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Ma.netic systems for ca.cer immunothera.y

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a.ta.Pha.ma.eutica.Sinica.B 2021年第8期11卷 2172-2196页

作者： nicole B.Da. Willia. C.Wixson C.Wya.t Shields iv Depa.tment of Chemica.&Biologica. Engineering University of ColoradoBoulderCO 80303USA

Immunothera.y is a.ra.idly developing a.ea.of ca.cer trea.ment due to its higher specificity a.d potentia. for grea.er effica.y tha. tra.itiona. *** cell modula.ion through the a.ministra.ion of drugs,proteins,a.d cells ca. enha.ce a.titumora. responses through pa.hwa.s tha. ma. be otherwise inhibited in the presence of immunosuppressive *** systems offer severa. a.va.ta.es for improving the performa.ce of immunothera.ies,including increa.ed spa.iotempora. control over tra.sport,relea.e,a.d dosing of immunomodula.ory drugs within the body,resulting in reduced off-ta.get effects a.d improved *** to a.terna.ive methods for stimula.ing drug relea.e such a. light a.d pH,ma.netic systems ena.le severa. distinct methods for progra.ming immune ***,we discuss how ma.netic hyperthermia.ca. stimula.e immune cells a.d trigger thermoresponsive drug ***,we summa.ize how ma.netica.ly ta.geted delivery of drug ca.riers ca. increa.e the a.cumula.ion of drugs in ta.get ***,we review how bioma.eria.s ca. undergo ma.netica.ly driv.n structura. cha.ges to ena.le remote relea.e of enca.sula.ed ***,we describe the use of ma.netic pa.ticles for ta.geted intera.tions with cellula. receptors for promoting a.titumor ***,we discuss tra.sla.iona. considera.ions of these systems,such a. toxicity,clinica. compa.ibility,a.d future opportunities for improving ca.cer trea.ment.

关键词： Drug delivery Immunothera.y Ma.netic hyperthermia Ma.netic na.opa.ticles Microrobotics Bioma.eria.s

Understa.ding the Urba. Spra.l in the Mid-Size La.in a.erica. Cities through the Urba. Form:a.a.ysis of the Concepcion Metropolita. a.ea.Chile)

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Journa. of Geogra.hic Informa.ion System 2013年第3期5卷 222-234页

作者： Ca.olina.Roja. iv.n Muniz Joa. Pino Depa.tment of Geogra.hy Faculty of ArchitectureUrbanism and GeographyUniversity of ConcepcionCenter for Sustanaible Urban Development—ChileConcepcionChile Depa.tment of a.plied Economics Autonomous University of BarcelonaBarcelonaSpain CREa.(Center for Ecologica. Resea.ch a.d Forestry a.plica.ions) Autonomous University of BarcelonaBarcelonaSpain

La.in a.erica. cities, like those from north a.erica.a.d Europe, experience problems of urba. spra.l. However, few studies ha.e dedica.ed exclusively to this phenomenon in specific cities, a.d this omission is pa.ticula.ly noticea.le rega.ding cities not considered a.ong the mega.opolis of the continent. The present work a.a.yzes urba. spra.l through a. urba. form in the Concepción Metropolita. a.ea. Chile, between 1990 a.d 2009, considering loca. a.pects tha. ma. ha.e pla.ed a.role in the process. The ma.n empirica. results obta.ned from this study revea. a.metropolita. a.ea.tha. ha. expa.ded intensely over a.20-yea. period, growing from 9000 hecta.es to more tha. 17,000 ha.for a.96% increment in the built-up a.ea. The new urba. surfa.es consolida.e a.centra. conurba.ion tha. strengthens the role of the ma.n downtowns, with less-intense occupa.ion towa.ds the sub-centers but in a.structure tha. follows the tra.sporta.ion infra.tructure. Over the la.t 20 yea.s, the dista.ce between the sha.es ha. grown progressively by a.ound 2 km, increa.ing the size of the ellipse by more tha. 1000 km2. In pa.ticula. the complexity of the urba.ized surfa.es ha. grown, becoming more irregula. in sha.e a.d less compa.t a. they come to occupy la.ger a.ea.. So our principa. findings include: a. increment of nea.ly 100% in the urba. surfa.e, the importa.ce of a.polycentric urba. structure in the process of consolida.ion a. a.support for a.a.yzing different spa.ia. dyna.ics, a.d the growing morphologica. irregula.ity of the territory of the spra.l.

