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Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy

World Journal of Gastroenterology 2013年第2期19卷 249-257页

作者： Takanori Hosokawa Masayuki Kurosaki Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki izumi Division of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan

AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative ***:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) *** mean age was 67.6 years and the mean observation period was 4.04 *** etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 *** Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 *** surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 *** associated with distant recurrence of HCC or survival were ***:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant *** 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of *** incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic *** 232 patients who had HCC recurrence,138 had a second *** 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1

关键词： Hyperglycemia Hepatocellular carcinoma Recurrence Radio frequency ablation Survival

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经睫状体平坦部行颞上或鼻下Baerveldt青光眼植入术的短期临床疗效比较

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国际眼科杂志 2021年第1期21卷 15-20页

作者： Masashi Sakamoto izumi Yoshida Takahiro Sodeno Kenichirou Aso Ryuya Hashimoto Hidetaka Masahara Takatoshi Maeno Toho大学Sakura医疗中心眼科日本樱井市2858741

目的:研究并探讨Baerveldt青光眼植入术(BGI)的不同植入部位对眼压(IOP)的影响。方法:对日本Toho大学Sakura医疗中心接受BGI治疗的新生血管性青光眼的病例进行回顾性分析。所有患者分为两组:颞上植入组(16例患者18眼,其中男性13例,女性3... 详细信息

目的:研究并探讨Baerveldt青光眼植入术(BGI)的不同植入部位对眼压(IOP)的影响。方法:对日本Toho大学Sakura医疗中心接受BGI治疗的新生血管性青光眼的病例进行回顾性分析。所有患者分为两组:颞上植入组(16例患者18眼,其中男性13例,女性3例;平均年龄62.9±14.4岁)和鼻下植入组(15例患者17眼,其中男性11例,女性4例;平均年龄56.9±10.7岁)。术后12mo随访复查。比较两组术后12mo与术前相比的眼压降低率。结果:颞上植入组:术前平均IOP为31.1±10.0 mmHg,术后平均IOP为14.4±4.5 mmHg;鼻下植入组:术前平均IOP为34.9±9.7 mmHg,术后平均IOP为15.9±3.7 mmHg。颞上植入组IOP降低率为(50.0±19.0)%,鼻下植入组降低率为(51.2±16.3)%。两组间无显著统计学差异(t-test,P=0.590)。结论:经睫状体平坦部行颞上或鼻下BGI的短期临床疗效无差异。

关键词： Baerveldt青光眼植入术眼压颞上鼻下睫状体平坦部

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Peeling a giant ileal lipoma with endoscopic unroofing and submucosal dissection

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World Journal of Gastroenterology 2010年第13期16卷 1676-1679页

作者： Takashi Morimoto Kuang-I Fu Hironori Konuma Yuko izumi Syujirou Matsuyama Kanako Ogura Akihisa Miyazaki Sumio Watanabe Department of Gastroenterology Juntendo University Nerima Hospital Department of Pathology Juntendo University Nerima Hospital Department of Gastroenterology Juntendo University School of Medicine

Lipoma is relatively common in the colon but is less often in the small intestine. Most lipomas are incidentally detected at endoscopy and are usually small and asymptomatic. However, some of them can present with obstruction and/or intussusceptions. Surgical resection is commonly recommended to remove such significant lipomas with a limited pedicle and larger than 2 cm in size, as endoscopic resection may result in unfavorable complications such as intestinal perforations. We report a case of 62-year-old man presenting with hematochezia. Colonoscopy showed a submucosal tumor, about 50 mm in size, in the terminal ileum. A clinical diagnosis of lipoma was established based on the findings of colonoscopy and abdominal computed tomography (CT). As the patient complained of hematochezia and mild iron deficiency anemia associated with repeated tumor prolapse, we decided to remove his lipoma. Consequently, the lesion was completely removed en bloc . Although abdominal CT immediately after removal of the lesion showed a small amount of free air, conservative treatment was successfully carried out for the perforation. Histologically, the removed lesion was a lipoma.

