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nonselective beta‐blockers reduce mortality in patients with acute‐on‐chronic liver failure

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Portal Hypertension & Cirrhosis 2022年第1期1卷 15-22页

作者： Anand V.Kulkarni Madhumita Premkumar Karan Kumar Juned A.Khan Baqar A.Gora Sowmya Tirumalle Sameer Shaik Mithun Sharma Rajesh Gupta nageshwar D.Reddy Padaki n.rao Department of Hepatology AIG HospitalsHyderabadIndia Department of Hepatology PGIMERChandigarhIndia Department of Hepatology Mahatma Gandhi HospitalsJaipurIndia Department of Hepatology Hopewell HospitalLucknowIndia

Aim:nonselective beta‐blockers(nSBBs)can reduce the incidence of complications in patients with cirrhosis and prolong *** safety and efficacy of nSBBs in real‐world settings in patients with acute‐on‐chronic liver failure(ACLF)identified by the Asian Pacific Association for the Study of Liver criteria are *** study aimed to assess the safety and efficacy of nSBBs in patients with Asian Pacific Association for the Study of Liver(APASL)‐defined ACLF Methods:In this retrospective,multicenter study,patients with ACLF with complete 30 days follow‐up from January 2019 to December 2021 were *** primary objective was to compare 30‐day mortality among standard of care(SOC)and nSBB(+SOC)*** secondary objectives were to compare the incidence of infection,variceal bleed,and recompensation among both the ***:A total of 346 patients were *** 26%(n=89)of them received nSBBs,while 74%(n=257)received only *** Kaplan-Meier analysis,the incidence of mortality was 21%(95%confidence interval[CI]:16.20-26.50)in SOC group compared to only 8%(95%CI:3.22-15.53)in nSBB group at Day 30(p=0.005).Similarly,mortality in SOC group was 63%(95%CI:56.81-69.00)compared to 46%(95%CI:35.44-57.00)in nSBB group at 1 year(p=0.001).nSBB therapy could not reduce the incidence of infections or variceal ***‐seven percent of patients in the SOC group and 73%of patients in the nSBB group(pn 77.5%and propranolol in 22.5%of ***:nSBBs reduce mortality without any effect on infection or variceal bleed in patients with ***,only one in four ACLF patients are suitable for nSBB therapy.

关键词： ACLF infection portal hypertension variceal bleed

A novel estimation algorithm for torpedo tracking in undersea environment

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Journal of Central South University 2019年第3期26卷 673-683页

作者： D.V.A.n.RAVI KUMAR S.KOTESWARA rao K.PADMA RAJU Department of ECE GVPCEW Department of ECE KLEF Department of ECE JNT University

A novel estimation algorithm is introduced to handle the popular undersea problem called torpedo tracking with angle-only measurements with a better approach compared to the existing filters. The new algorithm produces a better estimate from the outputs produced by the traditional nonlinear approaches with the assistance of simple noise minimizers like maximum likelihood filter or any other algorithm which belongs to their family. The introduced method is extended to the higher version in two ways. The first approach extracts a better estimate and covariance by enhancing the count of the intermediate filters, while the second approach accepts more inputs so as to attain improved performance without enhancement of the intermediate filter count. The ideal choice of the placement of towed array sensors to improve the performance of the proposed method further is suggested as the one where the line of sight and the towed array are perpendicular. The results could get even better by moving the ownship in the direction of reducing range. All the results are verified in the MATLAB environment.

关键词： estimation algorithm torpedo tracking angle-only measurements line of sight maximum likelihood filter

Crystallization and preliminary X-ray crystallographic analysis of yeast prion protein Ure2p with shortened n-terminal

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Chinese Science Bulletin 2001年第12期46卷 1012-1014页

作者： WAnG Liwei ZHU Li ZHOU Junmei rao Zihe Laboratory of Structural Biology Department of Biological Sciences and Biotechnology&Protein Sciences Laboratory of MOETsinghua UniversityBeijing 100084China national Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

An orthorhombic crystal form of a recombi-nant yeast prion protein with shortened n-terminal, 90Ure2p, has been obtained. Crystals were grown by the vapordiffu-sion technique against a mother liquor containing imidazole. Crystals belong to the primitive orthorhombic lattice with the cell parameters a = 54.5 A, b = 74.7 A, c = 131.0 A. The crystals diffract to beyond 3.0 A resolution at a synchrotron beamline.

关键词： yeast prion Ure2p crystallization.

