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EUS mini probes in diagnosis of cystic dystrophy of duodenal wall in heterotopic pancreas:A case report

World Journal of Gastroenterology 2004年第17期10卷 2609-2612页

作者： ivan jovanovic Srbislav Knezevic Miodrag Krstic Marjan Micev Clinic of Gastroenterology and Hepatology Institute of Digestive DiseasesBelgradeSerbia and Montenegro First Surgical Clinic BelgradeSerbia and Montenegro Clinical Center of Serbia BelgradeInstitute for Medical ResearchBelgradeSerbia and Montenegro

Cystic dystrophy of the duodenal wall is a rare condition characterized by the development of cysts in heterotopic pancreatic tissue localized in the duodenal wall.A 38-year- old man was admitted to the hospital for abdominal pain and vomiting after food *** diagnosis of acute pancreatitis was initially *** ultrasound examination revealed thickening of the second portion of duodenal wall within which,small cysts(diameter,less than 1 cm)were present in the vicinity of pancreatic head. The head of pancreas appeared enlarged(63 mm×42 mm) and *** endoscopy and barium X-ray series were performed revealing a severe circumferential deformation,as well as 4 cm long stenosis of the second portion of the *** examination revealed multiple cysts located in an enlarged,thickened duodenal wall with moderate to strong post-contrast *** suspected that patient had cystic dystrophy of duodenal wall developed in the heterotopic pancreas and diagnosis was confirmed by endoscopic ultrasound(EUS).Endoscopic ultrasound(EUS)revealed circular stenosis from the duodenal bulb onwards.A twenty megahertz mini-prope examination further showed diffuse(intramural)infiltration of duodenal wall limited to the submucosa and muscularis propria of the second portion of duodenum with multiple microcysts within the thickened mucosa and *** was successfully surgically treated and pancreatoduodenectomy was *** pathological examination confirmed a diagnosis of cystic dystrophy of a heterotopic pancreas. Endoscopic ultrasonography features allow preoperative diagnosis of cystic dystrophy of a heterotopic pancreas in duodenal wall,with intralumina120 MHz mini probe sonography being more efficient in cases of luminal stenosis.

关键词： Pancreas Adult Choristoma Cysts Duodenal Diseases Humans Male

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EUS diagnosis of ectopic opening of the common bile duct in the duodenal bulb: A case report

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World Journal of Gastroenterology 2005年第32期11卷 5068-5071页

作者： Miodrag Krstic Bojan Stimec Radmilo Krstic Milenko Ugljesic Srbislav Knezevic ivan jovanovic Clinical Center of SerbiaBelgrade Serbia and Montenegro Institute for AnatomySchool of Medicine BelgradeSerbia and Montenegro

Among the various congenital anomalies of the biliary system,an ectopic opening of the common bile duct (CBD) in the duodenal bulb is extremely rare. ERCP is essential for diagnosing the anomaly. A 55-year-old male was admitted to hospital for severe right upper quadrant abdominal pain,followed by fever, chills, elevated body temperature and mild icterus. The diagnosis of ectopic opening of CBD in the duodenal bulb was established on endoscopic ultraso-nography (EUS),which clearly demonstrated dilated CBD, with multiple stones and air in the lumen, draining into the bulb. A normal pancreatic duct, which did not drain into the bulb, was also observed. This finding was confirmed on ERCP and *** far as we know, this is the first case of this anomaly diagnosed by EUS. Ectopic opening of the CBD in the duodenal bulb is not an incidental finding, but a pathologic condition which can be associated with clinical entities such as recurrent or intractable duodenal ulcer, recurrent biliary pain,choledocholithiasis or acute cholangitis. Endoscopic ultrasonography features allow preoperative diagnosis of this anomaly and can replace ERCP as a first diagnostic tool in such clinical circumstances. Embryology of the anomalies of the extrahepatic biliary tree has been also reviewed.

