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Characterization of the salivary microbiome in healthy Thai children

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Asian Pacific Journal of Tropical Medicine 2019年第4期12卷 163-169页

作者： izumi Mashima Citra F.Theodorea Boonyanit Thaweboon Sroisiri Thaweboon Tippanart Vichayanrat Frank A.Scannapieco Futoshi Nakazawa Department of Microbiology School of Pharmacy Aichi Gakuin University Department of Oral Biology Faculty of Dentistry Universitas Indonesia Department of Oral Microbiology Faculty of Dentistry Mahidol University Department of Community Dentistry Faculty of Dentistry Mihidol University Department of Oral Biology School of Dental Medicine University at Buffalo the State University of New York Department of Microbiology School of Dentistry Health Sciences University of Hokkaido

Objective: To investigate the composition of the salivary microbiome of 50 healthy Thai children. Methods: A total 76 provinces in Thailand are grouped into 5 geographical clusters based on unique economics, foods and lifestyles. Geographical locations and the results of an oral assessment were also considered. Genomic DNA was extracted from stimulated saliva samples. Subsequently, amplicon libraries were prepared by 16 S Metagenomic Sequencing Library Preparation. The amplicons were sequenced using an Illumina Miseq platform followed by bioinformatics and statistical ***: The correlation between oral hygiene status and caries history varied from r^2=0.887 to r^2=0.999 in the geographical groups, suggesting oral hygiene status a strong association between caries history. Twenty taxonomic groups were found in all subjects and constituted 93.6%-96.5% of the microbiome. Of these, genus Veillonella and Prevotella showed significant differences in their proportions between the geographical groups(P<0.05). Furthermore, the proportion of Veillonella parvula, as well as Rothia aeria and Rothia dentocariosa tended to increase with worse oral hygiene status, which was also related to higher dental caries ***: The differences in the salivary microbiome as related to geographic regions suggest that environmental factors, which may include dietary habits, could influence the predominant bacteria found in the mouth of Thai children, especially the genus Veillonella and Prevotella. The ratio of Veillonella parvula, Rothia aeria and Rothia dentocariosa may be indicators of worse oral hygiene status and future caries in this population.

关键词： Saliva Microbiome Thai Children Region Simplified oral hygiene index

Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis

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World Journal of Gastroenterology 2009年第28期15卷 3480-3485页

作者： Daisuke Asaoka Akihito Nagahara Masako Oguro Yuko izumi Akihiko Kurosawa Taro Osada Masato Kawabe Mariko Hojo Michiro Otaka Sumio Watanabe Department of Gastroenterology Juntendo University School of Medicine

AIM:To explore the pathological flndings in the entire esophagus in rats with reflux esophagitis, and the effects of ecabet sodium(ES).METHODS:A rat model of chronic acid reflux esophagitis was *** the treatment group, ES was administered after surgery(n = 16).No drug was administered postoperatively to the esophagitis group(n = 9).Shamoperated rats were used as a control group(n = 5).Rats were sacriflced on day 7 after the *** epithelial thickness and leukocyte inflltration were examined in the upper, middle and lower areas of the *** survival rate, incidence of esophageal ulcer, and mean surface area and number of esophageal ulcers were determined in the esophagitis and ES *** histology was assessed in all three ***:Leukocyte infiltration in the esophagitis group was 26.3 ± 22.0 in the middle esophagus and 8.2 ± 4.9 in the upper esophagus, which was signiflcantly greater than that in the controls(1.3 ± 1.1 and 1.4 ± 1.0, respectively)(P < 0.05).The thickness of the epithelium in the esophagitis group was 210.8 ± 47.7 μm in the lower esophagus and 204.2 ± 60.1 μm in the middle esophagus, which was significantlygreater than that in the controls(26.0 ± 5.5 and 21.0 ± 6.5 μm, respectively)(P < 0.05).The mean number of ulcers per animal in the ES group in the entire esophagus was 5.4 ± 2.5, which was signiflcantly less than that in the esophagitis group(9.0 ± 3.5)(P < 0.05).The epithelial thickness in the ES group was 97.5 ± 32.2 μm in the lower esophagus, which was decreased compared with that in the esophagitis group(210.8 ± 47.7 μm)(P < 0.05).CONCLUSION:Mucosal inflammation extended to the upper esophagus close to the *** study suggested that ES may have a useful defensive role in reflux esophagitis.

关键词：特征和食管大鼠病理钠

Demonstrative Study of Vehicles Using Waste Vegetable Oil as Fuel

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Journal of Energy and Power Engineering 2015年第2期9卷 185-191页

作者： Yasuyuki Nemoto izumi Ushiyama Division of Renewable Energy and Environment Ashikaga Institute of Technology Ashikaga-shi 326-8558 Japan Graduate School Ashikaga Institute of Technology Ashikaga-shi 326-8558 Japan

SVO (straight vegetable oil) method means the direct use of vegetable oil as car fuel through installation of a heater unit in the car to decrease vegetable oil viscosity. In this study, the authors carried out performance tests on the direct use of waste cooking oil using a car with a heater unit. Moreover, the authors carried out long run driving on road tests in five years using a public car of Minami-Aizu Town in Fukushima Prefecture and analyzed the case of troubles and clarified the availability and problems of SVO vehicles. As a result, the car with a heater unit shows similar performance in both cases using vegetable oil or diesel fuel as fuel. The tested SVO vehicle of Minami-Aizu Town could be driven 38,127 km mainly by waste vegetable oil with a total driving distance of 52,293 km in long run driving tests in five years, and decreased about 3,813.5 liters of light oil which corresponds to 9.99 t of CO2.

