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Thoracic surgery in 2030

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中华胸部外科电子杂志 2021年第3期8卷 145-152页

作者： Joyce W.Y.chan Rainbow W.H.Lau Aliss T.c.chang ivan c.H.Siu Teddy H.Y.Wong Zheng Li calvin S.H.Ng Department of Surgery Prince of Wales Hospitalthe Chinese University of Hong KongHong Kong SARChina

Introduction Thoracic surgery has evolved at an exponential pace since the first clinical lung resection in *** first pneumonectomy was performed in 1895,the first lobectomy in 1901,while double lumen endotracheal intubation for pulmonary resection did not occur until *** 1990s saw the development of game-changer video-assisted thoracoscopic surgeries(VATS),while the 2000s gave witness to the explosive boom of robotic *** Abraham Lincoln once said,“The best way to predict the future is to create it”,in this article we discuss the current cutting-edge technologies and attempt to predict the future of thoracic surgery in 10 years’time.

关键词： surgery lung clinical

Mastoid obliteration and reconstruction techniques:A review of the literature

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Journal of Otology 2021年第3期16卷 178-184页

作者： Michelle Lupa Mendlovic Daniella Alejandra Monroy Llaguno ivan Hermann Schobert capetillo Juan carlos cisneros Lesser Otorhinolaryngology Resident Instituto Nacional de RehabilitacionMexico CityMexico Otorhinolaryngology Instituto Nacional de RehabilitacionMexico CityMexico Otorhinolaryngology and Neurotology Instituto Nacional de RehabilitacionMexico CityMexico

Objective To review the published literature related to the different obliteration and reconstruction techniques in the management of the canal wall down *** A PubMed(Medline)and LILAcS databases as well as crossed references search was performed with the following Mesh terms:“cholesteatoma”,“cholesteatoma-middle ear”,“otitis media”,“otitis media,suppurative”,“mastoiditis”,“mastoidectomy”,“canal wall down mastoidectomy”,“radical mastoidectomy”,“mastoid obliteration”and crossed *** criteria were adult patients subject to mastoid cavity obliteration and posterior canal wall *** technique and materials used,anatomic and functional results,complications,recurrence rates,and changes in quality of life,were analyzed.A total of 94 articles were screened,38 were included for full-text detailed *** Twenty-one articles fulfilled the inclusion *** and materials used for canal wall reconstruction,tympanoplasty,and ossiculoplasty were varied and included autologous,biosynthetic,or *** results were reported in 16 studies and were *** studies reported improvement in the quality of life using the GBI ***-up time ranged from 1 to 83 *** articles used imaging studies to evaluate postoperative disease *** highest recurrence rate reported for cholesteatoma after obliteration was 19%.The most frequently reported complications were retraction pockets and transient *** Plenty of techniques combining grafts and other materials have been used to overcome mastoidectomy cavity *** far,it is still not possible to standardize an ideal *** available level of evidence for this topic is low and limited.

关键词： chronic otitis media cholesteatoma Mastoidectomy Mastoid obliteration Quality of life

Molecular cloning and characterization of a lipid transfer protein gene(PsLTP1) from Pinus sylvestris(L.)

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Journal of Forestry Research 2019年第3期30卷 1149-1158页

作者： Nataliya Hrunyk Valentina Kovaleva Hryhoriy Krynytskyy ivan Gout Francisco Amil-Ruiz Juan Munoz-Blanco Jose Luis caballero Roman Gout Laboratory of Molecular-Genetic Markers in Woody Plants Ukrainian National Forestry UniversityGen. Chuprynka Str. 103Lviv 79057Ukraine Departamento de Bioquimica y Biologia Molecular Campus de Excelencia Internacional Agroalimentario ceiA3-Campus de RabanalesEdificio Severo Ochoa-C6Universidad de Cordoba14071 CordobaSpain Department of Structural and Molecular Biology University College LondonLondon WC1E 6BTUK