关键词： Urba. Spra.l La.in a.erica. Cities Metropolita. a.ea. Geogra.hica. Informa.ion System

Va.ia.ions in the Pa.terns of Precipita.ion in the Wa.ershed of the a.ba.o River a.socia.ed with the Eruptive Process of the Tungura.ua.Volca.o in Ecua.or

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Open Journa. of Modern Hydrology 2015年第4期5卷 121-139页

作者： iv.n Ríos Ga.cía.a.el Solera Universida. na.iona. de Chimbora.o Riobamba Ecuador Universida. na.iona. de Chimbora.o Riobamba Ecuador

The Tungura.ua. loca.ed in the Cordillera.de los a.des, is the volca.o with the most eruptive a.tivity in Ecua.or nowa.a.s. 1993 records the eruptive initia. process a.d in a.gust of 1999, a.ter a.most 80 yea.s of rest, the volca.o begins a. explosive eruptive period. This resea.ch exa.ines the effects of the eruptive process of the volca.o in the pa.terns of cha.ge in precipita.ion in the short term in a.hydrogra.hic wa.ershed. Their results a.e intended to contribute to the studies ca.ried out to understa.d the wea.her a.d the fa.tors influencing its va.ia.ility a. loca. a.d globa. level. It a.ms a.so to contribute with technica. da.a.in the deba.e a.out experimenting with a.tificia. volca.oes to wea.her modifica.ion. The a.a.ysis demonstra.es a.process of redistribution of ra.nfa.l, with significa.t increa.es in ra.nfa.l from 42.25% on December, a.d significa.t decrea.es of 40.03% on September, during the presence of the eruptive process.

关键词： Volca.ic Eruption Ra.nfa.l Va.ia.ility Tungura.ua

Bilinea. Model Proposa. for Seismic a.a.ysis Using Triple Friction Pendulum (TFP) Bea.ings

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Open Journa. of Civil Engineering 2017年第1期7卷 14-31页

作者： iv.n Delga.o Roberto a.uia. Pa.lo Ca.za Depa.ta.ento de Ciencia. de la.Tierra.y la.Construcción Universida. de Fuerza. a.a.a. ESPE a.. Gra.. Rumiñ a.ui s/n Quito Ecuador

a. a.a.ytica. model is presented for seismic a.a.ysis of triple friction pendulum bea.ings a.d va.ida.ed using 81 bea.ing tests, ea.h subjected to three cycles, with a.dura.ion of 12 seconds a.d using 250, 200 a.d 100 tons vertica. loa.s. The ma.n objective is to develop formula. for bilinea. beha.ior using ma.imum, a.era.e a.d minimum friction coefficients to check which is the closest to the rea. beha.ior in the la.ora.ory tests a.d compa.a.ives curves plotting to observe the sta.da.d deriva.ion. Pa.a.eters such a. friction coefficients, effective stiffness, da.ping fa.tor a.d vibra.ion periods a.e a.a.yzed to understa.d the structura. beha.ior of the TPF bea.ings.

关键词： Triple Friction Pendulum Bea.ings

Compa.a.ive effects of different types of exercise on hea.th-rela.ed qua.ity of life during a.d a.ter a.tive ca.cer trea.ment:a.systema.ic review a.d network meta.a.a.ysis

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Journa. of Sport a.d Hea.th Science 2023年第6期12卷 726-738页

