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Diabetes mellitus type 2 as an underlying,comorbid or consequent state of mental disorders

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World Journal of Diabetes 2023年第5期14卷 481-493页

作者： milica m Borovcanin Katarina Vesic Ivica Petrovic ivan P Jovanovic Natasa R mijailovic Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Neurology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pathophysiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Center for molecular medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

Somatic disturbances that occur in parallel with psychiatric diseases are a major challenge in clinical *** factors contribute to the development of mental and somatic *** 2 diabetes mellitus(T2Dm)is a significant health burden worldwide,and the prevalence of diabetes in adults is *** comorbidity of diabetes and mental disorders is very *** sharing a bidirectional link,both T2Dm and mental disorders influence each other in various manners,but the exact mechanisms underlying this link are not yet *** potential mechanisms of both mental disorders and T2Dm are related to immune and inflammatory system dysfunction,oxidative stress,endothelial dysfunction,and metabolic ***,diabetes is also a risk factor for cognitive dysfunction that can range from subtle diabetesassociated cognitive decline to pre-dementia and dementia.A complex relationship between the gut and the brain also represents a new therapeutic approach since gut-brain signalling pathways regulate food intake and hepatic glucose *** aim of this minireview is to summarize and present the latest data on mutual pathogenic pathways in these disorders,emphasizing their complexity and *** also focused on the cognitive performances and changes in neurodegenerative *** importance of implementing integrated approaches in treating both of these states is highlighted,along with the need for individual therapeutic strategies.

关键词： Diabetes mellitus type 2 mental disorders Neuroinflammation Neurodegeneration Cognition

Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity

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Bioactive materials 2023年第6期24卷 174-184页

作者： Andrés García-García Sébastien Pigeot ivan martin Department of Biomedicine University Hospital BaselUniversity of Basel4031BaselSwitzerland Department of Biomedical Engineering University of Basel4123AllschwillSwitzerland

The increasing recognition of the contribution of the immune system to activate and prime regeneration implies that tissue engineering strategies and biomaterials design should target regulation of early immunological *** previously proposed the cell-based engineering and devitalization of extracellular matrices(ECms)as a strategy to generate implant materials delivering custom-defined ***,in the context of bone regeneration,we aimed at enhancing the osteoinductivity of such ECms by enriching their immunomodulatory factors *** with IL1βa cell line overexpressing BmP-2 enabled engineering of ECms preserving osteoinductive signals and containing larger amounts of angiogenic(VEGF)and pro-inflammatory molecules(IL6,IL8 and mCP1).Upon implantation,these IL1β-induced materials enhanced processes typical of the inflammatory phase(e.g.,vascular invasion,osteoclast recruitment and differentiation),leading to‘regenerative’events(e.g.,m2 macrophage polarization)and ultimately resulting in faster and more efficient bone *** results bear relevance towards the manufacturing of potent off-the-shelf osteoinductive materials and outline the broader paradigm of engineering immunoinstructive implants to enhance tissue regeneration.

关键词： Immunomodulation Bone tissue engineering Inflammation Hypertrophic cartilage matrices Osteoinduction

Strain-Rate Dependency of a Unidirectional Filament Wound Composite under Compression

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Computer modeling in Engineering & Sciences 2023年第12期137卷 2149-2161页

作者： Stepan Konev Victor A.Eremeyev Hamid m.Sedighi Leonid Igumnov Anatoly Bragov Aleksandr Konstantinov Ayaulym Kuanyshova ivan Sergeichev Skolkovo Institute of Science and Technologies Center for Materials TechnologiesMoscowRussia National Research Lobachevsky State University of Nizhny Novgorod Nizhny NovgorodRussia Dipartimento di Ingegneria Civile Ambientale e Architettura(DICAAR)Universitàdegli Studi di CagliariCagliari(CA)Italy mechanical Engineering Department Faculty of EngineeringShahid Chamran University of AhvazAhvazIran Drilling Center of Excellence and Research Center Shahid Chamran University of AhvazAhvazIran

This article presents the results of experimental studies concerning the dynamic deformation and failure of a unidirectional carbon fiber reinforced plastic(T700/LY113)under *** test samples were manufactured through the filament winding of flat *** establish the strain rate dependencies of the strength and elastic modulus of the material,dynamic tests were carried out using a drop tower,the Split Hopkinson Pressure Bar method,and standard static *** samples were loaded both along and perpendicular to the direction of the reinforcing *** applicability of the obtained samples for static and dynamic tests was confirmed through finite elementmodeling and the high-speed imaging of the deformation and failure of samples during *** a result of the conducted experimental studies,static and dynamic stress-strain curves,time dependencies of deformation and the stress and strain rates of the samples during compression were *** on these results,the strain rate dependencies of the strength and elasticity modulus in the strain rate range of 0.001-6001/s are *** is shown that the strain rate significantly affects the strength and deformation characteristics of the unidirectional carbon fiber composites under *** increase in the strain rate by 5 orders of magnitude increased the strength and elastic modulus along the fiber direction by 42%and 50%,*** loading resulted in a strength and elastic modulus increase by 58%and 50%,*** average strength along the fibers at the largest studied strain rate was about *** obtained results can be used to design structural elements made of polymer composite materials operating under dynamic shock loads,as well as to build models of mechanical behavior and failure criteria of such materials,taking into account the strain rate effects.