关键词： Ectopic opening Common bile duct Congenital anomaly Endoscopic ultrasound

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Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression

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World Journal of Gastroenterology 2019年第43期25卷 6465-6482页

作者： Marina jovanovic Bojana Simovic Markovic Nevena Gajovic Milena Jurisevic Aleksandar Djukic ivan jovanovic Nebojsa Arsenijevic Aleksandra Lukic Natasa Zdravkovic Department of Internal Medicine Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Center for Molecular Medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pathophysiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Dentistry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Ulcerative colitis(UC)is a chronic disease characterized by inflammation of intestinal epithelium,primarily of the *** increasing prevalence of metabolic syndrome(MetS)in patients with UC has been documented ***,there is no evidence that MetS alters the course of the *** To test the influence of the MetS on the severity of UC and the local and systemic immune *** Eighty nine patients with de novo histologically confirmed UC were divided in two groups,according to ATP III criteria:Group without MetS(no MetS)and group with *** Clinically and histologically milder disease with higher serum level of immunosuppressive cytokine interleukin-10(IL-10)and fecal content of Galectin-3(Gal-3)was observed in subjects with UC and MetS,compared to subjects suffering from UC *** was accompanied with predomination of IL-10 over pro-inflammatory cytokines tumor necrosis factorα(TNF-α),interleukin-6(IL-6),and interleukin-17(IL-17)in the sera as well as Gal-3 over TNF-αand IL-17 in feces of UC patients with ***,the patients with both conditions(UC and MetS)had higher percentage of IL-10 producing and Gal-3 expressing innate and acquired immune cells in lamina *** Local dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC.

关键词： Ulcerative colitis Metabolic syndrome Galectin-3 Inflammation Interleukin-10 Systemic immune response

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Diabetes mellitus type 2 as an underlying,comorbid or consequent state of mental disorders

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World Journal of Diabetes 2023年第5期14卷 481-493页

作者： Milica M Borovcanin Katarina Vesic Ivica Petrovic ivan P jovanovic Natasa R Mijailovic Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Neurology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pathophysiology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Center for Molecular Medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

Somatic disturbances that occur in parallel with psychiatric diseases are a major challenge in clinical *** factors contribute to the development of mental and somatic *** 2 diabetes mellitus(T2DM)is a significant health burden worldwide,and the prevalence of diabetes in adults is *** comorbidity of diabetes and mental disorders is very *** sharing a bidirectional link,both T2DM and mental disorders influence each other in various manners,but the exact mechanisms underlying this link are not yet *** potential mechanisms of both mental disorders and T2DM are related to immune and inflammatory system dysfunction,oxidative stress,endothelial dysfunction,and metabolic ***,diabetes is also a risk factor for cognitive dysfunction that can range from subtle diabetesassociated cognitive decline to pre-dementia and dementia.A complex relationship between the gut and the brain also represents a new therapeutic approach since gut-brain signalling pathways regulate food intake and hepatic glucose *** aim of this minireview is to summarize and present the latest data on mutual pathogenic pathways in these disorders,emphasizing their complexity and *** also focused on the cognitive performances and changes in neurodegenerative *** importance of implementing integrated approaches in treating both of these states is highlighted,along with the need for individual therapeutic strategies.

关键词： Diabetes mellitus type 2 Mental disorders Neuroinflammation Neurodegeneration Cognition

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Biochemical markers for non-invasive assessment of disease stage in patients with primary biliary cirrhosis

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World Journal of Gastroenterology 2009年第5期15卷 591-594页

作者： Tamara Alempijevic Miodrag Krstic Rada Jesic ivan jovanovic Aleksandra Sokic Milutinovic Nada Kovacevic Slobodan Krstic Dragan Popovic Institute for Digestive Diseases Clinical Centre of Serbia 11000 Belgrade Serbia

