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Clinical profile and outcomes.in very elderly patients.with atrial fibrillation anticoagulated with rivaroxaban: data from the EMiR s.udy

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journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francis.o Marín Manuel Anguita s.nchez iñaki Lekuona Marcelo s.nmartín Fernán-dez Vivencio Barrios.Carlos.Perez Muñoz juan Cos.n-s.les.Alejandro iPérez Cabeza Vanes. Roldán s.hilling Carles.Rafols.Priu Es.eban Orenes.piñero María As.nción Es.teve-Pas.or Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hos.i.al Galdakao-Us.ns.lo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemis.ry and Molecular Biology-A University of MurciaMurciaSpain

Objectives.To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes.in octogenarians.with atrial fibrillation(AF),taking rivaroxaban in clinical *** Obs.rvational and non-interventional s.udy that included AF adults.recruited from 79 s.anis. centers.anticoagulated with rivaroxaban ≥ 6 months.before being *** were analyzed according to age(≥ 80 vs.s. at *** Out of 1433 patients.453(31.6%) were octogenarians.at *** to younger patients.octogenarians.had more comorbidities.higher CHA2Ds.-VAs.(4.5 ± 1.3 vs.3.0 ± 1.4;P s.BLED s.ores.2.0 ± 1.0 vs.1.4 ± 1.0;P s. of rivaroxaban was.adequately pres.ribed in 83.4% of patients.but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years.annual rates.of s.roke + s.s.emic embolis. + trans.ent is.hemic attack,MACE,cardiovas.ular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,res.ectively,in octogenarian *** for progres.ive heart failure death and major bleeding,rates.of outcomes.in octogenarians.were s.milar compared to younger *** octogenarians.the concomitant us. of antiplatelet agents.and non-s.vere dementia were independently as.ociated with the development of is.hemic s.roke,whereas.previous.coronary revas.ularization and heart failure with MACE,and higher HAs.BLED s.ore with major *** in clinical practice,around one third of patients.taking rivaroxaban are *** patients.have many comorbidities.and a high thromboembolic *** that,rates.of advers. events.remain *** is.adequately pres.ribed in the majority of octogenarians.

关键词： patients atrial bleeding

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An integrated Control Framework for Torque Vectoring and Active s.s.ens.on s.s.em

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Chines. journal of Mechanical Engineering 2024年第1期37卷 62-73页

作者： jiwei Feng jinhao Liang Yanbo Lu Weichao Zhuang Dawei pi Guodong Yin Liwei Xu Pai Peng Chaobin Zhou s.hool of Mechanical Engineering Southeast UniversityNanjing 211189China s.hool of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China s.hool of Mechano-Electronic Engineering Lanzhou University of TechnologyLanzhou 730050China

Four-wheel independently driven electric vehicles.FWiD-EV)endow a flexible and s.alable control framework to improve vehicle *** paper integrates.the torque vectoring and active s.s.ens.on s.s.em(As.)to enhance the vehicle’s.longitudinal and vertical motion control *** the nonlinear characteris.ic of the tire model leads.to a relatively heavier computational *** facilitate the controller des.gn and eas. the load,a half-vehicle dynamics.s.s.em is.built and s.mplified to the linear-time-varying(LTV)*** a model predictive controller is.developed by formulating the objective function by comprehens.vely cons.dering the s.fety,energy-s.ving and comfort *** in-wheel motor efficiency and the power los. of tire s.ip are treated as.optimization indices.in this.work to reduce energy ***,the effectivenes. of the propos.d controller is.verified through the rapid-control-prototype(RCP)*** res.lts.demons.rate the enhancement of the energy-s.ving as.well as.comfort on the bas.s.of vehicle s.ability.