关键词： Lipoma Endoscopic submucosal dissection Endoscopic unroofing Perforation

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Treatment and care for elderly patients with oral and maxillofacial malignant tumors

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中国口腔颌面外科杂志 2008年第B5期6卷 169-170页

作者： Mie Tsujiuchi Takahiro Oneyama Akira Tanaka Akira Yamaguchi Minako Suzuki izumi Mataga Oral and Maxillofacial Surgery The Nippon Dental University Niigata Hospital Department of Oral and Maxillofacial Surgery 2 The Nippon Dental University School of Life Dentistry at Niigata Niigata Japan

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Memory Improvement by Yokukansankachimpihange and Atractylenolide III in the Olfactory Bulbectomized Mice

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Advances in Alzheimer's Disease 2016年第2期5卷 35-45页

作者： Hisanao izumi Yuzuru Sasaki Yasushi Yabuki Yasuharu Shinoda Nina Fujita Satoshi Yomoda Kohji Fukunaga Department of Pharmacology Tohoku University Graduate School of Pharmaceutical Sciences Sendai Japan Department of Pharmacology Kampo Research Laboratories Kracie Pharma Ltd. Toyama Japan

Alzheimer’s Disease (AD) shows cognitive dysfunction as core symptoms and Behavioral and Psychological Symptoms of Dementia (BPSD). Since acetylcholine nerve system derived from septum is collapsed in the AD patients, we have used Olfactory Bulbectomized (OBX) mice whose cholinergic system is largely impaired in the septum. Recently, Yokukansankachimpihange (YKH), a traditional Japanese Kampo medicine has used for BPSD in addition to improve cognitive dysfunction in AD patients. However the essential components for cognition and BPSD improvement and their mechanism are largely unknown. In present study, we found that Atractylenolide III (Aen-III), one of the components of YKH, improved cognitive deficits and depression in the OBX mice. OBX mice were orally administered with Aen-III (1.0 and 3.0 mg/kg) and YKH extracts daily for 18 days. Like YKH extracts, the Aen-III treatments ameliorated cognitive deficits and depression-like behavior observed in OBX mice. Importantly, Aen-III administration significantly restored the decreases in Ca2+/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation and phosphorylation of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) and cyclic AMP response element binding protein (CREB). The restoration of CaMKII and CaMKIV signaling is closely related to the increased BDNF levels. Furthermore, ATP reduction in OBX mice was rescued by Aen-III (3.0 mg/kg) and YKH (1000 mg/kg) treatment. In summary, Aen-III as a component of YKH ameliorates cognitive dysfunctions and depression via restoring CaMKII and CaMKIV signaling.

关键词： Yokukansankachimpihange Atractylenolide III Olfactory Bulbectomized Mice CaMKII BDNF

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Retrospective Survey on Mesiodens and Corresponding Odontoparallaxis in Japanese Children

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Health 2022年第9期14卷 939-948页

作者： Koji Watanabe Daigo Yoshiga Teppei Sago Masafumi Oda izumi Yoshioka Seiji Watanabe Yasuhiro Morimoto Division of Developmental Stomatognathic Function Science Department of Health Promotion Kyushu Dental University Kitakyushu Japan Division of Oral Medicine Department of Physical Functions Kyushu Dental University Kitakyushu Japan Division of Dental Anesthesiology Department of Physical Functions Kyushu Dental University Kitakyushu Japan Division of Oral and Maxillofacial Radiology Department of Physical Functions Kyushu Dental University Kitakyushu Japan

Supernumerary tooth in the upper central incisor region is called mesiodens. Mesiodens causes serious complications such as displacement, retarded eruption, and rotation in the adjacent permanent incisors, inducing inhibition of oral development. This report was aimed to provide epidemiology of mesiodens in Japanese children. Using dental record, panoramic radiographs and images of cone-beam computed tomography in 128 non-syndromic child patients, patients’ age at their first visit, gender composition, shape of mesiodens, position of mesiodens, posture of mesiodens, and age distribution of the patients based on each complication were investigated. In addition to the survey, patient age was compared between the groups with and without each complication. Patients’ age ranged 3 - 10 years old. Male-to-female ratio was approximately 3:1. Conical shape (75%) and inverted position (49%) were the most frequent among the patients. Displacement was the commonest complication. Age comparison indicated that patients with displacement or retarded eruption consulted the dentist younger than those without the complications. The present study provided etiology of mesiodens in Japanese children that will contribute to daily clinical practice in the field of pediatric dentistry.

