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Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer

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World journal of Gastroenterology 2006年第8期12卷 1192-1197页

作者： Miklós tanyi judith Olasz Géza lukács Orsolya Csuka lászló Tóth Zoltán Szentirmay Zsuzsa Ress Zsolt Barta jános l tanyi lászló Damjanovich 1~(st)Department of Surgery University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Pathogenetics National Institute of OncologyBudapestHungary Department of Pathology University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Human and Experimental Tumor Pathology National Institute of OncologyBudapestHungary 3~(rd)Department of Medicine University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Obstetrics and Gynecology Baylor College of MedicineHoustonTXUnited States

AIM： To screen a suspected Hungarian HNPCC family to find specific mutations and to evaluate their effect on the presentation of the disease. METHODS： The family was identified by applying the Amsterdam and Bethesda Criteria. Immunohistochemistry was performed, and DNA samples isolated from tumor tissue were evaluated for microsatellite instability. The identification of possible mutations was carried out by sequencing the hMlH1 and hMSH2 genes. RESUlTS： Two different mutations were observed in the index patient and in his family members. The first mutation was located in exon 7, codon 422 of hMSH2, and caused a change from Glu to STOP codon. No other report of such a mutation has been published, as far as we could find in the international databases. The second mutation was found in exon 3 codon 127 of the hMSH2 gene, resulting in Asp→Ser substitution. The second mutation was already published, as a non-pathogenic allelic variation. CONClUSION： The pedigree analysis suggested that the newly detected nonsense mutation in exon 7 of the hMSH2 gene might be responsible for the development of colon cancers. In family members where the exon 7 mutation is not coupled with this missense mutation, colon cancer appears after the age of 40. The association of these two mutations seems to decrease the age of manifestation of the disease into the early thirties.

关键词： Hereditary nonpolyposis colon cancer Bethesda criteria Mutation hMlH1 hMSH2

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Application of Power Electronics and Control for Dual Battery Packs Management with Voltage Balancing and State of Charge Estimation

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Energy and Power Engineering 2022年第12期14卷 762-780页

作者： Stuart Brown Tsafack Pierre Fendji Marie Danielle Emmanuel tanyi Musong l. Katche Department of Electrical and Electronics Engineering University of Buea Buea Cameroon

Energy storage, such as lead acid batteries, is necessary for renewable energy sources’ autonomy because of their intermittent nature, which makes them more frequently used than traditional energy sources to reduce operating costs. The battery storage system has to be monitored and managed to prevent serious problems such as battery overcharging, over-discharging, overheating, battery unbalancing, thermal runaway, and fire dangers. For voltage balancing between batteries in the pack throughout the charging period and the SOC estimate, a modified lossless switching mechanism is used in this research’s suggested battery management system. The OCV state of charge calculation, in the beginning, was used in conjunction with the coulomb counting approach to estimate the SOC. The results reveal that correlation factor K has an average value of 0.3 volts when VM ≥ 12 V and an average value of 0.825 when VM ≤ 12 V. The battery monitoring system revealed that voltage balancing was accomplished during the charging process in park one after 80 seconds with a SOC difference of 1.4% between Batteries 1 and 2. On the other hand, the system estimates the state of charge during the discharging process in two packs, with a maximum DOD of 10.8 V for all batteries. The project’s objectives were met since the BMS estimated SOC and achieved voltage balance.

关键词： State of Charge Battery Management System lead Acid Battery

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靶向于胶原蛋白的血栓抑制剂lERNSTY开发

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天津大学学报（自然科学与工程技术版） 2018年第4期51卷 401-405页

作者：张麟郝坛义天津大学化工学院天津300350

通过荷电氨基酸残基替换lWWNSYY中的疏水性氨基酸残基W以优化其组成,设计获得血栓抑制剂lERNSTY.研究发现,lERNSTY溶解度好,能够有效结合胶原蛋白,K_d为(1.647±0.303)μmol/l,有效半抑制浓度(IC_(50))为(2.73±0.48)μg/m l,优于lWWNS... 详细信息

通过荷电氨基酸残基替换lWWNSYY中的疏水性氨基酸残基W以优化其组成,设计获得血栓抑制剂lERNSTY.研究发现,lERNSTY溶解度好,能够有效结合胶原蛋白,K_d为(1.647±0.303)μmol/l,有效半抑制浓度(IC_(50))为(2.73±0.48)μg/m l,优于lWWNSYY.因此,通过荷电氨基酸的引入优化获得有效的血栓抑制剂lERNSTY,将促进疗效显著而副作用小的抗血栓药物开发.

