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role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer

World journal of Gastroenterology 2014年第31期20卷 10758-10768页

作者： Barbara Bournet Marion Gayral jérme torrisani janick Selves Pierre Cordelier Louis Buscail Department of Gastroenterology CHU Toulouse Rangueil University of Toulouse INSErM UMr 1037 CHU Toulouse Rangueil University of Toulouse Department of Pathology CHU Toulouse Purpan University of Toulouse

Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mrNA and mirNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of mirNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials.

关键词： Pancreatic ductal adenocarcinoma Endoscopic ultras

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MicrorNAs as emerging biomarkers and therapeutic targets for pancreatic cancer

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World journal of Gastroenterology 2014年第32期20卷 11199-11209页

作者： Marion Gayral Sébastien jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline meulle Marlène Dufresne Marine Humeau Maёl Chalret du rieu Barbara Bournet janick Sèlves rosine Guimbaud Nicolas Carrère Louis Buscail jérome torrisani Pierre Cordelier Cancer research Center of Toulouse Team 10 UMR INSERM U1037Université Paul Sabatier P?le Digestif Centre Hospitalier Universitaire Toulouse

Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microrNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC.

关键词： MicrorNAs Biomarkers Pancreatic cancer Therapeutic

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