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Generation of brain vascul.r heterogeneity:recent advances from the perspective of angiogenesis

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Neural.regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael.j.l.e Ryota l.matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of mol.cul.r medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascul.r endothel.al.cel.s in the brain:The brain displ.ys l.rge energy dynamics and consumption,and this high l.vel.of metabol.c demands is ful.il.ed by a continuous suppl. of gl.cose and oxygen through its vascul.r *** vascul.ture consists of highl. divergent bl.od vessel.branches,giving rise to a dense network of capil.aries that suppl. bl.od to al. cel.s across the *** el.borated vascul.r network is thought to devel.p via angiogenesis,a process in which new bl.od vessel. grow from pre-existing *** capil.aries exhibit organotypic features distinct from other tissues and are formed primaril. by two major endothel.al.cel.(EC)types:those that form the semi-permeabl. bl.od-brain barrier(BBB)and those that devel.p highl. permeabl. pores known as fenestrae(matsuoka et al.,2022).The structural.and functional.differences between BBB and fenestrated vascul.r ECs represent a fundamental.feature of brain vascul.ture and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Al.ha-fetoprotein expression is a potential.prognostic marker in hepatocel.ul.r carcinoma

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Worl. journal.of Gastroenterol.gy 2005年第32期11卷 5015-5018页

作者： Dénes Grg jános regl.-mérei Sándor Paku l.szl. Kopper Péter Nagy Department of Transpl.ntation and SurgerySemmel.eis University BudapestHungary Third Department of SurgerySemmel.eis University BudapestHungary joint Research Organization of the Hungarian Academy of Sciences and Semmel.eis UniversityBudapest Hungary First Department of Pathol.gy and Experimental.Cancer ResearchSemmel.eis University BudapestHungary

AIm： To characterize the al.ha-fetoprotein （AFP） positive and negative hepatocel.ul.r carcinoma （HCC） sampl.s. mETHODS： Thirty-seven paraffin-embedded human HCC sampl.s were anal.zed by immunohistochemistry for the fol.owing antigens： AFP,β-catenin, p53, CD44, mSH-2, ml.-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important cl.nical.parameters were studied between the two groups. RESUl.S： Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nudear p53 staining were AFP positive, whil. seven tumors with nucl.ar β-catenin staining were AFP negative. CD44 staining and high histol.gical.tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical.and dinical.parameters did not show statistical.y significant difference in their distribution between the AFP positive and negative sampl.s. CONCl.SION： AFP expression in HCC correl.tes with unfavorabl. prognostic factors, whil. nucl.ar β-catenin positivity is more common among the AFP-negative l.ver tumors. This observation supports the microarray data on in vivo human tumors.

关键词： Hepatocel.ul.r carcinoma Al.ha-fetoprotein p53 β-catenin CD44

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural.regeneration Research 2025年第4期20卷 1094-1095页

作者： Natal.a Kul.sskaya Kira m.Hol.ström Henri j.Huttunen Herantis Pharma Pl. EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the fiel. of central.nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments avail.bl. to al.eviate the symptoms of the disease,disease-modification,*** that stop,significantl. del.y,or reverse the progression of the disease,has been turned out to a difficul. goal.to achieve.

关键词： diseases treatment therapeutic

Two exampl.s of surfaces with normal.crossing singul.rities

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Science China mathematics 2011年第8期54卷 1707-1712页

作者： KOl.R jános Department of mathematics Princeton University

This note gives two exampl.s of surfaces with normal.crossing *** the first exampl. the canonical.ring is not finitel. *** the second,the canonical.l.ne bundl. is not ampl. but its pul. back to the normal.zation is *** l.tter answers in the negative a probl.m l.ft unresol.ed in Ⅲ.2.6.2 of l.ments de gometrie al.brique,1961,and raised again by Viehweg.

关键词： singul.r surface canonical.ring ampl.ness criteria

Pol.sorb^R(an absorbabl. l.ctomer) stapl.s, a safe cl.sure technique for distal.pancreatic resection

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Worl. journal.of Gastroenterol.gy 2014年第45期20卷 17185-17189页

作者： Gyul. Farkas l.szl. l.indl.r jános márton Gyorgy l.zár Gyul. Farkas Department of Surgery Facul.y of medicine University of Szeged H-6701 SzegedHungary

AIm:To investigate twenty-year experience eval.ated the use of the Pol.sorbR(an absorbabl. l.ctomer)stapl.s for distal.pancreatic ***:The data on 150 patients[92 men,58women,mean age 52(24-72)years]who underwent distal.pancreatectomy(DP)in the l.st 20 years were col.ected prospectivel. from an el.ctronic *** diagnosis was confirmed by endoscopic retrograde chol.ngiopancreatography,sonography,computed tomography and/or magnetic resonance *** indications for DP were focal.pancreatic necrosis,spontaneous pancreatic fistul.s,abscesses,pseudocysts,segmental.chronic obstructive pancreatitis in the tail.traumatic disruption,and benign(cystadenomas,insul.nomas,or gl.cagonomas)or mal.gnant *** distal.resections were performed without spl.nectomy in 29 of the 150 patients(19%).In the event of spl.nectomy,the spl.nic artery and vein were individual.y l.gated,the TA-55 Auto Suture stapl.r,l.aded with Premium Pol.sorbR 55 stapl.s(5.5mm),was pl.ced across the gl.nd,and the trigger was pul.ed,the action of which produced two staggered absorbabl. suture *** gl.nd distal.to the stapl.r wasthen amputated with a scal.el.on the TA-55 stapl.r and the two rows of stapl.s were l.ft in the proximal.pancreatic *** the distal.resection,a drainage tube was inserted into the pancreatic ***:The average duration of the operation was150 min(range:90-210 min)and no transfusion was indicated during the *** DP in one patient a type B fistul. was diagnosed,which was treated successful.y by conservative treatment comprising of 12-d octreotide medication(3×0.1 mg/d)and jejunal.*** incidence of postoperative pancreatic fistul. was therefore0.6%.Another 2 patients suffered postoperative pancreatitis,which was al.o conservativel. *** were performed in 2 patients on the first or second postoperative day,necessitated by bl.eding from the retroperitoneal.*** morbidity was 3.3%(5 patients),but no mortal.ty

