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Aggregate 2024年第5期5卷 358-370页

作者： Alexey V.Yaremenko Roman O.Melikov Nadezhda A.Pechnikova Iaroslav B.Belyaev Alina Ringaci Tamara V.Yaremenko Aziz B.Mirkasymov Alexandr A.Tamgin Vladislav I.Rodionov Sofya M.Dolotova Grigory A.Plisko Evgeny D.Semivelichenko Anna S.Rogova Albert R.Muslimov Arina S.Ivkina Dmitry Yu.Ivkin Valery P.Erichev Sergey M.Deyev Sergey E.Avetisov Yongjiang Li Hai-Jun Liu ivan V.Zelepukin Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMassachusettsUSA Aristotle University of Thessaloniki ThessalonikiGreece Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences MoscowRussia Moscow Center for Advanced Studies MoscowRussia Faculty of Biology Saint Petersburg State UniversitySaint PetersburgRussia Saint Petersburg Pasteur Institute Saint PetersburgRussia Department of Chemistry Boston UniversityBostonMassachusettsUSA Sechenov University MoscowRussia Saint Petersburg State Chemical and Pharmaceutical University Saint PetersburgRussia Peter the Great St.Petersburg Polytechnic University Saint PetersburgRussia Sirius University of Science and Technology SiriusRussia RM Gorbacheva Research Institute Pavlov UniversitySaint PetersburgRussia Research Institute of Eye Diseases MoscowRussia Department of Medicinal Chemistry Uppsala UniversityUppsalaSweden

The prevention of blindness from glaucoma requires multiple treatments to lower intraocular ***,human contact lenses are modiﬁed with highly porous metal-organic frameworks with sustained release of brimonidine for prolonged glaucoma *** metal-organic frameworks were screened for their attachment to lenses,loading with brimonidine,and drug-release ***-mized therapeutic ocular lenses conjugated with MIL-101(Cr)frameworks maintain optical transparency and *** of lenses with MIL-101(Cr)nanoparticles reduced brimonidine washout with tears and ensured a gradual and localized release of the drug into the eyeball through the *** hybrid lenses provided a 4.5-fold better decrease in eye pressure,compared by area under the curve(AUC)value to a commercially available brimonidine tartrate *** lenses did not induce any notable eye irritation or corneal damage in *** newly devel-oped hybrid lenses are expected to provide a robust platform for the therapy and prevention of various ocular diseases.

关键词： brimonidine contact lenses drug delivery glaucoma intraocular pressure metal-organic frameworks nanoparticles

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Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期

作者： María Elena Martínez Luis Enrique Gutiérrez-Millan Melissa Bondy Adrian Daneri-Navarro María Mercedes Meza-Montenegro ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz María Adriana Balderas-Pe？a José Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chávez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary E. Edgerton María Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian K. Komenaka Zoila Arelí López Bujanda Dihui Lu Gilberto Morgan-Villela James L. Murray Jesse N. Nodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martínez Laura Pérez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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