all data was checked to ensure extraction and pooling processes were *** calculated absolute and relative gender inequalities in physical activity for each *** regression examined associations between country/region-level uniform practices(binary yes/no exposure variable) and country/region-level gender inequalities in physical activity guideline compliance(absolute and relative inequalities).We investigated moderation by school level,stratified analyses by income group,and repeated primary analyses using device-measured ***:Pooling data from 135 countries/regions(n=1,089,852),we found no association between population-level uniform practices and gender inequalities in physical activity across all ages(absolute:β=-0.2;95% confidence interval(95%CI):-1.7 to 1.3,p=0.74;relative:β=0.1;95%CI:-0.1 to 0.2,p=0.51).Subgroup analysis suggested a positive association in primary school settings(absolute:β=4.3;95%CI:-0.0 to 8.6,p=0.05).Among high-income countries,absolute inequalities were significantly greater in countries/regions with uniform practices(N=37) compared to those without(N=48)(9.1(SD=3.6) vs.7.8 per.entage points(SD=4.3)).repeating analyses using device-measured data(n=32,130;N=24) did not alter our primary *** initial descriptive statistics,we found that in countries/regions where a maj ority of schools(>50%) reportedly use uniforms,there was lower compli

关键词： School policy Clothing Child Adolescent Accelerometer

The Silk roads: phylogeography of Central Asian dice snakes (Ser.entes: Natricidae) shaped by rivers in deserts and mountain valleys

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Cur.ent Zoology 2024年第2期70卷 150-162页

作者： Daniel jablonski Konrad Mebert rafaqat Masroor Evgeniy Simonov Oleg Kukushkin Timur Abduraupov Sylvia hofmann Department of Zoology Comenius University in BratislavaBratislavaSlovakia Global Biology BirrSwitzerland Pakistan Museum of Natural History ShakarparianIslamabadPakistan Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscowRussia T.I.Vyazemski Karadag Scientific Station-Nature reserve—Branch of A.0.Kovalevsky Institute of Biology of the Southern Seas TheodosiaCrimea Zoological Institute of the rAS Saint PetersbourgRussia Institute of Zoology Academy of Sciences of the Republic of UzbekistanYunusabadTashkentUzbekistan Museum Koenig Bonn LIBLeibniz Institute for the Analysis of Biodiversity ChangeBonnGermany UFZ-Helmholtz Centre for.environmental research Department of Conservation BiologyPermoserstrasse 1504318 LeipzigGermany

Influenced by rapid changes in climate and landscape features since the Miocene,widely distributed species provide suitable models to study the environmental impact on their evolution and cur.ent genetic *** dice snake Natrix tessellata,widely distributed in the Western Palearctic is one such *** aimed to resolve a detailed phylogeography of *** with a focus on the Central Asian clade with 4 and the Anatolia clade with 3 mitochondrial lineages,trace their origin,and correlate the environmental changes that affected their distribution through *** expected time of diver.ence of both clades began at 3.7 Mya in the Pliocene,reaching lineage differentiation approximately 1 million years *** genetic diversity in both clades is rich,suggesting different ancestral areas,glacial refugia,demographic changes,and colonization *** Caspian lineage is the most widespread lineage in Central Asia,distributed around the Caspian Sea and reaching the foothills of the Hindu Kush Mountains in Afghanistan,and Eastern European lowlands in the *** distribution is limited by deserts,moun-tains,and cold steppe ***,Kazakhstan and Uzbekistan lineages followed the Amu Darya and the Syr Darya water systems in Central Asia,with ranges delimited by the large Kyzylkum and Karakum *** the western side,there are several lineages within the Anatolia clade that converged in the central part of the peninsula with 2 being endemic to Western *** distribution of both main clades was affected by expansion from their Pleistocene glacial refugia around the Caspian Sea and in the valleys of Central Asia as well as by environmental changes,mostly through aridification.

关键词： biogeography colonization Eurasia genetic diversity mitochondrial DNA Paratethys refugia water snakes.

