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Resveratrol as an Anti-inflammatory Agent in Coronary Artery Disease:A Systematic Review, Meta-Analysis and Meta-Regression

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Chinese Journal of Integrative Medicine 2024年第10期30卷 927-937页

作者： Vito A.Damay Ignatius ivan Department of Cardiovascular Medicine Universitas Pelita Harapan Jakarta Varices Clinic

background: Resveratrol is a non-flavonoid polyphenol that shows promise in reducing proinflammatory factors and maintaining endothelial function, which hints at its potential role in slowing atherosclerosis and preventing acute coronary events. Objective: To study the cardioprotective effects of resveratrol on inflammatory mediators and endothelial function in patients with coronary artery disease(CAD). Methods: A thorough search was conducted in databases(Cochrane Library, Pro Quest, Pub Med, LILACS, Science Direct, Springer, Taylor&Francis, CNKI, Wanfang, and Weipu) until September 24, 2023. The vasopro-inflammatory mediators, endothelial function and outcomes related to cardiovascular events were observed. Titles and abstracts were assessed, and bias was evaluated with Cochrane Ro b 2.0. Heterogeneity of results was explored by metaregression, certainty of evidence was assessed by the GRADE system, and conclusive evidence was enhanced by trial sequence analysis. Results: Ten randomized controlled trials and 3 animal studies investigated resveratrol's impact on inflammatory mediators and endothelial function. In primary prevention studies, meta-analysis showed a significant reduction(95% CI: –0.73 to –0.20; P=0.0005) in tumor necrosis factor-α(TNF-α) expression with resveratrol, demonstrating a dose-dependent relationship. No significant difference was observed in interleukin-6(IL-6) expression with P=0.58 for primary prevention and P=0.57 for secondary prevention. Vascular endothelial nitric oxide synthase(e NOS) expression was significantly increased after resveratrol pre-treatment following CAD events. Secondary prevention studies yielded no significant results; however, meta-regression identified associations between age, hypertension, and lower doses with the extent of TNF-α alterations. High certainty of evidence supported TNF-α reduction, while evidence for IL-6 reduction and e NOS elevation was deemed low. Conclusions: Resveratrol reduces TNF-α in individ

关键词： anti-inflammation coronary artery disease nitric oxide resveratrol systematic review

Products of Commutator Ideals of Some Lie-admissible Algebras

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1875-1892页

作者： ivan KAYGORODOV Farukh MASHUROV Tran Giang NAM Ze Rui ZHANG CMA-UbI Universidade da Beira InteriorCovilhaPortugal Shenzhen International Center for Mathematics(SICM) Southern University of Science and TechnologyShenzhen 518055P.R.China Institute of Mathematics VAST18 Hoang Quoc VietCau GiayHanoiVietnam School of Mathematical Sciences South China Normal UniversityGuangzhou 510631P.R.China

In this article,we mainly study the products of commutator ideals of Lie-admissible algebras such as Novikov algebras,bicommutative algebras,and assosymmetric *** precisely,we first study the properties of the lower central chains for Novikov algebras and bicommutative *** we show that for every Lie nilpotent Novikov algebra or Lie nilpotent bicommutative algebra A,the ideal of A generated by the set{ab−ba|a,b∈A}is ***,we study properties of the lower central chains for assosymmetric algebras,study the products of commutator ideals of assosymmetric algebras and show that the products of commutator ideals have a similar property as that for associative algebras.

关键词： Novikov algebra bicommutative algebra assosymmetric algebra Lie nilpotent algebra

Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A bernabe Joselyn Sanchez Matteo Fassan Katherine Tello Ignacio ivan Wistuba ivan Chavez Passiuri Eloy Ruiz Juvenal Sanchez Fernando barreda Daniel Valdivia Yaqueline bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegro Ebert Poquioma Raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

bACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HER2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(Ib)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HER2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(Pb(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

The transcription factor HSFA7b controls thermomemory at the shoot apical meristem by regulating ethylene biosynthesis and signaling in Arabidopsis

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Plant Communications 2024年第3期5卷 47-61页