AIM: To evaluate different biochemical markers and their ratios in the assessment of primary biliary cirrhosis (PBC) stages. METHODS: This study included 112 patients with PBC who underwent a complete clinical investigation. We analyzed the correlation (Spearman's test) between ten biochemical markers and their ratios with different stages of PBC. The discriminative values were compared using areas under receiver operating characteristic (ROC) curves. RESULTS: The mean age of patients included in the study was 53.88 ± 10.59 years, including 104 females and 8 males. We found a statistically significant correlation between PBC stage and Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) to platelet ratio (APRI), ALT/platelet count, AST/ALT, ALT/AST and ALT/Cholesterol ratios, with the values of Spearman's rho of 0.338, 0.476, 0.404, 0.356, 0.351 and 0.325, respectively. The best sensitivity and specificity was shown for AST/ALT, with an area under ROC of 0.660. CONCLUSION: Biochemical markers and their ratios do correlate with different sensitivity to and specificity of PBC disease stage. The use of biochemical markers and their ratios in clinical evaluation of PBC patients may reduce, but not eliminate, the need for liver biopsy.

关键词： Primary biliary cirrhosis Disease stage Fibrosis Biochemical markers

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Rock Mass Quality Rating Based on the Multi-Criteria Grey Metric Space

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2635-2664页

作者： Miloš Gligoric Zoran Gligoric Saša jovanovic Suzana Lutovac Dragan Pamucar ivan Jankovic Faculty of Mining and Geology University of BelgradeBelgrade11000Serbia Faculty of Technical Sciences University of PrištinaKosovska Mitrovica38220Serbia Department of Operations Research and Statistics Faculty of Organizational SciencesUniversity of BelgradeBelgrade11000Serbia College of Engineering Yuan Ze UniversityTaoyuan City320315TaiwanChina

Assessment of rock mass quality significantly impacts the design and construction of underground and open-pit mines from the point of stability and *** study develops the novel Gromov-Hausdorff distance for rock quality(GHDQR)methodology for rock mass quality rating based on multi-criteria grey metric *** usually presents the quality of surrounding rock by classes(metric spaces)with specified properties and adequate interval-grey *** the distance between surrounding rock sample characteristics and existing classes represents the core of this *** Gromov-Hausdorff distance is an especially useful discriminant function,i.e.,a classifier to calculate these distances,and assess the quality of the surrounding *** efficiency of the developed methodology is analyzed using the Mean Absolute Percentage Error(MAPE)*** existing methods,such as the Gaussian cloud method,Discriminant method,Mutation series method,Artificial neural network(ANN),Support vector machine(SVM),Grey wolf optimizer and Support vector classification method(GWO-SVC)and Rock mass rating method(RMR)are used for comparison with the proposed GHDQR *** share of the highly accurate category of 85.71%clearly indicates compliance with actual values obtained by the compared *** results of comparisons showed that the model enables objective,efficient,and reliable assessment of rock mass quality.

关键词： Rock mass rating multi-criteria class metric space interval-grey numbers

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Galectin-3 mediated risk of inflammation in stable schizophrenia,with only possible secondary consequences for cognition

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World Journal of Psychiatry 2022年第9期12卷 1183-1193页

作者： Slavica Minic Janicijevic ivan P jovanovic Nevena M Gajovic Milena M Jurisevic Monojit Debnath Nebojsa N Arsenijevic Milica M Borovcanin University of Kragujevac Faculty of Medical SciencesKragujevac 34000Serbia Center for Molecular Medicine and Stem Cell Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Human Genetics National Institute of Mental Health and NeurosciencesBangalore 560029India Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Evidence suggests that cytokines cause immune disturbances,shape immunological sequelae later in life,and modulate the risk of schizophrenia(SC).Galectin-3(Gal-3),a multifaceted molecule of the glycan family,is involved in the formation of the immunological synapse and modulates the signalling pathway and effector functions of T lymphocytes,which are major producers of *** have previously reported elevated serum Gal-3 levels in stable SC ***,Gal-3 as a link between cognitive functioning and inflammation has not yet been investigated in *** To investigate the relationship between serum Gal-3 levels and cognitive performance,serum cytokines,and white blood cell count in three-month stably treated SC *** Twenty-seven patients with SC in remission and 18 healthy volunteers participated in this casecontrol and correlational *** assessment was performed using the Positive and Negative Syndrome Scale and the Montreal-Cognitive *** results of previously measured serum levels of Gal-3,interleukin(IL)-33,soluble suppression of tumorigenicity 2(sST2),tumor necrosis factor-alpha(TNF-α),IL-6 and IL-17 were used for further statistical analyses,and IL-4,IL-23,IL-1βand transforming growth factor-beta(TGF-β)were now additionally measured with a sensitive enzyme-linked immunosorbent *** number of leukocytes in the blood and the percentage of neutrophils,lymphocytes,and monocytes were determined with a standardized routine measurement procedure(Sysmex Technology).Statistical analyses were performed using SPSS 20.0 *** We found no correlation between serum Gal-3 levels and cognitive functioning in SC patients.A positive correlation was found between the levels of Gal-3 and TNF-α(r=0.476;P=0.012),Gal-3and IL-23(r=0.417;P=0.031),and Gal-3 and sST2(r=0.402;P=0.038).The binary logistic model,which included all nine cytokines measured in this patient sample,indicated the particular role of Gal-3 and T

