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Venous and arterial thromboembolism in patients with inflammatory bowel diseases

World Journal of Gastroenterology 2021年第40期27卷 6757-6774页

作者： Antoni Stadnicki izabela stadnicka Department of Physiology Faculty of MedicineUniversity of TechnologyKatowice 41-209Poland Department of Molecular Medicine Medical University of SilesiaFaculty of PharmacySosnowiec 41-200Poland

The risk of thromboembolism(TE)is increased in patients with inflammatory bowel disease(IBD),mainly due to an increased risk of venous TE(VTE).The risk of arterial TE(ATE)is less pronounced,but an increased risk of cardiovascular diseases needs to be addressed in IBD *** predisposes to arterial and venous thrombosis through similar prothrombotic mechanisms,including triggering activation of coagulation,in part mediated by impairment of the intestinal barrier and released bacterial *** in IBD has clinical specificities,i.e.,an earlier first episode in life,high rates during both active and remission stages,higher recurrence rates,and poor *** increased likelihood of VTE in IBD patients may be related to surgery,the use of medications such as corticosteroids or tofacitinib,whereas infliximab is ***-term complications of VTE can include post-thrombotic syndrome and high recurrence rate during post-hospital discharge.A global clot lysis assay may be useful in identifying patients with IBD who are at risk for *** VTEs occur in IBD outpatients;therefore,outpatient prophylaxis in high-risk patients is *** is crucial to continue focusing on prevention and adequate treatment of VTE in patients with IBD.

关键词： Inflammatory bowel disease Thrombosis Coagulation Bacterial components Prophylaxis Post-thrombotic syndrome

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