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Evaluation of Dissolved Organic carbon Using Synchronized Fluorescence Emission Spectra and Unsupervised Method of Principal component Analysis (PcA) and Independent component Analysis (IcA)

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journal of Water Resource and Protection 2019年第3期11卷 244-279页

作者： Tais cristina Filippe Luana Mayumi Takahasi Marques Heloise G. Knapik júlio césar rodrigues de azevedo jorge costa Pereira department of chemistry and Biology Federal University of Technology—Paraná Curitiba Brazil department of Hydraulic and Sanitation Federal University of Technology—Paraná Curitiba Brazil department of chemistry University of Coimbra Coimbra Portugal

Dissolved organic matter (DOM) can be originated from autochthonous or allochthonous sources, where allochthonous DOM can be from pedogenic sources (humic substances—HSs) or anthropogenicsources (wastewater). The analysis of fluorescence emission, excitation, synchronous or excitation-emission matrix (EEM) have been used to identify the main source or probable contribution of dissolved compounds, such as humic acids (HA), fulvic acids (FA) and dissolved organic carbon (DOc) from sewage, but does not quantify. Fluorescence emission is a powerful technique to detect and qualify organic dissolved compounds but fails in quantitative aspects. In this work, we propose an in situ method for direct determination of DOc using synchronous fluorescence spectra with independent component analysis (IcA). Well known standard solutions were used for method development and validation. In this work, we show that it is possible to predict the number of independent contributions using an unsupervised method based on iterative Principal component Analysis and Independent component Analysis (PcA-IcA) approach over combined matrix results. Within these results it’s also possible to see that with a very small amount of independent components it is possible to describe environmental samples of HA, FA and primary productivity (PP).

关键词： Independent component Analysis Dissolved Organic carbon Spectra deconvolution Synchronized Fluorescence

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Use of caffeine for the Evaluation of the Anthropic Influence over the Upper and Middle Iguaçu River Basins

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journal of Water Resource and Protection 2022年第3期14卷 273-291页

作者： Bruna Scipioni Márcia cristiane Kravetz Andrade Luis Otávio Miranda Peixoto Alinne Mizukawa Tais cristina Filippe júlio césar rodrigues de azevedo Programa de Pós-Gradua&ccedil &atilde o em Engenharia de Recursos Hídricos e Ambiental Universidade Federal do Paraná Curitiba Brasil Universidade Tecnológica Federal do Paraná Curitiba Brasil

Many parameters are usually used as gauges to describe water quality worldwide, such as the concentrations of phosphorus, forms of nitrogen, dissolved oxygen (DO), among others. Though legislative limits for the concentrations of these substances are in place, such is not the case for caffeine. caffeine is a pharmacologically active alkaloid, from the xanthine group, which can be used as a chemical tracer for anthropic influence over water resources. The objective of this study was to analyze the pollution indicators over the Igua?u River, one of the main rivers in Southern Brazil, through the examination of nutrients, DO and their correlations to caffeine. The water samples were collected from 10 sampling sites along the river course, unevenly spaced to better represent the different environmental scenarios present in its basin, extracted from 2014 to 2017. caffeine was detected and quantified through high-efficiency liquid state chromatography. Results show that both nutrient and caffeine concentrations increased in intensely urbanized areas, specially from IG2 to IG5 sampling sites. Downstream from IG6 the contaminant concentrations decreased mainly due to higher river flows and lower population density. caffeine was detected in 82% of the samples, indicating that most of the sampling sites were under anthropic influence.

关键词： Water Resources Water Quality caffeine Urban Areas

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Foot reflexology in autoimmune diseases:Effectiveness and mechanisms

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World journal of clinical cases 2025年第7期13卷 1-5页

作者： jozélio Freire de carvalho Aaron Lerner carina Benzvi Núcleo de Pesquisa em Doenças crônicas não Transmissíveis Federal University of BahiaSalvador 40231-300BahiaBrazil department of Research Chaim Sheba Medical CenterThe Zabludowicz Research Center for Autoimmune DiseasesRamat Gan 52621Israel

Foot reflexology(FR)is a chinese-originated and non-invasive complementary therapy increasingly used by functional,alternative and para-medical *** attempts are made to study FR in non-functional organic *** present invited Editorial discusses the application of FR in autoimmune diseases(AD),highlighting a few successful studies demonstrating symptomatic relief and objective *** promising results,the FR domain remains under-investigated and an urgent need to confirm and understand the effect of FR in chronic diseases,including AD,is highly recommended.