关键词：汽车燃料车辆使用废食用油废植物油性能测试行驶距离公共停车场加热装置

Transformation of CSD When Crystal Shape Changes with Crystal Size into CLD from FBRM by Using Monte Carlo Analysis

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Advances in Chemical Engineering and Science 2017年第2期7卷 91-107页

作者： Joi Unno izumi Hirasawa Department of Applied Chemistry School of Science and Engineering Waseda University Tokyo Japan

In manufacturing process, it is necessary to measure change in CSD (Crystal Size Distribution) with time accurately because CSD is one of the most important indices that evaluate quality of products. FBRM (Focused Beam Reflectance Measurement) can measure CLD (Chord Length Distribution) in line, but CLD is different from CSD because of principle of FBRM. However, if CSD is determined beforehand, CLD can be calculated from the CSD with statistical method. First, when crystal shape is defined from the characteristic crystal size, the matrix of each crystal shape which transforms CSD into CLD in a uniform manner is calculated with Monte Carlo analysis. Characteristic crystal size is added to the variables defining chord length in order to avoid complex integrals and apply the change in crystal shape with characteristic crystal size to the transforming matrix. Secondly, CSD and CLD are actually measured in suspension of acetaminophen in ethanol and suspension of L-arginine in water to demonstrate the validity of 2 matrices. Lastly, these matrices are multiplied by some simple CSD models to test the properties of these matrices and demonstrate the utility of this transformation.

关键词： Focused Beam Reflectance Measurement (FBRM) Chord Length Distribution (CLD) Crystal Size Distribution (CSD) Monte Carlo Analysis Characteristic Crystal Size

Psychosocial Characteristics of Fathers Who Have Abused Their Children as Seen by Public Health Nurses

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Open Journal of Nursing 2014年第9期4卷 669-675页

作者： izumi Ueda Hisako izumi Kazuko Saeki Kyoko Namikawa Mizue Shiromaru Faculty of Health Sciences Hokkaido University Sapporo Japan School of Health Sciences Kawasaki University of Medical Welfare Kurashiki Japan School of Health Sciences Sapporo Medical University Sapporo Japan

This study aims to identify details of the psychosocial characteristics of fathers who have abused children as they appear to public health nurses (PHNs). In this study a qualitative descriptive design was applied to the data analysis. Interviewees were 10 public health nurses (PHNs), in charge of maternal and child health services for 5 or more years at public health centers. The study analyzed 13 cases reported in the PHNs interviews. The characteristics of the fathers who had abused children as seen by the PHNs were the psycho-social characteristics of ‘weak suppression and control of impulsiveness’, ‘cognitive dissonance in the fatherhood role’, ‘poor social sensitivity’, ‘unbalanced relationship with other members of the family’ and ‘weak relationships with people around the father’. The father’s impulsiveness and cognitive dissonances in the fatherhood role are associated with weaknesses in the family relationships and social adaptation. Conversely, the weakness in the strength of family relationships and social adaptation affects the father’s ability to control impulsiveness and give rise to the cognitive dissonance in the fatherhood role. These in turn interact to create a negative downward spiral, a steadily worsening situation. The findings of this study suggest the necessity for PHNs to focus on the background to the cognitive dissonance in the fatherhood role and to work to educate and guide the fathers.

关键词： Public Health Nurse Child Abuse Father Psychosocial Characteristics

Pharmacokinetics of paclitaxel in a hemodialysis patient with advanced gastric cancer: A case report

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World Journal of Gastroenterology 2006年第32期12卷 5237-5239页

作者： Susumu Kawate izumi Takeyoshi Yasuo Morishita Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan

我们第一次为一个病人报导每周的 paclitaxel 化疗的可能性与先进， nonresectable 胃的癌症经历牙齿过敏细胞溶解。有长期的肾衰竭的一个 50 岁的人由于双边的 polycystic，一个星期经历牙齿过敏细胞溶解三次 5 年了，在 2004 年 12 ... 详细信息

