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Growing importance of urogenital candidiasis in individuals with diabetes:A narrative review

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World Journal of Diabetes 2022年第10期13卷 809-821页

作者： Jasminka Talapko Tomislav Meštrović ivanaŠkrlec Laboratory for Microbiology Faculty of Dental Medicine and HealthJosip Juraj Strossmayer University of OsijekOsijek 31000Croatia University North University Centre VaraždinVaraždin 42000Croatia Institute for Health Metrics and Evaluation Department for Health Metrics SciencesUniversity of Washington School of MedicineSeattleWashington 98195United States Department of Biophysics Biologyand ChemistryFaculty of Dental Medicine and HealthJ.J.Strossmayer University of OsijekOsijek 31000Croatia

Both diabetes and fungal infections contribute significantly to the global disease burden,with increasing trends seen in most developed and developing countries during recent *** is reflected in urogenital infections caused by Candida species that are becoming ever more pervasive in diabetic patients,particularly those that present with unsatisfactory glycemic *** addition,a relatively new group of anti-hyperglycemic drugs,known as sodium glucose cotransporter 2 inhibitors,has been linked with an increased risk for colonization of the urogenital region with Candida spp.,which can subsequently lead to an infectious *** this review paper,we have highlighted notable virulence factors of Candida species(with an emphasis on Candida albicans)and shown how the interplay of many pathophysiological factors can give rise to vulvovaginal candidiasis,potentially complicated with recurrences and dire pregnancy *** have also addressed an increased risk of candiduria and urinary tract infections caused by species of Candida in females and males with diabetes,further highlighting possible complications such as emphysematous cystitis as well as the risk for the development of balanitis and balanoposthitis in(primarily uncircumcised)*** a steadily increasing global burden of diabetes,urogenital mycotic infections will undoubtedly become more prevalent in the future;hence,there is a need for an evidence-based approach from both clinical and public health perspectives.

关键词： Balanitis Balanoposthitis Candida Candidiasis Diabetes Pregnancy Urogenital infections Vulvovaginitis

Diversity of livestock associated methicillin-resistant Staphylococcus aureus

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 929-931页

作者： Henok A.Tegegne ivana Kolackova Renata Karpískova Department of Bacteriology Veterinary Research InstituteBrnoCzech Republic Faculty of Veterinary Hygiene and Ecology University of Veterinary and Pharmaceutical Sciences BrnoCzech Republic

Objective: To evaluate the diversity and molecular characteristics of livestock associated methicillin-resistant Staphylococcus aureus in livestock animals, food of animal origin and the environment in the Czech ***: After having been primarily enriched in buffered peptone water, the samples were cultured on Baird–Parker agar. Presumptive colonies were sub-cultured to blood agar and assessed morphologically. Furthermore, presumptive Staphylococcus aureus colonies were confirmed by MALDI-TOF. Multiplex PCR, spa-typing, and MLST have been used to characterize the strains. Each mec A-positive Staphylococcus aureus isolates were examined against 14 different antimicrobials by using disk diffusion ***: In this study, 13 different spa-types belonging to five sequence types(ST) were detected. Ninety four percent of tested strains belonged to CC/ST398 for which t011,t034, t2123 and t2346 were the vast major spa-types. In addition, non-ST398 clones such as CC1(t127), ST5(t3598), ST8(t064) and ST361(t315) were detected, which are known as human associated ***: The diversity of livestock associated methicillin-resistant Staphylococcus aureus has grown, and detecting lineages of human origin in animals and vice-versa becomes more common. Thus, livestock animal and its products will be a potential for the evolvement of methicillin-resistant Staphylococcus aureus in human *** of pigs as well as other food-producing animal species and their products is therefore recommended.

