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Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

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World Journal of Gastrointestinal surgery 2024年第2期16卷 331-344页

作者： Miran Bezjak ivan stresec Branislav Kocman stipislav Jadrijević Tajana Filipec Kanizaj Miro Antonijević Bojana Dalbelo Bašić Danko Mikulić Department of surgery University Hospital MerkurZagreb 10000Croatia Department of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia Development of software Nanobit Ltd.Zagreb 10000Croatia

BACKGROUND The growing disparity between the rising demand for liver transplantation(LT)and the limited availability of donor organs has prompted a greater reliance on older liver ***,utilizing livers from elderly donors has been associated with outcomes inferior to those achieved with grafts from younger *** accounting for additional risk factors,we hypothesize that the utili-zation of older liver grafts has a relatively minor impact on both patient survival and graft *** To evaluate the impact of donor age on LT outcomes using multivariate analysis and comparing young and elderly donor *** In the period from April 2013 to December 2018,656 adult liver transplants were performed at the University Hospital *** multivariate Cox propor-tional hazards models were developed to independently assess the significance of donor *** age was treated as a continuous *** approach involved univariate and multivariate analysis,including variable selection and assessment of interactions and ***,to exemplify the similarity of using young and old donor liver grafts,the group of 87 recipients of elderly donor liver grafts(≥75 years)was compared to a group of 124 recipients of young liver grafts(≤45 years)from the *** rates of the two groups were estimated using the Kaplan-Meier method and the log-rank test was used to test the differences between *** Using multivariate Cox analysis,we found no statistical significance in the role of donor age within the constructed *** when retained during the entire model development,the donor age's impact on survival remained insignificant and transformations and interactions yielded no substantial effects on *** insigni-ficance and low coefficient values suggest that donor age does not impact patient survival in our ***,there was no statistical evidence that the five developed models did not adhe

关键词： Liver transplantation Elderly donors survival analysis Postoperative complications Cox proportional hazard models

Intraplaque injections of hyaluronic acid for the treatment of stable-phase Peyronie’s disease:a retrospective single-center experience

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Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： simone Cilio Roberto La Rocca Giuseppe Celentano Claudio Marino Massimiliano Creta Gianluigi Califano Celeste Manfredi Giorgio ivan Russo Afonso Morgado Marco Falcone Marco Capece YAU Working Group sexual and Reproductive Health Department of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology section Department of SurgeryUniversityof CataniaCatania 95131Italy Department of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella salute edella scienza”-Molinette Hospital University of TurinTurin 10100Italy 不详

Peyronie’s disease(PD)is a condition of penile connective tissue affecting up to 10%of men *** the complexity ofits management,nonsurgical treatments,such as intraplaque injections,are gaining *** current literature shows dataon the efficacy of intraplaque injections of hyaluronic acid(HA)mainly in acute-phase ***,data on injections of HA instable-phase PD are *** for this retrospective study were derived from a prospectively maintained database of privatepatients presenting at a private medical practice affiliated to the University of Naples“Federico II”(Naples,Italy)with stable-phasePD between January 2020 and March *** underwent a standard protocol of three injections,each administered at atwo-week *** the intervals,patients performed vacuum device therapy,penile stretching,and modeling *** compiled the Peyronie’s Disease Questionnaire(PDQ)and Global Assessment of Peyronie’s Disease(GAPD)at baselineand 2 weeks after the third injection.A penile Doppler ultrasound was performed 2 weeks after the last injection to record thefinal ***,we recruited 62 patients with stable-phase PD and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)patients did not experience any curvature *** remaining 54 patientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with Ps(all P≤0.01),and 50(80.6%)patients reported subjective improvement of the penile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adopted protocol,patientswith stable-phase PD could experience significant improvements in penile curvature,and physical and psychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intraplaque injection Peyronie’s disease stable-phase therapy

Influence of statins and Fibrates Drugs on Bone Health and Regeneration

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Journal of Biomaterials and Nanobiotechnology 2024年第1期15卷 1-24页

作者： Octavio santiago ivan Nadir Camal Ruggieri Marina Ribeiro Paulini Valéria Paula sassoli Fazan João Paulo Mardegan Issa sara Feldman LABOATEM Laboratory of Bone Biology and Tissue Engineering School of Medicine Rosario National University Ros&#225rio Argentina school of Dentistry of Ribeirã o Preto University of S&#227o Paulo (FORP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil school of Medicine of Ribeirã o Preto University of S&#227o Paulo (FMRP/USP) Ribeir&#227o Preto S&#227o Paulo Brazil