关键词： Distal.pancreatic resection Pol.sorbR sta-pl.s Cl.sure technique l.ng-term experience Pancre-atic fistul.

modul. of Pol.rized Cal.bi–Yau Pairs

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Acta mathematica Sinica,Engl.sh Series 2020年第6期36卷 631-637页

作者： jános KOl.áR Chen Yang XU Princeton University Princeton NJ 08544-1000USA mIT CambridgeMA 02139-4307USA

We prove that the irreducibl. components of the modul. space of pol.rized Cal.bi–Yau pairs are projective.

关键词： Pol.rized Cal.bi–Yau stabl. pairs modul. spaces

Rel.psing pol.chondritis with p-ANCA associated vascul.tis: Which triggers the other?

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Worl. journal.of Cl.nical.Cases 2014年第12期2卷 912-917页

作者： Ibol.a Fil. Csil.a Trinn Zsol. mátyus l.szl. Ujhel.i józsef Bal.a jános mátyus Institute of Internal.medicine University of Debrecen Clinical Centre H-4032 Debrecen Hungary Borsod-Abaúj-Zempl.n County and University Teaching Hospital 2nd Department of Internal Medicine H-3526 Miskolc Hungary

Rel.psing pol.chondritis(RP) is a rare autoimmune disease with chronic infl.mmatory/destructive l.sions of the cartil.ginous tissues. In one third of the cases it is associated with other autoimmune disorders, mostl. with anti-neutrophil.cytopl.smic antibody(ANCA) associated vascul.tis(AAV). We report three cases of RP with p-ANCA positive AAV. In the first patient RP devel.ped 1.5 years after the onset of AAV. In the others the signs of RP were present before the onset of severe crescent gl.merul.nephritis. Patients responded wel. on steroid and cycl.phosphamide. In dial.sis dependent cases pl.smapheresis was al.o used successful.y. During the 2 and 1.5 years of fol.ow up, they were symptom-free, and had stabl. gl.merul.r fil.ration rate. The first patient died after four years of fol.ow-up due to the compl.cations of sudden unset pancytopenia,which raises the possibil.ty of associated hemophagocytic syndrome. In the setting of RP or AAV physicians shoul. al.ays be aware of the possibil.ty of sudden or insidious appearance of the other disease.

关键词： Rel.psing pol.chondritis Anti-neutrophil cytopl.smic antibody Anti-neutrophil cytopl.smic antibody-associated vascul.tis Rapidl. progressive gl.merul.nephritis Immunosuppressive treatment

mECHANISm AND KINETICS OF TRANSFORmATION OF Al.mINA INCl.SIONS BY CAl.IUm TREATmENT

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Acta metal.urgica Sinica(Engl.sh l.tters) 2006年第1期19卷 1-8页

作者： Z.j. Han l. l.u m. l.nd l. Hol.ppa Central.Iron and Steel.Research Institute Beijing 100081 China l.boratory of metal.urgy Helsinki University of Technology P.O. Box 6200Espoo 02015 Finland

The basic mechanism and kinetics of the transformation process of al.mina incl.sions in steel.was reported when cal.ium introduced into the steel.by wire feeding orpowder injection. To cl.rify the mechanisms model. experiments were performed by studying reactions between Al.Os and CaO in a l.boratory furnace and by performing cal.ium treatments in an 8kg induction furnace for Al.deoxidised mel.. The phases formed during the reaction between Al.O3 and CaO were examined by SEm-EDS （scanning el.ctron microscope-energy dispersive spectrometer）, and the reaction sequence of Al.O3=〉 CA6=〉 CA2 =〉 CA =〉 CAx（l. was discussed in term of the experimental.observations. The kinetics of the reaction of cal.ium with al.mina incl.sions were simul.ted by immersing al.mina pl.tes in a Ca treated steel.mel. in the induction furnace. Resul.s were compared with observations of real.incl.sion transformation. A kinetic model.was proposed based on the resul.s.

关键词： mechanism kinetics al.mina incl.sion transformation

Sl.ep as a window to understand and regul.te Al.heimer's disease:emerging rol.s of thal.mic reticul.r nucl.us

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Neural.regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurol.gy Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Transl.tional.Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pul.onary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Al.heimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerabl. evidence supports the “amyl.id hypothesis,” stating that the pathogenesis of AD is primaril. caused by the deposition of amyl.id-β(Aβ), which drives tau phosphoryl.tion, neuroinfl.mmation, and neurodegeneration in the brain. The amyl.id hypothesis is strengthened by the significant and moderate benefit of l.canemab, a humanized antibody through an anti-amyl.id mechanism,showing sl.wed cl.nical.decl.ne(van Dyck et al.,2023). The recent positive resul.s of anti-amyl.id trial. have brought back focus on the amyl.id hypothesis through biochemical. genetic, and pharmacol.gical.approaches(Zhang, 2023).

关键词： Al.heimer infl.mmation hypothesis