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Characterisation of a novel, multifunctional, co-processed excipient and its effect on release profile of paracetamol from tablets prepared by direct compression

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 739-742页

作者： Eraga Sylvester Okhuelegbe Arhewoh Matthew Ikhuoria Uhumwangho Michael Uwumagbe iwuagwu magnus amara Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmacy University of Benin

Objective: To characterise a novel multifunctional pharmaceutical excipient and investigate its ef ect on paracetamol release from tablets prepared by direct ***: The excipient was prepared by co-processing gelatinized maize starch with sodium carboxymethyl cellulose and microcrystalline cellulose in a ratio of 2:1:1, dried and pulverized into powder. The excipient formulated was characterized using Fourier transform infrared spectroscopy and dif erential scanning calorimetry. The excipient was used to prepare batches of tablets by direct compression with drug-excipient ratios of 1:1, 1:2, 1:3 and 1:4. Parameters evaluated on tablets include crushing strength, friability and in vitro dissolution studies. Results: Differential scanning calorimetry analysis revealed a crystalline excipient while Fourier transform infrared spectroscopy showed no interaction between the excipient and paracetamol. Tablets from all the batches gave average crushing strength values between 3.47 and 4.88 kp. The 1:1 and 1:2 tablet batches were comparable to each other while 1:3 and 1:4 were also comparable to one another in their dissolution proi les. The dissolution parameters of the 1:4 batch was faster with- m∞(90.5%), t50%(3.5 min), t70%(11.6 min) while that of ratio 1:1 was the least with- m∞(48.6%), m5min(23.8%). Their release kinetics followed a KorsmeyerPeppas model with a super case-II transport ***: The drug-excipient ratios of 1:3 and 1:4 gave pharmaceutically acceptable tablets that met the British Pharmacopoeia specii cations. The t50% value of the 1:4 batch of tablets may i nd its usefulness in formulating drugs for which a fast onset of action is desired.

关键词： Co-processed excipient Dissolution proiles Paracetamol tablet Direct compression

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A comparative UV-HPLC analysis of ten brands of ibuprofen tablets

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Asian Pacific Journal of Tropical Biomedicine 2015年第10期5卷 880-884页

作者： Sylvester Okhuelegbe Eraga Mathew Ikhuoria Arhewoh Rosemary Ngozi Chibuogwu magnus amara iwuagwu Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmacy University of Benin

Objective: To investigate the pharmaceutical equivalence of ten brands of ibuprofen tablets(400 mg) purchased from pharmacies in Benin City, ***: The drug samples were subjected to uniformity of weight, crushing strength,friability, melting point, disintegration and dissolution tests following acceptable and official protocols. The ibuprofen content was determined using UV and high performance liquid chromatography ***: Crushing strength values of the drug samples ranged between 6 and 16 kp while the disintegration times were between 7.43 and 10.40 min(for uncoated tablets) and3.25–37.32 min(for coated tablets). Friability values were less than 1% and the melting points of recrystallized ibuprofen from the samples ranged from 73.5 to 76.0 C. The amount of ibuprofen released within 1 h ranged between 18% and 102% and two brands failed the content of active ingredient in the UV method of assay while all the brands passed the test using ***: Ibuprofen(400 mg) tablets marketed in Benin City, Nigeria vary in pharmaceutical quality.

关键词： pharmaceutical tablets ingredient passed melting d

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