关键词： CC398 MLST PCR Spa-typing

Quadricuspid aortic valve and right ventricular type of myocardial bridging in an asymptomatic middle-aged woman:A case report

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World Journal of Clinical Cases 2022年第25期10卷 8954-8961页

作者： ivana Sopek Merkaš Nenad Lakušić Maja Hrabak Paar Department of Cardiology Special Hospital for Medical Rehabilitation Krapinske TopliceKrapinske Toplice 49217Croatia Department of Clinical Medicine Faculty of Dental Medicine and Health OsijekOsijek 31000Croatia Department of Internal Medicine Family Medicine and History of MedicineFaculty of Medicine OsijekOsjiek 31000Croatia Department of Diagnostic and Interventional Radiology University Hospital Centre ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

BACKGROUND Quadricuspid aortic valve(QAV)is a very rare congenital cardiac defect with the incidence of 0.0125%-0.033%(<0.05%)predominantly causing aortic regurgitation.A certain number of patients(nearly one-half)have abnormal function and often require surgery,commonly in their fifth or sixth *** usually appears as an isolated anomaly but may also be associated with other cardiac congenital *** is considered the main diagnostic method although more and more importance is given to computed tomography(CT)and magnetic resonance imaging(MRI)as complementary *** SUMMARY A 60-year-old female patient was referred for transthoracic ultrasound of the heart as part of a routine examination in the treatment of arterial *** did not have any significant *** was confirmed and there were no elements of valve stenosis with moderate aortic *** first,it seemed that in the projection of the presumed left coronary cusp,there were two smaller and equally large cusps along with two larger and normally developed *** CT imaging was performed to obtain an even more precise valve morphology and it showed that the location of the supernumerary cusp is between the right and left coronary cusp,with visible central malcoaptation of the ***,coronary computed angiography confirmed the right-type of myocardial bridging at the distal segment of the left anterior descending coronary *** valve dysfunction often occurs in middle-aged patients and results in surgical treatment,therefore,a 1-year transthoracic echocardiogram control examination and follow-up was recommended to our *** This case highlights the importance of diagnosing QAV since it leads to progressive valve dysfunction and can be associated with other congenital heart defects which is important to detect,emphasizing the role of cardiac CT and MRI.

关键词： Quadricuspid aortic valve Congenital cardiac defect Aortic insufficiency Multimodal imaging Myocardial bridging Case report

Immune defense of wild-caught Norway rats is characterized by increased levels of basal activity but reduced capability to respond to further immune stimulation

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Integrative Zoology 2018年第2期13卷 180-193页

作者： ivana MIRKOV Aleksandra POPOV ALEKSANDROV Vesna SUBOTA Dragan KATARANOVSKI Milena KATARANOVSKI Immunotoxicology Group Department of EcologyInstitute for Biological Research“Sinisa Stankovic”University of BelgradeBelgradeSerbia Institute for Medical Biochemistry Military Medical AcademyBelgradeSerbia Institute of Zoology Faculty of BiologyUniversity of BelgradeBelgradeSerbia Institute of Physiology and Biochemistry Faculty of BiologyUniversity of BelgradeBelgradeSerbia

Studies of wild animals’immunity often use comparison with laboratory-raised *** such an approach,various data were obtained concerning wild Norway rat’s *** or higher potential of immune system cells to respond to activation stimuli were shown,because of analysis of disparate parameters and/or small number of analyzed *** differences between laboratory and wild rats were shown too,owing to great response variability in wild *** hypothesized that wild rats will express more intense immune activity compared to their laboratory counterparts which live in a less demanding *** test this,we analyzed the circulating levels of inflammatory cytokine interleukin-6(IL-6),a mediator which has a central role in host immune *** addition,we examined the activity of the central immune organ,the spleen,including cell proliferation and production of pro-inflammatory cytokines interferon-γ(IFN-γ)and interleukin-17(IL-17),which are major effectors of cellular adaptive immune *** order to obtain reasonable insight into the immunity of wild Norway rats,analysis was conducted on a much larger number of individuals compared to other *** levels of plasma IL-6,higher spleen mass,cellularity and basal IFN-γproduction concomitantly with lower basal production of anti-inflammatory cytokine interleukin-10(IL-10)revealed more intense immune activity in the wild compared to laboratory ***,lower responsiveness of their spleen cells’proinflammatory cytokine production to concanavalin A(ConA)stimulation,along with preserved capacity of IL-10 response,might be perceived as an indication of wild rats’reduced capability to cope with incoming environmental stimuli,but also as a means to limit tissue damage.

