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Efficient fully blade-coated perovskite solar cells in air with nanometer-thick bathocuproine buffer layer

Nano Research 2021年第4期14卷 1034-1042页

作者： Sergio Castro-Hermosa Luana Wouk izabela silva bicalho Luiza de Queiroz Correa Bas de Jong Lucio Cina Thomas M.Brown Diego Bagnis CSEM Brasil Avenida Jose Candido da Silveira200031035-536 Belo HorizonteBrazil CHOSE(Centre for Hybrid and Organic Solar Energy) Department of Electronic EngineeringUniversity of Rome Tor VergataVia del Politecnico 100133 RomeItaly Hydro Engineering and Agricultural Development Research Group(GHIDA) Faculty of EngineeringUniversidad SurcolombianaAvenida Pastrana Borrero-Carrera 1410001 NeivaColombia Cicci Research srl via Giordania 227 58100 GrossetoItaly Department of Biotechnology Chemistry and PharmacyUniversity of SienaVia A.Moro 253100 SienaItaly

Fully printed perovskite solar cells(PSCs)were fabricated in air with all constituent layers,except for electrodes,deposited by the blade coating technique.The PSCs incorporated,for the first time,a nanometer-thick printed bathocuproine(BCP)hole blocking buffer using blade coating and deposited at relative humidity up to 50%.The PSCs with a p-i-n structure(glass/indium tin oxide(ITO)/poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS)/CH_(3)NH_(3)Pbl_(3)/[6,6]-phenyl-C_(61)-butyric acid methyl ester(PCBM)/BCP/Ag)delivered a maximum power conversion efficiency(PCE)of 14.9%on an active area of 0.5 cm^(2)when measured under standard test conditions.The PSCs with a blade coated BCP delivered performance of 10%and 63%higher(in relative terms)than those incorporating a spin coated BCP or without any BCP film,respectively.The atomic force microscopy(AFM)showed that blade coated films were more homogeneous and acted also as a surface planarizer leading to a reduction of roughness which improved BCP/Ag interface lowering charge recombination.The demonstration of 15%efficient devices with all constituent layers,including nanometer-thick BCP(〜10 nm),deposited by blade coating in air,demonstrates a route for industrialization of this technology.

关键词： perovskite buffer bathocuproine(BCP) blade coating printed electronics

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Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

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Journal of Pharmaceutical Analysis 2021年第6期11卷 726-731页

作者： Lisa Strasser Giorgio Oliviero Craig Jakes izabela Zaborowska Patrick Floris Meire Ribeiro da silva Florian Füssl Sara Carillo Jonathan Bones Characterization and Comparability Laboratory NIBRT-National Institute for Bioprocessing Research and TrainingDublinA94 X099Ireland School of Chemical and Bioprocess Engineering University College DublinDublinD04 V1W8Ireland

Ensuring the removal of host cell proteins(HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies(m Abs) remains a challenge.Since residual HCPs might affect product stability or safety,constant monitoring is required to demonstrate their removal to be below the regulatory accepted level of 100 ng/mg.The current standard analytical approach for this procedure is based on ELISA;however,this approach only measures the overall HCP content.Therefore,the use of orthogonal methods,such as liquid chromatography-mass spectrometry(LC-MS),has been established,as it facilitates the quantitation of total HCPs as well as the identification and quantitation of the individual HCPs present.In the present study,a workflow for HCP detection and quantitation using an automated magnetic bead-based sample preparation,in combination with a data-independent acquisition(DIA) LC-MS analysis,was established.Employing the same instrumental setup commonly used for peptide mapping analysis of m Abs allows for its quick and easy implementation into pre-existing workflows,avoiding the need for dedicated instrumentation or personnel.Thereby,quantitation of HCPs over a broad dynamic range was enabled to allow monitoring of problematic HCPs or to track changes upon altered bioprocessing conditions.

关键词： Data-independent acquisition Host cell proteins Critical quality attributes Liquid chromatography-mass spectrometry Monoclonal antibody Chinese hamster ovary cells

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Fruit-Based Non-Dairy Beverage: A New Approach for Probiotics

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Advances in Biological Chemistry 2021年第6期11卷 302-330页

作者： izabela Alves Gomes Armando Venâncio Janine Passos Lima Otniel Freitas-silva Graduate Program in Food Science and Nutrition (PPGAN) Federal University of the State of Rio de Janeiro Rio de Janeiro Brazil Centre of Biological Engineering (CEB) University of Minho Braga Portugal Embrapa Agroindústria de Alimentos Empresa Brasileira de Pesquisa Agropecuária Av das Américas Rio de Janeiro Brazil

The growing interest of consumers in using foods that improve health has motivated researchers and the food industry to develop new functional products such as foods with probiotics. Probiotic cultures, for example, from lactic acid bacteria and bifidobacteria have been highlighted for their ability to promote balance in the intestinal microbiota as well as other benefits such as anticarcinogenic and antimutagenic effects, reduced plasma cholesterol levels, decreased symptoms of lactose intolerance, and stimulation of the immune response. Traditionally, probiotics are incorporated into dairy products. However, because of the growing number of individuals affected by lactose intolerance and/or vegans, other food matrices have been studied as potential carriers for these microorganisms. Considering all the facts mentioned above, cereals, legumes, fruits, and vegetables could be potential substrates, where probiotic bacteria can be used for the development of non-dairy beverages. This review aimed to highlight the research carried out on 1) probiotic micro-organisms, including the more recent reclassification according to their phylogenetic position, 2) probiotic beverages from non-dairy sources which emerged as an alternative for lactose-intolerant consumers and, 3) the aspects of improving the gut microbiota.

