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Use of a rat model to characterize 35 arterial pulse wave parameters in a comparative study of isoflurane and Zoletil/ xylazine anesthesia and the effect of Acanthopanax senticosus extract

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动物模型与实验医学(英文) 2023年第5期6卷 474-488页

作者： Anton Misak Marian Grman Lenka Tomasova Ondrej Makara Zuzana Rostakova iveta waczulikova Karol Ondrias Institute of Clinical and Translational Research Department of Molecular PhysiologyBiomedical Research CenterSlovak Academy of SciencesBratislavaSlovak Republic Forest Arboretum Liptovsky Hradok Liptovsky HradokSlovak Republic Institute of Measurement Science Department of Theoretical MethodsSlovak Academy of SciencesBratislavaSlovak Republic Faculty of Mathematics Physics and InformaticsComenius UniversityBratislavaSlovak Republic

Background : Information obtained from arterial pulse waveforms (APW) can be usefulfor characterizing the cardiovascular system. To achieve this, it is necessary to know thedetailed characteristics of APWs in different states of an organism, which would allowAPW parameters (APW- Ps) to be assigned to particular (patho)physiological conditions.Therefore, our work aimed to characterize 35 APW- Ps in rats under the influence ofisoflurane (ISO) and Zoletil/xylazine (ZO/XY) anesthesia and to study the effect of rootextract from Acanthopanax senticosus (ASRE) in these anesthetic conditions.Methods : The right jugular vein of anesthetized rats was cannulated for the administrationof ASRE and the left carotid artery for the detection of APWs from which 35APW- Ps were evaluated.Results : We obtained data on 35 APW- Ps, which significantly depended on the anesthesia,and thus, they characterized the cardiovascular system under these two conditions.ASRE transiently modulated all 35 APW- Ps, including a transient decrease insystolic and diastolic blood pressure (BP) and heart rate or increases in pulse BP, d P /d t max , and systolic and diastolic areas. Whereas the transient effects of ASRE weresimilar, the extract had prolonged disturbing effects on the cardiovascular system inrats under ZO/XY but not under ISO anesthesia. This negative effect can result fromthe disturbance caused by ZO/XY anesthesia on the cardiovascular system.Conclusions : We characterized 35 APW- Ps of rats under ISO and ZO/XY anesthesiaand found that ASRE contains compounds that can modulate the properties of thecardiovascular system, which significantly depended on the status of the cardiovascularsystem. This should be considered when using ASRE as a nutritional supplementby individuals with cardiovascular problems.

关键词： Acanthopanax senticosus arterial pulse waveform blood pressure hemodynamic parameters isoflurane Zoletil/xylazine

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