关键词： circulating interleukin-6 levels spleen cell cytokine production spleen cell proliferation

Dietary habits of colorectal neoplasia patients in comparison to their first-degree relatives

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World Journal of Gastroenterology 2014年第17期20卷 5025-5030页

作者： ivana Mikoviny Kajzrlikova Petr Vitek Josef Chalupa Petr Dite Beskydy Gastrocentre Department of Internal MedicineHospital Frydek-Mistek73818 Frydek-MistekCzech Republic Center of Gastroenterology Department of Internal MedicineUniversity of OstravaFaculty of Medicine70852 OstravaCzech Republic

AIM: To compare the dietary habits between colorectal neoplasia patients, their first-degree relatives, and unrelated controls.

关键词： Colorectal neoplasms Family Food habits Risk factors Mass screening

Hypoxia-inducible factor-1αin myocardial infarction

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World Journal of Cardiology 2024年第4期16卷 181-185页

作者： ivanaŠkrlec Sergey N Kolomeichuk Faculty of Dental Medicine and Health Josip Juraj Strossmayer University of OsijekOsijek 31000Croatia Institute of Biology Karelia Research Center of Russian Academy of SciencesPetrozavodsk 185910Russia Laboratory for Genomics Proteomicsand MetabolomicsResearch Institute of Biomedicine and Biomedical TechnologiesTyumen State Medical UniversityTyumen 625023Russia

Hypoxia-inducible factor 1(HIF1)has a crucial function in the regulation of oxygen levels in mammalian cells,especially under hypoxic *** importance in cardiovascular diseases,particularly in cardiac ischemia,is because of its ability to alleviate cardiac *** oxygen-responsive subunit,HIF1α,plays a crucial role in this process,as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival,angiogenesis,and ***,HIF1αexpression induced reperfusion in the ischemic skeletal muscle,and hypoxic skin wounds in diabetic animal models showed reduced HIF1α*** expression of HIF1αhas been shown to reduce apoptosis and oxidative stress in cardiomyocytes during acute myocardial *** variations in HIF1αhave also been found to correlate with altered responses to ischemic cardiovascular *** addition,a link has been established between the circadian rhythm and hypoxic molecular signaling pathways,with HIF1αfunctioning as an oxygen sensor and circadian genes such as period circadian regulator 2 responding to changes in *** editorial analyzes the relationship between HIF1αand the circadian rhythm and highlights its significance in myocardial adaptation to *** the changes in molecular signaling pathways associated with diseases,specifically cardiovascular diseases,provides the opportunity for innovative therapeutic interventions,especially in low-oxygen environments such as myocardial infarction.

关键词： Cardiovascular pathologies Circadian genes Hypoxia-inducible factor 1 Hypoxia Gene-gene interaction

Surface modifications of biometallic commercially pure Ti and Ti–13Nb–13Zr alloy by picosecond Nd:YAG laser

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International Journal of Minerals,Metallurgy and Materials 2021年第2期28卷 285-295页

作者： Slađana Laketić Marko Rakin MilošMomčilović Jovan Ciganović Đorđe Veljović ivana Cvijović-Alagić Vinča Institute of Nuclear Sciences University of BelgradeP.O.Box 52211001 BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia

The effects of picosecond Nd:YAG laser irradiation on chemical and morphological surface characteristics of the commercially pure titanium and Ti–13Nb–13Zr alloy in air and argon atmospheres were studied under different laser output energy *** the interaction of laser irradiation with the investigated materials,a part of the energy was absorbed on the target surface,influencing surface *** beam interaction with the target surface resulted in various morphological alterations,resulting in crater formation and the presence of microcracks and hydrodynamic ***,different chemical changes were induced on the target materials’surfaces,resulting in the titanium oxide formation in the irradiation-affected area and consequently increasing the irradiation energy *** the high energy absorption at the site of interaction,the dimensions of the surface damaged area ***,surface roughness *** appearance of surface oxides also led to the increased material hardness in the surface-modified *** chemical and morphological changes were pronounced after laser irradiation of the Ti–13Nb–13Zr alloy surface.

