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Access to biologicals in Crohn's disease in ten European countries

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World journal of Gastroenterology 2017年第34期23卷 6294-6305页

作者： márta Péntek Peter L Lakatos Talitha Oorsprong László Gulácsi milena Pavlova Wim Groot Fanni Rencz Valentin Brodszky Petra Baji Crohn’s Disease Research Group department of health economics corvinus university of budapest mcgill university muhcmontreal general hospital 1st department of internal medicine semmelweis university department of health services research caphrimaastricht university medical centrefaculty of healthmedicine and life sciencesmaastricht university top institute evidence based education research (tier) teachers academymaastricht university 不详

AIm To analyze access(availability, affordability and acceptability) to biologicals for Crohn's disease(CD) in ten European countries and to explore the associations between these dimensions, the uptake of biologicals and economic *** A questionnaire-based survey combined with desk research was carried out in may 2016. Gastroenterologists from the Czech Republic, France, Germany, Hungary, Latvia, Poland, Romania, Slovakia, Spain and Sweden were invited to participate and provide data on the availability of biologicals/biosimilars, reimbursement criteria, clinical practice and prices, and use of biologicals. An availability score was developed to evaluate the restrictiveness of eligibility and administrative criteria applied in the countries. Affordability was defined as the annual cost of treatment as a share of gross domestic product(GDP) per capita. Correlations with the uptake of biologicals, dimensions of access and GDP per capita were *** At the time of the survey, infliximab and adalimumab were reimbursed in all ten countries, and vedolizumab was reimbursed in five countries(France, Germany, Latvia, Slovakia, Sweden). Reimbursement criteria were the least strict in Sweden and Germany, and the strictest in Hungary, Poland and Slovakia. Between countries, the annual cost of different biological treatments differed 1.6-3.3-fold. Treatments were the most affordable in Sweden(13%-37% of the GDP per capita) and the least affordable in the Central and Eastern European countries, especially in Hungary(87%-124%) and Romania(141%-277%). Biosimilars made treatments more affordable by driving down the annual costs. The number of patients with CD on biologicals per 100000 population was strongly correlated with GDP per capita(0.91), although substantial differences were found in the uptake among countries with similar economic development. Correlation between the number of patients with CD on biologicals per 100000 population and the availabi

关键词： Crohn’s disease Biological therapy Access Inequality Europe

Thermoelastic Analysis of Non-uniform Pressurized Functionally Graded Cylinder with Variable Thickness Using First Order Shear Deformation Theory(FSDT) and Perturbation method

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Chinese journal of mechanical Engineering 2015年第6期28卷 1149-1156页

作者： KHOSHGOFTAR m j mIRZAALI m j RAHImI G H Faculty of mechanical Engineering Tarbiat Modares University Department of mechanical Engineering Faculty of Engineering Arak University Department of mechanical Engineering Politecnico di Milano

Recently application of functionally graded materials（FGms） have attracted a great deal of interest. These materials are composed of various materials with different micro-structures which can vary spatially in FGms. Such composites with varying thickness and non-uniform pressure can be used in the aerospace engineering. Therefore, analysis of such composite is of high importance in engineering problems. Thermoelastic analysis of functionally graded cylinder with variable thickness under non-uniform pressure is considered. First order shear deformation theory and total potential energy approach is applied to obtain the governing equations of non-homogeneous cylinder. Considering the inner and outer solutions, perturbation series are applied to solve the governing equations. Outer solution for out of boundaries and more sensitive variable in inner solution at the boundaries are considered. Combining of inner and outer solution for near and far points from boundaries leads to high accurate displacement field distribution. The main aim of this paper is to show the capability of matched asymptotic solution for different non-homogeneous cylinders with different shapes and different non-uniform pressures. The results can be used to design the optimum thickness of the cylinder and also some properties such as high temperature residence by applying non-homogeneous material.