作者： Sheeba John Federico Apelt Amit Kumar ivan FAcosta Dominik bents Maria Grazia Annunziata Franziska Fichtner Caroline Gutjahr bernd Mueller-Roeber Justyna J.Olas University of Potsdam Institute of Biochemistry and BiologyKarl-Liebknecht-Straße 24-25Haus 2014476 PotsdamGermany Max Planck Institute of Molecular Plant Physiology Am Muehlenberg 114476 PotsdamGermany Laboratory of Molecular biology Wageningen University6700 AP Wageningenthe Netherlands Center of Plant Systems biology and biotechnology(CPSbb) 14 St.Knyaz Boris 1 Pokrastitel Str.4023 PlovdivBulgaria Present address:Institute of Plant biochemistry Heinrich Heine University DusseldorfUniversit€atsstr.140225 DusseldorfGermany Leibniz Institute of Vegetable and Ornamental Crops Theodor-Echtermeyer-Weg 114979 GroßbeerenGermany

The shoot apical meristem(SAM)is responsible for overall shoot growth by generating all aboveground *** research has revealed that the SAM displays an autonomous heat stress(HS)memory of a previous non-lethal HS *** the importance of the SAM for plant growth,it is essential to determine how its thermomemory is mechanistically ***,we report that HEAT SHOCK TRAN-SCRIPTION FACTOR A7b(HSFA7b)plays a crucial role in this process in Arabidopsis,as the absence of functional HSFA7b results in the temporal suppression of SAM activity after *** found that HSFA7b directly regulates ethylene response at the SAM by binding to the promoter of the key ethylene signaling gene ETHYLENE-INSENSITIVE 3 to establish ***,we demonstrated that HSFA7b regulates the expression of ETHYLENE OVERPRODUCER 1(ETO1)and ETO1-LIKE 1,both of which encode ethylene biosynthesis repressors,thereby ensuring ethylene homeostasis at the *** together,these results reveal a crucial and tissue-specic role for HSFA7b in thermomemory at the Arabidopsis SAM.

关键词： ethylene response heat stress adaptation shoot apical meristem SAM thermopriming thermomemory

Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation

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Life Metabolism 2024年第3期3卷 3-5页

作者： Tristram A.J.Ryan ivan Zanoni Division of Immunology and Division of Gastroenterology Boston Children’s Hospital and Harvard Medical SchoolBostonMA 02115United States

In a recent paper published in Nature,York et *** that the anti-inflammatory cytokine interleukin(IL)-10 regulates sphingolipid metabolism to limit NF-κb-mediated *** of Il10 in mice,or genetic mutation of IL10 in humans,predisposes to inflammatory bowel disease,which may be overcome by restoring homeostatic sphingolipid metabolism.

关键词： metabolism inflammation

Mapping Design of a Four-Dimensional 32-ary Signal Constellation over an AWGN Channel

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China Communications 2014年第7期11卷 64-73页

作者： ZHANG Jianyong ivan b. djordjevic Key Lab of Alloptical Network & Advanced Telecommunication Network ofEMC Beijing Jiaotong University Beijing 100044 P.R. China University of Arizona Tucson AZ 85721 USA Institute of Lightwave Technology Beijing Jiaotong University Beijing 100044 P.R. China

In the bit-interleaved coded modulation with iterative decoding,it is desired that any two Hamming neighbors,i.e..signal constellation points whose binary labels are at unit Hamming distance,be separated by a large Euclidean *** paper determines the mappings for the 32-ary fourdimensional generalized cross constellation（32-4D-GCC） so that the minimum squared Euclidean distance d_（min）~2 between Hamming neighbors is *** such mappings,those with minimum multiplicity N（d_（min）~2） are *** reduce the large search space,a set of ＂mapping templates,＂ each producing a collection of mappings with the same set partitions of binary labels,is *** enumeration of mapping templates,it is shown that the optimum d_（min）~2=16and the optimum N（d_（min）~2）=*** thousands optimum mappings found by computer search,two of the best performance are presented.

关键词： AWGN bICM-ID signalmapping hamming cube mapping template

Nonbinary LDPC bICM for Next-Generation High-Speed Optical Transmission Systems

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中兴通讯技术：英文版 2017年第1期15卷 61-66页

作者： LIN Changyu ivan b. djordjevic WANG Weiming CAI Yi Department of Electrical and Computer Engineering University of Arizona Tucson AZ 85721 USA ZTE Inc. 6 Huashiyuan Rd Donghu H.D.Z. Wuhan 430223 China ZTE (TX) Inc. 55 Madison Ave. Morristown NJ 07960 USA

We propose a nonbinary byte-interleaved coded-modulation scheme with inner and outer turbo-like iterative *** net coding gain is 0.6 d b higher than the state-of-the-art binary single parity check(SPC)low-density parity-check(LDPC)based turbo-product counterpart,with adjustable iterations and lower *** provide the details of bahl-CockeJelinek-Raviv(bCJR)based inner code decoder and optimum signal constellation design(OSCD)method in this *** single-mode fiber(SMF)channel simulation is also discussed.

