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Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet

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Natural Products and Bioprospecting 2012年第4期2卷 154-155页

作者： Agustin LUGO-RADILLO ivan delgado-enciso Elpidio PEÑA-BELTRÁN Instituto Nacional de Geriatría Periférico Sur 2767San Jerónimo LídiceMagdalena Contreras10200 México D.F.México Facultad de Medicina Universidad de ColimaAv.Universidad 333Colonia Las Víboras28040 ColimaColimaMéxico Facultad de Ciencias Biológicas y Agropecuarias Universidad de Colima.Carr.Colima-Manzanillo km 4028100 TecománColimaMéxico

Six weeks BALB/c mice were fed with an atherogenic diet for 24 weeks and purified water ad *** experimental group was given betanidin,orally,during the last 40 days of the experiment at a dose of 9.6 mg per mouse per *** controls were fed with standard rodent chow *** was measured at the end of the experiment,after overnight *** group treated with betanidin presented a highly significant reduction of 50.94%compared to positive *** conclude that betanidin reduces glycemia in BALB/c mice by an unidentified mechanism.

关键词： betalains betanidin blood glucose hypoglycemiant

Liquid superlubricity of lubricants containing hydroxyl groups and their aqueous solution under rolling/sliding conditions

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Friction 2024年第1期12卷 164-173页

作者： Tomáš POLÁČEK Petr ŠPERKA ivan KŘUPKA Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic

Macroscale rolling/sliding conditions are in the superlubricity,a little-studied topic so *** purpose of this paper is to examine the formation of elastohydrodynamic lubrication(EHL)films by water-based lubricants(glycerol and polyethylene glycol(PEG)),providing superlubricous *** were carried out on an optical ball-on-disc tribometer under rolling/sliding *** film thickness was measured by the thin film colorimetric interferometry,and the viscosity of liquids was measured by rotational and high-pressure falling body *** results show that tribochemical reactions are not the mandatory reason for friction to reach the superlubricity level when using the water-based *** studied liquids themselves are almost *** the addition of water,the signs of shear thinning behavior disappear even *** conditions for this type of lubricant can be predicted using the known Hamrock–Dowson *** anomaly in the thickness of the lubricants was observed as an abrupt change at certain *** more PEG there is in the lubricant,the higher the thickness at the beginning of the jump.

关键词： macroscale superlubricity super low traction water-based lubricants elastohydrodynamic lubrication(EHL) film thickness

Interatomic Interaction Models for Magnetic Materials:Recent Advances

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Chinese Physics Letters 2024年第6期41卷 54-66页

作者： Tatiana S.Kostiuchenko Alexander V.Shapeev ivan S.Novikov Emanuel Institute of Biochemical Physics RAS 4 Kosygin StreetMoscow119334Russian Federation Independent investigator

Atomistic modeling is a widely employed theoretical method of computational materials *** has found particular utility in the study of magnetic ***,magnetic empirical interatomic potentials or spinpolarized density functional theory(DFT)served as the primary models for describing interatomic interactions in atomistic simulations of magnetic ***,in recent years,a new class of interatomic potentials known as magnetic machine-learning interatomic potentials(magnetic MLIPs)has *** MLIPs combine the computational efficiency,in terms of CPU time,of empirical potentials with the accuracy of DFT *** this review,our focus lies on providing a comprehensive summary of the interatomic interaction models developed specifically for investigating magnetic *** also delve into the various problem classes to which these models can be ***,we offer insights into the future prospects of interatomic interaction model development for the exploration of magnetic materials.

