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Storylines of family medicine Ⅴ:ways of thinking—honing the therapeutic self

Family Medicine and Community Health 2024年第S3期12卷 43-51页

作者： William b Ventres Leslie A Stone johanna F Shapiro Cynthia Haq jéssic. r b leao Donald E Nease jr Liz Grant Stewart W Mercer john C M Gillies Pablo González blasco Maria Auxiliadora C De benedetto Graziela Moreto Marcelo r Levites jennifer E DeVoe William r Phillips jane M Uygur Thomas r Egnew Colette S Stanley Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of California Irvine School of MedicineIrvineCaliforniaUSA Faculty of Medicine University of Sao PauloSao PauloBrazil Family Medicine University of Colorado Anschutz Medical Campus School of MedicineAuroraColoradoUSA Usher Institute Edinburgh Medical SchoolUniversity of EdinburghEdinburghUK SObrAMFA-Medical Education and Humanism Sao PauloBrazil Family Medicine Oregon Health&Science University School of MedicinePortlandOregonUSA Family Medicine University of Washington School of MedicineSeattleWashingtonUSA General Practice Royal College of Surgeons in IrelandDublinIreland General Internal Medicine Geriatrics&Palliative MedicineTulane University School of MedicineNew OrleansLouisianaUSA

Storylines of Family Medicine is a 12-part series of thematically linked essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅴ:ways of thinking—honing the therapeutic self’,authors present the following sections:‘reflective practice in action’,‘The doctor as drug—balint groups’,‘Cultivating compassion’,‘Towards a humanistic approach to doctoring’,‘Intimacy in family medicine’,‘The many faces of suffering’,‘Transcending suffering’and‘The power of listening to stories.’May readers feel a deeper sense of their own therapeutic agency by reflecting on these essays.

关键词： illustration dimensions suffering

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Canopy Management of Table Grapes Cultivar in Tropical Conditions

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journal of Agricultural Science and Technology(b) 2018年第4期8卷 228-233页

作者： Patricia Coelho de Souza leao Maria Auxiliadora Coelho Lima Embrapa Semiarido BR 428 Km 152 Zona Rural Petrolina PE PO Box 23 Zip Code 56.302-970 Brazil

The production of some seedless table grapes under tropical conditions presents low bud fertility on the main canes and low yield, which leads to the need of pruning in the lateral shoots. The objective of this study was to evaluate the influence of the canopy management for the formation of lateral shoots associated with dellsity of canes on the yield and quality of grapes ＂Sugraone＂ in the Sao Francisco Valley. The experiment was carried out over two growing seasons （2011-2012） in a commercial vineyard of Sugraone in Petrolina, Pernambuco state, brazil. The treatments consisted of two canopy managements （shoot topping associated to elimination of lateral shoots and shoot topping and formation of lateral shoots） combined with two to three densities of canes after pruning （1.8, 2.8 and 3.8 canes/m^2）. The formation of ＂lateral shoots＂ increased yield and number of clusters per plant during two consecutive growing seasons, besides using 2.8 varas/m^2 resulted in highest yields only in 2011 growing season. The variables mass bunch, mass berry, soluble solids （SS）, soluble sugar, titxatable acidity （TA） and pulp firmness were not affected by treatments, while the attributes related to color, as like brightness and hue angle of the skin, and total extractable polyphenols content were influenced by canopy management, especially in the 2012 growing season. Shoot topping to induce formation of laterals shoots associated with density of 2.8 canes/m2 increased the yield of seedless grapes cultivar Sugraone grown in the Sao Francisco Valley, not significantly affecting the quality of the grape.

关键词： Vitis vinifera L. seedless grapes tropical viticulture.

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Novel Cancer Treatment Using Targeted Delivery of Short-Lived radiologically Activated Nanoparticles

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journal of Health Science 2019年第1期7卷 43-47页

作者： P.L.Andrade j.b.leao Núcleo de Engenharias Centro Universitário Boa Viagem Wyden Recife-PE 51200-060 Brazil NIST Center for Neutron research National Institute of Standards and Technology Gaithersburg Maryland 20899 USA

The goal of our preliminary study is to show that a minimal of overall body toxicity while maximizing the cancer tumor treatment may be achieved in a novel approach where minute amounts of coated nanoparticles may be radiologically activated prior to treatment and“coerce”tumor cells into readily absorb these *** targeted intracytoplasmic delivery of short-lived radiologically activated nanoparticles could provide less“whole-body”radiation dose while delivering a short lived potent tumor localized dose,along with their low toxicity may prove to be another tool in the treatment of diverse cancers.