关键词： non-homogenous cylinder First order Shear Deformation Theory matched asymptotic method perturbation method functionally graded material

Knowledge explosion for monogenic skin diseases

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World journal of Dermatology 2015年第1期4卷 44-49页

作者： Nikoletta Nagy Katalin Farkas Lajos Kemény márta Széll Dermatological Research Group of the Hungarian Academy of Sciences University of Szeged Department of Dermatology and Allergology University of Szeged Department of medical Genetics University of Szeged Dermatological Research Group of the Hungarian Academy of Sciences University of Szeged

During the past few decades, the investigative technologies of molecular biology- especially sequencing-underwent huge advances, leading to the sequencing of the entire human genome, as well as the identification of several candidate genes and the causative geneticvariations that are responsible for monogenic skin diseases. These advances provided a solid basis for subsequent studies elucidating mechanisms of monogenic skin diseases and improving our understanding of common skin diseases. Furthermore, these discoveries also contributed to the development of novel therapeutic modalities for monogenic skin diseases. In this review, we have used the disease spectrum caused by mutations in the CYLD gene- Brooke-Spiegler syndrome, familial cylindromatosis and multiple familial trichoepithelioma type 1- as a model for demonstrating the knowledge explosion for this group of diseases.

关键词： Familial trichoepitheliomatosis Familial cylindromatosis Brooke-Spiegler syndrome monogenic skin diseases

Severe dystrophy in DiGeorge syndrome

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World journal of Gastroenterology 2009年第11期15卷 1391-1393页

作者： Barnabás Rózsai kos Kiss Gyrgyi Csábi márta Czakó Tamás Decsi Department of Pediatrics University of PécsPécs H-7623 Hungary Department of medical Genetics and Child Development University of PécsPécs H-7623Hungary

We present the case history of a 3-year-old girl who was examined because of severe *** the background,cow’s milk allergy was found,but her body weight was unchanged after eliminating milk from her *** types of malabsorption were *** on nasal regurgitation and facial dysmorphisms,the possibility of DiGeorge syndrome was suspected and was confirmed by fluorescence in situ *** authors suggest a new feature associated with DiGeorge syndrome.

关键词： DiGeorge syndrome Dystrophy Cow's milkallergy Nasal regurgitation Hypoparathyroidism

One in four patients with gastrointestinal bleeding develops shock or hemodynamic instability:A systematic review and meta-analysis

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World journal of Gastroenterology 2023年第28期29卷 4466-4480页

作者： mahmoud Obeidat Brigitta Teutsch Anett Rancz Edina Tari Katalin márta Dániel Sándor Veres Nóra Hosszúfalusi Emese mihály Péter Hegyi Bálint Erőss Centre for Translational medicine Semmelweis UniversityBudapest 1085Hungary Institute for Translational medicine Medical SchoolUniversity of PécsPécs 7623Hungary Department of Internal medicine and Hematology Semmelweis UniversityFaculty of MedicineBudapest 1085Hungary Institute of Pancreatic Diseases Semmelweis UniversityBudapest 1083Hungary Department of Biophysics and Radiation Biology Semmelweis UniversityBudapest 1085Hungary

BACKGROUND Hemodynamic instability and shock are associated with untoward outcomes in gastrointestinal ***,there are no studies in the existing literature on the proportion of patients who developed these outcomes after gastrointestinal *** To determine the pooled event rates in the available literature and specify them based on the bleeding *** The protocol was registered on PROSPERO in advance(CRD42021283258).A systematic search was performed in three databases(Pubmed,EmBASE,and CENTRAL)on 14^(th) October *** proportions with 95%CI were calculated with a random-effects model.A subgroup analysis was carried out based on the time of assessment(on admission or during hospital stay).Heterogeneity was assessed by Higgins and Thompson’s I^(2) *** joanna Briggs Institute Prevalence Critical Appraisal Tool was used for the risk of bias *** Reference Citation Analysis(https://***/)tool was applied to obtain the latest highlight *** We identified 11589 records,of which 220 studies were eligible for data *** overall proportion of shock and hemodynamic instability in general gastrointestinal bleeding patients was 0.25(95%CI:0.17-0.36,I^(2)=100%).In non-variceal bleeding,the proportion was 0.22(95%CI:0.14-0.31,I^(2)=100%),whereas it was 0.25(95%CI:0.19-0.32,I^(2)=100%)in variceal *** proportion of patients with colonic diverticular bleeding who developed shock or hemodynamic instability was 0.12(95%CI:0.06-0.22,I^(2)=90%).The risk of bias was low,and heterogeneity was high in all *** One in five,one in four,and one in eight patients develops shock or hemodynamic instability on admission or during hospitalization in the case of non-variceal,variceal,and colonic diverticular bleeding,respectively.