Effect of ramp-cavity on hydrogen fueled scramjet combustor

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Propulsion and Power Research 2014年第1期3卷 22-28页

作者： J.V.S.Moorthy B.Rajinikanth B.V.n.Charyulu G.Amba Prasad rao Scientist Defence Research and Development LaboratoryHyderabadAndhra Pradesh 500058India Professor in Mechanical Engineering National Institute of TechnologyWarangalAndhra Pradesh 506004India

Sustained combustion and optimization of combustor are the two challenges being faced by combustion scientists working in the area of supersonic *** mixing,lower stagnation pressure losses,positive thrust and sustained combustion are the key issues in the field of supersonic *** fluid mechanism is required to achieve good *** induce such mechanisms in supersonic inflows,the fuel injectors should be critically shaped incurring less flow *** investigations are focused on the effect of fuel injection scheme on a model scramjet combustor *** at supersonic flow generate axial vortices that help in macro-mixing of fuel with *** of shocks generated by ramps with the fuel stream generates boro-clinic torque at the air&liquid fuel interface,enhancing *** zones present in cavities increase the residence time of the combustible *** use of the advantageous features of both,a ramp-cavity combustor is *** combustor has two ***,constant height section consists of a backward facing step followed by ramps and cavities on both the top and bottom *** ramps are located alternately on top and bottom *** complete combustor width is utilized for the *** second section of the combustor is diverging area *** is provided to avoid thermal *** the present work gaseous hydrogen is considered as *** study was mainly focused on the mixing different fuel injection *** was found that injecting fuel upstream of the ramp was beneficial from fuel spread point of view.

关键词： Supersonic combustion Combustion instabilities Ramps Cavities Mixing

Early Report of the Source Characteristics,Ground Motions,and Casualty Estimates of the 2023 Mw 7.8 and 7.5 Turkey Earthquakes

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Journal of Earth Science 2023年第2期34卷 297-303页

作者： Wenkai Chen Gang rao Dengjie Kang Zhifan Wan Dun Wang Lanzhou Institute of Seismology China Earthquake AdministrationLanzhou730000China School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500China State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan430074China

InTRODUCTIOn,At 01:17 UTC(04:17 on local time)on Feb.6,2023,a devastating earthquake with a moment magnitude(Mw)7.8 occurred in the Gaziantep,southern *** earthquake was located at 37.174°n and 37.032°E,with a hypoc... 详细信息

关键词： earthquake magnitude Earthquake

Developing potent PROTACs tools for selective degradation of HDAC6 protein

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Protein & Cell 2019年第11期10卷 606-609页

作者： Zixuan An Wenxing Lv Shang Su Wei Wu Yu rao MOE Key Laboratory of Protein Sciences School of Life Sciences Tsinghua University Beijing 100084 China MOE Key Laboratory of Protein Sciences School of Pharmaceutical Sciences MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Beijing Advanced Innovation Center for Structural Biology Tsinghua University Beijing 100084 China

Dear Editor, Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups on histone and non-histone proteins, thereby playing a vital role in the modulation of gene expression and protein activity. Eighteen HDACs have been identified in human and subdivided into four classes including I, II (Ila, lib), III and IV (Seto et al., 2014). Among them, HDAC6 is a unique lib HD AC with dominant cytoplasmic localization and two functional catalytic domains. Besides the functions for deacetylation of histone, and modulation of a-tubulin, HSP90 and cortactin, HDAC6 also participates in protein trafficking and degradation, cell shape and migration (Valenzuela-Fernandez et al., 2008). The deregulation of HDAC6 is related to various diseases, such as neurodegenerative diseases, cancer and pathological autoimmune response (Batchu et al., 2016). Hence, it is especially important for directly controlling cellular HDAC6 protein levels to achieve therapeutic purposes. The traditional approaches of red u ci ng cellular protein levels mainly rely on genetic modifications, such as RnA interference, transcription activator-like effector nucleases, recombination-based gene knockout and clustered regularly interspaced short palindromic repeats (CRISPR-Cas9)(Boettcher et al., 2015). However, these approaches have failed to a certain degree to achieve acute and reversible changes of gene function. Furthermore, the complications of potential genetic compensation and/or spontaneous mutations arising in geneknockout models may lead to misinterpretations (Davisson etal., 2012;El-Brolosy etal., 2017). Therefore, it is urgent for developing a rapid, robust, and reversible approach to directly modulate HDAC6 protein levels.

