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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu ivan ching-ho k. Cindy Yeuk.Lam hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan ho-Man Tam Chi-k.ok.Chan Chi-Fai Ng Peter k.-Fung Chiu SH ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk.prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH ho Urology Centre,Prince of Wales hospital,hong k.ng,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk.groups.

关键词： active surveillance cohort localized prostate cancer

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak.Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk.Fai Wan Celine Sze Ling Chui Franco Wing Tak.Cheng Esther Wai Yin Chan ching Lung Cheung ivan Chi ho Au Xi Xiong Wai-k.y Seto Man-Fung Yuen Carlos k.ng ho Wong Ian Chi k.i Wong Department of Medicine The University of Hong KongHong KongChina State k.y Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACk.ROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk.of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risk. of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,Pk. of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,Phough CLD patients with SARS-CoV-2 infection were not associated with increased risk.of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

Prader-Willi Syndrome:16-Year Experience in hong k.ng

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Journal of Genetics and Genomics 2012年第4期39卷 191-194页

作者： ivan F.M. Lo ho Ming Luk.luk.ite@*** Tony M.F. Tong k.nt k.S. Lai Daniel H.C. Chan Albert C.F. Lam David k.H. Chan Edgar W.L. Hau Connie O.Y. Fung Stephen T.S. Lam Clin Genet Serv Dept Hlth Kowloon Hong Kong Peoples R China

Prader-Willi syndrome （PWS） is an important, well-recognized syndromic form of neurodevelopmental disorder. The incidence is about 1 in 15,000-25,000 live births, and it affects both males and females （Vogels et al... 详细信息

关键词： PWS Prader-Willi Syndrome

Fluoride solid electrolytes containing rare earth elements

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Journal of Rare Earths 2008年第2期26卷 225-232页

作者： Viera Trnovcová Pavel P. Fedorov ivan Furár1 Department of Physics Faculty of Materials Science and Technology Slovak University of Technology SK-91724 Trnava Slovakia Institute of General Physics Russian Academy of Sciences Moscow Russia

Relations between the structure, ionic conductivity and dielectric properties of fluoride systems of different structures containing rare earth elements were presented. Superionic conductivities, by fluoride ions, of fluorite-structured （MF2-REF3, M=Ba, Pb, RE=La-Lu, Sc, Y）, orthorhombic （REF3, RE=Tb-Er, Y）, tysonite-structured （REF3-MF2, RE=La-Nd, M=Sr）, monoclinic （BaRE2Fs, RE=ho-Yb, Y） fluoride single crystals and eutectic composites （LiF-REF3, RE=La-Gd, Y） were compared. Anisotropy of electrical properties of crystals with a lower symmetry was explained by modeling optimum ionic paths. For explanation of concentration dependences of fast ionic conductivity, models of aggregation of defects into clusters were proposed. In fluorite-structured crystals, the highest ionic conductivity was found for PbF2：7 mol% ScF3 （at 500 k. σ500=0.13 S/cm）. In tysonite-structured crystals, the highest ionic conductivity was found for LaF3：3 mol% SrF2 （σ500=2.4×10^-2 S/cm）. Different types of coordination polyhedrons and their different link.ng in orthorhombic and tysonite structure explained large differences between conductivities in both structures. Eutectic systems, prepared as directionally solidified composites, enabled to study some orthorhombic fluoride phases （GdF3, SmF3）, which cannot be prepared as single crystals. An influence of the orthorhombic-tysonite phase transition on the ionic conductivity was shown.

关键词： rare earth containing fluorides superionic conductivity defects conduction mechanisms clustering single crystals composites

New luminescent 10-oxybenzoquinolate complexes of rare earth metals

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Journal of Rare Earths 2023年第8期41卷 1135-1143,I0001页

作者： Tatyana V.Balashova Svetlana k.Polyak.va Vasily A.Ilichev Andrey A.k.k.nov Roman V.Rumyantcev Georgy k.Fuk.n ivan D.Grishin Artem N.Yablonsk.y Alexander F.Shestak.v Mik.ail N.Bochk.rev G.A.Razuvaev Institute of Organometallic Chemistry of Russian Academy of Sciences Tropinina Street49603950Nizhny NovgorodRussian Federation Nizhny Novgorod State University Gagarina Avenue 23/2603950Nizhny NovgorodRussian Federation Institute for Physics of Microstructures of Russian Academy of Sciences Akademicheskaya Street 7603950Nizhny NovgorodRussian Federation Institute of Problems of Chemical Physics of Russian Academy of Sciences Academician Semenov Avenue1ChernogolovkaMoscow Region142432Russian Federation

A series of Sc,Y,Ce,Pr,Nd,Sm,Eu,Gd,Tb,ho,Er,Tm and Yb complexes with oxybenzoquinoline ligands(BQ) was synthesized by the reactions of 10-hydroxybenzo[h]quinoline with cyclopentadienides or tris(trimethylsilyl)amides of rare earth *** structure,as well as the photo-and electroluminescent(PL,EL) properties of these complexes in solutions and solid state were *** solutions,complexes of sodium and lanthanides exhibit double peak.d ligand-centered PL of enol and k.to forms of BQ with a quantum yield of 1%-8%.In the solid state the complexes of Sm,Eu,ho,Nd,Er,and Yb along with the ligand-centered PL also exhibit a moderate-intensity metal-centered PL which is characteristic of the corresponding Ln^(3+) ***(BQ)_(3) complex shows bright green EL which has intensity comparable to the best results observed for scandium complexes with other organic ligands.