关键词： Nanoparticles neutron activation irradiation cancer metabolism Warburg effect glutamine glucose

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Evaluation of Some New Wine Grape Cultivars under S^o Francisco Valley Conditions

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journal of Agricultural Science and Technology(b) 2017年第5期7卷 320-325页

作者： Patricia Coelho de Souza leao bruna Thais Goncalves Nunes Emille Mayara Carvalho de Souza jessic. Islane de Souza rego jose Henrique bemardino do Nascimento Embrapa Semifrido BR 428 Km 152 Zona Rural PO Box 23 Petrolina 56302-970 Pernambuco State Brazil Universidade de Pernambuco (UPE) Petrolina 56302-970 Pernambuco State Brazil

This study aimed to evaluate the performance and characteristics of the grapes as subsidies to the recommendation of new wine grape cultivars for the S^o Francisco Valley. An experiment was carried out in Petrolina, Pernambuco state, during four seasons in 2014 and 2015 and the treatments were represented by 10 cultivars and three breeding selections： Grenache, Tempranillo, Merlot, Cabernet Sauvignon, Malbec, Petit Verdot and Syrah for red wines and Sauvignon blanc, Chardonnay, Chenin blanc and breeding selections 46, 14 and 47 for white wines. The experimental design was a randomized block with four replicates and two useful plants per plot. The following variables were evaluated： sprouting, bud fertility rate, ravaz index, production, number of clusters, weight, length and width of cluster, weight and volume of 100 berries, soluble solids and titratable acidity. A better balance between production and vigour was obtained in Grenache, Merlot and Tempranillo cultivars, presenting values of 7.56, 6.50 and 5.93, respectively, for ravaz index. Grenache, Chenin blanc and Tempranillo were the most productive cultivars with average yields estimated at 10.4, 8.7 and 8.4 ton/ha/season. Selection 14 had longer, wider and less compact clusters, which can reduce clusters rottenness. The percentage of sprouting ranged from 38.13% in selection 14 to 77.6% in cv. Chenin blanc. The average index of bud fertility was 0.79 cluster/bud, with no significant differences among cultivars. Greater potential for sugar accumulation was found in the selections 14, 46 and 47, while the titratable acidity ranged from 0.63% in cv. Merlot to 0.89% in selection 47. Grenache and Tempranillo have showed potential to obtain adequate yield and balanced vines, while Sauvignon blanc, Chardonnay, Cabemet Sauvignon, Malbec and Petit Verdot presented low yield being necessary to select clones more productive and well adapted to the tropical conditions. Further information about the quality of grapes and w

关键词： Tropical viticulture wine grape yield.

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Subversion of cellular stress responses by poxviruses

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World journal of Clinical Infectious Diseases 2014年第4期4卷 27-40页

作者： Thiago Lima leao Flávio Guimaraes da Fonseca Laboratório de Virologia básica e Aplicada Departamento de Microbiologia Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Belo Horizonte MG 31270-901 Brasil

Cellular stress responses are powerful mechanisms that prevent and cope with the accumulation of macromolecular damage in the cells and also boost host defenses against pathogens. Cells can initiate either protective or destructive stress responses depending, to a large extent, on the nature and duration of the stressing stimulus as well as the cell type. The productive replication of a virus within a given cell places inordinate stress on the metabolism machinery of the host and, to assure the continuity of its replication, many viruses have developed ways to modulate the cell stress responses. Poxviruses are among the viruses that have evolved a large number of strategies to manipulate host stress responses in order to control cell fate and enhance their replicative success. remarkably, nearly every step of the stress responses that is mounted during infection can be targeted by virally encoded functions. The fine-tuned interactions between poxviruses and the host stress responses has aided virologists to understand specific aspects of viral replication; has helped cell biologists to evaluate the role of stress signaling in the uninfected cell; and has tipped immunologists on how these signals contribute to alert the cells against pathogen invasionand boost subsequent immune responses. This review discusses the diverse strategies that poxviruses use to subvert host cell stress responses.

关键词： Poxvirus Cell stress response Heat shock response Chaperones Unfolded protein response Host translational control Hypoxia Oxidative stress DNA damage

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Carryover Effect of Imidazolinone Herbicides for Crops Following rice

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American journal of Plant Sciences 2014年第8期5卷 1049-1058页

作者： L.O.Santos j.j.O.Pinto L.b.Piveta j.A.Noldin L.Galon G.Concenco Plant Health Department Federal University of PelotasCapao do LeaoBrazil ItajaíExperimental Station Santa Catarina State Institution for Agricultural Research and Extension(Epagri)ItajaiBrazil Plant Science Department Federal University of the Southern BorderErechimBrazil Weed Science Embrapa Western AgricultureDouradosBrazil

