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Immunology demystified: A guide for transplant hepatologists

World Journal of Transplantation 2024年第1期14卷 48-61页

作者： iva.Kosuta Tomislav Kelava Ana Ostojic Vibor Sesa Anna Mrzljak Hrvoje Lalic Department of Intensive Care Medicine University Hospital Centre ZagrebZagreb 10000Croatia Department of Physiology School of MedicineUniveristy of ZagrebZagreb 10000Croatia Laboratory for Molecular Immunology Croatian Institute for Brain ResearchZagreb 10000Croatia Department of Gastroenterology and Hepatology Liver Transplant CenterUniversity Hospital Centre ZagrebZagreb 10000Croatia Department of Medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Physiology University of Zagreb School of MedicineZagreb 10000Croatia Laboratory for Cell Biology Croatian Institute for Brain ResearchUniversity of Zagreb School of MedicineZagreb 10000Croatia Department of Laboratory Immunology Clinical Department of Laboratory DiagnosticsUniversity Hospital Center ZagrebZagreb 10000Croatia

Liver transplantation has become standard practice for treating end-stage liver *** success of the procedure relies on effective immunosuppressive medications to control the host's immune *** the liver's inherent capacity to foster tolerance,the early post-transplant period is marked by significant immune *** ensure favorable outcomes,it is imperative to identify and manage various rejection types,encompassing T-cell-mediated,antibody-mediated,and chronic ***,the approach to prescribing immunosuppressants relies heavily on clinical judgment rather than evidencebased *** that the majority of patients will require lifelong immunosuppression as the mechanisms underlying operational tolerance are still being investigated,healthcare providers must possess an understanding of immune responses,rejection mechanisms,and the pathways targeted by immunosuppressive *** knowledge enables customization of treatments and improved patient care,even though a consensus on an optimal immunosuppressive regimen remains elusive.

关键词： Liver transplantation Allograft rejection Operational immune tolerance Immune reaction Immunosuppression

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Expect the unexpected:Brown tumor of the mandible as the first manifestation of primary hyperparathyroidism

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World Journal of Clinical Cases 2024年第7期12卷 1200-1204页

作者： Ana Majic Tengg Maja Cigrovski Berkovic iva. Zajc iva. Salaric Danko Müller iva.Markota Department of Endocrinology DiabetesMetabolic Diseases and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Department for Sport and Exercise Medicine Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Oral Surgery Clinical Hospital DubravaZagreb 10000Croatia University of Zagreb School of Dental Medicine Zagreb 10000Croatia Clinical Department of Pathology and Cytology Clinical Hospital DubravaZagreb 10000Croatia

Hyperparathyroidism(HPT)is a condition in which one or more parathyroid glands produce increased levels of parathyroid hormone(PTH),causing disturbances in calcium *** commonly HPT presents with asymptomatic hypercalcemia but the clinical spectrum may include disturbances reflecting the combined effects of increased PTH secretion and *** tumors are rare,benign,tumor-like bone lesions,occurring in 1.5%to 4.5%of patients with HPT,as a complication of an uncontrolled disease pathway,and are nowadays rarely seen in clinical *** tumor can appear either as a solitary or multifocal lesion and usually presents as an asymptomatic swelling or a painful exophytic ***,it can cause a pathological fracture or skeletal pain and be radiologically described as a lytic bone *** diagnosis of a brown tumor in HPT is typically confirmed by assessing the levels of serum calcium,phosphorus,and *** when present,brown tumor is quite pathognomonic for HPT,the histologic finding often suggests a giant cell tumor,while clinical presentation might suggest other more frequent pathologies such as metastatic *** of brown tumors frequently focuses on managing the underlying HPT,which can often lead to regression and resolution of the lesion,without the need for surgical ***,in refractory cases or when dealing with large symptomatic lesions,surgical treatment may be necessary.