关键词： Gastrointestinal bleeding Hemodynamic instability Shock meta-analysis Statistics Review

STUDENTS' PERCEPTION OF THE ROLE OF COmPETITION IN THEIR RESPECTIVE COUNTRIES:HUNGARY,jAPAN,USA,CHINA

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STUDENTS' PERCEPTION OF THE ROLE OF COMPETITION IN THEIR RES...

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

第十届全国心理学学术大会

作者： márta Fülp 雅寅耳 Institute for Psychology Hungarian Academy of Sciences Budepest Hungary 中国科学院心理研究所

The topic of this paper is young people’s understanding of the role of competition in their particular societies, namely Hungarian, japanese, and American. Competition is seen by many experts not only the key for individual advancement but national survival too (Rich, DeVitis, 1992). According to this study the way a society builds up and constructs its competitive norms, rules, values and processes mirrors that particular society, its history and culture. Thus the way young people perceive and conceive competition in a society is particularly interesting to study, because their ideas represent the past, the present and also

关键词： competition cross-cultural perception high-school students

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria jiménez Carretero IrisÁlvarez-merz jorge Hernández-Campano Sergei A.Kirov jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis

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World journal of Gastroenterology 2019年第6期25卷 729-743页

作者： Dalma Dobszai Péter mátrai Zoltan Gyongyi Dezso Csupor judit Bajor Balint Eross Alexandra mikó Lajos Szakó Agnes meczker Roland Hágendorn Katalin márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group Institute for Translational medicine Medical SchoolUniversity of PécsPécs 7624Hungary Clinical medicine Doctoral School University of SzegedSzeged 6720Hungary Institute for Bioanalysis Medical SchoolUniversity of PécsPécs 7624Hungary Department of Public Health medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pharmacognosy University of SzegedSzeged 6720Hungary Division of Gastroenterology First Department of MedicineUniversity of PécsMedical SchoolPécs 7624Hungary jános Szentágothai Research Center University of PécsPécs 7624 Hungary mTA-SZTE momentum Translational Gastroenterology Research Group University of SzegedSzeged 6720Hungary 不详

BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BmI) affects the outcome of the *** To quantify the association between subgroups of BmI and the severity and mortality of *** A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and meta-Analysis(PRISmA) Protocols. Three databases(Pubmed, EmBASE and the Cochrane Library) were searched for articles containing data on BmI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 june 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(mD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number *** A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BmI. BmI mI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BmI(OR = 2.87, 95%CI: 1.90-4.35, P mportantly,the mean BmI of patients with severe AP is higher than that of the non-severe group(mD = 1.79, 95%CI: 0.89-2.70, P mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BmI most two-fold increase in risk of mortality compared to normal BmI(OR = 1.82, 95%CI: 1.32-2.50, P mortality

关键词： Acute pancreatitis Body-mass index Obesity Severity mortality Prognostic meta-analysis

Nanostructured grinding wheels for ultra-precision engineering applications

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Nanotechnology and Precision Engineering 2021年第3期4卷 63-75页

作者： m.j.jackson Integrated Studies College of Technology and AviationKansas State UniversitySalinaKansas 67401USA

manufacturers face challenges when dealing with abrasives that lose roundness,wear excessively,and suffer from pitting of the surface of the grinding wheel that needs rectification using dressing *** abrasive grits manufactured by hybrid fusion processes and by sintering/extrusion/printing processes are found to reduce pitting quite *** phenomenon of wheel collapse is increasing and cycle times developed during the grinding of aerospace alloys are much smaller compared to using conventional *** paper reviews the phenomenon of wheel collapse induced by pitting and takes a critical look at the production and analysis of hybrid fused and printed/sintered abrasives.A mathematical analysis is carried out of the diffusion of primary and secondary phases due to mechanical and ultrasonic agitation with the aim of producing abrasive grits with improved strength and *** developments in extruded,printed,and sintered grits for use in precision grinding applications are critically *** paper concludes by explaining how such abrasives are used in practice by industrial manufacturers of high-precision products.

关键词： Nanotechnology Abrasives Alloys Finishing Grinding machining