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Hypoxia-inducible factor-1αin myocardial infarction

World Journal of Cardiology 2024年第4期16卷 181-185页

作者： ivanaŠkrlec Sergey n Kolomeichuk Faculty of Dental Medicine and Health Josip Juraj Strossmayer University of OsijekOsijek 31000Croatia Institute of Biology Karelia Research Center of Russian Academy of SciencesPetrozavodsk 185910Russia Laboratory for Genomics Proteomicsand MetabolomicsResearch Institute of Biomedicine and Biomedical TechnologiesTyumen State Medical UniversityTyumen 625023Russia

Hypoxia-inducible factor 1(HIF1)has a crucial function in the regulation of oxygen levels in mammalian cells,especially under hypoxic *** importance in cardiovascular diseases,particularly in cardiac ischemia,is because of its ability to alleviate cardiac *** oxygen-responsive subunit,HIF1α,plays a crucial role in this process,as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival,angiogenesis,and ***,HIF1αexpression induced reperfusion in the ischemic skeletal muscle,and hypoxic skin wounds in diabetic animal models showed reduced HIF1α*** expression of HIF1αhas been shown to reduce apoptosis and oxidative stress in cardiomyocytes during acute myocardial *** variations in HIF1αhave also been found to correlate with altered responses to ischemic cardiovascular *** addition,a link has been established between the circadian rhythm and hypoxic molecular signaling pathways,with HIF1αfunctioning as an oxygen sensor and circadian genes such as period circadian regulator 2 responding to changes in *** editorial analyzes the relationship between HIF1αand the circadian rhythm and highlights its significance in myocardial adaptation to *** the changes in molecular signaling pathways associated with diseases,specifically cardiovascular diseases,provides the opportunity for innovative therapeutic interventions,especially in low-oxygen environments such as myocardial infarction.

关键词： Cardiovascular pathologies Circadian genes Hypoxia-inducible factor 1 Hypoxia Gene-gene interaction

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Potential of contemporary earth-sheltered buildings to achieve Plus Energy status in various European climates during the heating season

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Building Simulation 2024年第1期17卷 41-52页

作者： Aleksandar nesovic nebojsa Jurisevic Robert Kowalik lvana Terzic Faculty of Engineering University of KragujevacSestre Janjic 634000 KragujevacSerbia Faculty of Environmental Geomatic and Energy EngineeringKielce University of TechnologyTysigclecia Panstwa Polskiego725-314 KielcePoland

This study investigates the potential of contemporary Earth-Sheltered Buildings to contribute to sustainable societies by achieving Plus Energy Building status during the heating *** buildings analyzed are intended to house a four-member family(102.5 m^(2)).The house is equipped with a ground source heat pump,geothermal vertical probes,floor heating panels,an energy recovery ventilator,and building-integrated photovoltaic panels installed on the exposed building *** numerical analysis(using EnergyPlus software)was carried out for nine European sites covering five different climatic zones(namely:southern,Atlantic,continental,alpine,and northern climate)and three latitude belts spanning Europe from south to *** above 65°n(northern and alpine climate)could not achieve Plus Energy status with 20% efficient *** 15% efficient BIPVs,the building above 59°n(northern climate)was incapable of achieving this as *** the monthly time step,the buildings in the southern and Atlantic climates with 15% efficient BiPVs were able to produce an energy surplus every month,as was the building in theAlps with 20% efficientBIPVs.

关键词： civil engineering earth-sheltered buildings renewable energy sustainable societies Plus Energy Buildings Energy Plus software

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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic ivana Stevanovic Milica ninkovic Tihomir V.Ilic nadezda nedeljkovic Milorad Dragic Laboratory for neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e n/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Diversity of livestock associated methicillin-resistant Staphylococcus aureus

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 929-931页

作者： Henok A.Tegegne ivana Kolackova Renata Karpískova Department of Bacteriology Veterinary Research InstituteBrnoCzech Republic Faculty of Veterinary Hygiene and Ecology University of Veterinary and Pharmaceutical Sciences BrnoCzech Republic