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氢能技术的成功无需怀疑

现代制造 2024年第7期 32-34页

作者： Benedikt hofmann 不详

Lauda ***有限两合公司是一家专注于温度精确控制技术的专业厂。十多年时间里,Lauda公司一直致力于氢能技术的研究开发。在接受本刊记者的采访时,Lauda两合公司的业务发展经理jasper Laug先生介绍了氢能技术的最大机遇在哪里,介绍了工... 详细信息

Lauda ***有限两合公司是一家专注于温度精确控制技术的专业厂。十多年时间里,Lauda公司一直致力于氢能技术的研究开发。在接受本刊记者的采访时,Lauda两合公司的业务发展经理jasper Laug先生介绍了氢能技术的最大机遇在哪里,介绍了工业企业为什么要开发氢能技术。

关键词：两合公司专业厂控制技术氢能技术

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用智能化对抗劳动力缺乏

现代制造 2024年第6期 36-38页

作者： Bendikt hofmann 不详

对Hückeswagen市Förster&Krause公司的专家来讲,如何在Frank Flechtwaren公司的物流项目中把现代化的物流解决方案、现代化技术和符合“人体工程学原理”的物流工作场合相互结合在一起、解决缺乏劳动力的难题才是最重要的。尽管有各种... 详细信息

对Hückeswagen市Förster&Krause公司的专家来讲,如何在Frank Flechtwaren公司的物流项目中把现代化的物流解决方案、现代化技术和符合“人体工程学原理”的物流工作场合相互结合在一起、解决缺乏劳动力的难题才是最重要的。尽管有各种各样的危机报警、危机提示,但网上购物仍然可能实现大幅度的增长。目前,室内装饰领域中的网上商店正在蓬勃发展,这也要归功于社交媒体上许多成功者的大力宣传。

关键词：人体工程学原理物流项目物流解决方案网上商店室内装饰社交媒体网上购物大力宣传

Quantitative Absolute Continuity of Harmonic Measure and the Dirichlet Problem: A Survey of recent Progress

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Acta Mathematica Sinica,english Series 2019年第6期35卷 1011-1026页

作者： Steve hofmann Department of Mathematics University of Missouri

It is a well-known folklore result that quantitative, scale invariant absolute continuity(more precisely, the weak-A∞ property) of harmonic measure with respect to surface measure, on the boundary of an open set Ω ? r^(n+1) with Ahlfors–David regular boundary, is equivalent to the solvability of the Dirichlet problem in Ω, with data in L^p (?Ω) for some p rawing an analogy to the famous Wiener criterion, which characterizes the domains in which the classical Dirichlet problem, with continuous boundary data, can be solved, one may seek to characterize the open sets for which L^psolvability holds, thus allowing for singular boundary *** has been known for some time that absolute continuity of harmonic measure is closely tied to rectifiability properties of ?Ω, but also that rectifiability alone is not sufficient to guarantee absolute continuity. In this note, we survey recent progress in this area, culminating in a geometric characterization of the weak-A∞ property, and hence of solvability of the L^p Dirichlet problem for some finite p. This characterization, obtained under rather optimal background hypotheses, follows from a combination of the present author's joint work with Martell, and the work of Azzam, Mourgoglou and Tolsa.

关键词： Harmonic measure Poisson kernel uniform rectifiability weak local john condition big pieces of chord-arc domains Carleson measures

review of accelerator driven heavy ion nuclear fusion

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Matter and radiation at Extremes 2018年第1期3卷 1-11页

作者： Ingo hofmann GSI Helmholtzzentrum fur Schwerionenforschung GmbH Planckstr64291 DarmstadtGermany

Using high energy accelerators for.energy production by nuclear fission goes back to the 1950's with plans for“breeder accelerators”as well as with early ideas on subcritical reactors,which are cur.ently pursued in China and other ***,fusion came in,when the idea emerged in the mid 1970's to use accelerators and their highly time and space compressed beams in order to generate the extremely high density and temperatures required for inertial fusion energy *** to the higher repetition rates and efficiencies of accelerators,this was seen as a promising alternative to using high power *** an introduction to nuclear fission applications of accelerators,this review summarizes some of the scientific developments directed towards this challenging application e with focus on the European HIDIF-study-and outlines parameters of future high energy density experiments after construction of the FAIr/Germany and HIAF/China heavy ion accelerator projects.

关键词： repetition accelerator heavy