关键词： fiber optics and optical communications modulation forward error correction (FEC) coded modulation

Maternal Group b Streptococcus Infection Correlates Inversely With Preeclampsia in Pregnant African American Women

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Maternal-Fetal Medicine 2024年第1期6卷 23-28页

作者： Keun Soo Kwon Tzu Hsuan Cheng Simone A。Reynolds Jordan Zhou Huchong Cai Sharon Lee ivan Velickovic Mudar Dalloul David Wlody Ming Zhang Department of Anesthesiology State University of New York-Downstate Health Sciences UniversityNew York 11203USA Department of Epidemiology and biostatistics School of Public HealthState University of New York-Downstate Health Sciences UniversityNew York 11203USA Department of Obstetrics and Gynecology State University of New York-Downstate Health Sciences UniversityNew York 11203USA

Objective:To determine whether an association exists between group b Streptococcus(GbS)colonization and preeclampsia among pregnant black ***:This retrospective cross-sectional study involved black women who gave birth at State University of New York Downstate Hospital between January 2010 and December *** were collected from the Obstetric Department,including delivery date,time,mode of delivery,age of the mother,weeks of gestation at delivery,and antepartum *** GbS test results were originally determined using the eSwab transport *** was defined based on the American College of Obstetricians and Gynecologists criteria for the periods 2010–2012 and 2013–*** primary outcome was whether GbS was associated with the outcome of preeclampsia in the population of black ***,including smoking status,gestational age,parity,body mass index,maternal age,and presence of herpes simplex virus(HSV)and human immunodeficiency virus(HIV)were examined as potential ***-squared test and logistic regression model were used,presenting odds ratios with 95%confidence intervals(Pblack women included in this study,GbS-positive women(n=977)had a 53%reduction in the likelihood of being diagnosed with preeclampsia compared to GbS-negative women(adjusted odds ratio,0.47;95%confidence interval,0.32–0.70).We did not find evidence of differences in the distribution of smoking habits(P=0.783)or maternal age(P=0.107)between GbS-positive and GbS-negative ***,the GbS-positive women tended to be less likely to have a preterm delivery(9.62%(94/977)vs.24.24%(1707/7042),Pbe nulliparous(33.37%(326/977)vs.37.87%(2667/7042),P=0.006),and less likely to be obese(51.38%(502/977)vs.55.30%(3894/7042),PbS-negative *** contrast,GbS-positive women were more likely to have a comorbid infecti

关键词： Pregnancy outcome Preeclampsia GbS colonization African American Afro-Caribbean

Solar flares with similar soft but different hard X-ray emissions： case and statistical studies

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Research in Astronomy and Astrophysics 2016年第1期16卷 39-50页

作者： ivan N.Sharykin Alexei b.Struminsky ivan V.Zimovets Wei-Qun Gan Space Research Institute Russian Academy of Sciences Moscow 117997 Russia Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China

From the Reuven Ramaty High Energy Solar Spectroscopic Imager （RHESS1） catalog we select events which have approximately the same GOES class （high C - low M or 500-1200 counts s-1 within the RHESSI 6-12 keV energy band）, but with different maximal energies of detected hard X-rays. The selected events are subdivided into two groups：（1） flares with X-ray emissions observed by RHESSI up to only 50 keV and （2） flares with hard X-ray emission observed also above 50 keV. The main task is to understand observational peculiarities of these two flare groups. We use RHESSIX-ray data to obtain spectral and spa- tial information in order to find differences between selected groups. Spectra and images are analyzed in detail for six events （case study）. For a larger number of samples （85 and 28 flares in the low-energy and high-energy groups respectively） we only make some generalizations. In spectral analysis we use the thick- target model for hard X-ray emission and one temperature assumption for thermal soft X-ray emission. RHESSI X-ray images are used for determination of flare region sizes. Although thermal and spatial prop- erties of these two groups of flares are not easily distinguishable, power law indices of hard X-rays show significant differences. Events from the high-energy group generally have a harder spectrum. Therefore, the efficiency of chromospheric evaporation is not sensitive to the hardness of nonthermal electron spectra but rather depends on the total energy flux of nonthermal electrons.

关键词： Sun: flares -- Sun: X-rays -- gamma rays