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CleftGeneDB: a resource for annotating genes associated with cleft lip and cleft palate

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Science Bulletin 2021年第23期66卷 2340-2342页

作者： Haodong Xu Fangfang Yan Ruifeng Hu Akiko Suzuki Chihiro Iwaya Peilin Jia Junichi iwata Zhongming Zhao Center for Precision Health School of Biomedical InformaticsThe University of Texas Health Science Center at HoustonHouston TX 77030USA Department of Diagnostic&Biomedical Sciences The University of Texas Health Science Center at HoustonSchool of DentistryHouston TX 77054USA Center for Craniofacial Research The University of Texas Health Science Center at HoustonSchool of DentistryHouston TX 77054USA Pediatric Research Center The University of Texas Health Science Center at HoustonSchool of MedicineHouston TX 77030USA MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX 77030USA Human Genetics Center School of Public HealthThe University of Texas Health Science Center at HoustonHouston TX 77030USA

Cleft lip with/without cleft palate(CL/P) is one of the most common congenital human birth defects with a prevalence estimated at approximately 1/700 live births worldwide, varying with gender,ethnicity, and geographi... 详细信息

关键词：唇裂 congenital pathogenesis

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山西中部方言“兄”和“姊”同音冲突研究

云南师范大学学报（哲学社会科学版） 2017年第4期49卷 26-33页

作者：刘艳岩田礼陕西师范大学文学院陕西西安710119 金泽大学历史言语文化学系

同音冲突是语言中常见的一种现象,也是语言地理学的一个重要概念。文章通过山西中部地区79个方言点的语料,对亲属称谓词"兄"和"姊"的类型和地理分布进行了系统的考察,发现"兄"和"姊"的称谓在部分调查点同音,称"大大",造成了称谓上的混... 详细信息

同音冲突是语言中常见的一种现象,也是语言地理学的一个重要概念。文章通过山西中部地区79个方言点的语料,对亲属称谓词"兄"和"姊"的类型和地理分布进行了系统的考察,发现"兄"和"姊"的称谓在部分调查点同音,称"大大",造成了称谓上的混乱。研究证明,"大大"是后来产生的,当来源于"大哥"或"大姐"。文章进一步以此为基础,对汉语方言回避同音冲突的几种方法做了总结。

关键词：山西中部方言亲属称谓词同音冲突

Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer

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World Journal of Gastroenterology 2017年第14期23卷 2519-2526页

作者： Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera Department of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine Division of Biostatistics Clinical Research Center Aichi Medical University Hospital

AIMTo identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative ***-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy (distal gastrectomy or total gastrectomy) were included in the analysis. Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications (grade II or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease ***-six patients (21.1%) experienced grade II or higher postoperative complications. The platelet-lymphocyte ratio (PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value (0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71 (sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94 (95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications (OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative *** preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer.

关键词： Gastric cancer Gastrectomy Platelet-lymphocyte ratio Postoperative complication Prediction

Helicobacter cinaedi bacteremia with cellulitis after ABO-incompatible living-donor liver transplantation: Case report

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World Journal of Gastroenterology 2015年第25期21卷 7911-7915页

作者： Kohei Mishima Hideaki Obara Kayoko Sugita Masahiro Shinoda Minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Kentaro Matsubara Takehiko Mori Yaoko Takano Hiroshi Fujiwara Osamu Itano Naoki Hasegawa Satoshi iwata Yuko Kitagawa Department of Surgery Keio University School of Medicine Center for Infectious Diseases and Infection Control Keio University School of Medicine Division of Hematology the Department of Medicine Keio University School of Medicine Department of Infectious Diseases Keio University School of Medicine

