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Involvement of interleukin-15 and interleukin-21, two γ-chain-related cytokines, in celiac disease

World Journal of Gastroenterology 2009年第37期15卷 4609-4614页

作者： Daniela De Nitto ivan monteleone Eleonora Franzè Francesco Pallone Giovanni monteleone Department of Internal Medicine University of Rome "Tor Vergata" 00133 Rome Italy

Celiac disease (CD), an enteropathy caused by dietary gluten in genetically susceptible individuals, is histologically characterized by villous atrophy, crypt cell hyperplasia, and increased number of intra-epithelial lymphocytes. The nature of CD pathogenesis remains unclear, but recent evidence indicates that both innate and adaptive immune responses are necessary for the phenotypic expression and pathologic changes characteristic of CD. Extensive studies of molecules produced by immune cells in the gut of CD patients have led to identification of two cytokines, namely interleukin (IL)-15 and IL-21, which are thought to play a major role in orchestrating the mucosal inflammatory response in CD. Here we review the current knowledge of the expression and function of IL-15 and IL-21 in CD.

关键词： Interleukin-21 Interleukin-15 Celiac disease

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Impairment of ghrelin synthesis in Helicobacter pyloricolonized stomach:New clues for the pathogenesis of ***-related gastric inflammation

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World Journal of Gastroenterology 2014年第3期20卷 639-646页

作者： Omero Alessandro Paoluzi Giovanna Del Vecchio Blanco Roberta Caruso ivan monteleone Giovanni monteleone Francesco Pallone Department of Systems Medicine University of Rome "Tor Vergata"

Ghrelin,the ligand of growth hormone secretagogue receptor 1a,takes part in several functions of the digestive system,including regulation of appetite,energy homeostasis,gastric acid secretion and *** has also immunoregulatory properties and is supposed to inhibit some inflammatory pathways that can mediate gastric ***,ghrelin synthesis is reduced in the gastric mucosa of patients with Helicobacter pylori(***)infection,a worldwide condition inducing a T helper(Th)1/Th17 cell responsedriven gastritis,which may evolve towards gastric atrophy and *** this article,we review the available data on the expression of ghrelin in *** infection and discuss how the defective ghrelin synthesis may contribute to sustain the ongoing inflammatory response in this disease.

关键词： Gastritis Ghrelin Helicobacter pylori T helper 1 cells

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