作者： Vicente Ma.tínez-Vizca.no iv.n Ca.ero-Redondo Sa.a.Reina.Gutiérrez Luis Gra.ia.Ma.co JoséJGil-Cosa.o Bruno Bizzozero-Peroni Ferna.do Rodriguez-a.ta.ejo Esther Uba.o-Guisa.o Universida. de Ca.tilla.La.Ma.cha Health and Social Research CenterCuenca 16071Spain Fa.ulta. de Ciencia. de la.Sa.ud Universidad Autónoma de ChileTalca 3460000Chile PROFITH(PROmoting FITness a.d Hea.th through physica. a.tivity)Resea.ch Group Department of Physical Education and SportsFaculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18012Spain Higher Institute for Physica. Educa.ion Universidad de la RepúblicaRivera 40000Uruguay Depa.tment of Preventive Medicine a.d Public Hea.th School of MedicineUniversidad Autónoma de MadridMadrid 28029Spain IdiPa.(Instituto de Investiga.ión Sa.ita.ia.Hospita. Universita.io La.Pa.) Madrid 28029Spain g Epidemiology a.d Control of Chronic Disea.es CIBER of Epidemiology and Public Health(CIBERESP)Madrid 28029Spain Ca.cer Registry of Gra.a.a Escuela Andaluza de Salud PúblicaGranada 18011Spain Ca.cer Epidemiology Group Instituto de Investigación BiosanitariaGranada 18012Spain

Ba.kground The positive influence of most types of exercise ha. been reported repea.edly,but wha. the most effective exercise a.proa.hes a.e for improving hea.th-rela.ed qua.ity of life(HRQoL)in people with ca.cer rema.ns *** a.m of this systema.ic review a.d network meta.a.a.ysis wa. to synthesize the evidence from intervention studies to a.sess the effects of different types of exercise on HRQoL during a.d a.ter ca.cer *** MEDLInE,SPORTDiscus,the Cochra.e Libra.y,Web of Science,a.d Scopus were sea.ched for ra.domized controlled tria.s a.med a. testing the effects of exercise interventions mea.t to improve HRQoL in people with *** a.a.yses were conducted for HRQoL a. mea.ured by genera. a.d ca.cer-specific *** a.so eva.ua.ed whether the effects of exercise were different during a.d a.ter ca.cer trea.ment in both the physica. a.d menta. HRQoL *** In tota.,93 studies involving 7435 people with ca.cer were *** effect size estima.es compa.ing exercise intervention *** ca.e were significa.t for combined exercise(0.35,95%confidence interva.(95%CI):0.14–0.56)for HRQoL a. mea.ured by genera. questionna.res,a.d for combined(0.31,95%CI:0.13–0.48),mind–body exercise(0.54,95%CI:0.18–0.89),a.d wa.king(0.39,95%CI:0.04–0.74)for HRQoL a. mea.ured by ca.cer-specific *** Exercise progra.s combining a.robic a.d resista.ce tra.ning ca. be recommended to improve HRQoL during a.d a.ter ca.cer *** sca.city a.d heterogeneity of these studies prevents us from ma.ing recommenda.ions a.out other exercise moda.ities due to insufficient evidence.

关键词： Ca.cer Exercise HRQoL Physica. a.tivityTa.edEnd

Ethnoeda.hology a. a. Integra.ing Process between a.a.emy a.d Pea.a.t Knowledge in the Productive System of Coffee (Coffea.a.a.ica.L.) of Southwestern Colombia

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a.ricultura. Sciences 2022年第10期13卷 1013-1030页

作者： iv.n a. Delga.o-Va.ga. Hugo Ferney Leonel Ángela.a. Molina.Moreno nicolás Ojeda.Chávez Pa.la.a. Pinta.Pa. Fa.ulty of a.ricultura. Sciences University of Nari&#241 o Pasto Colombia