我们第一次为一个病人报导每周的 paclitaxel 化疗的可能性与先进， nonresectable 胃的癌症经历牙齿过敏细胞溶解。有长期的肾衰竭的一个 50 岁的人由于双边的 polycystic，一个星期经历牙齿过敏细胞溶解三次 5 年了，在 2004 年 12 月与吐血介绍了。与淋巴节点转移基于胃的癌症的诊断，外科被执行。在第 15 手术后的天，病人用 paclitaxel 与化疗被对待。Paclitaxel 在 saline 的 250 mL 作为 1 h iv 注入在 60 mg/m2 的剂量被管理。血液透析被开始在 paclitaxel 注入的结束以后的 1 h 并且为 3 h 被执行。Paclitaxel 在 d 上每周被管理 1， 8，和 15 在 28-d 上骑车。paclitaxel 的最大的血浆集中是 1390 microg/L。在 paclitaxel 的曲线下面的区域是 4398.6 microg x h/L。等级 2 白细胞减少在第一个周期期间被遇到。到在注入以后的超过 24 h 的从 6 的 paclitaxel 的血浆集中是在我们的病人的 0.01 ～ 0.1 micromol/L，并且这些集中被显示了在没有在病人生产不利副作用，禁止胃的癌症房间的生长上有效。paclitaxel 的血浆集中没被牙齿过敏细胞溶解影响。我们断定 paclitaxel 的 pharmacokinetics 没与肾衰竭在一个病人被改变，并且那每周的 paclitaxel 是为有先进胃的癌症的牙齿过敏细胞溶解病人的合适的治疗政体。

关键词：药物代谢动力学血液透析胃癌临床

Evaluation of the effects of a leader-training program on public health nurse leadership for staff in Japan

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Open Journal of Nursing 2012年第3期2卷 246-253页

作者： izumi Ueda Kazuko Saeki Mariko Kawaharada Michiyo Hirano Miyuki Seki Hisako izumi Department of Nursing Saitama Prefectural University Koshigaya Japan Department of Nursing Sapporo Medical University Sapporo Japan Faculty of Health Science Hokkaido University Sapporo Japan

This paper is a report of a study of the effects of a leader-training program, focusing on how public health nurse (PHN) leaders manage staff. In Japan, a system of training after graduation or training after acquisition of the PHN license has not been established. At present, PHN leaders are unable to devote as much time as they previously could to in-service education, and this has made it difficult to establish a suitable full-fledged in-service education system. Therefore, it is paramount for PHN leaders to acquire the necessary competence to train staff efficiently and, ultimately, play a more prominent role in the in-service education of novice PHNs. The effecttiveness of this program was evaluated before and after conducting the program over a 1-year period. A total of 145 leaders working for local government agencies in Japan participated in the program, and data from 87 participants were analyzed. Before the training program, Plan-Do-Check-Act cycle activities were less frequent than after the program. Intervention using a leader-training program that combines group and on-the-job training is effective for PHN leaders.

关键词： PHN Leaders Leader-Training Program In-Service Education Management Practice Japan

钆钡铜氧超导单晶块材的冷籽晶诱导生长及铁镍合金的掺杂作用(英文)

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Transactions of Nonferrous Metals Society of China 2013年第7期23卷 2042-2046页

作者：周迪帆徐坤 Shogo HARA 李备战 Mitsuru izumi Department of Marine Electronics and Mechanical Engineering Tokyo University of Marine Science and Technology2-1-6 Etchu-jimaKoto-kuTokyo 135-8533Japan

介绍了利用在MgO衬底上生长NdBa2Cu3Oy(Nd123)薄膜从而诱导生长GdBa2Cu3Oy(Gd123)超导单畴块材的工艺,并在此基础上研究了使用MgO缓冲层诱导生长钆钡铜氧单畴块材的工艺。通过调整热处理参数和缓冲层中Gd2BaCuO5(Gd211)相的含量,克服了... 详细信息

介绍了利用在MgO衬底上生长NdBa2Cu3Oy(Nd123)薄膜从而诱导生长GdBa2Cu3Oy(Gd123)超导单畴块材的工艺,并在此基础上研究了使用MgO缓冲层诱导生长钆钡铜氧单畴块材的工艺。通过调整热处理参数和缓冲层中Gd2BaCuO5(Gd211)相的含量,克服了MgO与Gd123母体的晶格失配和低反应率的问题。成功制备了Gd123单畴块材,研究了铁镍软磁合金粒子在超导块材中的掺杂作用。结果表明,0.4%(摩尔分数)为最优掺杂比例,超导临界电流在低场和中场下得到了很大的提升,对工业应用有重要意义。超导电流的提升主要源于铁、镍离子对铜位的替代,并提供了额外的磁通钉扎。

关键词：高温超导体单晶生长冷籽晶化学掺杂磁通钉扎临界电流二次峰效应

Optimal treatment for castration-resistant prostate cancer

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Asian Journal of Andrology 2014年第3期16卷 498-498页

作者： Kouji izumi Mikio Namiki Department of Integrative Cancer Therapy and Urology Kanazawa UniversityGraduate School of Medical Science Kanazawa Japan.

The review article of treatments for castration-resistant prostate cancer （CRPC） by Sartor and Gillessen describes available sequencing data in detail with outlines of each agent.~ Currently, the efficacy of docetaxel, radium-223, sipuleucel-T, abiraterone and enzalutamide （this is upcoming） as front-line agents and cabazitaxel, radium-223, abiraterone and enzalutamide as post-docetaxel agents have been confirmed by phase III randomized controlled trials （RCTs）. While the development of treatment options should be of great benefit to CRPC patients, physicians may need to pay attention to patient selection for each treatment as these agents have not been compared with one another by head-to-head RCT.

关键词： castration-resistant cancer pay attention