关键词： Mesiodens Displacement Retarded Eruption Rotation

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A case of a patient positive for anti-cardiolipin antibodies with recurrent fetal wastage and cerebral infarction who was successfully treated with Sairei-to, low dose aspirin, and heparin

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Open Journal of Obstetrics and Gynecology 2012年第4期2卷 398-401页

作者： Taro Nonaka Makoto Chihara izumi Ooki Masaki Tamura Takumi Kurabayashi Koichi Takakuwa Department of Obstetrics and Gynecology Niigata City General Hospital Niigata Japan Department of Obstetrics and Gynecology Niigata University General Hospital of Medical and Dental Sciences Niigata Japan

We report a successful case of a pregnant female positive for anti-cardiolipin antibodies who experienced two abnormal pregnancies with postpartum cerebral hemispheric infarctions. A 38-year-old female diagnosed as being positive for anti-cardiolipin antibodies was referred to our hospital due to her strong desire to have a baby. The administration of Japanese herbal medicine, Sairei-to, as immunosuppressive therapy, and low dose aspirin, as anti-coagulation therapy, were initiated prior to the patient’s pregnancy. Five months after beginning the treatment, the patient conceived spontaneously. At 34 weeks of gestation, emergency cesarean section was performed due to increasing genital bleeding resulting from coincidental placenta previa and the patient delivered an appropriate-for-date female infant (1970 g). Treatment with Japanese herbal medicine (Sairei-to) and low-dose aspirin is considered to be an effective treatment option for patients positive for anti-phospholipid antibodies with past histories of abnormal pregnancies.

关键词： Anti-Cardiolipin Antibody Postpartum Cerebral Hemispheric Infarction Abnormal Pregnancy Sairei-to Low Dose Aspirin

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Fatal hemophagocytic lymphohistiocytosis presenting as Reye’s syndrome: Report of two cases

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Open Journal of Pediatrics 2012年第2期2卷 161-164页

作者： Shinji Kounami Koichi Minami Megumi Yoshiyama Genkichi izumi Noriyuki Aoyagi Norishige Yoshikawa Department of Pediatrics Wakayama Medical University Kimiidera Wakayama City Japan

We report two cases of rapidly fatal hemophagocytic lymphohistiocytosis (HLH) that presented as Reye’s syndrome (RS). The patients were referred to our hospital because of altered level of consciousness with hyperammonemia and hypoglycemia. The first patient, a 24-month-old girl (Case 1), died soon after arrival and was clinically diagnosed as having RS, but a diagnosis of HLH was established on the basis of autopsy findings. The other patient, a 4-month-old boy (Case 2), was diagnosed as having HLH in view of the bone marrow findings on admission, but immunosuppressive therapy failed to prevent a rapidly fatal course. Marked hypercytokinemia was found in both patients, and liver pathology demonstrated panlobular microvesicular steatosis of hepatocytes, resembling that in RS. Mononuclear cell infiltration with hemophagocytosis in the liver was evident in case 2, but not in case 1. In both cases, hypercytokinemia was thought to have caused mitochondrial dysfunction, resulting in RS-like microvesicular steatosis of hepatocytes. HLH is an important differential diagnosis of children presenting with RS-like picture.