关键词： Reflexology Foot reflexology Sensorineural hearing loss Autoimmune diseases Autoimmunity

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Importance of neonatal screening:A case study of sickle cell disease and cystic fibrosis coexistence

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World journal of clinical Pediatrics 2025年第1期14卷 113-118页

作者： Nathalia Noyma Sampaio Magalhães Lucas Barra Mathiasi Daniela de Oliveira Werneck rodrigues department of Pediatrics Faculdade de Ciências Médicas e da Saúde de Juiz de ForaJuiz de Fora 36033-003Brazil department of Internal Medicine Rede D'Or Rio de JaneiroRio de Janeiro 22270-010Brazil department of Hematology Fundação HemominasJuiz de Fora 36010-560MGBrazil department of Internal Medicine Universidade Presidente Antônio Carlos-Faculdade de Medicina Juiz de ForaJuiz de Fora 36010-560Minas GeraisBrazil

BAcKGROUND Neonatal screening(NS)is a public health policy to identify genetic pathologies such as cystic fibrosis(cF),sickle cell disease,and other *** cell disea-se is the comprehensive term for a group of hemoglobinopathies characterized by the presence of hemoglobin *** is an autosomal recessive multisystemic disease with pathophysiology involving deleterious mutations in the transmembrane re-gulatory gene that encodes a protein that regulates the activity of chloride and sodium channels in the cell surface *** is crucial for early diagnosis and management,which ensures a better quality of *** To report a case of the coexistence of sickle cell anemia(ScA)and cF and perform an integrative literature *** This is an observational study and a review of the literature focusing on two rare genetic pathologies identified simultaneously in NS from the perspective of a clinical *** authors identified only 5 cases of ScA associated with *** clinical trials or review articles were identified considering the rarity of the coexistence of these two *** Herein,the authors reported the case of a girl who after undergoing NS on day 8 of life was diagnosed with ScA with an alteration in the dosage of immunoreactive *** diagnosis of cF was confirmed by the coulometry Sweat *** rarity of the co-occurrence of these two severe genetic pathologies(cF and ScA)is a challenge for medical *** This study adds to the few case reports present in the literature that highlight the identification of two severe diseases via NS.

关键词： Sickle cell disease Sickle cell anemia children cystic fibrosis Neonatal Screening case reports

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Growth mechanism of octahedron-like BaMoO_4 microcrystals processed in microwave-hydrothermal:Experimental observations and computational modeling

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Particuology 2009年第5期7卷 353-362页

作者： Laécio Santos cavalcante júlio césar Sczancoski Rircado Luis Tranquilin josé Arana Varela Elson Longo Marcelo Ornaghi Orlandi departamento de Química UFSCarP.O. Box 67613565-905So CarlosSPBrazil Instituto de Química-UNESP P.O. Box 35514801-907AraraquaraSPBrazil

Octahedron-like BaMoO4 microcrystals were synthesized by the co-precipitation method at room temperature and processed in microwave-hydrothermal at 413 K for different times （from 30 min to 5 h）. These microcrystals were analyzed by X-ray diffraction （XRD）, field-emission gun scanning electron microscopy （FEG-SEM） and transmission electron microscopy （TEM）. XRD patterns showed that this material presents a tetragonal structure without the presence of deleterious phases. FEG-SEM and TEM micrographs revealed that the BaMoO4 microcrystals present an octahedron-like morphology with agglomerate nature and polydisperse particle size distribution. These micrographs also indicated that the microcrystals grow along the [0 01 ] direction. The observed crystallographic planes in these structures were modeled computationally and a crystal growth model was proposed in order to explain the morphological changes as a function of processing time.

