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Antidepressant Drugs Modulate Differentially Anti-inflammatory Lithium＇s Property： An in Vitro and in Vivo Study

Journal of Pharmacy and Pharmacology 2018年第4期6卷 287-304页

作者： Femanda Barbisan Pedro Antonio Schmidt do Prado-Lima Veronica Farina Azzolin Maiquidieli Dal Berto Claudia Giuliano Bica Cibele Ferreira Teixeira Dianni Capeleto Ivo Emilio da Cruz Jung Euler Esteves Ribeiro Marta Maria Medeiros Frescura Duarte ivana Beatrice Manica da Cruz Graduate Program in Pharmacology Federal University of Santa Maria Santa Maria-RS 97105900 Brazil Brain Institute Catholic University of Rio Grande do Sul Porto Alegre-RS 91410000 Brazil Graduate Program in Pathology Federal University of Health Sciences of Porto Alegre Porto Alegre-RS 90050170 Brazil Open University of the Third Age State University of Amazonas Manaus-AM 69029040 Brazil Lutheran University of Brazil Santa Maria-RS 97030080 Brazil

Li （lithium）, a mood stabilizer has anti-inflammatory effect. However, in clinical practice, Li can be administered together with other antidepressants drugs, such as FLX （fluoxetine）, IMI （imipramine）, NOR （nortriptyline） and ESC （escitalopram）. As interaction between Li and these antidepressant drugs on inflammatory modulation has not been investigated yet, we performed an in vitro protocol using a non-human macrophage cell line. Oxidative and inflammatory markers, as well as cell cycle analysis and cytokine gene expressions were compared among treatments. An IR （inflammatory ratio） was calculated based on the following oxidative-inflammatory variables： nitric oxide, superoxide anion, reactive oxygen molecules, cytokines IL-113, IL-6, TNF-ct and IL-10. The in vitro calculated IR data were validated through an in vivo analysis of 154 human subjects with similar IR. Li and control cells presented similar IR values. FLX, NOR and IMI increased slightly IR values indicating some proinflammatory effect, whereas ESC decreased IR values indicating some anti-inflammatory effect. However, cells exposed to Li ＋ ESC triggered a proinflammatory response on macrophages. Thus, IR comparison results suggest that the Li anti-inflammatory effect is not universal and could be influenced by both basal macrophage-inflammatory state and interaction of other psychiatric drugs. These results could be useful to understand some inconsistencies observed in human studies involving Li and other psychiatric drugs.

关键词： Mood disorders inflammation selective serotonin reuptake inhibitors bipolar disorder lithium.

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大梅沙村·10号楼

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建筑实践 2019年第7期 86-87页

作者： HUANG Jiebin WU Lixian ZHANG Jiyuan HONG Di YANG Jiahui HUANG Zanning XU Zhibo ivana LI Shiyao CreatAR Images NODE Office 南沙原创

对页,上:傍晚的10号楼对页,下:10号楼二层展览空间Opposite,above:House 10 in the evening Opposite,below:Exhibition space on the second floor of House 10主持建筑师刘珩建筑面积206 m2设计周期2017.4-2017.10建筑周期2017.10-201... 详细信息

关键词：梅沙榕树榕属

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流感与COVID-19患者的免疫球蛋白G糖基化差异（英文）

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Engineering 2023年第7期 54-62页

作者： Marina Kljakovi?-Ga?pi? Batinjan Tea Petrovi? Frano Vu?kovi? Irzal Had?ibegovi? Barbara Radovani ivana Jurin Lovorka Derek Eva Huljev Alemka Markoti? Ivica Luk?i? Irena Trbojevi?-Akma?i? Gordan Lauc Ivan Gudelj Rok ?ivljak University Hospital Centre Zagreb Genos Glycoscience Research Laboratory Department of Cardiology University Hospital Dubrava Faculty of Dental Medicine and Health Josip Juraj Strossmayer University Department of Biotechnology University of Rijeka Department for Laboratory Diagnostics University Hospital Dubrava Department for Acute Respiratory Infections University Hospital for Infectious Diseases “Dr. Fran Mihaljevi?” 8. Department for Urogenital Infections University Hospital for Infectious Diseases “Dr. Fran Mihaljevi?” 9. Department for Infectious Diseases School of Medicine Catholic University of Croatia Postdoctoral Study Faculty of Medicine University of Rijeka Department of Maxillofacial Surgery University of Zagreb School of Medicine Dubrava University Hospital Faculty of Pharmacy and Biochemistry University of Zagreb Department of Infectious Diseases University of Zagreb School of Medicine