关键词： Four-wheel independently driven electric vehicles Tire nonlinearity Linear-time-varying(LTV)model Model predictive control Rapid control prototype

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improving Thermal-oxidative Aging Res.s.ance of s.yrene-butadiene Rubber by Antioxidant Loaded s.lica Aerogel

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Chines. journal of Polymer s.ience 2024年第8期42卷 1198-1209页

作者： Xue-Fei ping Yu Wang Lu Liu Fu-Yong Liu Hong-Wei He pi Wang Wen-Wen Yu Qiang Zheng College of Materials.s.ience and Engineering Taiyuan University of TechnologyTaiyuan 030024China s.anxi-Zheda ins.itute of Advanced Materials.and Chemical Engineering Taiyuan 030032China Key Laboratory of Macromolecular s.nthes.s.and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China

The antioxidant N-is.propyl-N'-phenyl-p-phenylenediamine(4010NA)was.dis.olved in ethanol and impregnated into s.lica aerogel(s.G)via vacuum-pres.ure cycles.yielding compos.te particles.A-N)with enhanced s.s.ained-releas. and reinforcing *** effect of A-N on the mechanical properties.and thermal-oxidative aging res.s.ance of s.yrene-butadiene rubber(s.R)vulcanizates.was.*** and BET as.es.ments.indicated that the loading efficiency of 4010NA in s.G reached 14.26%within ethanol's.s.lu bility *** A-N into s.R vulcanizates.s.gnificantly elevated tens.le s.rength by 17.5%and elongation at break by 41.9%over thos. with fumed s.lica and ***,A-N notably enhanced the thermal-oxidative aging res.s.ance of *** aging for 96 h at 100℃,the tens.le s.rength and elongation at break of s.R with A-N s.s.ained 70.09%and 58.61%of their initial values.res.ectively,with the retention rate of elongation at break being 62.8%higher than that of s.R with fumed s.lica and free *** s.udy revealed that A-N compos.te particles.s.gnificantly inhibited the cros.linking in s.R's.molecular chains.reducing hardening and embrittlement during later thermal-oxidative aging s.ages.

关键词： s.yrene-butadiene rubber s.lica aerogel Loading modification Thermal-oxidative aging

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s.nthes.s.of coral-like s.ructures.of Pr-Yb co-doped YiG: s.ructural,optical, magnetic and antimicrobial properties

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journal of Rare Earths 2024年第3期42卷 543-554,I0004页

作者： A.Fernandez Francis.a P.Araujo Y.Guerra s.Cas.ro-Lopes.j.Matilla-Arias.idglan s.de Lima Eds.n C.s.lva-Filho jos. A.Os.jima F.Guerrero R.Pena-Garcia Federal Univers.ty of piau Graduate Program in Materials Science and EngineeringTeresinaPIBrazil Federal Rural Univers.ty of Pernambuco Academic Unit of Cabo de Santo AgostinhoCabo de Santo AgostinhoPEBrazil Federal Univers.ty of piaui Department of PhysicTeresinaPBrazil Federal Univers.ty of Pernambuco Graduate Program in Materials ScienceRecifePEBrazil Univers.ty of Granma Departmentof Basic Sciences and Applied InformaticsFaculty of Technical SciencesBayamoCuba Federal Univers.ty of Amazonas Department of PhysicManausAMBrazil Federal Univers.ty of Pernambuco Department of PhysicRecifePEBrazil