关键词： Brown tumor Hyperparathyroidism Lytic bone lesions Giant cell tumor

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Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activa.or receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-López iva.Tic David Valle-García Marta Ribalta-Vilella Luis Labrador Deb Ranjan Banerjee Ana guer.er. Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activa.or receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell surviva. and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activa.or receptorγ(PPARγ) PPARG SAMP8

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Genitourinary tumors and liver transplantation: A comprehensive review

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World Journal of Transplantation 2024年第3期14卷 52-58页

作者： Vibor Sesa Hrvoje Silovski Nikolina Basic-Jukic iva.Kosuta Maja Sremac Anna Mrzljak Department of Gastroenterology and Hepatology University Hospital Center ZagrebZagreb 10000Croatia Department of Hepatobiliary Surgery and Transplantation University Hospital Center ZagrebZagreb 10000Croatia Department of Medicine School of MedicineZagreb 10000Croatia Department of Nephrology Arterial hypertensionDialysis and TransplantationUniversity Hospital Center ZagrebZagreb 10000Croatia Department of Intensive Care Medicine University Hospital Center ZagrebZagreb 10000Croatia

Liver transplantation is as a crucial therapeutic option for patients with end-stage liver disease,but the persistent organ shortage emphasizes a need to explore unconventional donor sources,including individuals with a history of *** review investigates the viability of liver donation from individuals with current or past genitourinary malignancies,focusing on renal,prostate and urinary bladder *** rising incidence of urogenital malignancies among potential donors is thought to result from increasing donor *** of transmission risks reveals low rates of donor-derived cancer transmission,partic-ularly for early-stage renal and prostate *** with a history of genitourinary malignancy pose complex challenges regarding post-transplant immunosuppression and cancer ***,the evidence suggests acceptable outcomes can be achieved with careful patient selection and tailored management *** for pre-transplant evaluation and post-transplant surveillance are discussed,highlighting the need for individualized approaches in this patient *** prospective studies are warranted to refine guidelines and optimize outcomes in liver transplantation for patients with genitourinary malignancies.

关键词： Liver transplantation Genitourinary malignancies Donor-transmitted cancer Malignancy recurrence Immunosuppression

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Solid-state single-crystal growth of YAG and Nd: YAG by spark plasma sintering

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Journal of Materials Science & Technology 2022年第11期106卷 118-127页

作者： iva.Milisavljevic Guangran Zhang Yiquan Wu Kazuo Inamori School of Engineering New York State College of CeramicsAlfred UniversityAlfredNY 14802USA

Recent studies have shown that many challenges encountered in conventional single crystal growth methods, including high production costs, can be overcome by using the solid-state single-crystal growth(SSCG) approach, which has been recognized as a simple and cost-effective alternative for obtaining single crystals. In this work, YAlO(YAG) and Nd-doped YAG(Nd:YAG) single crystals were grown via the SSCG method using spark plasma sintering(SPS). The growth of single crystals was initiated at the surface of(110) YAG single-crystal seeds embedded inside YAG and Nd:YAG powder beds, and this growth continued as the surrounding polycrystalline matrix was converted into a single crystal. The application of external pressure during the SPS process has been found beneficial for reducing the porosity of the grown single crystals. Moreover, high Nddoping levels had a positive effect on the conversion kinetics,with a growth rate of almost 50 μm/h, which increased the driving force for single-crystal growth through the solute drag effect. EDS elemental mapping and line scans confirmed the compositional uniformity of the grown single crystals, while EBSD images verified their crystallization in the(110) direction. The obtained results confirm the strong potential of the SSCG technique coupled with SPS for the growth of undoped and highly doped YAG single crystals with excellent quality.

关键词： Single-crystal growth Solid-state growth Spark plasma sintering YAG

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Remote monitoring of implantable cardioverters defibrillators:a comparison of acceptance between octogenarians and younger patients

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Journal of Geriatric Cardiology 2020年第7期17卷 417-426页

作者： iva.Safarikova Alan Bulava Premysl Hajek Faculty of Health and Social Sciences the University of South Bohemia in Ceske BudejoviceCeske BudejoviceCzech Republic Cardiac Center Department of CardiologyCeske Budejovice HospitalCeske BudejoviceCzech Republic Faculty of Medicine and Dentistry of Palacky University Olomouc OlomoucCzech Republic

