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星形胶质细胞对维持成年小鼠脑血脑屏障是必需的

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神经损伤与功能重建 2021年第11期16卷 F0003-F0003页

作者： Benjamin P Heithoff Kijana K George Aubrey N Phares ivan A Zuidhoek Carmen Munoz-Ballester Stefanie Robel 杜一星(编译) Fralin Biomedical Research Institute at Virginia Tech Carilion RoanokeVirginiaUSA. Department of Biological Sciences Virginia TechBlacksburgVirginiaUSA. Graduate Program in Translational Biology Medicineand HealthVirginia TechRoanokeVirginiaUSA. School of Neuroscience Virginia TechBlacksburgVirginiaUSA. 不详

已知在成年大脑中多种细胞类型会产生调节血脑屏障(BBB)特性的因子,包括星形胶质细胞。然而,最近的几项研究对成熟星形胶质细胞在BBB中的作用提出了质疑。我们使用他莫昔芬诱导的星形胶质细胞消融小鼠模型,以确定星形胶质细胞在维持成年... 详细信息

已知在成年大脑中多种细胞类型会产生调节血脑屏障(BBB)特性的因子,包括星形胶质细胞。然而,最近的几项研究对成熟星形胶质细胞在BBB中的作用提出了质疑。我们使用他莫昔芬诱导的星形胶质细胞消融小鼠模型,以确定星形胶质细胞在维持成年BBB中是否有有着非冗余和必要功能。在成年小鼠中,他莫昔芬诱导在2 h内导致星形胶质细胞稀疏的凋亡性死亡。早在星形胶质细胞消融出现时即可检测到小分子尸胺的渗漏和进入脑实质的大血浆蛋白纤维蛋白原等表明BBB损伤的迹象。在星形胶质细胞丢失区域内和邻近的血管,紧密连接蛋白zonula occludens-1的表达降低,而内皮葡萄糖转运蛋白1的表达不受干扰。尸胺渗漏持续数周,表明缺乏BBB的修复。这与消融的星形胶质细胞未被替换的发现一致。相邻的星形胶质细胞出现部分非增殖性胶质细胞增生,其特征是形态变化和STAT3的延迟磷酸化。这使泄漏入脑内的染料在消融1月后仍局限于缺乏星形胶质细胞覆盖的血管表面区域。总之,星形胶质细胞是维持成年大脑BBB完整性所必需的。其他细胞类型(如周细胞)分泌的BBB调节因子不足以补偿星形胶质细胞的缺失的影响。

关键词：星形胶质细胞增生接触抑制胶质疤痕胶质血管单位紧密连接

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轴孔配合零件位置矫正装置研究

煤矿机械 2015年第7期36卷 182-184页

作者：谢尔盖.尼古拉耶维奇.苏索耶夫伊万.谢尔盖耶维奇.利特维诺夫曹湧杰郑凯俄罗斯弗拉基米尔国立大学机电工程学院弗拉基米尔600000

针对轴孔类零件组合装配过程中,容易产生位姿偏差的问题,采用杠杆矫正装置,结合零件位置矫正的方法,设计开发了一套适用于轴孔类零件装配的位置矫正装置。详细介绍了该装置的工作原理,并对该装置矫正效果进行了计算机模拟分析和实物验证... 详细信息

针对轴孔类零件组合装配过程中,容易产生位姿偏差的问题,采用杠杆矫正装置,结合零件位置矫正的方法,设计开发了一套适用于轴孔类零件装配的位置矫正装置。详细介绍了该装置的工作原理,并对该装置矫正效果进行了计算机模拟分析和实物验证,结果表明该装置通过多次矫正方法,可满足轴孔类零件装配位姿存在偏差时的装配要求,实现了配合零件快速而准确的装配目的。

关键词：装配位姿偏差杠杆矫正装置位置矫正多次矫正

Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants:The case of Artemisia vulgaris *** for Artemisia annua *** Western Uganda