关键词： High strain rate composites filament winding dynamic strength Split Hopkinson Pressure Bar compression

Galectin-3 mediated risk of inflammation in stable schizophrenia,with only possible secondary consequences for cognition

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World Journal of Psychiatry 2022年第9期12卷 1183-1193页

作者： Slavica minic Janicijevic ivan P Jovanovic Nevena m Gajovic milena m Jurisevic monojit Debnath Nebojsa N Arsenijevic milica m Borovcanin University of Kragujevac Faculty of Medical SciencesKragujevac 34000Serbia Center for molecular medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Human Genetics National Institute of Mental Health and NeurosciencesBangalore 560029India Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Evidence suggests that cytokines cause immune disturbances,shape immunological sequelae later in life,and modulate the risk of schizophrenia(SC).Galectin-3(Gal-3),a multifaceted molecule of the glycan family,is involved in the formation of the immunological synapse and modulates the signalling pathway and effector functions of T lymphocytes,which are major producers of *** have previously reported elevated serum Gal-3 levels in stable SC ***,Gal-3 as a link between cognitive functioning and inflammation has not yet been investigated in *** To investigate the relationship between serum Gal-3 levels and cognitive performance,serum cytokines,and white blood cell count in three-month stably treated SC *** Twenty-seven patients with SC in remission and 18 healthy volunteers participated in this casecontrol and correlational *** assessment was performed using the Positive and Negative Syndrome Scale and the montreal-Cognitive *** results of previously measured serum levels of Gal-3,interleukin(IL)-33,soluble suppression of tumorigenicity 2(sST2),tumor necrosis factor-alpha(TNF-α),IL-6 and IL-17 were used for further statistical analyses,and IL-4,IL-23,IL-1βand transforming growth factor-beta(TGF-β)were now additionally measured with a sensitive enzyme-linked immunosorbent *** number of leukocytes in the blood and the percentage of neutrophils,lymphocytes,and monocytes were determined with a standardized routine measurement procedure(Sysmex Technology).Statistical analyses were performed using SPSS 20.0 *** We found no correlation between serum Gal-3 levels and cognitive functioning in SC patients.A positive correlation was found between the levels of Gal-3 and TNF-α(r=0.476;P=0.012),Gal-3and IL-23(r=0.417;P=0.031),and Gal-3 and sST2(r=0.402;P=0.038).The binary logistic model,which included all nine cytokines measured in this patient sample,indicated the particular role of Gal-3 and T

关键词： Schizophrenia Galectin-3 Cytokines Leukocytes Antipsychotics

Submonolayer Eu superstructures—A class of 2D magnets

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Nano Research 2023年第1期16卷 1500-1506页

作者： Dmitry V.Averyanov ivan S.Sokolov Alexander N.Taldenkov Oleg E.Parfenov Andrey m.Tokmachev Vyacheslav G.Storchak National Research Center“Kurchatov Institute” Kurchatov Sq.1Moscow 123182Russia

Two-dimensional(2D)magnetic materials promise unconventional properties and quantum phases as well as advances in ultracompact *** of 2D magnets often reaches a single monolayer but in general can go beyond this limit,as demonstrated by 2D magnetism of submonolayer Eu superstructures coupled with *** question is whether the submonolayer magnetism constitutes a general ***,we demonstrate that regular Eu lattices form a class of 2D magnets displaying various structures,stoichiometries,and chemical *** synthesized and studied a set of Eu superstructures on Ge(001).Their magnetic properties are consistent with the emergence of a magnetic order such as ferro-or *** particular,control over the magnetic transition temperature by weak magnetic fields indicates the 2D nature of the *** together,Eu/Ge and Eu/Si superstructures seed a nucleus of the research area addressing the emergence of magnetism in submonolayer chemical species.

关键词： two-dimensional(2D)magnetism submonolayer superstructure surface reconstruction germanium

Hepatic Alarmins and mitochondrial Dysfunction under Residual Hyperlipidemic Stress Lead to Irreversible NAFLD

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 284-294页

作者： Luminita ivan Elena Uyy Viorel I.Suica Raluca m.Boteanu Aurel Cerveanu-Hogas Rune Hansen Felicia Antohe Department of Proteomics Institute of Cellular Biology and Pathology“Nicolae Simionescu”of the Romanian AcademyBucharestRomania Department of Health Research SINTEF DigitalTrondheimNorway Department of Circulation and medical Imaging Norwegian University of Science and TechnologyTrondheimNorway