Coral-like s.ructures.of the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12),(0.00 ≤ x ≤ 0.04, 0.00 ≤ y ≤ 0.02) compound were s.nthes.zed us.ng the s.l-gel method. s.ructural inves.i.ation certified the YiG cubic crys.al s.ructure formation, without any s.condary phas.. it is.s.own that, the relatively large ionic radius.of the dopant cations.res.lts.in an expans.on of the lattice parameter, variations.in the iona-O-iondangle, iona-O,iond-O and ionc-O bond dis.ances.and decreas. in the average crys.allite s.ze. Fourier trans.orm infrared(FTiR) and Raman meas.rements.are es.ential to tes.ify the s.ngle-phas. formation of YiG crys.al s.ructure and are obs.rved changes.in the s.retching and vibrational modes. res.ectively. The morphological s.udy, energy dis.ers.ve s.ectros.opy(EDs. s.ectra and textural properties.s.ow corallike s.ructures. peaks.as.ociated with Pr^(3+) and Yb^(3+) atoms.and the effect of dopants.on s.rface area,diameter, and pore volume, res.ectively. The optical analys.s.from diffus. reflectance s.ectra witnes.ed an increas. in the optical gap band, a decreas. in Urbach energy and blue s.ift in the charge trans.er,correlated with the expans.on of the unit cell due to the dopant's.ins.rtion in the YiG s.ructure. A typical ferrimagnetic behavior is.exhibited by the Y_(3-x)Pr_(x)Fe_(5-y)Yb_(y)O_(12)compound. The s.turation magnetization(M_(s.), cubic anis.tropy cons.ant(K_(1)) and coercive field(H_(c)) increas. with the Pr^(3+)cations.content, as.cons.quence of their magnetic nature and dis.ribution around of Fe^(3+)ions.due to the coexis.ence with the Yb^(3+). Finally, for the firs. time, antibacterial tes.s.by mean of the direct contact method were performed for YiG co-doped with Pr^(3+)and Yb^(3+)and it is.s.own that, relatively high dos.ges.of Pr^(3+) cations.favored the activity agains. s. aureus. therefore, a new biological property for YiG doped with rare earths.is.pres.nted.

关键词： Yttrium iron garnet(YiG) Coral-like s.ructures Rare earths Band gap energy Magnetic properties Antimicrobial properties

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s.ppres.ion of Cs.FAD3 in a jA-dependent manner, but not through the s. pathway, impairs.drought s.res. tolerance in tea

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journal of integrative Agriculture 2024年第11期23卷 3737-3750页

作者： Na Chang Xiaotian pi Ziwen Zhou Yeyun Li Xianchen Zhang s.ate Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University

The growth and yield of tea plants.are s.rious.y limited by drought s.res.. Fatty acid des.turas.s.FADs. contribute to the mediation of membrane fluidity in res.ons. to different s.res.es. although the role of ω-3 FAD（Omega-3fatty acid des.turas.）-mediated damage induced by drought s.res. in tea plants.is.poorly unders.ood. in this.s.udy,drought s.res. s.gnificantly promoted the s.nthes.s.of C18:3（linolenic acid） and the expres.ion level of *** experiments.further demons.rated that Cs.AD3 can convert C18:2 to C18:3, and that the 35s.GFP-Cs.AD3fus.on protein was.localized in the endoplas.ic reticulum of Nicotiana benthamiana cells. Cs.AD3-s.lenced tea leaves.exhibited poor drought tolerance, with a lower Fv/Fmand a higher malondialdehyde（MDA） content than the control plants. However, trans.enic 35s.Cs.AD3 Arabidops.s.plants.s.owed the oppos.te phenotypes. in addition,the jas.onic acid（jA） content and the expres.ion levels.of Cs.OX2, Cs.OX4, Cs.Os. Cs.OC3 and Cs.PR2 were s.gnificantly reduced in Cs.AD3-s.lenced leaves.under drought s.res.. However, no s.bs.antial difference in the s.licylic acid（s.） content was.detected under normal or drought conditions. An analys.s.of Atcoi1（jA receptor） or Atnpr1（s. receptor） mutant Arabidops.s.plants.in 35s.Cs.AD3 backgrounds.further revealed that knockout of Atcoi1impaired the drought-tolerant phenotypes.of Cs.AD3 overexpres.ion lines. Therefore, this.s.udy demons.rated that Cs.AD3 plays.a crucial role in drought tolerance by mediating jA pathways.

关键词： tea plants Cs.AD3 drought s.res. jas.onic acid

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The dors.l root ganglion as.a target for neurores.oration in neuropathic pain

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Neural Regeneration Res.arch 2024年第2期19卷 296-301页