Helicobacter cinaedi(H. cinaedi), a Gram-negative spiral-shaped bacterium, is an enterohepatic nonHelicobacter pylori Helicobacter species. We report the first case of H. cinaedi bacteremia with cellulitis after liver transplantation. A 48-year-old male, who had been a dog breeder for 15 years, underwent ABO-incompatible living-donor liver transplantation for hepatitis C virus-induced decompensated cirrhosis using an anti-hepatitis B core antibody-positive graft. The patient was preoperatively administered rituximab and underwent plasma exchange twice to overcome blood type incompatibility. After discharge, he had been doing well with immunosuppression therapy comprising cyclosporine, mycophenolate mofetil, and steroid according to the ABO-incompatible protocol of our institution. However, 7 mo after transplantation, he was admitted to our hospital with a diagnosis of recurrent cellulitis on the left lower extremity, and H. cinaedi was detected by both blood culture and polymerase chain reaction analysis. Antibiotics improved his symptoms, and he was discharged at day 30 after admission. Clinicians should be more aware of H. cinaedi in immunocompromised patients, such as ABO-incompatible transplant recipients.

关键词： Helicobacter cinaedi Bacteremia Cellulitis Liver transplantation Hepatitis C Living-donor ABOincompatible HBc-Ab-positive donor

动态旋叶压滤机滤室中符合幂函数规律的非牛顿型流体的流动特性

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流体工程 1992年第11期20卷 52-57,37页

作者： Haruo YAMAZAKI Toshiro MURASE Masashi iwata Mompei SHIRATO 杨志文朱萍

测定了在无渗透滤室中符合幂函数规律的非牛顿型流体在无槽与有槽转盘旋转下的流动状况,并且研究了转盘的形式、转速、滤室尺寸以及悬浮液的流变特性对速度分布和摩擦阻力的影响。

关键词：压滤机流动特性过滤机

Evaluation of diagnostic cytology via endoscopic naso-pancreatic drainage for pancreatic tumor

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World Journal of Gastrointestinal Endoscopy 2014年第8期6卷 366-372页

作者： Tomoyuki iwata Katsuya Kitamura Akira Yamamiya Yu Ishii Yoshiki Sato Tomohiro Nomoto Akitoshi Ikegami Hitoshi Yoshida Division of Gastroenterology Department of Medicine Showa University School of Medicine Shinagawa-ku Tokyo 142-8666 Japan

AIM: To evaluate the usefulness of cytology of the pancreatic juice obtained via the endoscopic naso-pancreatic drainage tube(ENPD-C).METHODS: ENPD was performed in cases where a diagnosis could not be made other than by using en-doscopic retrograde cholangiopancreatography and in cases of pancreatic neoplasms or cystic tumors, includ-ing intraductal papillary mucinous neoplasm(IPMN) suspected to have malignant potential. 35 patients(21 males and 14 females) underwent ENPD between January 2007 and June 2013. The pancreatic duct was imaged and the procedure continued in one of ENPD-C or ENPD-C plus brush cytology(ENPD-BC). We checked the cytology result and the final ***: The mean patient age was 69 years(range, 48-86 years). ENPD-C was performed in 24 cases andENPD-C plus brush cytology(ENPD-BC) in 11 cases. The ENPD tube was inserted for an average of 3.5 d. The final diagnosis was confirmed on the basis of the resected specimen in 18 cases and of follow-up findings at least 6 mo after ENPD in the 18 inoperable cases. Malignancy was diagnosed in 21 cases and 14 patients were diagnosed as having a benign condition. The ratios of class Ⅴ/Ⅳ:Ⅲ:Ⅱ/Ⅰ?findings were 7:7:7 in malignant cases and 0:3:11 in benign cases. The sensitivity and specificity for all patients were 33.3% and 100%, re-spectively. The cytology-positive rate was 37.5%(6/16) for pancreatic cancer. For IPMN cases, the sensitivity and specificity were 33% and 100%, ***: Sensitivity may be further increased by adding brush cytology. Although we can diagnosis cancer in cases of a positive result, the accuracy of ENPD-C remains unsatisfactory.