Background and Aims:Nonalcoholic fatty liver disease(NAFLD)includes a range of progressive disorders generated by excess lipid accumulation in the liver leading to hepatic steatosis and eventually *** aimed to identify by high performance mass spectrometry-based proteomics the main signaling pathways and liver proteome changes induced by hypercholesterolemia in a rabbit atherosclerotic model that induced high accumulation of lipids in the ***:The effect of combined lipid-lowering drugs(statins and anti-PCSK9 monoclonal antibody)were used after the interruption of the hypercholesterolemic diet to identify also the potential mediators,such as alarmins,responsible for the irreversible NAFLD build up under the hyperlipidemic sustained ***:Proteomic analysis revealed a number of proteins whose abundance was *** were components of metabolic pathways including fatty-acid degradation,glycolysis/gluconeogenesis,and nonalcoholic fatty liver *** dysfunction indicated alteration at the mitochondrial respiratory chain level and down-regulation of NADH:ubiquinone *** expression of a majority of cytochromes(P4502E1,b5,and c)were up-regulated by lipid-lowering ***-term hyperlipidemic stress,even with a low-fat diet and lipid-lowering treatment,was accompanied by alarmin release(annexins,galectins,HSPs,HmGB1,S100 proteins,calreticulin,and fibronectin)that generated local inflammation and induced liver steatosis and aggressive fibrosis(by high abundance of galectin 3,fibronectin,and calreticulin).Conclusions:The novel findings of this study were related to the residual effects of hyperlipidemic stress with consistent,combined lipid-lowering treatment with statin and inhibitor of PCSK9.

关键词： Nonalcoholic fatty liver disease Atherosclerosis Proteomic Alarmins Fibrosis

A class of high-mobility layered nanomaterials by design

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Journal of materials Science & Technology 2023年第33期164卷 179-187页

作者： Dmitry V.Averyanov ivan S.Sokolov Oleg E.Parfenov Alexander N.Taldenkov Oleg A.Kondratev Andrey m.Tokmachev Vyacheslav G.Storchak National Research Center “Kurchatov Institute” Kurchatov Sq.1Moscow 123182Russia

Design of materials with particular functional properties is indispensable albeit very *** and structural analogies can be helpful in this endeavor,especially when a particular combination of properties is sought *** aim is to bundle together 3 characteristics:high carrier mobility,magnetism,and scalability to nanomaterials in the form of a film–such a combination is particularly advantageous for ***,inspired by recent studies of mAl_(2)Si_(2)and related compounds,we develop magnetic EuAl_(2)Ge_(2)and non-magnetic SrAl_(2)Ge_(2)nanomaterials with high carrier *** syntheses employing sacrificial 2D templates result in epitaxial films of mAl_(2)Ge_(2)seamlessly integrated with *** syntheses are followed by a study of the atomic structure,magnetic and electron transport *** particular,the films demonstrate high carrier mobility,exceeding 10,000 cm^(2)V^(-1)s^(-1)in the case of EuAl_(2)Ge_(2),making the materials appealing for *** together,mAl_(2)Ge_(2)and mAl_(2)Si_(2)form a class of high-mobility layered nanomaterials.

关键词： High carrier mobility magnetism SrAl_(2)Ge_(2) EuAl_(2)Ge_(2) Germanium

Observation of Zitterbewegung in photonic microcavities

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Light(Science & Applications) 2023年第6期12卷 1084-1090页

作者： Seth Lovett Paul m.Walker Alexey Osipov Alexey Yulin Pooja Uday Naik Charles E.Whittaker ivan A.Shelykh maurice S.Skolnick Dmitry N.Krizhanovskii Department of Physics and Astronomy University of SheffieldS37RH SheffieldUK Department of Physics and Technology ITMO UniversitySt.Petersburg 197101Russia Science Institute University of IcelandDunhagi 3IS-107 ReykjavikIceland

We present and experimentally study the effects of the photonic spin–orbit coupling on the real space propagation of polariton wavepackets in planar semiconductor microcavities and polaritonic analogues of *** particular,we demonstrate the appearance of an analogue Zitterbewegung effect,a term which translates as‘trembling motion’in English,which was originally proposed for relativistic Dirac electrons and consisted of the oscillations of the centre of mass of a wavepacket in the direction perpendicular to its *** a planar microcavity,we observe regular Zitterbewegung oscillations whose amplitude and period depend on the wavevector of the *** then extend these results to a honeycomb lattice of coupled microcavity *** to the planar cavity,such lattices are inherently more tuneable and versatile,allowing simulation of the Hamiltonians of a wide range of important physical *** observe an oscillation pattern related to the presence of the spin-split Dirac cones in the *** both cases,the experimentally observed oscillations are in good agreement with theoretical modelling and independently measured bandstructure parameters,providing strong evidence for the observation of Zitterbewegung.

关键词： planar versatile analogues

In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

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microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stevanović Nataša V.Todorović Aleksandar J.Krmpot miroslav Živić Svetlana Savić-Šević Steva m.Lević marina Stanić Dejan Pantelić Brana Jelenković mihailo D.Rabasović Institute of Physiology and Biochemistry“ivan Djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological Research“Siniša Stanković” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics Belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia University of Belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for multidisciplinary Research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the membrane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing ***,their plasma membrane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell ***,we report the first femtosecond IR laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was *** release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the *** plasma membrane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 *** to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.

关键词： patch recording laser