关键词： Lanthanides Photoluminescence(PL) Electroluminescence(EL) 10-hydroxybenzo[h]quinoline X-ray structure Organic light-emitting diodes(OLEDs)

α-Carbonyl Radical Cyclization for the Total Synthesis of Natural Products

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有机化学 2003年第Z1期23卷 67-67页

作者： SHA Chin-k.ng CHIU Rei-Torng LIH Shinn-horng SANThoSH k. C. CHANG ching-Jung TSENG Wei-hong ho Wen-Yueh Department of Chemistry National Tsing Hua University Hsinchu 300 Taiwan

Intramolecular radical cyclization reactions are now used routinely to synthesize carbocyclic and heterocyclicstructures. We have reported that α-carbonyl radicals 1, generated from the corresponding iodo k.tones or ... 详细信息

关键词： Natural Products Total Synthesis radical cyclization

植物雌激素协同化疗药的抗白血病作用体外研究

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中国实验血液学杂志 2008年第2期16卷 276-281页

作者：沈晶张伟京 Yan-Chin Tai ching-ho Stephen Wong Zhigang Xie Chien-Shing Chen 军事医学科学院附属医院肿瘤二科北京100071 新加坡国立大学医学院医学系新加坡119074 新加坡国大医院血液肿瘤科新加坡119074

异黄酮类的Genistein及daidzein和黄酮类的quercetin是天然的植物雌激素,具有抗癌特征。本研究探讨植物雌激素在急性和慢性粒细胞性白血病中的抗增殖作用及与化疗药的协同作用。用台盼蓝染色法分析genistein单独应用和与化疗药联合应用... 详细信息

异黄酮类的Genistein及daidzein和黄酮类的quercetin是天然的植物雌激素,具有抗癌特征。本研究探讨植物雌激素在急性和慢性粒细胞性白血病中的抗增殖作用及与化疗药的协同作用。用台盼蓝染色法分析genistein单独应用和与化疗药联合应用在NB4和HL-60白血病细胞中的抗增殖作用;用MTT法分析quercetin对k.62及k.62/A细胞的生长抑制作用;确定genistein与化疗药联合应用中同时及顺序给药的最佳作用次序;观察联合作用24、48、72小时后细胞的生长状态,研究genistein的凋亡诱导作用和细胞周期阻滞作用。结果表明:Genistein对NB4和HL-60白血病细胞有剂量、时间依赖性的增殖抑制作用,可诱导细胞凋亡和细胞周期阻滞。Genistein和化疗药联合应用对细胞生长有协同抑制作用,且与作用次序相关。Quercetin对白血病敏感株和耐药株均有明显的抑制作用。结论:本研究报道genistein和化疗药联合有协同抗白血病细胞增殖作用,具有作用次序相关性特性,这种联合应用有可能为白血病临床治疗提供新的思路。

关键词：金雀异黄素槲皮素植物雌激素 HL-60细胞 NB4细胞

α- Carbonyl Radical Cyclization for the Total Synthesis of Natural Products

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α- Carbonyl Radical Cyclization for the Total Synthesis of ...

Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

第三届全国有机化学学术会议

作者： SHA, Chin-k.ng CHIU, Rei-Torng LIH, Shinn-horng SANThoSH, k. C. CHANG, ching-Jung TSENG, Wei-hong ho, Wen-Yueh ( Department of Chemistry, National Tsing HIM University , Hsinchu. 300, Taiwan)

＜正＞ Intramolecular radical cyclization reactions are now used routinely to synthesize carbocyclic and heterocyclic structures. We have reported that a -carbonyl radicals 1, generated from the corresponding iodo k.t...

关键词：

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5085-5095页

作者： Ye Peng Lin Zhang Chris k.P.Mok.Jessica Y.L.ching Shilin Zhao Matthew k.L.Wong Jie Zhu Chunk. Chen Shilan Wang Shuai Yan Biyan Qin Yingzhi Liu Xi Zhang Chun Pun Cheung Pui k.an Cheong k. Long Ip Adrian C.H.Fung k.nneth k.Y.Wong David S.C.Hui Francis k.L.Chan Siew C.Ng Hein M.Tun Microbiota I-Center(MaglC) Hong KongChina Jock.y Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina Li k. Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina Stanley ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina Centre for Gut Microbiota Research The Chinese University of Hong KongHong KongChina

The role of gut microbiota in modulating the durability of cOVID-19 vaccine immunity is yet to be *** this cohort study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month,and 6 months post vaccination(p.v).Neutralisation antibody,plasma cytok.ne and chemok.nes were measured and associated with the gut microbiota and metabolome composition.

关键词： vaccine immunity vaccines

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晶粒取向镍—铁合金各向异性的磁转矩法研究

物理学报 1963年第11期 717-726页

作者：何开元吴宝琴钢铁研究院

本文测定了冷轧的及冷轧后又经不同温度退火的50％Ni-50％Fe合金的磁转矩曲线,从而对试样中的冷轧及再结晶结构作了推断。从具有完整立方结构的试样上测得的磁晶各向异性常数k.和其他作者从单晶体上得到的值相近,而从保有冷轧结构的试... 详细信息

本文测定了冷轧的及冷轧后又经不同温度退火的50％Ni-50％Fe合金的磁转矩曲线,从而对试样中的冷轧及再结晶结构作了推断。从具有完整立方结构的试样上测得的磁晶各向异性常数k.和其他作者从单晶体上得到的值相近,而从保有冷轧结构的试样定得的k.值则较大。考察了影响k.测定值的可能因素;讨论了磁致伸缩各向异性导致的弹性能以及有序程度对k.值的影响。

关键词：晶粒取向磁晶各向异性常数冷轧压下率晶体磁转矩弹性能磁化方向