We aimed with this study to evaluate the effects of residual activity in soil of formulated mixtures of the herbicides imazethapyr + imazapic and imazapyr + imazapic on ryegrass and on rice cultivars, IrGA 424 and brS Querencia. Two experiments were conducted under greenhouse in randomized blocks design with four replications in split-plot and split-split-plot designs, respectively for the first (E1) and second (E2) experiments. For E1, main plots allocated herbicides (imazethapyr + imazapic and imazapyr + imazapic), and subplots the doses [(0, 0.5, 1.0, 1.5 and 2.0 fold the label dose of imazethapyr + imazapic (1 L·ha-1) and imazapyr + imazapic (140 g·ha-1) plus 0.5% of the adjuvant Dash→)];for E2, sub-subplots allocated rice cultivars (brS 424 and IrGA Querência). Phytotoxicity, plant height and shoot dry weight (E1 and E2) and plant stand (E2) were evaluated. results showed that the annual ryegrass and rice cultivars IrGA 424 and brS Querencia are sensitive to imazethapyr + imazapic and imazapyr + imazapic, serving as bioindicators of its residual activity in soils following Clearfield→rice. Imazapyr + imazapic, applied post-emergence in irrigated rice at doses of 1.0, 1.5 and 2.0× the label dose, present longer residual activity in soil compared to imazethapyr + imazapic for ryegrass and non-Clearfield→rice.

关键词： Clearfield Imidazolinones Soil Persistence Oryza sativa

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Ursolic Acid Derivatives Induced Apoptosis and reduces the NF-κb in Human Lung Adenocarcinoma Cells

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journal of Cancer Therapy 2019年第10期10卷 863-876页

作者： Elaine Carlos Scherrer Ydia Mariele Valadares Caio Cesar Souza Alves Gabriella Freitas Ferreira Marcela Pereira leao jessic. Aline Soares Fernando Sa Silva Alessandra Paula Carli Oswaldo Cardoso jr. Fabiana Simao Machado Sandra bertelli ribeiro Castro Life Sciences Institute Federal University of Juiz de ForaGovernador ValadaresMGBrazil Faculty of Medicine Federal University of the Valleys of Jequitinhonha and MucuriTeofilo OtoniMGBrazil Department of biochemistry and Immunology Federal University of Minas GeraisBelo HorizonteMGBrazil

Lung cancer is the major cause of death in the neoplastic diseases. In spite of the advances in the chemotherapy, the lung cancer treatments are still complex and costly, being necessary the seeking of new drugs. In this context, the ursolic acid (UA) becomes the target of studies that investigate its antitumor potential and, thus, structural modifications can enhance its biological activities. Eight UA semisynthetic derivative compounds (UAD1-8) were synthesized and evaluated their cytotoxic activity against human alveolar adenocarcinoma cells (A549). UAD1, UAD3, UAD5, UAD6 and UAD8 were able to reduce the viability of the A549 cells. Only UAD1 and UAD6 reduced the viability at 24 h, and only UAD3 didn’t reduce the NF-κb expression. The compound UAD1 showed the greater apoptosis induction. Moreover, the compound UAD1 showed better results than UA in all assays. The present study shows, for the first time, the action of these compounds in the apoptotic effect, in the expression of NF-κb and in the A549 cell line. The ursolic acid derivatives showed substantial results in the apoptosis, cytotoxicity and NF-κb inhibition of A549 cells, and further studies are necessary for the development of possible new therapeutic drugs.

关键词： Ursolic Acid Apoptosis NF-κb A549 Cells Tumoral

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HELLP综合征引起的肝破裂的特点及治疗

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世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 10-10页

作者： Araujo A.C.P.F. leao M.D. Nobrega M.H. S.M.b. jeronimo 张新艳 Health Graduating Program Health Sciences Center Dr.

Objective: The purpose of this study was to review the management of hepatic rupture caused by HELLP(hemolysis, elevated liver enzymes, and low platelet count) syndrome and to assess maternal and perinatal outcomes of these cases. Study design: A retrospective study of HELLP syndrome cases that were complicated by hepatic rupture was conducted. results: Ten cases of hepatic rupture were identified. The median maternal age was 42.5±5.9 years(median±SD), and the median gestational age at delivery was 35.5±4.9 weeks. The most frequent signs and symptoms of hepatic rupture were the sudden onset of abdominal pain, acute anemia, and hypotension. Laboratory findings included low platelet count and increased hepatic enzymes. Surgery was performed in 9 cases. One case was treated nonsurgically. The maternal mortality rate was 10%, and the perinatal mortality rate was 80%. Conclusion: A combination of surgical treatment with hepatic artery ligation and omental patching with supportive measures was effective in decreasing the mortality rate in hepatic rupture caused by HELLP syndrome.

关键词： HELLP 肝破裂肝酶升高围生儿死亡率非外科手术围生期肝动脉结扎研究设计

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