关键词： Hemophagocytic Lymphohistiocytosis Reye’s Syndrome Cytokine Mitochondria Encephalopathy

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Relationship between muscle strength and anthropometric, body composition parameters in Japanese adolescents

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Health 2012年第1期4卷 1-5页

作者： Nobuyuki Miyatake Motohiko Miyachi izumi Tabata Noriko Sakano Tomohiro Hirao Takeyuki Numata 不详

We investigated the link between muscle strength and anthropometric, body composition parameters in Japanese adolescents. Forty eight men and 189 women, aged 15 - 19 years, were enrolled in this cross-sectional investigation study. Anthropometric and body composition parameters i.e. height, body weight, abdominal circumference, hip circumference and body fat percentage were measured. Muscle strength i.e. grip strength and leg strength were also evaluated. In men, grip strength was positively correlated with height and lean body mass. Leg strength was significantly correlated with height, body weight, hip circumference and lean body mass (r = 0.708). However, leg strength per body weight was negatively correlated with body mass index (BMI), abdominal circumference, hip circumference, body fat percentage (r = –0.719) and body fat mass. In women, grip strength was positively correlated with height. Leg strength was positively correlated with lean body mass (r = 0.482). Leg strength per body weight was negatively correlated with body fat percentage (r = –0.457) and body fat mass. Grip and leg strength was positively correlated with height and lean body mass, especially in men. However, leg strength per body weight was closely linked to body fat percentage in both sexes.

关键词： Anthropometric Parameters Body Composition Grip Strength Leg Strength Leg Strength Per Body Weight

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日本汉语学习者汉语鼻韵母感知及偏误研究

日本汉语学习者汉语鼻韵母感知及偏误研究

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作者：长坂泉（NAGASAKA izumi）上海外国语大学

学位级别：硕士

日本学习者在汉语“听”与“说”的方面,问题较多,尤其是汉语鼻韵母对日本学习者来说困难较大。日语中前后鼻韵母都属于拔音,然而汉语鼻韵母可以分为前鼻韵母与后鼻韵母的两种,所有汉语词汇中含有鼻韵母的汉字占全体汉字的48%。日本汉... 详细信息

日本学习者在汉语“听”与“说”的方面,问题较多,尤其是汉语鼻韵母对日本学习者来说困难较大。日语中前后鼻韵母都属于拔音,然而汉语鼻韵母可以分为前鼻韵母与后鼻韵母的两种,所有汉语词汇中含有鼻韵母的汉字占全体汉字的48%。日本汉语学习者在听力与发音上有很大的困难,给交流沟通带来不少的麻烦。从前人研究可知,鼻韵母发音偏误是日语的母语负迁移导致的,其中最大的区别是发音能力方面,日本汉语学习者在发音前后鼻韵母时张口度与发音部位不准确。并且在听辨能力方面也有困难,日本母语者的前鼻韵母听辨能力高于后鼻韵母听辨能力。但这一现象也可能是因为在无法分辨前后鼻韵尾的情况下,学习者将听到的韵尾归为前鼻韵尾。目前有关鼻韵母偏误的研究论文相对较少,而且每个鼻韵母偏误的原因因人而异。本文鉴于前人的研究,通过针对鼻韵母偏误进行了不同汉语水平(初级Ⅰ、初级Ⅱ、中级、高级Ⅰ、高级II)的日本学习者的感知听辨实验,从而确定鼻韵母发音偏误的问题,可以用来帮助日本汉语教学,提高针对日本汉语学习者的鼻韵母偏误纠正方法的有效性。研究结果显示,一是日本汉语学习者在前后鼻韵母单音节听辨能力上没有大的困难。二是从不同汉语水平被试的正确率来看,除了ong/eng韵母组的听辨能力随着汉语学习时长的增加而提高,其他前后鼻韵母组的听辨在不同学习水平中没有统计意义上的差异,即没有表现出听辨能力与学习时长或汉语水平的相关性。最后,基于研究结果,本论文探讨了针对日本汉语学习者的前后鼻韵母发音教学教材的改进方案,例如在教堂上积极选用电影或新闻节目等说地道汉语的影视作为教材,教师可以采用视听说法培养学生的听力与口语的两个不同方面能力。

关键词：汉语鼻韵母日语拔音听辨能力发音能力汉语教学

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