In the medical and dental field, the importance and need for the study of materials and drugs for use as bone grafts or regeneration in injured areas due to the presence of fractures, infections or tumors that cause extensive loss of bone tissue is observed. Bone is a specialized, vascularized and dynamic connective tissue that changes throughout the life of the organism. When injured, it has a unique ability to regenerate and repair without the presence of scars, but in some situations, due to the size of the defect, the bone tissue does not regenerate completely. Thus, due to its importance, there is a great development in therapeutic approaches for the treatment of bone defects through studies that include autografts, allografts and artificial materials used alone or in association with bone grafts. Pharmaceuticals composed of biomaterials and osteogenic active substances have been extensively studied because they provide potential for tissue regeneration and new strategies for the treatment of bone defects. statins work as specific inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoAreductase). They represent efficient drugs in lowering cholesterol, as they reduce platelet aggregation and thrombus deposition;in addition, they promote angiogenesis, reduce the β-amyloid peptide related to Alzheimer’s disease and suppress the activation of T lymphocytes. Furthermore, these substances have been used in the treatment of hypercholesterolemia and coronary artery disease. By inhibiting HMG-CoAreductase, statins not only inhibit cholesterol synthesis, but also exhibit several other beneficial pleiotropic effects. Therefore, there has been increasing interest in researching the effects of statins, including simvastatin, on bone and osteometabolic diseases. However, statins in high doses cause inflammation in bone defects and inhibit osteoblastic differentiation, negatively contributing to bone repair. Thus, different types of studies with different conc

关键词： Bone statins Rosuvastatin sinvastatin Fibrates Fenofibrate Bone Regeneration

A theoretical justification of the slip index concept in fretting analysis

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Friction 2023年第7期11卷 1265-1275页

作者： ivan I.ARGATOV Young s.CHAI Institut für Mechanik Technische Universität Berlin10623 BerlinGermany school of Mechanical Engineering Yeungnam UniversityGyeongsan 712-749Republic of Korea

Fretting in the partial-slip and gross-slip regimes under a constant normal load is *** tangential force-displacement relations for the forward and backward motions are described based the generalized Cattaneo-Mindlin theory of tangential contact and Masing's hypothesis on modelling the force-displacement hysteretic *** the critical force and displacement parameters(characterizing the triggering of sliding),the model includes one dimensionless fitting parameter that tunes the tangential contact stiffness of the friction-contact *** expressions are derived for the main tribological parameters of the fretting loop,including the slip index and the signal *** presented phenomenological modelling approach has been applied to the analysis of two sets of experimental data taken from the *** has been shown that the experimentally observed simple relation of a rational type between the slip index and the slip ratio corresponds to the gross-slip asymptotics of the corresponding model-based predicted *** known quantitative criteria for the transition from the partial slip regime to the gross slip regime are expressed in terms of the stiffness parameter,and a novel geometric transition criterion is formulated.

关键词： fretting wear slip index signal index partial slip energy ratio

Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity

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Bioactive Materials 2023年第6期24卷 174-184页

作者： Andrés García-García sébastien Pigeot ivan Martin Department of Biomedicine University Hospital BaselUniversity of Basel4031BaselSwitzerland Department of Biomedical Engineering University of Basel4123AllschwillSwitzerland

The increasing recognition of the contribution of the immune system to activate and prime regeneration implies that tissue engineering strategies and biomaterials design should target regulation of early immunological *** previously proposed the cell-based engineering and devitalization of extracellular matrices(ECMs)as a strategy to generate implant materials delivering custom-defined ***,in the context of bone regeneration,we aimed at enhancing the osteoinductivity of such ECMs by enriching their immunomodulatory factors *** with IL1βa cell line overexpressing BMP-2 enabled engineering of ECMs preserving osteoinductive signals and containing larger amounts of angiogenic(VEGF)and pro-inflammatory molecules(IL6,IL8 and MCP1).Upon implantation,these IL1β-induced materials enhanced processes typical of the inflammatory phase(e.g.,vascular invasion,osteoclast recruitment and differentiation),leading to‘regenerative’events(e.g.,M2 macrophage polarization)and ultimately resulting in faster and more efficient bone *** results bear relevance towards the manufacturing of potent off-the-shelf osteoinductive materials and outline the broader paradigm of engineering immunoinstructive implants to enhance tissue regeneration.

关键词： Immunomodulation Bone tissue engineering Inflammation Hypertrophic cartilage matrices Osteoinduction

Author Correction: ITO-free silicon-integrated perovskite electrochemical cell for light-emission and light-detection

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Opto-Electronic Advances 2024年第3期7卷 50-50页

作者： Maria Baeva Dmitry Gets Artem Polushkin Aleksandr Vorobyov Aleksandr Goltaev Vladimir Neplokh Alexey Mozharov Dmitry VKrasnikov Albert GNasibulin ivan Mukhin sergey Makarov Alferov University Khlopina 8/3St.Petersburg 194021Russia Department of Physics and Engineering ITMO UniversityLomonosova 9St.Petersburg 197101Russia Institute of Automation and Control Processes(IACP) Far Eastern Branch of Russian Academy of SciencesUlitsa Radio 5Vladivostok 690041Primorsky KraiRussia Peter the Great st.Petersburg Polytechnic University Polytechnicheskaya 29St.Petersburg 195251Russia skolkovo Institute of science and Technology Nobel 3Moscow 121205Russia Qingdao Innovation and Development Center Harbin Engineering UniversityQingdao 266000China.