关键词： Functional Foods Fruit Juice Lactobacillus Non-Dairy Beverages Gut Microbiota

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ID7 Isolated from Bauhinia variegata Stem Inhibits Tumor Progression and Metastatic Mechanisms of Triple Negative Breast Cancer in Vivo

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 368-384页

作者： Kamilla Monteiro dos Santos izabela Natalia Faria Gomes Renato Josésilva Oliveira Fernanda E.Pinto Bruno Oliveira Fabrício P.Batista Rafael Cesar Russo Chagas Hélio B.Santos Ralph G.Thomé Wanderson Romao Rui Manuel Reis Maria Luiza Vilela Oliva Rosy Iara Maciel de Azambuja Ribeiro Laboratory of Experimental Pathology Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Josédo Rosário Vellano University UnifenasDivinópolisMGBrazil Molecular Oncology Research Center(CPOM) Barretos Cancer HospitalBarretosSPBrazil Petroleomic and Forensic Chemistry Laboratory Department of ChemistryFederal Institute of Espírito Santo(IFES)VitóriaESBrazil Chemistry Department Federal University of Sao PauloBrazil Tissue Processing Laboratory Federal University of Sao Joao del-Rei(UFSJ)DivinópolisMGBrazil Life and Health Sciences Research Institute(ICVS) Medical SchoolUniversity of MinhoBragaPortugal 3ICVS/3B’s-PT Government Associate Laboratory GuimaraesBragaPortugal

Background:The breast cancer has been the most common form of cancer among women.The triple negative subtype represents 20%of all breast cancer cases in the world and is standing out by affecting young women and being aggressive.The main cause of death of patients with cancer is due to metastasis,which can reach the liver and lungs.Objective:The activities of ID7 fraction of the stems of Bauhinia variegata L.on breast cancer,lung metastasis and liver inflammatory process were evaluated.Method:ID7 was characterized by mass-spectrometry.The viability of murine mammary cells(4T1)treated with ID7 was assessed by MTT,trypan blue and fluorescence assay and viability of BT-20,MDA-MB-231 and MCF-7 human breast cancer tumor lines by MTS.The cell migration,invasion using matrigel and adhesion were performed.The expression of cell death proteins was quanitified by western blot and the gelatinases by zimogram.The ID7 activity of the tumor(4T1)and metastatic progession in vivo was evaluated.Results:ID7 reduced the 4T1 and MDA-MB-231viability and increased the late apoptosis,inhibited the 4T1 migration and invasion,increased the 4T1 adhesion and decreased the secreted active gelatinases.ID7 also increased the expression of PARP,caspase-7 and caspase-8,RIP and TNF-R1.In vivo,the ID7 decreased the volume and weight of the tumors and decreased lung metastasis and inflammation in the liver.The characterization showed mainly the presence of oleic acid,myricetin,quercetin and kaempferol in ID7.Conclusion:Thus,it was found that ID7 fraction exhibits selective antitumor and on the mechanisms of breast cancer metastasis activity,preventing lung metastasis and inflammation in the liver.It is suggested that fatty acids and flavonoids are correlated with such activities.

关键词： 4T1 cells MDA-MB-231 medicinal plants kaempferol gelatinases apoptosis cell viabilty in vivo

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Feasibility of Prototyping the Jominy Test Device: Corroborating for Studies and Preliminary Results of the Heating and Data Acquisition Subsystems

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Journal of Materials Science and Chemical Engineering 2021年第3期9卷 23-38页

作者： Giulliano A. S. Boaventura Ramon O. B. Santos Renann P. Gama Regina E. S. Cabette Mariana F. B. Motta Cesar A. Botura Adriano C. M. Rosa Any M. Rosa Wilson F. Muniz Carlos D. Jaeger Luiz F. F. Honorato Thiago A. Bimestre Edward P. I. silva Beatriz Santos Livya V. M. Oliveira Theresa C. G. Venuto Henrique C. Sampaio Samuel F. V. silva izabela F. L. Calazans Felipe A. Santos Fagner C. F. Santos Fernando H. A. Oliveira Department Mechanical Engineering Salesian University Center of Sao Paulo (UNISAL) S&#227 o Paulo Brazil Department Management and Business State College of Technology (FATEC) S&#227 o Paulo Brazil Department Mathematics International University Center (UNINTER) S&#227 o Paulo Brazil

This work contributed to a detailed study on a better understanding of the Jominy test, adopted a proportion of study to create the Jominy test device, exhibited favorable conceptions for the development of a prototype of the device, covering the four aspects of the project, being they: test device, test body heating system, test automation and instrumentation using embedded electronics and financial analysis for the elaboration of this project in Brazil. It was possible to observe in the results that the system is efficient, simple and functional, it was possible to obtain the first test carried out in the controlled environment the temperature data in degrees centigrade, the recorded data were automatically launched in Microsoft Excel by the PLX DAQ software, making the acquisition of the data. In the matter of preparing the test device, the drawings are presented in the 3D modeling software, cost tables of the materials used for assembly in Brazil. In terms of the heating system, a heating system was adopted that uses electromagnetic induction, the cost of materials related to the heating system design was also presented. Another relevant factor that contributes to the research and improvement of the prototype is the municipality, located in the Paraiba Valley region, located in the state of São Paulo, consisting of a fertile and relevant scenario of regional, national, international and multinational statistics, thus concluding the effectiveness for the mainly metallurgical industries. The results obtained were satisfactory and consistent, when they were created for the Jominy test device with the ability to submit small pieces for testing and mainly essential in the didactic point of view for a higher education institution of engineering and technology.

关键词： Tempering Jominy Test Data Acquisition Heating

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