Background Remote monitoring(RM)is increasingly employed for all types of cardiac implantable devices(CIED).However,there are only limited data on the acceptance of RM by the *** aim of our study was to ascertain how octogenarians assess RM technologies compared to younger,presumably technically more literate patients,and what concerns or technical problems the system presents to both groups of *** The trial was designed as a descriptive,register-based single-center *** study population consisted of all consecutive patients≥80 years of age(group A,n=94)and all consecutive patients aged≤40 years(group B,n=71),who had undergone implantation of an implantable cardioverter-defibrillator(ICD)between the years of 2009 and 2018 and were using a Home Monitoring?(HM,Biotronik,Berlin,Germany)*** patients fulfilling entry criteria were approached with a request to participate in the *** A total of 85(90.4%)and 65(91.5%)valid surveys were obtained for groups A and B,***-two percent of patients in both groups(P=0.903)were satisfied with the limited number of planned ambulatory follow-ups(i.e.,once a year).All patients in both groups(100%)reported that they were satisfied with the HM system,and 97%and 94%of patients in Groups A and B,respectively,ranked it highly beneficial(P=0.68).A significant proportion of patients in both groups were completely unaware of any health-related benefits associated with the use of the HM system(42%in Group A vs.49%in Group B,P=0.4).Among the most frequently reported personal benefits of HM were a sense of safety and security and savings on travel expenses and time.5%and 9%of patients in Groups A and B,respectively,reported that usage of HM caused them some degree of psychological stress(P=0.27).Nearly all patients in both groups reported receiving information on HM from their doctor after ICD *** of Group A reported receiving information from a nurse either before or after

关键词： Education Implantable electronic devices Remote monitoring The elderly

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Lost Memories of Winter： Breaking the FLC Silence

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Molecular Plant 2017年第12期10卷 1477-1479页

作者： Miyuki Nakamura iva.Mozgova Lars Hennig Department of Plant Biology Uppsala BioCenter Swedish University of Agricultural Sciences and Linnean Center for Plant Biology 75007 Uppsala Sweden Institute of Microbiology of the Czech Academy of Sciences Centre Algatech Opatovický mlýn 37981 Třeboň Czech Republic Faculty of Science University of South Bohemia in Ceske Budejovice 37005 Ceske Budejovice Czech Republic

Vernalization, the acquisition of competence to flower after extended cold treatment, has puzzled researchers throughout the last century. Great progress in understanding the molecular mechanisms of vernalization in Arabidopsis has been made in the course of the last 20 years, placing the flowering repressor- encoding gene FLOWerING LOCUS C （FLC） in the limelight （Bouch6 et al., 2017）. In vernalization-dependent accessions, FRIGIDA （FRI） ensures strong expression of FLC that delays flowering, and extended exposure to low temperatures such as during winter leads to stable repression of FLC, which in turn clears the way for induction of flowering.

关键词： FLOWerING-LOCUS-C TRANSCRIPTION FACTOR VerNALIZATION INHerITANCE ARABIDOPSIS EXPRESSION

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Does shifting to professional emergency department staffing affect the decision for chest radiography?

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World Journal of Emergency Medicine 2021年第2期12卷 87-92页

作者： Marin Pavlov Lucija Klobucar iva.Klobučar Kristinazgela Vesna Degoricija Department of Cardiology Sestre Milosrdnice University Hospital CentreZagreb 10000Croatia Institute of Emergency Medicine Osijek-Baranja CountyOsijek 31000Croatia University of Zagreb School of Medicine Zagreb 10000Croatia Department of Medicine Sestre milosrdnice University Hospital CentreZagreb 10000Croatia

BACKGROUND: The study aims to determine whether shifting to professional emergency department(ED) teams leads to a higher rate of radiologic ***: We retrospectively analyzed a total of 2,000 patients presenting to the ED of a tertiary teaching hospital in two time periods: group 1(G1) comprised 1,000 consecutive patients enrolled from December 21, 2012 to January 5, 2013(all patients were examined by an internal medicine specialist);group 2(G2) comprised 1,000 consecutive patients enrolled from December 21, 2018 to January 3, 2019(all patients were examined by an emergency physician).RESULTS: The chest X-ray(CXR) was performed in 40.6% of all patients. There was no difference in the frequency of CXR(38.9% in G1 vs. 42.3% in G2, P=0.152). More CXRs were performed in G2 patients older than 65 years, in female patients older than 65 years, in patients presenting during the evening and night shifts or off-hours, in patients with a history of malignancy, in patients with gastrointestinal bleeding, and in patients with bradycardia, but fewer in patients presenting with arrhythmia. No difference in the rates of pathological CXR was found(47.3% in G1 vs. 52.2% in G2, P=0.186). Compared with G2, higher sensitivity and specificity were obtained for the binary logistic regression model predicting pathological findings in ***: Shifting to professional ED teams does not increase radiologic workup. By implementing deliberate usage of ultrasound, some self-governing procedures, case-oriented investigations, and center-specific recommendations, unnecessary radiologic workup can be avoided. Professional ED teams could lead to a higher standard of emergency care.