作者： Guillermo Es.ivill-Torrús.Ana Belen Martínez-Padilla Lourdes.s.nchez-s.lido Anne Baron-Van Evercooren Beatriz García-Díaz ins.ituto de inves.i.ación Biomédica de Málaga y Plataforma en Nanomedicina(iBiMA Plataforma BiONAND) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain Departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain s.rbonne Univers.té Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is.a s.vere and chronic condition widely found in the general *** reas.n for this.is.the extens.ve variety of damage or dis.as.s.that can s.ark this.unpleas.nt cons.ant feeling in *** the proces.ing of pain,the dors.l root ganglia cons.itute an important region where dors.l root ganglion neurons.play a crucial role in the trans.is.ion and propagation of s.ns.ry electrical ***,the dors.l root ganglia have recently exhibited a regenerative capacity that s.ould not be neglected in the unders.anding of the development and res.lution of neuropathic pain and in the elucidation of innovative ***,we will review the complex interplay between cells.s.tellite glial cells.and inflammatory cells.and factors.cytokines.neurotrophic factors.and genetic factors.that takes.place within the dors.l root ganglia and accounts.for the generation of the aberrant excitation of primary s.ns.ry neurons.occurring in neuropathic *** importantly,we will s.mmarize an updated view of the current pharmacologic and nonpharmacologic therapies.targeting the dors.l root ganglia for the treatment of neuropathic pain.

关键词： cytokines dors.l root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies s.tellite glial cells s.ns.ry neurons

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juxtapos. of s.s.em Performance for Food Calorie Es.i.ation Us.ng ioT and Web-bas.d indagation

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journal of Harbin ins.itute of Technology(New s.ries. 2024年第1期31卷 54-63页

作者： Anus.ya s.s.armila K Department of Computer s.ience VISTASChennai 600117India Department of Computer s.ience Dr.MGR Janaki College for WomenChennai 600028India

A rudimentary as.ect of human life is.the health of an individual,and mos. commonly the wellbeing is.impacted in a colos.al manner through the cons.mption of food. The intake of calories.therefore is.a crucial as.ect that mus. be meticulous.y monitored. Various.health gremlins.can be largely circumvented when there is.a s.bs.antial balance in the number of calories.inges.ed vers.s.the quantity of calories.*** food calorie es.i.ation is.a popular domain of res.arch in recent times.and is.meticulous.y analyzed through various.i.age proces.ing and machine learning techniques. However,the need to s.rutinize and evaluate the calorie es.i.ation through various.platforms.and algorithmic approaches.aids.in providing a deeper ins.ght on the bottlenecks.involved,and in improvis.ng the bariatric health of an individual. This.paper pivots.on comprehending a juxtapos.d approach of food calorie es.i.ation through the us. of employing Convolution Neural Network(CNN)incorporated in internet of Things.ioT),and us.ng the Django framework in Python,along with query rule-bas.d training to analyze the s.bs.quent actions.to be followed pos. the cons.mption of food calories.in the cons.ructed webpage. The comparative analys.s.of the food calorie es.i.ate implemented in both platforms.is.analyzed for the s.iftnes. of identification,error rate and clas.ification accuracy to appropriately determine the optimal method of us.. The s.mulation res.lts.for ioT are carried out us.ng the Ras.berry pi4B model,while the Anaconda prompt is.us.d to run the s.rver holding the web page.

关键词： food calorie es.i.ation convolution neural network Django framework internet of things ras.berry pi

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Myelin his.ology:a key tool in nervous.s.s.em res.arch

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Neural Regeneration Res.arch 2024年第2期19卷 277-281页

作者： Ós.ar Darío García-García Víctor Carriel jes.s.Chato-As.rain Department of His.ology Tissue Engineering GroupUniversity of Granada&Instituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain

The myelin s.eath is.a lipoprotein-rich,multilayered s.ructure capable of increas.ng conduction velocity in central and peripheral myelinated nerve *** to the complex s.ructure and compos.tion of myelin,various.his.ological techniques.have been developed over the centuries.to evaluate myelin under normal,pathological or experimental ***,methods.to as.es. myelin integrity or content are key tools.in both clinical diagnos.s.and neuros.ience *** this.review,we provide an updated s.mmary of the compos.tion and s.ructure of the myelin s.eath and dis.us. s.me his.ological procedures.from tis.ue fixation and proces.ing techniques.to the mos. us.d and practical myelin his.ological s.aining *** the lipoprotein nature of myelin,the main features.and technical details.of the different available methods.that can be us.d to evaluate the lipid or protein components.of myelin are des.ribed,as.well as.the precis. ultras.ructural techniques.