The essential role of immunoglobulin G(IgG) in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the fragment crystallizable(Fc) domain that occur under such *** glycans impact the antibody stability, half-life, secretion, immunogenicity, and effector ***, in this study, we analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylation traits(sialylation, galactosylation, fucosylation, and bisecting N-acetylglucosamine(GlcNAc))—of 64 patients with influenza, 77 patients with coronavirus disease 2019(COVID-19), and 56 healthy controls. Our study revealed a significant decrease in IgG galactosylation, sialylation, and bisecting GlcNAc(where the latter shows the most significant decrease) in deceased COVID-19 patients, whereas IgG fucosylation was increased. On the other hand, IgG galactosylation remained stable in influenza patients and COVID-19 survivors. IgG glycosylation in influenza patients was more time-dependent: In the first seven days of the disease, sialylation increased and fucosylation and bisecting GlcNAc decreased; in the next 21 days, sialylation decreased and fucosylation increased(while bisecting GlcNAc remained stable). The similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence of an adequate immune response to enveloped viruses, while the observed changes in deceased COVID-19 patients may indicate its deviation.

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Human IgG1 antibodies suppress angiogenesis in a target-independent manner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia Division of Immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche Médicale(INSERM)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly Department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage *** approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： CD64 angiogenesis antibodies

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Absolute Lymphocyte/Monocyte Ratio at Diagnosis and Interim Positron-Emission Tomography Predict Survival in Classical Hodgkin Lymphoma

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Journal of Cancer Therapy 2013年第3期4卷 452-459页

作者： Luis F. Porrata Kay M. Ristow Thomas M. Habermann Thomas E. Witzig Joseph P. Colgan David J. Inwards Stephen M. Ansell ivana N. Micallef Patrick B. Johnston Grzegorz Nowakowski Carrie A. Thompson Svetomir N. Markovic Division of Hematology Internal Medicine Mayo College of Medicine Rochester USA

Interim Positron-Emission Tomography (int-PET) and the peripheral blood absolute lymphocyte/monocyte ratio at di- agnosis (ALC/AMC-DX) have been shown to be predictors for progression-free survival (PFS) and time to progression (TTP) in classical Hodgkin lymphoma (cHL). Therefore, we studied if the combination of ALC/AMC-DX and the (int-PET) can further stratified PFS and TTP in cHL patients. Patients were required to be diagnosed, treated, and followed with int-PET at Mayo Clinic, Rochester, Minnesota. From 2000 until 2008, 111 cHL patients qualified for the study. The median follow-up was 2.8 years (range: 0.3 - 10.4 years). Patients with a negative int-PET (N = 98) pre- sented with a higher ALC/AMC-DX (median of 2.32, range: 0.26 - 37.5) compared with patients with a positive int-PET (N = 13) (median of 0.9, range: 0.29 - 3.10), p 1.1. Group 1 experienced superior PFS and TTP in comparison with the other groups. In conclusion, the combination of ALC/AMC-DX and the int-PET provides a simple model to assess clinical outcomes in cHL.

关键词： Classical Hodgkin Lymphoma Absolute Lymphocyte/Monocyte Ratio at Diagnosis Interim PET-Scan Progression-Free Survival Time to Progression

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采食赭曲霉毒素A污染日粮猪只的可食用组织及生物体液中OTA残留比较

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猪业科学 2023年第9期40卷 18-21页

作者：朱秋凤张一诺王梦晨(编译) Jelka Pleadin Nina Kudumija Dragan Kovačević Giampiero Scortichini Salvatore Milone ivana Kmeti 中国农业大学动物科技学院动物营养学国家重点实验室北京100193 禾丰食品股份有限公司辽宁沈阳110164 不详

赭曲霉毒素A(OTA)是一组由曲霉菌(较温暖地区)或青霉菌(较寒冷地区)等真菌产生的次级代谢有毒产物,广泛污染多种农作物(Peraica等,1999;Marin等,2009)。环境温度和水分含量是造成谷物收获和储存期间OTA污染的主要因素(Abramson等,1987)... 详细信息

赭曲霉毒素A(OTA)是一组由曲霉菌(较温暖地区)或青霉菌(较寒冷地区)等真菌产生的次级代谢有毒产物,广泛污染多种农作物(Peraica等,1999;Marin等,2009)。环境温度和水分含量是造成谷物收获和储存期间OTA污染的主要因素(Abramson等,1987)。早期研究已经引起人们对OTA污染农作物、饲料以及人类和动物接触该污染物的关注(Petzinger and Weidenbach 2002;Binder等,2007;PfohlLeszkowicz和Manderville2007;Amezequ等,2009)

关键词：赭曲霉毒素A 生物体液次级代谢储存期间环境温度 OTA 青霉菌曲霉菌

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Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina

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World Journal of Clinical Oncology 2022年第6期13卷 423-428页