关键词： Chest radiography Emergency department Emergency physicians Healthcare organization

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Do Exchange Rate Changes drive Foreign Direct Investment:An Empirical Analysis of Six OECD Countries

Do Exchange Rate Changes Drive Foreign Direct Investment:An ...

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作者： iva.MARINOVIC 浙江工商大学

学位级别：硕士

在过去几年中,在外商直接投资方面,其流入和流出都向前迈出了一大步。今天,发达国家和发展中国家都在外商直接投资中看到了经济前景,因此大量的研究都集中在这个问题上。在我们的研究中,我们将探讨六个经济合作与发展组织国家——澳大... 详细信息

在过去几年中,在外商直接投资方面,其流入和流出都向前迈出了一大步。今天,发达国家和发展中国家都在外商直接投资中看到了经济前景,因此大量的研究都集中在这个问题上。在我们的研究中,我们将探讨六个经济合作与发展组织国家——澳大利亚、加拿大、英国、瑞士、德国和俄罗斯——的外商直接投资流入情况。其中,除了俄罗斯是发展中国家,其他五个国家都是发达国家。不管他们是否是该组织（也包括其他组织）的成员,这个国家的经济都具有相对稳定和强劲的特点。今天,外商直接投资——不管是流入还是流出——是国际资本流动的最重要形式之一。发达国家在资本流动中发挥着关键作用,主要是作为投资者,但也是外商直接投资的受益者。考虑到全球的经济趋势以及外商直接投资的数额逐步全球化,在全球范围内,问题在于在某一特定地区对外商直接投资产生影响的相关因素是什么。从宏观经济的角度来看,外商直接投资代表一种国际资本跨界流动的特殊形式,从投资者所在国流向东道国,并记录在国际收支的资本部分。外商直接投资流入不仅使发展中国家受益,而且也使发达国家及其经济受益。外商直接投资的流入通常在一个国家的经济中起着关键的作用,而且它往往是一个国家发展的主要推动力。本文旨在展现外国直接投资在全球（包括发达国家和发展中国家）的重要性和趋势。本文将对这些国家的汇率、经济增长等因素进行综合分析,并对其外商直接投资流入情况进行分析。本文的主要目的是确定在1996年至2016年这一段时期内,汇率是否推动了上述提到的国家的外商直接投资。从进行的测试中,我们可以看到变量之间的关系,并可以得出变量与FDI之间存在关系的结论。

关键词：外商直接投资外商直接投资流入汇率

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Mesalamine treatment mimicking relapse in a child with ulcerative colitis

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World Journal of Pediatrics 2014年第4期10卷 371-373页

作者： iva.Hojsak Ana M Pavić Sanja Kolaček Referral Center for Pediatric Gastroenterology and Nutrition Children's Hospital ZagrebZagrebCroatia University of Zagreb Medical School ZagrebCroatia

Background:There are reports on mesalamine-induced bloody diarrhea mimicking ulcerative colitis(UC)relapse,mostly in ***:Herein we present a case of a child with UC who developed relapse of hemorrhagic colitis related to ***:A 10-year-old girl developed severe symptoms mimicking UC relapse 3 weeks after introduction of mesalamine *** mesalamine was withdrawn,her symptoms improved,but deteriorated again during the challenge of mesalamine despite concomitant use of ***:This is the fi rst case report on such a young child during the concomitant use of corticosteroids.

关键词： 5-aminosalicylic acid mesalamine ulcerative colitis

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