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World journal of Gastroenterology 2014年第32期20卷 11069-11079页

作者： jérme dumortier Olivier Boillot jean-Yves Scoazec Unité de Transplantation Hépatique-Fédération des Spécialités Digestives HCL H?pital Edouard Herriot 69437 Lyon France Olivier Boillot Jean-Yves Scoazec Université Claude Bernard Lyon 1 69437 Lyon France Service d’Anatomie et Cytologie Pathologiques HCL H?pital Edouard Herriot 69437 Lyon France

Hepatitis C virus(HCV)-related liver disease, including cirrhosis and hepatocellular carcinoma is the main indication for liver transplantation(LT) worldwide. Posttransplant HCV re-infection is almost universal and results in accelerated progression from acute hepatitis to chronic hepatitis, and liver cirrhosis. Comprehension and treatment of recurrent HCV infection after LT have been major issues for all transplant hepatologists and transplant surgeons for the last decades. The aim of this paper is to review the evolution of our knowledge on the natural history of HCV recurrence after LT, including risk factors for disease progression, and antiviral therapy. We will focus our attention on possible ways(present and future) to improve the final longterm results of LT for HCV-related liver disease.

关键词： Hepatitis C Liver transplantation recurrence Fibrosis Treatment

肝细胞癌患者辅助性131I-碘油治疗后的生存和预后因素:对20年间106例患者的回顾性分析

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中华核医学与分子影像杂志 2018年第1期38卷 71-72页

作者：唐军 jonathan Olesinski Frangois Mithieux Olivier Guillaud Mane-Noёlle Hilleret Catherine Lombard-Bohas Luc Henry Olivier Boillot Thomas Walter Christian Partensky Pierre Pahardt Pierre-jean Valette jean-Philippe Vuillez Frangoise Borson-Chazot jean-Yves Scoazec jérme dumortier 上海交通大学医学院附属苏州九龙医院核医学科 Hospices cwils de Lyon Hpital Edouard Herriot Fédération des Spécialités Digestivespavilion L Service de Médecine nucleaire CHU de Grenoble Hdpital A.Michallon

目的肝细胞癌根治性治疗后的复发率较高。该研究对长时间随访的较大样本量根治性治疗后接受了I-碘油辅助性治疗的肝细胞癌患者进行了回顾性分析,报道评估此类患者生存和预后因素的经验。方法将1991年至2009年间法国2个医疗中心中所有因... 详细信息

目的肝细胞癌根治性治疗后的复发率较高。该研究对长时间随访的较大样本量根治性治疗后接受了I-碘油辅助性治疗的肝细胞癌患者进行了回顾性分析,报道评估此类患者生存和预后因素的经验。方法将1991年至2009年间法国2个医疗中心中所有因肝细胞癌根治性治疗后接受I-碘油辅助性治疗的患者纳入该回顾性研究。结果共106例患者纳入研究,中位随访时间为6(0.3～22)年。43例患者(41%)有肝硬化。患者1、2、5、10和20年的无复发生存率分别为73%、57%、40%、30%和14%,肝硬化是复发的独立预测因素[相对危险度(rr)=1.18,95%CI:1.11～3.02,P=0.019];1、2、5、10和20年的总生存率分别为90%、83%、59%、37%和23%,预后因素分别为复发(rr=2.73,95%CI:1.35～5.54;P=0.005)、年龄大于60岁(rr=1.91,95%CI:1.02～3.61;P=0.044)和肿瘤病灶多于3个(rr=3.31,95%CI:1.25～8.77;P=0.016)。结论肝细胞癌患者根治性治疗后的I-碘油辅助性治疗可能会降低早期复发的风险,可使用放射性核素栓塞方法进行进一步的研究。

关键词：肝细胞癌辅助性治疗碘油生存

Predictive factors for survival and score application in liver retransplantation for hepatitis C recurrence

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World journal of Gastroenterology 2016年第18期22卷 4547-4558页