Correction to:Opto-Electronic Advances https://***/10.29026/oea.2023.220154 published online 26 April 2023 After the publication of this article1,it was brought to our attention that calculations of the PeLEC device elec-troluminescent(EL)efficiency contained a mistake,leading to an inaccurate quantity *** device’s maxim-um EL efficiency constitutes not‘~120 klm/W’but‘4.3 lm/W’*** details are listed below.

关键词： value. perovskite listed

Targeted therapy for capillary-venous malformations

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signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot sanela Protic Clément Hoguin Amandine Thomas sylvie Fraitag Jean-Paul Duong sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INsERM U1151 Institut Necker-Enfants MaladesParisFrance service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIs UMR 5220 Villeurbanne 69100France service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INsERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRs UMR8253 Institut Necker-Enfants MaladesParisFrance

sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Coupled thermo-mechanical constitutive damage model for sandstone

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第6期14卷 1710-1721页

作者： savani Vidana Pathiranagei ivan Gratchev school of Engineering and Built Environment Gold Coast CampusGriffith UniversitySouthportQLD 4222Australia

Underground rock dynamic disasters are becoming more severe due to the increasing depth of human operations *** temperature and pressure conditions contribute significantly to these ***,it is important to understand the coupled thermo-mechanical(TM)behaviour of rocks for the long-term safety and maintenance of underground tunnelling and ***,investigation of the damage,strength and failure characteristics of rocks under triaxial stress conditions is important to avoid underground rock *** this study,based on Weibull distribution and Lemaitre's strain equivalent principle,a statistical coupled TM constitutive model for sandstone was established under high temperature and pressure *** triaxial test results of sandstone under different temperature and pressure conditions were used to validate the *** proposed model was in good agreement with the experimental results up to 600℃.The total TM damage was decreased with increasing temperature,while it was increased with increasing confining *** model's parameters can be calculated using conventional laboratory test results.

关键词： High temperature Confining pressure Thermo-mechanical(TM)damage Thermal damage Mechanical damage

Combined influence of Ce(Ⅲ)and iodide ions for corrosion protection of AA 2024-T3 in acidic to neutral chloride-rich environments:Electrochemical and surface characterization studies

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Journal of Rare Earths 2023年第2期41卷 309-320页

作者： Mohammed A.El-Hashemy Anthony E.Hughes Thomas Gengenbach A.Matthew Glenn ivan s.Cole Chemistry Department College of ScienceJouf UniversityP.O.Box 2014SakakaAljoufSaudi Arabia Air Pollution Research Department Environmental and Climate Change Research InstituteNational Research CentreDokkiGiza12622Egypt CsIRO Mineral Resources ClaytonVic3168Australia CsIRO Manufacturing ClaytonVic3168Australia school of Engineering RMIT UniversityCarltonVic3053Australia

It has been reported that trivalent cerium salts are effective inhibitors for corrosion of AA2024-T3 in neutral to alkaline co rrosive enviro nments,but poor in acidic *** this study,work was done for extending corrosion resistance provided by Ce(NO_(3))_(3)to acidic pHs as low as 2.5 through the addition of iodide *** this end,potentiodynamic polarization was used to ascertain the optimum Ce(Ⅲ)concentration for the inhibition of AA2024-T3 corrosion in 3.5%NaCl *** optimum concentration is found to be in a range between 0.1 and 0.3 mmol/L Ce(Ⅲ).This optimum concentration also gives a maximum width of the passive region under the pitting potential(Epit).Based on this optimization,further work was performed as a function of pH without and in the presence of 0.01 mol/L KI at five pH values(2.5,4,5,7,and 8).Without iodide the best inhibition provided by the Ce(Ⅲ)cation is at pH=7 but active corrosion is observed at pH=2.5 with an estimated inhibitor efficiency(-37.6%).The addition of iodide ions(I^(-))reverses the poor corrosion resistance whereby the inhibitor efficiency becomes 47.7%.Moreover,at pH=4 the efficiency is also increased from 54.0%to 81.0%with iodide addition providing a significant improvement over Ce(Ⅲ)cations alone under acidic *** is a synergistic effect between I-anion and Ce(Ⅲ)cation,which is determined to be 2.4 and 2.1 at pH=2.5and 4.0,*** pH=5 and 7 there is virtually no change in inhibition but at pH=8 the inhibition falls away due to a considerable amount of cerium precipitating out of solution as cerium *** protective film formed on sites in the aluminium alloy surface at different pH values was examined by both scanning electron microscopy with energy dispersive X-ray analysis and X-ray photoelectron spectroscopy to determine the role of these ions as a function of pH in surface *** is proposed that at pH=2.5 protection is provided by a bilayer adsorption of iodide with"cap

关键词： Aluminium alloy Cerium(Ⅲ)salt Potassium iodide Corrosion inhibitor XPs Rare earths