关键词： materials interaction empirical

Influence of Methane-Hydrogen Mixture Characteristics on Compressor Vibrations

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Fluid Dynamics & Materials Processing 2024年第5期20卷 1031-1043页

作者： Vladimir Ya.Modorskii ivan E.Cherepanov High Performance Computing Center Perm National Research Polytechnic UniversityPerm614990Russia

A transition to clean hydrogen energy will not be possible until the issues related to its production, transportation,storage, etc., are adequately resolved. Currently, however, it is possible to use methane-hydrogen *** gas can be transported using a pipeline system with the required pressure being maintained by gascompression stations. This method, however, is affected by some problems too. Compressors emergency stopscan be induced by vibrations because in some cases, mechanical methods are not able to reduce the vibrationamplitude. As an example, it is known that a gas-dynamic flow effect in labyrinth seals can lead to increasedvibrations. This paper presents the numerical simulation of rotor oscillations taking into account a gas-dynamicload. The influence of a transported mixture on the oscillatory process is investigated. Mixtures consisting ofmethane and hydrogen in various proportions and an air mixture are considered. The results are discussed forvarious operating pressures and include the rotor motion trajectories and oscillation frequency spectra obtainednumerically. It is shown that the gas mixture composition has a significant effect on the oscillations and theiroccurrence. Hydrogen as a working fluid reduces the vibration amplitude. Operating a compressor with hydrogenleads to a decrease in the resonant frequency, bringing it closer to the operating one. However, the operatingpressure at which maximum oscillations are observed depends slightly on the gas mixture composition.

关键词： Seal stabilities vibration FSI CFD multiphase flows hydrogen

Witness for resolution: post-conflict quadratic affiliation in semi-free ranging pigs

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Current Zoology 2024年第2期70卷 233-243页

作者： ivan Norscia Edoardo Collarini Carlo Robino Elena Chierto Giada Cordoni Department of Life Sciences and Systems Biology University of TorinoVia Accademia Albertina 1310123 TorinoItaly Department of Public Health Sciences and Pediatric s University of TorinoC.So Galileo Galilei 2210126 TorinoItaly

In social mammals,post-conflict resolution can involve the reunion of former opponents(reconciliation),spontaneous/solicited post-conflict affliation of a third party with either opponent(triadic contacts),and affiliation between other individuals(hereafter bystanders;quadratic contacts).Quadratic contacts-possibly informing complex cognitive abilities-have been neglected in post-conflict *** investi-gated quadratic affliation in semi-free ranging pigs Sus scrofa,at the ethical farm Parva-Domus(Cavagnolo,Italy).Kinship was *** collected behavioral data on adult pigs(n=104)via video recordings(43 h)followed by video *** and anxiety behaviors between bystanders were collected under post-conflict(PC;following a conflict between non-bystanders)and matched-control(MC;no conflict)*** affiliation was present in pigs,as bystanders affliated more in PC than MC,and such affiliation was followed by a decrease in the anxiety behaviors of both the interacting ***,quadratic contacts may be partly aimed at reducing one's own anxiety(intrinsic regulation).Quadratic affiliation was highest between closely related bystanders,which suggests that such affiliation may be most effective when close kin is *** affiliation was lowest after reconciliation and spontaneous triadic *** suggests that direct peacemaking between opponents and spontaneous triadic contacts with close kin may most likely replace quadratic ***,pigs can be influenced by the negative events that affect other pigs-but not themselves-and their response may be modulated by social *** non-random quadratic affiliation may point toward the presence of elements of social appraisal abilities inpigs.

关键词： anxiety reduction emotional regulation reconciliation social appraisal triadic contacts.

Expect the unexpected:Brown tumor of the mandible as the first manifestation of primary hyperparathyroidism

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World Journal of Clinical Cases 2024年第7期12卷 1200-1204页

作者： Ana Majic Tengg Maja Cigrovski Berkovic ivan Zajc ivan Salaric Danko Müller Iva Markota Department of Endocrinology DiabetesMetabolic Diseases and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Department for Sport and Exercise Medicine Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Oral Surgery Clinical Hospital DubravaZagreb 10000Croatia University of Zagreb School of Dental Medicine Zagreb 10000Croatia Clinical Department of Pathology and Cytology Clinical Hospital DubravaZagreb 10000Croatia