关键词：动脉血栓胶原蛋白血栓抑制剂水溶性

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Synthesis and Structural Characterization of a New Two-Dimensional Polymeric Hybrid Material {[Cu3(μ3-1,2,3-BTC)(μ2-1,2,3-BTC)(en)3(OH2)2(OH)(μ2-OH2)]2·5H2O·O}n

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Open journal of Inorganic Chemistry 2020年第4期10卷 52-62页

作者： Alvine l. Djoumbissie Francis W. Njifack Alain T. Djampouo tanyi R. Fomuta Golngar Djimassingar Alain C. Tagne Kuate jean Ngoune Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Chemistry Mongo Polytechnique University Institute (IUPM) Mongo Chad

The reaction of benzene-1,2,3-tricarboxylate copper(II) trihydrate (Cu3(1,2,3-BTC)2·3H2O) and ethylenediamine (en) gave after recrystallization from methanol at room temperature violet crystalline solid of the polymeric two dimensional material {[Cu3(μ3-1,2,3-BTC)(μ2-1,2,3-BTC)(en)3(OH2)2(OH)(μ2-OH2)]2·5H2O·O}n (1) as identified by single crystal X-ray diffraction analysis. The compound was also characterized by elemental analysis, FT-IR spectroscopy, UV-vis spectroscopy, thermogravimetric analysis (TGA) and magnetic susceptibility. The molecular structure indicates crystallization in the triclinic space group P-1 with the unit cell parameters a = 12.1205(3) Å, b = 12.7026(3) Å, c = 13.9890(3) Å, α = 75.034(1)°, β = 74.957(1)°, γ = 68.415(1)°. Structural analysis also revealed that the dimeric compound is connected by Cu-O-Cu bridges and the dimer is further converted into a polymeric chain structure through bridging of one benzene-1,2,3-tricarboxylate ligand. Different coordination modes are observed at the copper atom. The Cu atom at the center is octahedral while the two other ones are pentacoordinated. Thermal analysis of the compound showe

关键词： Copper Ethylenediamine Benzene-1 2 3-Tricarboxylate Coordination Polymer Magnetism

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Synthesis, Characterization and DFT Studies of Two Zinc(II) Complexes Based on 2-Isopropylimidazole

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Open journal of Inorganic Chemistry 2018年第4期8卷 105-124页

作者： jean jacques Anguile Odette Nana Ngnabeuye Ndosiri Ndoye Bridget tanyi Rogers Fomuta Alvine loris Djoumbissie Alain Charly Kuate Tagne jean Ngoune Department of Chemistry University of Sciences & Techniques of Masuku Franceville Gabon Department of Chemistry University of Dschang Dschang Cameroon Department of Inorganic Chemistry University of Yaounde 1 Yaounde Cameroon

Two novel coordination compounds, [Zn(l)2(OOCH)2] (1) and [Zn(l)3(OCHO)](OCHO)]·H2O (2) (where l = 2-isopropylimidazole, C6H10N2) have been prepared by reaction of 2-isopropylimidazole with zinc(II) formate at room temperature using toluene as solvent. These compounds were characterized by elemental and thermal analyses, IR, 1HNMR and 13CNMR spectroscopies, single crystal X-ray diffraction and DFT studies. The Zn centers in 1 and 2 adopt pseudo-tetrahedral coordination geometries. Compound 1 crystallizes in the monoclinic system P2/c space group whereas compound 2 crystallizes in the P-1 space group of the triclinic crystal system. Several types of hydrogen intra-/intermolecular interactions are observed in these materials and extend into a two-dimensional leaf like network in 1 and a two-dimensional lattice of rectilinear pillars in 2. Compounds 1 and 2 were also optimized and their frontier molecular orbitals, global reactivity descriptors, molecular electrostatic potential, natural bond orbitals were investigated using density functional theory (DFT). In fact the induced structural differences from complex 1 to complex 2 led to the reduction of the frontier molecular orbital energy gap by 1.338 eV and a decrease of the chemical hardness by 0.669 eV.

关键词： Zinc(II) Complexes of 2-Isopropylimidazole Thermogravimetric Analysis 1H-MR 13C-MR Crystal Structure DFT Studies

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Application of Power Electronics and Control for Dual Battery Packs Management with Voltage Balancing and State of Charge Estimation

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Energy and Power Engineering（能源与动力工程） 2022年第12期

作者： Stuart Brown Tsafack Pierre Fendji Marie Danielle Emmanuel tanyi Musong l. Katche

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便携式血糖仪与全自动生化分析仪临床标本血糖比对检验评价

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国际检验医学杂志 2015年第24期36卷 3556-3558,3560页

作者：龙国文龙臣何穗谭熠毛福青湖南省湘潭市中心医院检验科湖南湘潭411100 湖南省湘潭市中心医院急症科重症监护室湖南湘潭411100 湖南省湘潭市中心医院麻醉科湖南湘潭411100

目的比较便携式血糖仪和全自动生化仪测定临床患者血液葡萄糖结果的一致性,评价血糖仪测定血糖的准确度。方法四种型号42台血糖仪与全自动生化仪比对检测433例患者血液葡萄糖。由90位护士用血糖仪检测患者毛细血管血(手指)血糖,同时抽... 详细信息