Objective: To evaluate the diversity and molecular characteristics of livestock associated methicillin-resistant Staphylococcus aureus in livestock animals, food of animal origin and the environment in the Czech ***: After having been primarily enriched in buffered peptone water, the samples were cultured on Baird–Parker agar. Presumptive colonies were sub-cultured to blood agar and assessed morphologically. Furthermore, presumptive Staphylococcus aureus colonies were confirmed by MALDI-TOF. Multiplex PCR, spa-typing, and MLST have been used to characterize the strains. Each mec A-positive Staphylococcus aureus isolates were examined against 14 different antimicrobials by using disk diffusion ***: In this study, 13 different spa-types belonging to five sequence types(ST) were detected. ninety four percent of tested strains belonged to CC/ST398 for which t011,t034, t2123 and t2346 were the vast major spa-types. In addition, non-ST398 clones such as CC1(t127), ST5(t3598), ST8(t064) and ST361(t315) were detected, which are known as human associated ***: The diversity of livestock associated methicillin-resistant Staphylococcus aureus has grown, and detecting lineages of human origin in animals and vice-versa becomes more common. Thus, livestock animal and its products will be a potential for the evolvement of methicillin-resistant Staphylococcus aureus in human *** of pigs as well as other food-producing animal species and their products is therefore recommended.

关键词： CC398 MLST PCR Spa-typing

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Aneuploidy in pluripotent stem cells and implications for cancerous transformation

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Protein & Cell 2014年第8期5卷 569-579页

作者： Jie na Duncan Baker Jing Zhang Peter W. Andrews ivana Barbaric School of Medicine Tsinghua University Beijing 100084 China Sheffield Diagnostic Genetic Services Sheffield Children's Hospital Sheffield S10 2TH UK Centre for Stem Cell Biology Department of Biomedical Science The University of Sheffield Sheffield S10 2TN UK

Owing to a unique set of attributes, human pluripotent stem cells （hPSCs） have emerged as a promising cell source for regenerative medicine, disease modeling and drug discovery. Assurance of genetic stability over long term maintenance of hPSCs is pivotal in this endeavor, but hPSCs can adapt to life in culture by acquiring non-random genetic changes that render them more robust and easier to grow. In separate studies between 12.5% and 34% of hPSC lines were found to acquire chromosome abnormalities over time, with the incidence increasing with passage number. The predominant genetic changes found in hPSC lines involve changes in chromosome number and structure （particularly of chromosomes 1, 12, 17 and 20）, remi- niscent of the changes observed in cancer cells. In this review, we summarize current knowledge on the causes and consequences of aneuploidy in hPSCs and highlight the potential links with genetic changes observed in human cancers and early embryos. We point to the need for comprehensive characterization of mechanisms underpinning both the acquisition of chromosomal abnormalities and selection pressures, which allow mutations to persist in hPSC cultures. Elucidation of these mechanisms will help to design culture conditions that minimize the appearance of aneuploid hPSCs. Moreover, aneuploidy in hPSCs may provide a unique platform to analyse the driving for- ces behind the genome evolution that may eventually lead to cancerous transformation.

关键词： human pluripotent stem cells (hPSCs),culture adaptation aneuploidy cancer genetic changes

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Impact of natural disturbance, forest management and vegetation cover on topsoil biochemical characteristics of Tatra Mts.(Slovakia)

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Journal of Mountain Science 2020年第6期17卷 1294-1309页

作者： Jana GáFRIKOVá Milan ZVARíK Peter HAnAJíK Marek SúLOVSKY ivana VYKOUKOVá Faculty of natural Sciences Comenius UniversityBratislava84104Slovak Republic Faculty of Mathematics Physics and InformaticsComenius UniversityBratislava84104Slovak Republic Water Research Institute Bratislava81249Slovak Republic

Perturbations caused by windstorms usually lead to the harvesting and clearcutting of fallen trees and wood debris,especially in the areas of managed forest *** shifts in soils due to management practices play a crucial role in the restoration and maintaining of key ecosystem *** paper focuses on topsoil chemical properties in relation to vegetation type(trees,shrubs and herbs)evolving at windstorm damaged(in 2004)areas with former norway spruce(Picea abies)forests in the Tatra ***(Slovakia).We assessed the content of topsoil organic matter fractions(extractives,holocellulose(HC)and lignin(Lig)),carbon in microbial biomass(Cmic),soil organic matter(SOM)and the content of elements n,C,H and *** study plots represent different types of post-windthrow disturbance history/regime:wooden debris extraction(EXT),wooden debris not extracted(nEX),wooden debris extraction followed by wildfire(FIR),affected by the windstorm in 2014 with the subsequent wooden debris extraction(REX)and unaffected(REF).Our results revealed significant differences among sites in the content of dichloromethane extractives(EXT *** and FIR),acetone extractives(nEX ***,FIR and REF),ethanol extractives(FIR ***,nEX and REF),water extractives(FIR ***,nEX)and Cmic(EXT ***,FIR and REF).The topsoil of Vaccinium myrtillus and Picea abies showed a higher ratio of C/n,n/Lig,and Lig/HC compared to Rubus idaeus,Avenella flexuosa,Calamagrostis villosa,and Larix *** content of n,C,H and S varied between topsoil with shrubs(Vaccinium myrtillus,Rubus idaeus)and grasses(Avenella flexuosa,Calamagrostis villosa).A positive correlation between soil organic matter(SOM)and polar extractives(r=0.81)and a negative correlation between SOM and HC(r=-0.83)was *** carbon content in microbial biomass(Cmic)is positively correlated with acid soluble lignin(ASL)(r=0.85).We also identified a strong correlation between Klason lignin(KL)and the Lig/HC ratio(r=0.97).