关键词： Schizophrenia Galectin-3 Cytokines Leukocytes Antipsychotics

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Remnants of embryonic arteries on the brain base:A case report

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World Journal of Neuroscience 2012年第2期2卷 133-137页

作者： Vasovic Ljiljana jovanovic ivan Ugrenovic Sladana Trandafilovic Milena Department of Anatomy Faculty of MedicineUniversity of NisNisSerbia

The posterior communicating artery (PCoA) arises from the cerebral part of the internal carotid artery and reaching the interpeduncular cistern unites with the posterior cerebral artery, marking the beginning of its post-communicating part. We accidentally found a case of an unusual origin and termination of the right PCoA associated with a presence of the right olfactory artery remnant in a 35-year-old male cadaver routinely dis-sected at Institute of Forensic Medicine. Presented vascular variations have not been reported previously in the literature. In the event of PCoA origin from the right middle cerebral artery normally developed from the cra-nial end of primitive internal carotid artery, as well as the PCoA junction with basilar tip, this PCoA could be the most cranial carotid-basilar anastomosis. Simultaneously, here presented right olfactory artery remnant could be the third variant of this persistent embryonic artery.

关键词： Human Brain Base Posterior Communicating Artery Origin Termination Embryonic Arterial Remnants

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Endoscopic and retrograde cholangiographic appearance of hepaticojejunostomy strictures:A practical classifi cation

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World Journal of Gastrointestinal Endoscopy 2011年第11期3卷 213-219页

作者： Klaus Mnkemüller ivan jovanovic Department of Internal Medicine Gastroenterology and Infectious DiseasesMarienhospital BottropBottrop 46236Germany Department of Gastroenterology Hepatology and Infectious Diseases and Department of PathologyOttovon-Guericke University of MagdeburgMagdeburg 39120Germany Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaBelgradeFaculty of MedicineUniversity of BelgradeBelgrade 11000Serbia

AIM:To study the endoscopic and radiological characteristics of patients with hepaticojejunostomy(HJ)and propose a practical HJ stricture classif ***:In a retrospective observational study,a balloon-assisted enteroscopy(BAE)-endoscopic retrograde cholangiography was performed 44 times in 32 patients with surgically-altered gastrointestinal(GI)***-endoscopic retrograde cholangio pancreatography(ERCP)was performed 23 times in 18 patients with *** HJ was carefully studied with the endoscope and using ***:The authors observed that the hepaticojejunostomies have characteristics that may allow these to be classif ied based on endoscopic and cholangiographic appearances:the HJ orif ice aspect may appear as small(type A)or large(type B)and the stricture may be short(type 1),long(type 2)and type 3,intrahepatic biliary strictures not associated with anastomotic *** total,7 patients had type A1,4 patients A2,one patient had B1,one patient had B(large orif ice without stenosis)and one patient had type ***:This practical classification allows for an accurate initial assessment of the HJ,thus potentially allowing for adequate therapeutic planning,as the shape,length and complexity of the HJ and biliary tree choice may mandate the type of diagnostic and thera-peutic accessories to be *** additional importance,a standardized classif ication may allow for better com-parison of studies of patients undergoing BAE-ERCP in the setting of altered upper GI anatomy.