关键词： commercially pure titanium Ti-13Nb-13Zr alloy surface modification Nd:YAG laser laser-induced damage hard oxidized surface

Study of polygalacturonase production by an Antarctic yeast and obtention of dragon fruit juice by maceration at mild temperature

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Food Bioscience 2022年第5期49卷 893-903页

作者： Brenda Bezus Juan Carlos Contreras Esquivel Sebasti´an Cavalitto ivana Cavello Centro de Investigaci´on y Desarrollo en Fermentaciones Industriales(CINDEFI UNLPCCT-La PlataCONICET)Calle 47 y 115B1900ASHLa PlataProvincia de Buenos AiresArgentina Laboratory of Applied Glycobiotechnology Academic Group of Food Science and TechnologySchool of ChemistryUniversidad Autonoma de CoahuilaUnidad SaltilloSaltillo2528CoahuilaMexico

The objectives of the present survey were to study the production and the biochemical characterization of an enzymatic cold-active extract with polygalacturonase activity,to perform a first insight into its possible application in fruit-juice obtention process,and to use this juice for food products *** enzymatic extract was produced by the Antarctic yeast Mrakia *** January 7,2016 in a bioreactor with citric pectin as *** polygalacturonase activity showed optimum conditions for reaction at 45◦C and pH *** activity was stable until 40◦C but deactivated at higher *** by Hg+2 suggested the presence of a thiol-dependent enzyme.A high-molecular polygalacturonase was detected in an SDS-PAGE and zymography ***-products were observed by thin-layer chromatography and suggested the endo-mode of *** enzymatic extract had some accessory enzymes,such as pectin methylesterase,β-glucosidase,cellulase and *** a first insight into the potential use of this enzymatic extract for fruit maceration at mild temperatures,red and white dragon fruits were selected as *** 23◦C,juice yields of 15%-23%higher than control were obtained after treatments,with a decrease of remanent solid of 25%-35%.The color of red dragon fruit juice increased with enzymatic *** balls that were prepared with the juices demonstrated a hardness of~10 *** compression force of low-calorie sugar gels was 3.8 *** work provided a complete study of the production,characterization,application and food product production using a new cold-active polygalacturonase extract of Antarctic origin.

关键词： Antarctic enzymes Cold active pectinases Mrakia sp Hylocereus monacanthus Hylocereus undatus

Aneuploidy in pluripotent stem cells and implications for cancerous transformation

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Protein & Cell 2014年第8期5卷 569-579页

作者： Jie Na Duncan Baker Jing Zhang Peter W. Andrews ivana Barbaric School of Medicine Tsinghua University Beijing 100084 China Sheffield Diagnostic Genetic Services Sheffield Children's Hospital Sheffield S10 2TH UK Centre for Stem Cell Biology Department of Biomedical Science The University of Sheffield Sheffield S10 2TN UK

Owing to a unique set of attributes, human pluripotent stem cells （hPSCs） have emerged as a promising cell source for regenerative medicine, disease modeling and drug discovery. Assurance of genetic stability over long term maintenance of hPSCs is pivotal in this endeavor, but hPSCs can adapt to life in culture by acquiring non-random genetic changes that render them more robust and easier to grow. In separate studies between 12.5% and 34% of hPSC lines were found to acquire chromosome abnormalities over time, with the incidence increasing with passage number. The predominant genetic changes found in hPSC lines involve changes in chromosome number and structure （particularly of chromosomes 1, 12, 17 and 20）, remi- niscent of the changes observed in cancer cells. In this review, we summarize current knowledge on the causes and consequences of aneuploidy in hPSCs and highlight the potential links with genetic changes observed in human cancers and early embryos. We point to the need for comprehensive characterization of mechanisms underpinning both the acquisition of chromosomal abnormalities and selection pressures, which allow mutations to persist in hPSC cultures. Elucidation of these mechanisms will help to design culture conditions that minimize the appearance of aneuploid hPSCs. Moreover, aneuploidy in hPSCs may provide a unique platform to analyse the driving for- ces behind the genome evolution that may eventually lead to cancerous transformation.

关键词： human pluripotent stem cells (hPSCs),culture adaptation aneuploidy cancer genetic changes