Plant nonspecific lipid transfer proteins (nsLTPs) are widely distributed through plant kingdom and are characterized by the presence of a central hydrophobic cavity, suitable for binding various hydrophobic molecules. Despite extensive research on nsLTP in different plant species, mostly angiosperm, and the great diversity of physiological processes in which they seem to be involved, their exact functions still remain unclear. Also, very limited experimental data are available on nsLTP in gymnosperm. In this study, we report for the first time on the molecular cloning of nsLTP, from Pinus sylvestris L.(PsLTP1, GenBank accession JN980402.1) and the expression pattern of PsLTP1 during ontogenesis and in response to environmental stress conditions. Total RNA from roots of 7-day old pine seedlings was used to isolate the cDNA clone, corresponding to Scots pine lipid transfer protein. The open reading frame of PsLTP1 consists of 372 bp encoding a protein of 123 amino acids. Amino acid sequence alignment revealed that mature PsLTP1 shares high level of similarity with nsLTP from other conifers and with well-studied nsLTPs from angiosperms. The PsLTP1 contains a 27-amino-acid N-terminal signal sequence and presents all the features of a plant nsLTP. Amino acid comparison analysis and 3D structure prediction showed that PsLTP1 is a type 1 nsLTP. The results of the expression analysis of Scots pine PsLTP1 gene revealed that its transcripts accumulate in actively growing tissues. Furthermore, transcription of PsLTP1 was upregulated in response to cold and salt treatments, and downregulated during acidic, osmotic and water stresses.

关键词： Scots pine Nonspecific lipid transfer protein (nsLTP) Molecular cloning Expression Abiotic stresses

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民用飞机起落架噪声及其控制技术研究进展

航空学报 2022年第8期43卷 137-173页

作者：赵鲲梁俊彪 ivan BELYAEV Victor KOPIEV Gareth BENNETT 中国空气动力研究与发展中心低速空气动力研究所气动噪声控制重点实验室绵阳621000 俄罗斯中央空气流体动力研究院气动噪声部莫斯科105005 都柏林大学圣三一学院工程系都柏林D02PN40

起落架是民用飞机起降阶段的主要噪声源之一,是气动噪声控制领域的一项重要难题。经过近半个世纪的研究,起落架噪声特性及控制技术发展方面已经取得了相当丰富的成果。首先,简单回顾了起落架噪声的研究历程,介绍了噪声产生机理;然后,概... 详细信息

起落架是民用飞机起降阶段的主要噪声源之一,是气动噪声控制领域的一项重要难题。经过近半个世纪的研究,起落架噪声特性及控制技术发展方面已经取得了相当丰富的成果。首先,简单回顾了起落架噪声的研究历程,介绍了噪声产生机理;然后,概述了国内外利用风洞试验、飞行试验、数值计算等多种手段在民用飞机起落架气动噪声及控制技术研究领域所取得的成果和最新进展,内容涉及整流罩、小孔封堵、部件优化、空气幕等多种方法;最后,给出了国外研究带来的启示,剖析了当前存在的问题,并对未来发展作出了展望。

关键词：起落架噪声噪声控制技术整流罩空气幕大型声学风洞飞行试验

Device-based neuromodulation for cardiovascular diseases and patient’s age

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Journal of Geriatric cardiology 2022年第11期19卷 876-893页

作者： Evgeny N Mikhaylov Nigar Z Gasimova Natalia N Belyaeva Heber ivan condori Leandro Aleksandr D Vakhrushev Evgeny V Shlyakhto Almazov National Medical Research centre Saint-PetersburgRussia

The autonomic nervous system plays an important role in the pathogenesis of cardiovascular *** aging,autonomic activity changes,and this impacts the physiological reactions to internal and external *** sympathetic and parasympathetic responses seem to decline,reflecting functional and structural changes in nervous *** some investigators suggested that both the sympathetic and parasympathetic activities were suppressed,others found that only the parasympathetic activity was suppressed while the sympathetic activity *** addition,cardiac innervation progressively diminishes with ***,one may suggest that neuromodulation interventions may have different effects,and older age groups can express an attenuated *** article aims to discuss the effect of device-based neuromodulation in different cardiovascular diseases,depending on the patient’s ***,we cover renal denervation,pulmonary artery denervation,baroreceptor activation therapy,vagus nerve stimulation,spinal cord stimulation,ganglionated plexi ablation for the management of arterial and pulmonary hypertension,heart failure,angina and *** results of many clinical studies appeared to be *** view of the low rate of positive findings in clinical studies incorporating neuromodulation approaches,we suggest the underestimation of advanced age as a potential contributing factor to poorer *** of outcomes between different age groups in clinical trials may shed more light on the true effects of neuromodulation when neutral/ambiguous results are obtained.