关键词： BaMoO4 Growth process Microwave-hydrotherma Supersaturated solution

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Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease

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Neural Regeneration Research 2023年第12期18卷 2611-2614页

作者： júlio césar claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto camilla Teixeira Pinheiro Gusmão Gerly Anne de castro Brito Glauce Socorro de Barros Viana christus University center-UNIcHRISTUS FortalezaCEBrazil Postgraduate Program in Morphofunctional Sciences Federal University of Ceará-UFCFortalezaCEBrazil Universidade católica de Brasília-UcB BrasíliaDFBrasil Postgraduate Program in Physiology and Pharmacology department of the Federal University of ceará-UFc FortalezaCEBrazil Physiology and Pharmacology department of the Federal University of ceará-UFc FortalezaCEBrazil

This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's *** vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of *** can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous *** and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment *** findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's *** studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit.

关键词： alpha-synuclein enteric microbiota gastrointestinal tract Parkinson's disease vagus nerve

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creeping fat and gut microbiota in crohn’s disease

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World journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen cS de Oliveira Luiz c Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of crohn’s disease(cD).cD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in cD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing cD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and cD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with cD.

关键词： creeping fat Mesenteric adipose tissue Gut microbiota crohn’s disease Inflammatory bowel disease

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ENSO impacts on litter stocks and water holding capacity in secondary forests in eastern Amazonia

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journal of Forestry Research 2024年第1期35卷 83-89页

作者： julia Isabella de Matos rodrigues Walmer Bruno Rocha Martins Victor Pereira de Oliveira Myriam Suelen da Silva Wanzerley Hélio Brito dos Santos júnior Francisco de Assis Oliveira Graduate Program in Forestry Sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Institute of Amazonia Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Among the impacts of climate change,there is the intensification of phenomena such as the El Niño South-ern Oscillation(ENSO)responsible for El Niño and La Niñ***,understanding their effects on the functional pro-cesses of forests is ***,this study evaluated the effects of ENSO on litter stock and water holding capac-ity(WHc)in a successional forest in eastern *** occurred in periods with the most rainfall in El Niño(2019)and least in La Niña(2021)*** permanent plots were used to sample *** effects were evident for WHc,higher during El Niñ***,this influence was not clear for litter,as only in the rainy season effects were *** was a positive correlation of WHc with precipitation and humidity,while litter stocks were negatively correlated with temperature and wind *** the subject of this study requires long-term assessments,preliminary results suggests that,depending on the intensity of ENSO,forest functional processes can be strongly impacted and *** conclusion reinforces warnings by the scientific community about the impacts of climate change on the maintenance of litter stocks,decomposition and,consequently,the biogeochemical cycle and essential ecosystem services for the maintenance of Amazonia *** need to develop long-term research to understand the effects of climatic change on litter stocks and water holding capacity is highlighted,especially in Amazonia.

关键词： Seasonality climate change Succession ecosystem Biogeochemical cycle Amazonia biodiversity

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy department of Surgery Morehouse School of MedicineAtlantaGAUSA department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA department of Pediatrics Emory UniversityAtlantaGAUSA department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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Neutrino masses,cosmological inflation and dark matter in a variant U(1)B-L model with type II seesaw mechanism

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chinese Physics c 2021年第2期45卷 621-630页

作者： j.G.rodrigues A.c.O.Santos j.G.Ferreira jr c.A.de S.Pires departamento de Física Universidade Federal da ParaíbaCaixa Postal 500858051-970João PessoaPBBrasil departamento de Física Universidade Federal do Rio Grande do Norte59078-970NatalRNBrasil

In this study,we implemented the type Ⅱ seesaw mechanism into the framework of the U(l)B-L gauge *** achieve this,we added a scalar triplet,A,to the canonical particle content of the U(l)B-Lgauge *** imposing that the U(l)B-L gauge symmetry be spontaneously broken at TeV scale,we show that the type Ⅱ seesaw mechanism is realized at an intermediate energy scale,more precisely,at approximately 109 *** prevent heavy right-handed neutrinos from disturbing the mechanism,we evoke a Z2 discrete ***,as a result,we have standard neutrinos with mass around eV scale and right-handed neutrinos with mass in TeV scale,with the lightest one fulfilling the condition of dark *** developed all of these in this *** addition,we show that the neutral component of Δ may perform unproblematic non-minimal inflation with loss of unitarity.

关键词： models beyond the standard model particle-theory and field-theory models of the early universe neutrino mass and mixing

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