关键词： Windthrow Wildfire Organic matter fractions Vegetation type norway spruce Topsoil chemical properties

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Current concept in the diagnosis,treatment and rehabilitation of patients with congestive heart failure

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World Journal of Cardiology 2021年第7期13卷 183-203页

作者： ivana Sopek Merkas Ana Marija Sliskovic nenad Lakusic Department of Cardiology Special Hospital for Medical Rehabilitation Krapinske TopliceKrapinske Toplice 49217Croatia Department of Cardiology University Hospital Centre ZagrebZagreb 10000Croatia Department of Clinical Medicine Faculty of Dental Medicine and Health OsijekOsijek 31000Croatia Department of Internal Medicine Family Medicine and History of MedicineFaculty of Medicine OsijekOsijek 31000Croatia

Heart failure(HF)is a major public health problem with a prevalence of 1%-2%in developed *** underlying pathophysiology of HF is complex and as a clinical syndrome is characterized by various symptoms and *** is classified according to left ventricular ejection fraction(LVEF)and falls into three groups:LVEF≥50%-HF with preserved ejection fraction(HFpEF),LVEFn fraction(HFrEF),LVEF 40%-49%-HF with mid-range ejection *** HF is primarily a clinical approach and it is based on anamnesis,physical examination,echocardiogram,radiological findings of the heart and lungs and laboratory tests,including a specific markers of HF-brain natriuretic peptide or n-terminal pro-B-type natriuretic peptide as well as other diagnostic tests in order to elucidate possible *** diagnostic algorithms for HFpEF have been recommended(H2FPEF,HFA-PEFF).new therapeutic options improve clinical outcomes as well as functional status in patients with HFrEF(e.g.,sodium-glucose cotransporter-2-SGLT2 inhibitors)and such progress in treatment of HFrEF patients resulted in new working definition of the term“HF with recovered left ventricular ejection fraction”.In line with rapid development of HF treatment,cardiac rehabilitation becomes an increasingly important part of overall approach to patients with chronic HF for it has been proven that exercise training can relieve symptoms,improve exercise capacity and quality of life as well as reduce disability and hospitalization *** gave an overview of latest insights in HF diagnosis and treatment with special emphasize on the important role of cardiac rehabilitation in such patients.

关键词： Heart failure Classification of heart failure Diagnosis of heart failure Treatment of heart failure Cardiac rehabilitation Heart failure rehabilitation

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Partial Derivatives, Singular Integrals and Sobolev Spaces in Dyadic Settings

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Analysis in Theory and Applications 2023年第3期39卷 287-298页

作者： Hugo Aimar Juan Comesatti ivana Gómez Luis nowak Instituto de Matemática Aplicada del Litoral“Dra.Eleonor Harboure” UNLCONICETCCT CONICET Santa FePredio“Dr.Alberto Cassano”Colectora Ruta Nac.168 km 0Paraje El PozoS3007ABA Santa FeArgentina Instituto de Investigación en Tecnologías y Ciencias de la Ingeniería Universidad Nacional del ComahueCONICET/Departamento de Matemática-FaEA-UNComaNeuquénArgentina

In this note we show that the general theory of vector valued singular integral operators of Calderón-Zygmund defined on general metric measure spaces,can be applied to obtain Sobolev type regularity properties for solutions of the dyadic fractional *** doing so,we define partial derivatives in terms of Haar multipliers and dyadic homogeneous singular integral operators.