关键词： stimulation cardiovascular diseases

Repeat hepatectomy for recurrent colorectal liver metastases:A comparative analysis of short-and long-term results

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 162-167页

作者： Paulo Figueiredo costa Fabricio Ferreira coelho Vagner Birk Jeismann Jaime Arthur Pirola Kruger Gilton Marques Fonseca ivan cecconello Paulo Herman Digestive Surgery Brazilian college of Digestive Surgery(colégio Brasileiro de cirurgia Digestiva-cBcD) São PauloBrazil Digestive Surgery Division Department of GastroenterologyUniversity of São Paulo School of MedicineSão PauloBrazil Instituto do câncer do Estado de São Paulo(IcESP) São PauloBrazil

Background: Liver recurrence after resection of colorectal liver metastases(cRLM) is frequent. Repeat hepatectomy has been shown to have satisfactory perioperative results. However, the long-term outcomes and the benefts for patients with early recurrence have not been clarifed. The aim of this study was to compare the short-and long-term outcomes of patients undergoing single hepatectomy and repeat hepatectomy for cRLM. Additionally, the oncological outcomes of patients with early( ≤ 6 months) and late recurrence who underwent repeat hepatectomy were compared. Methods: consecutive adult patients undergoing hepatectomy for cRLM between June 20 0 0 and February 2020 were included and divided into two groups: single hepatectomy and repeat hepatectomy. Results: A total of 709 patients were included: 649 in the single hepatectomy group and 60 in the repeat hepatectomy group. Patients in the repeat hepatectomy group underwent more cycles of preoperative chemotherapy [4(3-6) vs. 3(2-4), P = 0.003]. Patients in the single hepatectomy group more frequently underwent major hepatectomies(34.5% vs. 16.7%, P = 0.004) and had a greater number of lesions resected(2.9 ± 3.6 vs. 1.9 ± 1.8, P = 0.011). There was no increase in operative time, estimated blood loss, length of hospital stay, complications, or mortality in the repeat hepatectomy group. There were no differences in overall survival( P = 0.626) and disease-free survival( P = 0.579) between the two groups. Similarly, for patients underwent repeat hepatectomy, no difference was observed between the early and late recurrence groups in terms of overall survival( P = 0.771) or disease-free survival( P = 0.350). conclusions: Repeat hepatectomy is feasible and safe, with similar short-and long-term outcomes when compared to single hepatectomy. Surgical treatment of early liver recurrence offers similar oncological outcomes to those obtained for late recurrence.

关键词： colorectal cancer Metastasis Hepatectomy Postoperative complications Survival analysis

Isomerization and Dissociation of α-carbon-centered and π-centered Glycylglycyltryptophan Radical cations: Structural, Energetic, Mechanistic, and Spectroscopic Investigations

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Isomerization and Dissociation of α-Carbon-Centered and π-...

Formation, Isomerization and Dissociation of Peptide Radical cations: Structural, Mechanistic, and Photodissociation Spectroscopic Investigations

2018年中国质谱学术大会（cMSc2018）

作者： Mengzhu Li Andre Sze Jonathan Martens Andy c.K.Siu Jos Oomens ivan K.chu Department of chemistry The University of Hong Kong

Dissociation of ligated copper()–peptide complexes, [cu (L)M](L, ligand;M, peptide), generates peptide radical cations(M) through single electron transfer. [1] Diversity is introduced into the ion chemistry of a peptide radical cation through the possibility of the radical migrating in a number of different ways to corresponding prerequisite radical sites prior to fragmentation;some of these competitive reactions are charge– and radical carrier–specific, and can be perturbed upon varying the nature or location of the radical/charge site, the basicity of the residue at that site, or the peptide sequence, all of which can substantially impact the isomerization barriers for radical or charge mobility and the subsequent reactions. [2–5] The major impetus of this study was to use a simple prototypical system, [cu (L)YGW], to track the location of the radical and charge sites, starting from the copper()–peptide complex to the predetermined radical sites of the peptide radical cations after a complex permutation of intramolecular hydrogen atom migrations—potentially allowing us to determine whether or not the individual isomerization, rearrangement, or fragmentation pathways would predominate. A wide variety of site-specific radical peptides can be produced efficiently with judicious choice of the metal–ligand–peptide system;[1–2] we used isomeric π-centered [GGW](formed directly through dissociation of [cu (amine)GGW] complexes) and α-centered [GGW](generated through side-chain cleavage of the tyrosyl residue of the YGW radical cation) species for our initial infrared multiple photon dissociation(IRMPD) investigations, in conjunction with density functional theory calculations. The IRMPD spectrum of GGW displays a strikingly different set of product ions than those obtained from [GGW]. It appears that the two-isomeric radical cationic GGW structures did not interconvert on the time scale of our IRMPD experiments. Such isomeric π-and a-centered radical cationic peptides co