作者： Federico Esteso Natalia Soledad Tissera Juan Manuel O'Connor Romina Luca Eduardo Huertas Fernando Sánchez Loria ivana Pedraza Alejandro Pairola Fernando Brancato Lisandro Paganini Mariana Kucharczyk Mora Amat Maria Teresa Pombo Mariana Galli Luisina Bruno Luis Caro Andrés Rodriguez Diego Enrico Federico Waisberg Matías Chacón Department of Gastrointestinal Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Surgery Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Pathology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiation Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Gastroenterology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina

Given the increasing complexity of cancer care,multidisciplinary tumor boards have become essential in daily clinical oncology *** Project Extension for Community Healthcare Outcomes(ECHO)initiative developed an innovative telementoring model using a"hub and spoke"design consisting of a team of experts(hub)that offers a full service to multiple participants(the spokes)during regularly scheduled sessions discussing patients'clinical *** Alexander Fleming Cancer Institute in Buenos Aires was the first hub in Latin America to implement Project ECHO for gastrointestinal *** our 3-year experience,80 patients from 37 centers were evaluated within Project ECHO and a range of three to five cases were discussed in each *** our perspective,the impact of this novel approach was a remarkable strategy to reduce care disparities by equalizing access to high-quality medical knowledge in a multidisciplinary environment for medical ***,it was shown to have a cost-effective impact directly on the patients and the local health system,since relevant costs were saved after unnecessary treatments,studies and travel expenses were avoided.

关键词： Tumor board Virtual Gastrointestinal Cancer disparities Oncology Extension for Community Healthcare Outcomes project

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自然老化下针织物的性能

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国际纺织导报 2022年第9期50卷 13-16页

作者： I.S.Cubric G.Cubric 刘琪(译) 付少举(校) 萨格勒布大学纺织技术学院不详

为了给特定的终端用户提供舒适的小气候,纺织专家必须对每种运动服的细节进行界定,并从从业者那里获得关于特定问题的反馈。主要研究用于生产泳装的针织面料。针织物根据不同的老化方案进行自然老化,然后测试以下参数:厚度、面密度、弯... 详细信息

为了给特定的终端用户提供舒适的小气候,纺织专家必须对每种运动服的细节进行界定,并从从业者那里获得关于特定问题的反馈。主要研究用于生产泳装的针织面料。针织物根据不同的老化方案进行自然老化,然后测试以下参数:厚度、面密度、弯曲长度、润湿时间和干燥时间。研究结果表明,在海水中老化后,织物厚度增加高达10%。针织物在游泳池中老化也会导致厚度增加,但是相比海水老化相比,这种增加并不显著。织物润湿时间和干燥时间遵循以前描述的趋势。

关键词：自然老化针织物泳装织物厚度

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釜山电影中心/釜山国际电影节

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城市环境设计 2020年第4期126卷 186-199页

作者：沃尔夫·狄·普瑞克斯 Markus Baumann Jan Brosch Jasmin Dieterle Sergio Gonzalez Hallstein Guthu Rob Henderson Veronica Janovska ivana Jug Matt Kirkham Jana Kucerova Dieter Segerer Anja Sorger Duccio Malagamba COOP HIMMELB(L)AU

项目大事记/CHRONOLOGY竞赛（一等奖）/Competition （1st Prize）:11/2005规划设计/Start of Planning:01/2007动工/Start of Construction:10/2008开放/Opening:29/09/2011项目参数/PROJECT DATA用地面积/Site Area:32 100m2建筑毛面积（室内）/Gross Floor Area （interior spaces）:57 981m2建筑净面积（室内）/Net Floor Area （interior spaces）:51 067m2建成区面积/Built-up Area:10 005m2（不包含屋顶/without roofs）

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迹福州茶馆

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城市环境设计 2023年第2期 53-65页

作者： Jorik Bais 李奕男胡云清黄永福 James Beadnall ivana Li Jesper Evertsson 杜尚芳郑冰苗蒋征玲金洙诺 Ath Supornchai 辛海鸥黄惠子张妍吴震海陈灏

如恩用福州的历史文化为画笔,将这座茶馆描画成了一件城市文物。茶馆内的古代木结构是一栋清代古宅,属于典型的徽派建筑,其上雕刻着丰富的装饰木雕,复杂而精美。如恩将木结构包裹于新建筑结构之内,这是福州茶馆的点睛之笔。近年来,城市...

如恩用福州的历史文化为画笔,将这座茶馆描画成了一件城市文物。茶馆内的古代木结构是一栋清代古宅,属于典型的徽派建筑,其上雕刻着丰富的装饰木雕,复杂而精美。如恩将木结构包裹于新建筑结构之内,这是福州茶馆的点睛之笔。近年来,城市的快速发展逐渐侵蚀着传统文化与人们的文化认同。在此背景下,福州茶馆的设计不失为一例独特的历史传承案例。

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