关键词： Sobolev regularity Haar basis space of homogeneous type Calder´on-Zygmund operator dyadic analysis

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Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix

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World Journal of Clinical Cases 2020年第17期8卷 3697-3707页

作者： Jelena Saponjski Djuro Macut Dragana Sobic-Saranovic Sanja Ognjanovic ivana Bozic Antic Djordje Pavlovic Vera Artiko Center for nuclear Medicine Clinical Center of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic DiseasesClinical Center of SerbiaFaculty of MedicineUniversity of BelgradeBelgrade 11000Serbia Center for nuclear Medicine Clinical Center of Serbia Faculty of Medicine University of BelgradeBelgrade 11000Serbia University Children's Clinic Belgrade 11000Serbia

BACKGROUnD neuroendocrine tumors of appendix(AnETs)known as carcinoids,are rare endocrine neoplasms originated from enterochromaffin cells of gastrointestinal *** are the third most frequent(16.7%)gastrointestinal neuroendocrine tumors,with the incidence of 0.08-0.2 cases/100000 during one *** AnETs occur in 0.2%-0.7%of emergency surgical resections because of suspected appendicitis which is usually the first manifestation of *** there are a lot of papers about application of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumors,there are very rare sporadic cases described about AnETs *** To establish the role of somatostatin receptor scintigraphy(SRS)in the management of patients with neuroendocrine tumors of appendix(AnET).METHODS The total of 35 patients was investigated,23 females and 12 males,average age(43.7±17.3 years).All patients had histological diagnosis of AnET(34 carcinoids of appendix and one tubular carcinoid).Majority of tumors have been found incidentally during surgery of:Acute appendicitis(n=15),perforated appendicitis(n=2),ileus(n=3),hysterectomy(n=3),ruptured ovarian cyst(n=2),caecal volvulus(n=1),while 9 patients had diagnosis of appendiceal tumor before the *** patients had tumor grade(G)G1,12 G2 and 6 *** right hemicolectomy was performed in 13,while the rest of the patients had appendectomy *** was done early(2 h)and late(24 h)after *** of 740 MBq technetium-99 m ethylenediamine-n,n’-diacetic acid Hydrazinonicotinyl-Tyr3-Octreotide(technetium-99 m-Tektrotyd,Polatom,Poland).SRS was performed for restaging in all the patients after *** There were 12 true positive(TP),19 true negative,3 false positive and 1 false negative SRS *** of the method was 92.31%,specificity was 86.36%,positive predictive value was 80.00%,negative predictive value was 95.00%and accuracy 88.57%.Receiver operating characteristics analysis showed t

关键词： Somatostatin receptor scintigraphy Carcinoid Appendix Follow up nuclear medicine Radionuclide

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Free bisphenol A(BPA),BPA-Glucuronide(BPA-G),and total BPA concentrations in maternal serum and urine during pregnancy and umbilical cord blood at delivery

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Emerging Contaminants 2019年第1期5卷 279-287页

作者： Warren G.Foster Cariton Kubwabo ivana Kosarac Sandra Gregorovich Garima Aryal Kaela Coleman Department of Obstetrics&Gynaecology McMaster UniversityHamiltonOntarioL8S 4K1Canada Environmental Health Science and Research Bureau Health CanadaOttawaOntarioK1A 0K9Canada Tobacco Control Directorate Health CanadaOttawaOntarioK1A 0K9Canada

While adult exposure to total bisphenol A(BPA)has been well documented,developmental exposure to BPA and fetal exposure to the bioactive form(free BPA)remains poorly ***,pregnant women(n?199)between 28 and 35 weeks of pregnancy were invited to participate in this *** serum free of hemolysis(n?189)and urine(n?112)were collected at third trimester and delivery along with umbilical cord blood(UCB)at *** BPA,BPA mono-glucuronide(BPA-G)and total BPA concentrations were measured using gas chromatography coupled with tandem mass *** concentrations of free BPA were quantifiable above the method detection limit(MDL?0.026 ng/mL)in approximately 34%of serum samples in the third trimester and 21%of samples at delivery whereas BPA-G and total BPA were quantified in 43 and 70%of third trimester and delivery samples,*** geometric mean of free BPA,BPA-G and total BPA concentrations in maternal serum during the third trimester and at delivery were 0.62 ng/L andnd 0.28 ng/mL,and 0.24 and 0.31 ng/mL,*** mean urinary concentrations of free BPA,BPA-G,and total BPA(MDL?0.027 ng/mL)in the third trimester and delivery samples were 0.07 and 0.06 ng/mL,0.36 and 0.09 ng/mL,and 0.36 and 0.09 ng/mL,*** the UCB,the geometric means for free BPA,BPA-G,and total BPA concentrations were 0.05,0.08 and 0.10 ng/mL,*** results suggest that,in our study population,free BPA concentrations were low compared to other Canadian cohorts.

关键词： Bisphenol A Free BPA Conjugated BPA Pregnancy Exposure Fetal development Cord blood

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