关键词： radical peptide,[GGWπ]●+ [G●GW]+,IRMPD

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Formation, Isomerization and Dissociation of Peptide Radical...

Oil emulsions in naturally fractured Porous Media

2018年中国质谱学术大会（cMSc2018）

作者： Mengzhu Li Jonathan Martens Andre Sze Andy c.K.Siu Jos Oomens ivan K.chu Department of chemistry The University of Hong Kong

Fundamental mass spectrometric studies of peptide radicals fragmentation is not just a scientific foundation for next-generation MS-based sequencing technology and unambiguous protein identification, but also offers insights into the intrinsic chemical properties of peptide radicals including intriguing radical-mediated peptide chemical processes. [1-3] Studies of radical-medical peptide/protein ion-chemistry can also facilitate in-depth understanding of the intrinsic factors that govern the structure, stability, and reactivity of organic radical systems. In the interior of proteins, solvation effects are minimal, or at least significantly reduced. Thus, the gas-phase results give the intrinsic reactivity of the peptide radical ions;in solution, this property will be modified by solvation. The major impetus of this study was to use a simple prototypical system, [cu(dien)peptide](dien= Diethylenetriamine, ligand;peptide = Y(G/A)W, G(G/A)W), to track the location of the radical and charge sites, starting from the copper(II)–peptide complex to the predetermined radical sites of the peptide radical cations after a complex permutation of intramolecular hydrogen atom migrations[3–5]. Isomeric π-centered [G(G/A)W] and α-centered [G(G/A)W] species were used for our initial infrared multiple photon dissociation(IRMPD) investigations, in conjunction with density functional theory calculations. The IRMPD spectrum of GGW displays a strikingly different set of product ions than those obtained from [GGW]. It appears that the two-isomeric radical cationic GGW structures did not interconvert on the time scale of our IRMPD experiments. Elucidating such fundamental factors controlling these intriguing radical-mediated protein chemistry will contribute greatly to studies of the chemical processes behind the biological function of redox enzymes and oxidative stress.

关键词： radical peptide ion chemistry distonic ion action spectroscopy

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Petroleum 2019年第3期5卷 215-226页

作者： A.Paulina Gomora-Figueroa Rodolfo G.camacho-Velazquez Jose Guadarrama-cetina T.ivan Guerrero-Sarabi División de Ingeniería en ciencias de la Tierra Facultad de IngenieríaUniversidad Nacional Autónoma de MéxicoCircuito ExteriorCiudad Universitaria04510Ciudad de MéxicoMexico Instituto de Alta Investigación Universidad de TarapacáAntofagastaCasilla 7D AricaChile

Most of the studies regarding the formation and stability of emulsions focus on the conditioning and management of crude oil on surface *** a great deal of the crude oil produced is in the form of stable emulsions,it is often claimed that these emulsions are formed through chokes and other flow constrictions in oil field ***,emulsions are produced in wells,which not only lack these constrictions but also are produced at low flow rates,demonstrating the fact that emulsions can be formed within the well *** present work reviews the literature regarding the formation and properties of heavy and extra-heavy oil emulsions in naturally fractured porous media due to the current relevance that these types of crude oil exploitation take,satisfying the hydrocarbon energy ***,emulsions have received more attention recently since they can be formed in-situ and improve oil *** understand the flow mechanics of emulsions in porous media,different models to describe their transportation are ***,the formation of emulsions in the reservoir for enhanced oil recovery purposes,including the use of nanoparticlestabilized emulsions is discussed.

关键词： Oil emulsions Naturally fractured Porous media Heavy and extra-heavy oil Transportation Enhanced recovery