Hyperparathyroidism(HPT)is a condition in which one or more parathyroid glands produce increased levels of parathyroid hormone(PTH),causing disturbances in calcium *** commonly HPT presents with asymptomatic hypercalcemia but the clinical spectrum may include disturbances reflecting the combined effects of increased PTH secretion and *** tumors are rare,benign,tumor-like bone lesions,occurring in 1.5%to 4.5%of patients with HPT,as a complication of an uncontrolled disease pathway,and are nowadays rarely seen in clinical *** tumor can appear either as a solitary or multifocal lesion and usually presents as an asymptomatic swelling or a painful exophytic ***,it can cause a pathological fracture or skeletal pain and be radiologically described as a lytic bone *** diagnosis of a brown tumor in HPT is typically confirmed by assessing the levels of serum calcium,phosphorus,and *** when present,brown tumor is quite pathognomonic for HPT,the histologic finding often suggests a giant cell tumor,while clinical presentation might suggest other more frequent pathologies such as metastatic *** of brown tumors frequently focuses on managing the underlying HPT,which can often lead to regression and resolution of the lesion,without the need for surgical ***,in refractory cases or when dealing with large symptomatic lesions,surgical treatment may be necessary.

关键词： Brown tumor Hyperparathyroidism Lytic bone lesions Giant cell tumor

Rock Mass Quality Rating Based on the Multi-Criteria Grey Metric Space

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2635-2664页

作者： MilošGligoric Zoran Gligoric Saša Jovanovic Suzana Lutovac Dragan Pamucar ivan Jankovic Faculty of Mining and Geology University of BelgradeBelgrade11000Serbia Faculty of Technical Sciences University of PrištinaKosovska Mitrovica38220Serbia Department of Operations Research and Statistics Faculty of Organizational SciencesUniversity of BelgradeBelgrade11000Serbia College of Engineering Yuan Ze UniversityTaoyuan City320315Taiwan

Assessment of rock mass quality significantly impacts the design and construction of underground and open-pit mines from the point of stability and *** study develops the novel Gromov-Hausdorff distance for rock quality(GHDQR)methodology for rock mass quality rating based on multi-criteria grey metric *** usually presents the quality of surrounding rock by classes(metric spaces)with specified properties and adequate interval-grey *** the distance between surrounding rock sample characteristics and existing classes represents the core of this *** Gromov-Hausdorff distance is an especially useful discriminant function,i.e.,a classifier to calculate these distances,and assess the quality of the surrounding *** efficiency of the developed methodology is analyzed using the Mean Absolute Percentage Error(MAPE)*** existing methods,such as the Gaussian cloud method,Discriminant method,Mutation series method,Artificial neural network(ANN),Support vector machine(SVM),Grey wolf optimizer and Support vector classification method(GWO-SVC)and Rock mass rating method(RMR)are used for comparison with the proposed GHDQR *** share of the highly accurate category of 85.71%clearly indicates compliance with actual values obtained by the compared *** results of comparisons showed that the model enables objective,efficient,and reliable assessment of rock mass quality.

关键词： Rock mass rating multi-criteria class metric space interval-grey numbers

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： ivan Sarabia Kyle M.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;M1 and M2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

Is Veillonella a unique marker of physical exercise?Commentary on:"Is physical performance(in mice)increased by Veillonella atypica or decreased by Lactobacillus bulgaricus?"

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Journal of Sport and Health Science 2024年第5期13卷 682-684页

作者： Viktor Bielik ivan Hric Riadh Hammami Department of Biological and Medical Science Faculty of Physical Education and SportComenius University in BratislavaBratislava 81469Slovakia Department of Molecular Biology Faculty of Natural SciencesComenius University in BratislavaBratislava 84215Slovakia Biomedical Research Center Institute of Clinical and Translational ResearchSlovak Academy of SciencesBratislava 84505Slovakia School of Nutrition Sciences Faculty of Health SciencesUniversity of OttawaOttawaON K1N 6N5Canada Department of Biochemistry Microbiology and ImmunologyFaculty of MedicineUniversity of OttawaOttawaON K1N 6N5Canada

In 2020,Kostic1 published commentary on the bacterial genus Veillonella associated with the interaction between the intestinal microbiota and skeletal *** then,novel perspectives on the bidirectional gut-muscle communication axis have gained a lot of *** purpose of this commentary is to explore some of the challenging issues presented in Scheiman et al.

关键词： skeletal gained