关键词： PROTACs tools selective degradation HDAC6 protein

Deep convolutional neural network models for weed detection in polyhouse grown bell peppers

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Artificial Intelligence in Agriculture 2022年第1期6卷 47-54页

作者： A.Subeesh S.Bhole K.Singh n.S.Chandel Y.A.Rajwade K.V.R.rao S.P.Kumar D.Jat ICAR-Central Institute of Agricultural Engineering(CIAE) BhopalMadhya PradeshIndia

Conventional weed management approaches are inefficient and non-suitable for integration with smart agricultural *** identification and classification of weeds can play a vital role in weed management contributing to better crop *** and smart spot-spraying system's efficiency relies on the accuracy of the computer vision based detectors for autonomous weed *** the present study,feasibility of deep learning based techniques(Alexnet,GoogLenet,InceptionV3,Xception)were evaluated in weed identification from RGB images of bell pepper *** models were trained with different values of epochs(10,20,30),batch sizes(16,32),and hyperparameters were tuned to get optimal *** overall accuracy of the selected models varied from 94.5 to 97.7%.Among the models,InceptionV3 exhibited superior performance at 30-epoch and 16-batch size with a 97.7%accuracy,98.5%precision,and 97.8%*** this Inception3 model,the type 1 error was obtained as 1.4%and type II error was 0.9%.The effectiveness of the deep learning model presents a clear path towards integrating them with image-based herbicide applicators for precise weed management.

关键词： Bell pepper Computer vision Convolutional neural networks Deep learning Weed identification

A new Species of Glyphoglossus Günther,1869(Anura:Microhylidae) from Western Yunnan,China

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Asian Herpetological Research 2021年第4期12卷 371-380页

作者： Dongru ZHAnG Shuo LIU Lixia ZHAnG Hong HUI Heng XIAO Dingqi rao State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223YunanChina Colege of Life Sciences Yunnan UniversityKunming 650091YunanChina Kunming natural History Museum of Zoology Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223YunanChina Department of Ecology College of Life SciencesHenan Normal UniversityXinxiang 453007HenanChina Research Center for ecological management and protection of the Yellow River Basin Xinxiang 453007HenanChina

A new species of microhylid frog of the genus Glyphoglossus Gunther,1869 is described from Huadianba,Cangshan Mountain,Dali Bai Autonomous Prefecture,Yunnan Province,*** huadianensis,new species,is compared with congeners from China and other parts of Southeast Asia,and was distinguished from the others by the following combination of characters:adult male body size up to 37.8 mm;pupil rounded;supra tympanic fold distinct;tympanum concealed;toe tips obtuse;subarticular tubercles prominent and rounded;foot webbing extensive;outer metatarsal tubercle present;dorsum tuberculate,yellowish-brown/earth-yellow;and a pair of conspicuous large round spots in *** new species is the tenth species of Glyphoglossus to be described,and the second known from China.

关键词： Glyphoglossus huadianensis sp.n. taxonomy morphology China

An integrated and efficient process for borax preparation and magnetite recovery from soda-ash roasted ludwigite ore under CO–CO_(2)–n_(2) atmosphere

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International Journal of Minerals,Metallurgy and Materials 2023年第11期30卷 2169-2181页

作者： Jinxiang You Jing Wang Mingjun.rao Xin Zhang Jun Luo Zhiwei Peng Guanghui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

To realize the comprehensive utilization of ludwigite ore,an integrated and efficient route for the boron and iron separation was proposed in this work,which via soda-ash roasting under CO–CO_(2)–n_(2) atmosphere followed by grind-leaching,magnetic separation,and CO_(2) *** effects of roasting temperature,roasting time,CO/(CO+CO_(2))composition,and na_(2)CO_(3) dosage on the boron and iron separation indices were primarily *** the optimized conditions of the roasting temperature of 850℃,roasting time of 60 min,soda ash dosage of 20 wt%,and CO/(CO+CO_(2)) of 10 vol%,92%of boron was leached during wet grinding,and 88.6%of iron was recovered during the magnetic separation and magnetic concentrate with a total iron content of 61.51 wt%.Raman spectra and^(11)B nMR results indicated that boron exists asB(OH)_(4)^(-) in the leachate,from which high-purity borax pentahydrate could be prepared by CO_(2) carbonation.

关键词： ludwigite ore soda-ash roasting CO-CO_(2)-n_(2)atmosphere borax