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Clinical Experience with Generic Rasagiline (Ralago<sup>®</sup>) in Patients with Parkinson’s Disease: An Open-Label, Multicenter, Observational Study

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Advances in Parkinson's Disease 2019年第2期8卷 18-34页

作者： Dávid Pintér júlia lajtos józsef janszky Norbert Kovács Doctoral School of Clinical Neuroscience University of Pécs Pécs Hungary Kenézy Hospital Debrecen Hungary Department of Neurology University of Pécs Pécs Hungary MTA-PTE Clinical Neuroscience MR Research Group Pécs Hungary

Background: Antiparkinsonian pharmacotherapy represents one of the most important expenses related to Parkinson’s disease. The application of generic drugs may help to reduce the economic burden of the disease;however, efficacy and safety of these products have been less studied. Objective: To investigate the efficacy and safety of generic rasagiline (Ralago?) from a clinical perspective. Methods: The Clinical Global Impression of Severity scale was used to rate the most important motor and non-motor symptoms at baseline and 12 weeks after the initiation of Ralago?. Patients also identified symptoms which were the main sources of their disability and distress in everyday life. Results: A total of 499 patients were enrolled (231 females, mean age: 73.2 ± 9.1 years, mean duration of disease: 3.6 ± 3.7 years). Of them, 486 patients completed the study protocol. Both motor and non-motor symptoms showed improvement during 12-week Ralago? treatment. Adverse events were rare, and the majority of them were not considered as serious. Conclusions: The generic rasagiline (Ralago?) is an effective and safe generic product.

关键词： Parkinson’s Disease Rasagiline Generic Antiparkinsonian Drugs Health-Related Quality of Life

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