关键词： Endoscopic naso-pancreatic drainage Pancreatic juice Cytology Pancreatic cancer Intraductal papillary mucinous neoplasm

Pro-vs anti-stenotic capacities of type-Ⅰ vs type-Ⅱ human induced pluripotent-derived endothelial cells

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World Journal of Translational Medicine 2015年第3期4卷 113-122页

作者： Miwako Nishio Masako Nakahara Koichi Saeki Katsuhito Fujiu Hiroshi iwata Ichiro Manabe Akira Yuo Kumiko Saeki Department of Disease Control Research Institute National Center for Global Health and Medicine Section of Cell Engineering Department of Basic Research DNAVEC Center ID Pharma Co. Ltd. Department of Cardiovascular Medicine Graduate School of Medicine the University of Tokyo Translational Systems Biology and Medicine Initiative the University of Tokyo PRESTO Japan Science and Technology Agency

AIM:To verify in vivo relevance of the categorization of human vascular endothelial cells(VECs)into type-I(proproliferative)and type-II(anti-proliferative).METHODS:Endothelial layers of murine femoral arteries were removed by wire injury(WI)operation,a common technique to induce ***-I and type-II VECs produced from human induced pluripotent stem cells(iPSCs),whose characters were previously determined by their effects on the proliferation of vascular smooth muscle cells in in vitro co-culture experiments,were mixed with Matrigel?*** mixtures were injected into subcutaneous spaces around WI-operated femoral arteries for the transplanted human iPSC-derived VECs(iPSdECs)to take a route to the luminal surface via vasa vasorum,a nutrient microvessel for larger *** of the femoral arteries were examined over *** presence of human iPSdECs was checked by immunostaining studies using an antibody that specifically recognizes human *** of stenosis of the femoral arteries were calculated after three *** determine the optimal experimental condition,xenotransplantation experiments were performed under various conditions using immunocompromised mice as well as immunocompetent mice with or without administration of ***:Because immunocompromised mice showed unexpected resistance to WI-induced arteriostenosis,we performed xenotransplantation experiments using immunocompetent mice along with immunosuppressant *** one week,luminal surfaces of the WI-operated arteries were completely covered by human iPSdECs,showing the efficacy of our novel transplantation *** three weeks,type-IiPSdECs-transplanted arteries underwent total stenosis,while type-II-iPSdECs-transplanted arteries remained ***,untransplanted arteries of immunosuppressant-treated mice also remained intact by unknown *** found that transplanted human VECs had already been replaced by murine endothel

关键词： Vascular endothelial cells Vasa vasorum Arteriostenosis Wire injury Human induced pluripotent stem cells

High Quality and High Speed Casting Technologies for Round Billet Caster

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High Quality and High Speed Casting Technologies for Round B...

Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis

2007中国钢铁年会

作者： Masaya Asano Atsushi Hirata Hiroshi Hayashi Katsuyoshi iwata Yuichi Tsukaguchi Masayuki Kawamoto Sumikin Iron ＆ Steel Corporation 1850 Minato Wakayama-cityWakayama 640-8555Japan Sumikin Iron ＆ Steel Corporation 1850 Minato Wakayama-cityWakayama 640-8555Japan Sumikin Iron ＆ Steel Corporation 1850 Minato Wakayama-cityWakayama 640-8555Japan Sumikin Iron ＆ Steel Corporation 1850 Minato Wakayama-cityWakayama 640-8555Japan Sumitomo Metal Industries.Ltd. Sumitomo Metal Industries.Ltd.

＜正＞1 Introduction The advanced round billet casting technologies, mild cooling mold flux,short stroke oscillation,mold taper of multiple type and secondary cooling of short pitch ring header,etc.,have been developed at Wakayama Steel Works. Round billets are directly supplied to seamless pipe mill without blooming process. So, round billet casting is superior to bloom casting because of the lower cost,shorter lead time and higher quality.

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World Journal of Hepatology 2012年第1期4卷 11-17页

作者： Nobuhiro Aizawa Hirayuki Enomoto Hiroyasu Imanishi Masaki Saito Yoshinori iwata Hironori Tanaka Naoto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji Nakamura Shuhei Nishiguchi Division of Hepatobiliary and Pancreatic Disease Department of Internal Medicine Hyogo College of Medicine Department of Gasteroenterology Nissay Hospital

AIM: To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver ***: The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS: Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant dif- ference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P 3.0) was as follows: its sensitivity

关键词： Glycated albumin Glycated hemoglobin Liver fibrosis Liver biopsy Hepatitis C virus