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TMR Integrative Medicine 2023年第4期7卷 1-13页

作者： ivan Kahwa Clement Olusoji Ajayi Reenu Yadav Nagendra Singh Chauhan Kamal Shah Abdelgadir Alamin Abdelgadir Efrata Ashuro Shegena Salome Daniel Timothy Omara John Baptist Asiimwe Hilda Ikiriza Shabnoor Iqbal Casim Umba Tolo Anke Weisheit Patrick Engeu Ogwang Pharm-BioTechnology and Traditional Medicine Centre Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy Faculty of MedicineMbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Pharmacy IES UniversityBhopal-462044Madhya PradeshIndia Drugs Testing Laboratory Avam Anusandhan Kendra Raipur(CG)492010India Institute of Pharmaceutical Research GLA UniversityMathuraUttar Pradesh 281406India Department of Pharmacognosy Faculty of PharmacyUniversity of GeziraP.O Box 20Wad MadaniSudan Department of Pharmaceutics and Pharmacy Practice Kampala International UniversityP.O.Box 9790Dares SalaamTanzania Institute of Chemistry of Renewable Resources Department of ChemistryUniversity of Natural Resources and Life Sciences Vienna(BOKU)Konrad-Lorenz-Straße 243430Tulln an der DonauAustria Aga Khan University P.O.Box 8842KampalaUganda Department of Biology Mbarara University of Science and TechnologyP.O.Box 1410MbararaUganda Department of Zoology Government College UniversityFaisalabadPunjab 38000Pakistan

Background:Different parts of Artemisia vulgaris L.(***)are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever,ulcers,and ***,anecdotal evidence shows that the plant is often substituted for Artemisia annua L.(***)by herbalists in Western Uganda due to similarities in their *** of medicinal plants and mislabelling of herbal products have been incriminated in toxicity and adverse health outcomes in traditional medicine *** safety continues to be a major issue with the use of herbal remedies,it becomes imperative therefore that medicinal plants should be correctly ***:This study focused on investigating the macroscopic,microscopic,physicochemical characteristics and phytochemical composition of *** leaves compared to *** to ease its correct ***:The results showed that there are some colour differences between the leaves of the two species,with a close arrangement of microscopic features but different leaf *** leaves of the two Artemisia species had similar tastes,but their shapes and colours(greenish-yellow for *** and dark green for ***)can be used by the local community to distinguish between *** artemisinin content was higher in *** leaves(1.72%)than in ***(1.43%),but the reverse was observed for the total flavonoid ***:This observation could justify the change in the use of *** by the indigenous community in western *** studies should consider the pharmacognostic comparison of *** with other species in the genus Artemisia and the use of molecular techniques such as DNA barcoding.

关键词： Artemisinin traditional medicine misidentification microscopic studies

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低密度Fe-Mn-Al-C钢的组织及性能

水钢科技 2021年第3期 50-62页

作者： ivan GUTIERREZ-URRUTIA 高长益(译) 叶雅妮(译) 张东升(译) 谢祥(译) 刘立德(译) 吴学林(译) 日本国家材料科学院战略材料研究中心首钢水钢制造管理部贵州六盘水553028

本文介绍了低密度Fe-Mn-Al-C钢的相结构、微观组织特点和相关的室温及低温性能遥低密度Fe-Mn-Al-C钢具有优异的物理和机械性能,同时提供了高达18%的减重,使其成为轻型耐碰撞汽车车身结构和低温工业中结构部件的优异材料。本文介绍了最... 详细信息

本文介绍了低密度Fe-Mn-Al-C钢的相结构、微观组织特点和相关的室温及低温性能遥低密度Fe-Mn-Al-C钢具有优异的物理和机械性能,同时提供了高达18%的减重,使其成为轻型耐碰撞汽车车身结构和低温工业中结构部件的优异材料。本文介绍了最新的钢种设计方法。特别是,总结了L'1_(2)(Fe,Mn)_(3)AlC碳化物(资碳化物)和B2型富Ni或富Cu析出物的相结构及其变形行为遥未来的科学和技术挑战使这些钢成为工业应用的结构材料。

关键词：低密度钢相结构变形机制强化机制应变硬化机制力学性能低温力学性能 κ碳化物

Onboard Laser Time Transfer Payload and Its Application for Chinese Navigation Satellites

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Onboard Laser Time Transfer Payload and Its Application for ...