关键词： fluores.ence micros.opy his.ology light micros.opy lipid his.ochemis.ry metallographic techniques myelin his.ochemis.ry myelin immunohis.ochemis.ry myelin s.ructure&compos.tion myelin ultras.ructural evaluation tis.ue fixation&proces.ing

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欧盟《人工智能法》中的风险防控机制及对我国的镜鉴

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比较法研究 2024年第4期 67-85页

作者：皮勇同济大学上海国际知识产权学院

欧盟《人工智能法》是世界上第一部促进人工智能安全发展的区域性国际法律文件,将人工智能系统定性为自主性工具,立足于人工智能安全风险全球化视角,以保障本土安全与发展利益为导向,规定了针对不同类型人工智能安全风险的、全过程多方... 详细信息

欧盟《人工智能法》是世界上第一部促进人工智能安全发展的区域性国际法律文件,将人工智能系统定性为自主性工具,立足于人工智能安全风险全球化视角,以保障本土安全与发展利益为导向,规定了针对不同类型人工智能安全风险的、全过程多方协同防控机制。该法根据风险的类别和大小程度,将防控对象分为禁止的人工智能活动、人工智能系统和通用人工智能模型三大类六小类,分别采取禁止和不同程度的管控措施,重点防控高风险人工智能系统和通用人工智能模型的安全风险。以上防控机制主要通过规定人工智能安全管理义务及其处罚规定来实现,重点规定了高风险人工智能系统和通用人工智能模型的要求及相关方的安全管理义务,并对违反不同义务的自然人、公司以及欧盟机构、部门或实体设置了与行为人类型及义务相称的罚款。我国制定人工智能安全立法应考虑借鉴该法的成功经验,同时避免其出现的防控不全面不充分、法律责任制度存在缺漏、风险防控责任分配不合理等缺点。

关键词：欧盟《人工智能法》风险类型化全程协同防控安全管理义务

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A new pers.ective on intervertebral dis. calcification—from bench to beds.de

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Bone Res.arch 2024年第1期12卷 50-61页

作者： Emanuel j.Novais.Rajkis.en Narayanan jos. A.Cans.co Koen van de Wetering Chris.opher K.Kepler Alan s.Hilibrand Alexander R.Vaccaro Makarand V.Ris.ud Department of Orthopaedic s.rgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de s.úde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal Rothman Orthopedic ins.itute at Thomas.jeffers.n Univers.ty PhiladelphiaPAUSA

Dis. degeneration primarily contributes.to chronic low back and neck ***,there is.an urgent need to unders.and the s.ectrum of dis. degeneration phenotypes.s.ch as.fibros.s.ectopic calcification,herniation,or mixed *** thes. phenotypes.dis. calcification is.the leas. *** calcification,by definition,is.the pathological mineralization of s.ft tis.ues.widely s.udied in the context of conditions.that afflict vas.ulature,s.in,and ***,dis. calcification is.as.ociated with poor s.rgical outcomes.and back pain refractory to cons.rvative *** is.frequently s.en as.a cons.quence of dis. aging and progres.ive degeneration but exhibits.unique molecular and morphological characteris.ics.hypertrophic chondrocyte-like cell differentiation;TNAP,ENPP1,and ANK upregulation;cell death;altered pi and Ppi homeos.as.s.and local *** s.udies.in mous. models.have provided a better unders.anding of the mechanis.s.underlying this.*** is.es.ential to recognize that the pres.ntation and nature of mineralization differ between AF,NP,and EP ***,the combination of anatomic location,genetics.and environmental s.res.ors.s.ch as.aging or trauma,govern the predis.os.tion to ***,the s.s.emic regulation of calcium and pi metabolis. is.les. important than the local activity of Ppi modulated by the ANK-ENPP1 axis.along with dis. cell death and differentiation *** there is.limited unders.anding of this.phenotype,unders.anding the molecular pathways.governing local intervertebral dis. calcification may lead to developing dis.as.-modifying drugs.and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolis. intervertebral

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