目的比较便携式血糖仪和全自动生化仪测定临床患者血液葡萄糖结果的一致性,评价血糖仪测定血糖的准确度。方法四种型号42台血糖仪与全自动生化仪比对检测433例患者血液葡萄糖。由90位护士用血糖仪检测患者毛细血管血(手指)血糖,同时抽取静脉血用罗氏Cobas8000全自动生化仪己糖激酶法以急症方式检测血清葡萄糖。血糖仪与生化仪测定血糖的差异按照Bland-Altman方法进行绘图分析。并进行Parkes误差网格分析。结果血糖仪与生化仪血糖比对结果差异有显著性意义(t=-4.128,Pl/l,生化分析仪为(6.72±3.27)mmol/l,偏倚0.16mmol/l,精密度(标准差)0.79mmol/l,平均绝对偏差0.57mmol/l。四种型号血糖仪与生化仪差值相互之间的差异无显著性意义(F=1.276,P=0.282)。红细胞比容水平对两种方法间差异的影响无显著性意义。两种方法血糖相差不低于1.11mmol/l的有58例(占13.4%)。100%的结果落在Parkes误差网格分析的A区和B区。结论血糖仪与生化仪检测患者血糖的差异有显著性意义。当血糖仪检测结果异常有可能影响患者安全时,应当送检验科确认。

关键词：便携式血糖仪生化分析仪偏倚准确度比对检验

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电针复合七氟烷麻醉对断尾大鼠急性应激反应调控的影响

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重庆医学 2016年第10期45卷 1306-1308,1312页

作者：胡越刘莉熊威威谭毅黄志华李爱国杨华蒋奕红桂林医学院研究生院广西桂林541001 湖北省武汉市第三医院麻醉科 430000 桂林医学院附属医院麻醉科广西桂林541001 桂林医学院附属医院中医科广西桂林541001

目的探讨不同穴位电针刺激复合七氟烷麻醉对断尾大鼠急性应激反应调控作用的影响。方法健康成年雄性SD大鼠50只,体质量280~320g,分为正常组（Ⅰ组）、模型组（Ⅱ组）、七氟烷吸入组（Ⅲ组）、七氟烷吸入加体针组（Ⅳ组）和七氟烷吸入加... 详细信息

目的探讨不同穴位电针刺激复合七氟烷麻醉对断尾大鼠急性应激反应调控作用的影响。方法健康成年雄性SD大鼠50只,体质量280~320g,分为正常组（Ⅰ组）、模型组（Ⅱ组）、七氟烷吸入组（Ⅲ组）、七氟烷吸入加体针组（Ⅳ组）和七氟烷吸入加耳针组（Ⅴ组）,每组10只。Ⅰ组不作处理置于氧流量30%的混合气体玻璃箱中（流量2l/min）,Ⅱ组断尾后置于氧流量30%的混合气体玻璃箱中（流量2l/min）,Ⅲ、Ⅳ、Ⅴ组断尾后置于含体积分数为2%的七氟烷麻醉箱中（流量2l/min）,Ⅳ组持续刺激双侧＂足三里＂穴30min（刺激参数3V,3Hz,2ms）,共4次,每次间隔30min,Ⅴ组刺激双侧＂耳尖＂穴,刺激参数及时间同Ⅳ组。各组治疗方法结束后,处死各组大鼠,取断颈血采用ElISA测促肾上腺皮质激素（ACTH）和外周血皮质酮（CORT）水平。采用Western blot法测定下丘脑组织c-fos蛋白的表达水平。结果与Ⅰ组相比,Ⅱ组血清ACTH、CORT水平、下丘脑c-fos蛋白表达明显升高（P〈0.01）;与Ⅱ组相比,Ⅲ、Ⅳ、Ⅴ组大鼠外周血ACTH、CORT水平均有所下降,差异有统计学意义（P〈0.05）;Ⅲ组与Ⅳ组的ACTH和CORT水平差异无统计学意义（P〉0.05）;Ⅴ组的ACTH水平与Ⅲ组相比明显下降（P〈0.05）,Ⅴ组CORT水平与Ⅳ组相比明显下降（P〈0.05）。Ⅲ、Ⅳ、Ⅴ组c-fos表达与Ⅱ组相比均降低（P〈0.05）,Ⅲ、Ⅳ、Ⅴ组3组组间差异有统计学意义（P〈0.05）。结论七氟烷吸入复合电刺激＂耳尖＂穴治疗时,对应激的作用优于单纯的七氟烷治疗和七氟烷复合电刺激＂足三里＂穴。电针复合吸入全身麻醉对应激的调控机制可能与下丘脑调节室旁核c-fos蛋白分泌并影响下丘脑-垂体-肾上腺（HPA）轴有关。

关键词：应激电针原癌基因蛋白质c-fos 七氟烷耳针

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