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Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells

Cellular & Molecular Immunology 2020年第5期17卷 547-549页

作者： Ghizlane Maarifi Magdalena A.Czubala Justine Lagisquet Matthew O.ivory Kyra Fuchs Laure Papin James C.Birchall Sébastien Nisole Vincent Piguet Fabien P.Blanchet Institut de Recherche en Infectiologie de Montpellier(IRIM) Universitéde MontpellierCNRSMontpellierFrance Systems Immunity University Research Institute and Division of Infection and Immunity Cardiff University School of MedicineHeath ParkCardiffUK School of Pharmacy and Pharmaceutical Sciences Cardiff UniversityCardiffUK Division of Dermatology Women’s College HospitalTorontoCanada Division of Dermatology Department of MedicineUniversity of TorontoTorontoCanada

Interferons(IFNs)are“warning signal”cytokines released upon pathogen *** control the expression of interferonstimulated genes(ISGs),which are often crucial to restrict viral infections and establish a cellular antiviral state.1,2 Langerin(CD207),a well-known surface receptor on Langerhans cells(LC),belongs to the C-type lectin receptor(CLR)family and constitutes a major pathogen binding receptor able to regulate both innate and adaptive immune responses.3,4 Importantly,this CLR was reported as an antiviral receptor.

关键词： Langerhans interferon belongs

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