关键词： Endoscopic retrograde cholangio pancreatography Roux en Y anastomosis Hepaticojejunostomy Biliary strictures Bile duct strictures Double balloon enteroscopy

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COVID-19 in the endoscopy unit:How likely is transmission of infection?Results from an international,multicenter study

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World Journal of Gastrointestinal Endoscopy 2021年第9期13卷 416-425页

作者： Ioannis S Papanikolaou Georgios Tziatzios Alexandros Chatzidakis Antonio Facciorusso Stefano Francesco Crinò Paraskevas Gkolfakis Gjorgi Deriban Mario Tadic Goran Hauser Antonios Vezakis ivan jovanovic Nicola Muscatiello Anna Meneghetti Konstantinos Miltiadou Kalina Stardelova Alojzije Lacković Maria-Zoi Bourou Srdjan Djuranovic Konstantinos Triantafyllou Hepatogastroenterology Unit 2nd Department of Internal Medicine-PropaedeuticNational and Kapodistrian University of Athens"Attikon"University General HospitalAthens 12462Greece Gastroenterology Unit Department of Surgical and Medical SciencesUniversity of Foggia AOUFoggia 1245Italy Gastroenterology and Digestive Endoscopy Unit The Pancreas InstituteUniversity of VeronaVerona 37138Italy Department of Gastroenterology Hepatopancreatology and Digestive OncologyErasme University HospitalUniversitéLibre de BruxellesBrussels 1070Belgium Department of Medical Oncology Institut Jules BordetBrussels 1000Belgium University Clinic of Gastroenterohepatology Medical FacultyUniversity"Ss.Cyril and Methodius"SkopjeSkopje 12345Republic of North Macedonia Department of Gastroenterology Dubrava University Hospital ZagrebZagreb 10040Croatia Clinical Hospital Center Rijeka Faculty of MedicineUniversity of RijekaRijeka 51000Croatia 2nd Department of Surgery Aretaieio HospitalSchool of MedicineNational and Kapodistrian University of AthensAthens 11528Greece Clinical Center of Serbia Clinic for Gastroenterology and HepatologyUniversity of Belgrade Faculty of MedicineBeograd 12345Serbia

BACKGROUND Coronavirus disease 2019(COVID-19)significantly affected endoscopy practice,as gastrointestinal endoscopy is considered a risky procedure for transmission of infection to patients and personnel of endoscopy units(PEU).AIM To assess the impact of COVID-19 on endoscopy during the first European lockdown(March-May 2020).METHODS Patients undergoing endoscopy in nine endoscopy units across six European countries during the period of the first European lockdown for COVID-19(March-May 2020)were *** to the endoscopy procedure,participants were stratified as low-or high-risk for potential COVID-19 infection according to the European Society of Gastrointestinal Endoscopy(ESGE)and the European Society of Gastroenterology and Endoscopy Nurses and Associates(ESGENA)joint statement,and contacted 7-14 d later to assess COVID-19 infection *** were questioned regarding COVID-19 symptoms and/or infection via questionnaire,while information regarding hospitalizations,intensive care unitadmissions and COVID-19-related deaths were *** number of weekly endoscopies at each center during the lockdown period was also *** A total of 1267 endoscopies were performed in 1222 individuals across nine European endoscopy departments in six ***-seven(7%)were excluded because of initial positive *** the 1135 pre-endoscopy low risk or polymerase chain reaction negative for COVID-19,254(22.4%)were tested post endoscopy and 8 were eventually found positive,resulting in an infection rate of 0.7%[95%CI:0.2-0.12].The majority(6 of the 8 patients,75%)had undergone *** the 163 PEU,5[3%;(95%CI:0.4-5.7)]tested positive during the study period.A decrease of 68.7%(95%CI:64.8-72.7)in the number of weekly endoscopies was recorded in all centers after March *** centers implemented appropriate personal protective measures(PPM)from the initial phases of the *** COVID-19 transmission in endoscopy unit

关键词： COVID-19 SARS-CoV-2 Gastrointestinal endoscopy Personal protection measures Transmission Lockdown

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