作者： Alice Tung Wan Song rodolphe Sobesky Carmen Vinaixa jérome dumortier Sylvie radenne Francois Durand Yvon Calmus Géraldine rousseau Marianne Latournerie Cyrille Feray Valérie Delvart Bruno roche Stéphanie Haim-Boukobza Anne-Marie roque-Afonso Denis Castaing Edson Abdala Luiz Augusto Carneiro D’Albuquerque jean-Charles Duclos-Vallée Marina Berenguer Didier Samuel INSErM Unit 785 Villejuif 94800France Liver and Digestive Organ Transplantation Division Gastroenterology DepartmentUniversity of Sao Paulo Medical SchoolSao Paulo 05403-900Brazil Universite Paris-Sud Villejuif 94800France Liver Transplantation Laboratory LIM-37 Sao Paulo 01246-903Brazil AP-HP Hopital Paul Brousse Villejuif 94800France La Fe Hospital University of Valencia and CiberehdValencia 46026Spain Hopital Edouard Herriot Lyon 69003France Hopital Croix rousse Lyon 69004France AP-HP Hopital Beaujon Clichy 92110France AP-HP Hopital St Antoine Paris 75011France AP-HP Hopital Salpetriere Paris 75013France CHU Pontchaillou Rennes 35000France AP-HP Hopital Henri Mondor Creteil 94010France Viral Hepatitis Laboratory LIM-47 Sao Paulo 01246-903Brazil

AIM: To identify risk factors associated with survival in patients retransplanted for hepatitis C virus(HCV) recurrence and to apply a survival score to this ***: We retrospectively identified 108 patients retransplanted for HCV recurrence in eight European liver transplantation centers(seven in France, one in Spain). Data collection comprised clinical and laboratory variables, including virological and antiviral treatment data. We then analyzed the factors associated with survival in this population. A recently published score that predicts survival in retransplantation in patients with hepatitis C was applied. Because there are currently no uniform recommendations regarding selection of the best candidates for retransplantation in this setting, we also described the clinical characteristics of 164 patients not retransplanted, with F3, F4, or fibrosing cholestatic hepatitis(FCH) post-first graft presenting with hepatic decompensation. rESULTS: Overall retransplantation patient survival rates were 55%, 47%, and 43% at 3, 5, and 10 years, respectively. Patients who were retransplanted for advanced cirrhosis had survival rates of 59%, 52%, and 49% at 3, 5, and 10 years, while those retransplanted for FCH had survival rates of 34%, 29%, and 11%, respectively. Under multivariate analysis, and adjusting for the center effect and the occurrence of FCH, factors associated with better survival after retransplantation were: negative HCV viremia before retransplantation, antiviral therapy after retransplantation, non-genotype 1, a Model for End-stage Liver Disease(meLD) score replaced on the waiting list, and a retransplantation donor age rs. Although the numbers were small, in the context of the new antivirals era, we showed that outcomes in patientswho underwent retransplantation with undetectable HCV viremia did not depend on donor age and meLD score. The Andrés score was applied to 102 patients for whom all score variables were available,

关键词： Antivirals Hepatitis C Mortality Prognosis retransplantation risk factors

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阳极焙烧炉的烟气处理方法

轻金属 1982年第12期 38-42页

作者： Philippe dumortier 王京生

本文介绍铝工业中干法处理阳极焙烧炉烟气的发展趁势和工业气体净化公司的净化方法。一、密闭式和敞开式阳极焙烧炉目前,密闭炉和敞开炉的产能分别为25％和7.5％。两种炉子各有利弊,一般根据投资费、能量消耗、管道的使用寿命和耐火砖的供

关键词：焙烧炉干法处理焙烧窑阳极焦粉电解槽电解池

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彼施涅工业气体净化公司干法净化方法的改进

轻金属 1981年第2期 29-33页

作者： Philippe dumortier 顾其根

在原铝生产过程中,所有氟化氢气体的干法净化都是用活性氧化铝来吸附氟化氢气体。氧化铝的活性取决于它的比表面积,这种比表面是采用BET法测定的。普通的砂状氧化铝对氟化氢气体具有良好的吸附能力,如果

关键词：活性氧化铝氟化氢布袋收尘器铝厂催化剂载体氟化物有色金属冶炼厂过滤面积净化设备废水处理设备工业用织物滤布过滤织物干法净化气体净化

食管胶囊内镜与食管胃十二指肠内镜检查对门脉高压症的评价:一项性能和耐受性的前瞻性、对照研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 28-29页

作者： Lapalus M.-G. dumortier j. Fumex F. 纪泛扑 Fédération des Spécialités Digestives Hpital Edouard Herriot Pavillon H. 69437 Lyon Cedex 03 France Dr.