Notes,outline and divergence times of Basidiomycota

第三届中国卫星导航学术年会

作者： Meng Wendong(1),Zhang Haifeng(1),Zhang Zhongping(1),Huang Peicheng(1),Wang Jie(2),Liao Ying(2),Ye Yang(2),Hu Wei(2),Wang Yuanming(1),Chen Wanzhen(1),Yang Fumin(1),ivan Prochazka(3) (1)Shanghai Astronomical Observatory,Chinese Academy of Sciences,Shanghai,20030 China (2)China Academy of Space Technology,Beijing,100094,China (3)Czech Technical University in Prague,115 19 Prague 1,Czech Republic

High-precision time synchronization between satellite and ground station plays the vital role in satellite navigation *** Time Transfer（LTT）technology is widely recognized as the highest accuracy way to achieve time synchronization derived from Satellite Laser Ranging（SLR）*** LTT payload has been designed and developed by Shanghai Astronomical Observatory,and successfully applied to Chinese navigation *** using the SLR system,with strictly controlling laser fire time and developing LTT data processing system on ground, the high precise onboard laser time transfer experiment has been first performed for satellite navigation system in the *** clock difference and relative frequency differences between the ground hydrogen maser and space rubidium clocks have been obtained,with the precision of approximately 300ps and relative frequency stability of *** article describes the development of onboard LTT payload,introduces the principle,system composition,applications and LTT measuring results for Chinese satellite navigation system.

关键词： navigation satellites time synchronization laser time transfer(LTT) measuring experiment,satellite laser ranging(SLR)

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Fungal Diversity 2019年第6期99卷 105-367页

作者： Mao-Qiang He Rui-Lin Zhao Kevin D.Hyde Dominik Begerow Martin Kemler Andrey Yurkov Eric H.C.McKenzie Olivier Raspe Makoto Kakishima Santiago Sanchez-Ramırez Else C.Vellinga Roy Halling Viktor Papp ivan V.Zmitrovich Bart Buyck Damien Ertz Nalin N.Wijayawardene Bao-Kai Cui Nathan Schoutteten Xin-Zhan Liu Tai-Hui Li Yi-Jian Yao Xin-Yu Zhu An-Qi Liu Guo-Jie Li Ming-Zhe Zhang Zhi-Lin Ling Bin Cao Vladimir Antonin Teun Boekhout Bianca Denise Barbosa da Silva Eske De Crop Cony Decock Balint Dima Arun Kumar Dutta Jack W.Fell Jozsef Geml Masoomeh Ghobad-Nejhad Admir J.Giachini Tatiana B.Gibertoni Sergio P.Gorjon Danny Haelewaters Shuang-Hui He Brendan P.Hodkinson Egon Horak Tamotsu Hoshino Alfredo Justo Young Woon Lim Nelson Menolli Jr Armin Mesic Jean-Marc Moncalvo Gregory M.Mueller La szlo G.Nagy RHenrik Nilsson Machiel Noordeloos Jorinde Nuytinck Takamichi Orihara Cheewangkoon Ratchadawan Mario Rajchenberg Alexandre G.S.Silva-Filho Marcelo Aloisio Sulzbacher Zdenko Tkalcec Ricardo Valenzuela Annemieke Verbeken Alfredo Vizzini Felipe Wartchow Tie-Zheng Wei Michael WeiB Chang-Lin Zhao Paul M.Kirk State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand College of Life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408People’s Republic of China Ruhr-Universitat Bochum AG GeobotanikND03UniversitatsstraBe 15044801 BochumGermany Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures InhoffenstraBe 7B38124 BrunswickGermany Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Research Department Meise Botanic GardenNieuwelaan 381860 MeiseBelgium Service General de l'Enseignement superieur et de la Recherche scientifique Federation Wallonie-BruxellesLavallee 11080 BrusselsBelgium University of Tsukuba TsukubaIbaraki 305-8572Japan Department of Ecology and Evolutionary Biology University of Toronto25 Willcocks St.TorontoON M5S 3B2Canada Berkeley USA Institute of Systematic Botany The New York Botanical GardenBronxNY 10458-5126USA Department of Botany Szent Istvan University1518 BudapestHungary Komarov Botanical Institute Russian Academy of SciencesProfessor Popov st.2Saint PetersburgRussia 197376 Institut pour Systematique Ecologie Biodiversite(ISYEB UMR 7205) Sorbonne universiteMuseum National d’Histoire Naturelle CP 39CNRSDepartement Origines et Evolution12 Rue Buffon75005 ParisFrance Institute of Microbiology Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Institute of MicrobiologyGuangzhou 510070People’s Republic of China Department of Botany Moravian Mu