Background and study aims: Esophagogastroduodenoscopy (EGD) is the most effective method for examining the upper gastrointestinal tract, and particularly for evaluating portal hypertion cirrhotic patients, especially for screening purposes. The aim of this study was to assess the feasibility, safety, accuracy, and tolerance of PillCam ESO capsule endoscopy for this indication. Patients and methods: In this prospective study, unsedated EGD and capsule endoscopy examinations were conducted on the same day in cirrhotic patients at the time of diagnosis. The patients quantified the tolerability (relative to pain, nausea, choking sensations, etc.) of the two procedures using a 100 mm visual analogue scale. The time required for the recording and for diagnosis with the capsule examination were documented, as were the patients’ preferences in comparison with EGD. Two independent endoscopists blinded to the EGD diagnoses assessed the diagnostic accuracy of the images obtained. results: Twenty-one patients were included in the study (mean age 62, mean Model for End-Stage Liver Disease score 10.5, mean Child-Pugh score 7.3). The procedure was safe. One patient was unable to swallow the capsule. The mean recording time was 213 s (range 6-1200 s); the procedure accurately assessed the presence or absence of esophageal varices in 16 of 19 patients (84.2 % ); and it correctly indicated a need for primary prophylaxis (esophageal varices of grade 2 or more and/or red signs) in 100 % of cases. The tolerability of the capsule endoscopy examination was significantly better, and all of the patients preferred capsule endoscopy to EGD (which was transnasal in 11 patients). Conclusions: Capsule endoscopy was feasible, safe, accurate, highly acceptable, and preferred by cirrhotic patients undergoing screening for portal hypertension. This new technique requires further and more extensive evaluation, as well as assessment of its cost-effectiveness.

关键词：胶囊内镜检查门脉高压症食管胃耐受性 Child-Pugh评分胃十二指肠对照研究肝硬化患者食管静脉曲张查对

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肝脏脂肪浸润:应用临床Mr系统的双相T1梯度回波进行检测和分级

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 23-24页

作者： Pilleul F. Chave G. dumortier j. 成虹(译) 郑世成(校) Service de radiologie Digestive Hopital Edouard Herriot Place d'Arsonval 69003 Lyon 不详

Aim-To evaluate the relationship between histopathology results and magnetic resonance imaging (MrI) on in-and opposed-phase sequences grading of fat deposition within human liver. Materials and methods-In-and opposed-phase T1-weighted gradient-echo sequences (double echo time 2.3 ms and 4.6ms)were performed in 25 patients,using a 1.5-T clinical Mr imaging system. Fat/water ratio on in-and opposed-phase images of the liver was compared with pathologically defined degree or steatosis. The signal intensity in the images was acquired with operator-defined regions of interest at the same location in both fat and water images and the ratio was calculated by dividing signal intensity of liver in opposed phased sequence on signal intensity of liver in phased sequence. Fat/water ratio and the degree of steatosis were compared using linear regression. The sensitivity and specificity of opposed-phase for diagnosing steatosis were defined by rOC analysis. Furthermore, a correlation between visual signal intensity variation (SIV)and the degree of steatosis was assessed using Pearson correlation coefficient. results-Histology demonstrated fatty liver infiltrations in 81 %of specimens. The percentage of fatty hepatocytes was 28 +/-30 %. Fat/water ratio was significantly correlated with the pathologic grading of steatosis (r = 0.816, P r imaging sensibility and specificity for the diagnosis of hepatic steatosis were respectively 80%and 71%. We obtained a statistically significant correlation between visual SIV and fatty liver grading (P = 0.017). Conclusion-We demonstrated a significant correlation between fat/water ratio and histological findings for the detection and grading of fatty liver.

关键词：肝脏脂肪浸润梯度回波序列 Mr系统应用临床双相检测肝脏脂肪变性组织病理学成像系统

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