The Basidiomycota constitutes a major phylum of the kingdom Fungi and is second in species numbers to the *** present work provides an overview of all validly published,currently used basidiomycete genera to date in a single *** outline of all genera of Basidiomycota is provided,which includes 1928 currently used genera names,with 1263 synonyms,which are distributed in 241 families,68 orders,18 classes and four *** provide brief notes for each accepted genus including information on classification,number of accepted species,type species,life mode,habitat,distribution,and sequence ***,three phylogenetic analyses with combined LSU,SSU,5.8s,rpb1,rpb2,and ef1 datasets for the subphyla Agaricomycotina,Pucciniomycotina and Ustilaginomycotina are conducted,*** time estimates are provided to the family level with 632 species from 62 orders,168 families and 605 *** study indicates that the divergence times of the subphyla in Basidiomycota are 406-430 Mya,classes are 211-383 Mya,and orders are 99-323 Mya,which are largely consistent with previous *** this study,all phylogenetically supported families were dated,with the families of Agaricomycotina diverging from 27-178 Mya,Pucciniomycotina from 85-222 Mya,and Ustilaginomycotina from 79-177 *** times as additional criterion in ranking provide additional evidence to resolve taxonomic problems in the Basidiomycota taxonomic system,and also provide a better understanding of their phylogeny and evolution.

关键词： Classification Molecular clock Fungi Systematics Taxonomy

Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

Accretion in strong field gravity with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

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那些欧洲旷野里的隐秘居所

艺术与设计 2020年第8期9卷 110-115页

作者：张丹枫莫里森夫妇(图) 詹格法特·弥尔顿(图) 中林希(图) 埃埃斯彭·福尔格(图) 罗伯托·迪尼(图) 阿列克西·豪塔马基(图) 不详

地球的确太挤了,所以对世外桃源的追求从来都是同一个世界同一个梦想。在建筑界,无论是名师还是新锐,于荒野中打造一个能够满足人们"诗与远方"想象的作品,都是兼具吸引力与挑战度的——它们既要藏身自然,与周遭原生态环境和谐共处,但又... 详细信息

地球的确太挤了,所以对世外桃源的追求从来都是同一个世界同一个梦想。在建筑界,无论是名师还是新锐,于荒野中打造一个能够满足人们"诗与远方"想象的作品,都是兼具吸引力与挑战度的——它们既要藏身自然,与周遭原生态环境和谐共处,但又要不失自身魅力,展现现代建筑美学光彩。在那些点缀在欧洲旷野中的隐秘居所里,你会感受到,对建筑与自然互联的思考.

关键词：建筑美学建筑与自然原生态环境和谐共处世外桃源居所隐秘吸引力