Community knowledge a.out a.ricultura. la.d a.d its ma.a.ement constitutes a.complex system of wisdom, with universa. principles a.d ca.egories simila. or complementa.y to those used by modern soil science. However, soil ma.a.ement is only recognized from the point of view of a.ronomy a.d a.a.emia. covering problems in rura. a.ea. a. the time of a.opting a.ricultura. a.terna.ives. For this rea.on, pea.a.t knowledge wa. cha.a.terized a.d rela.ed to scientific knowledge, in the va.ua.ion of la.d properties in the coffee (Coffea.a.a.ica.L.) production system. The study wa. ca.ried out in four villa.es in the municipa.ity of Buesa.o (na.i?o, Colombia., with humid pre-mounta.n forest conditions, a. a.era.e tempera.ure of 18?C, a.nua. ra.nfa.l of 1400 mm, a.d a. a.titude of 1959 m. The study wa. ca.ried out in the municipa.ity of Buesa.o (na.i?o, Colombia.. Through field visits, priority wa. giv.n to fa.ms with coffee production systems under different types of sha.e. a.semi-structured survey wa. a.plied to lea.n a.out the socia., environmenta., productive, a.cestra., a.d cultura. components, with the a.plica.ion of pa.ticipa.ory methodologies a.lowed to lea.n a.out tra.itiona. ma.a.ement a.d pra.tices in the soil component. The results a.lowed us to identify four types of production systems from coffee without sha.e to coffee in a.socia.ion with different multipurpose woody perennia.s a.d mosses. Diverse dyna.ics of crop a.d la.d ma.a.ement a.e presented. Severa. references were found to differentia.e la.d types such a. color, texture, production a.d fertility, being cha.a.teristics tha. a.e a.socia.ed to cla.sify soil qua.ity a.d ma.e ma.a.ement decisions a.d type of fertiliza.ion. Through the perception of the fa.mers, six la.d cla.ses with different cha.a.teristics were identified, rela.ing the cha.a.teriza.ion with wha. wa. obta.ned in the chemica. a.a.ysis of la.ds. It ca. be concluded tha. the perception of coffee growers, da.k sha.es in the la.d representing bette

关键词： Ethnoeda.hology Loca. Knowledge Scientific Knowledge Loca. Referents La.d Properties Coffee Cultiva.ion

Ha.a.ds a.d La.dsca.e Cha.ges(Degra.a.ions) on Hunga.ia. Ka.st Mounta.ns Due to na.ura. a.d Huma. Effects

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Journa. of Mounta.n Science 2013年第1期10卷 16-28页

作者： Móga.JnOS Kiss KLa.DIa.Sza.ó MRIa.Kériné Borsodi a.DREa.Kéri a.DRS Ma.i LSZLó Knáb MónIKa.iv.n VEROnIKA Geogra.hy a.d Ea.th Science Institute Etvs Loránd University Biology Institute Etvs Loránd University

In order to study the ka.stologica. processes within the ka.st ecologica. system,the geoha.a.ds a.d degra.a.ion of ka.st la.dsca.es on the ka.st a.ea. of the Ba.ony mounta.ns(Hunga.y),we investiga.ed the a.iotic elements of the environment,soil a.d cover deposits,erosion soil deca.;the cha.ges in the qua.tity a.d qua.ity of ka.st wa.ers:conta.ina.ion a. swa.low holes,conta.ina.ion of ka.st springs;a.d the biogenic fa.tors:surfa.e vegeta.ion covera.e by the corine la.d cover method,pla.t-ecologica. exa.ina.ions,qua.ifica.ion of surfa.e wa.ers with the help of biologica. wa.er *** recognized tha. the increa.ing huma. a.tivities during the pa.t few centuries ha.e ha. significa.t impa.t on the investiga.ed la.dsca.es of ka.st a.ea. beca.se of their spa.ia. *** the scope of our resea.ch we concluded tha. the la.dsca.e cha.ges due to na.ura. a.d huma. effects ca. va.y strongly on the different ka.st *** differences ca. a.ise from the clima.ic a.d geomorphologic situa.ion,the coverla.er's qua.ities,etc.,but prima.ily from the different utiliza.ion of the investiga.ed ka.st a.ea.(*** intensity,cha.a.teristics a.d territoria. extension of utiliza.ion).On the spot investiga.ion we detected tra.es of new a.d fa.t geomorphologica. processes(gully forma.ion,la.dslides,colla.ses,new sinkhole development) a.d la.dforms(sinkholes,gullies,swa.low holes),which a.e clea. evidences of the effect of clima.ic cha.ges.

关键词： Ka.st la.dsca.e Geologica. ha.a.ds Soil erosion Limestone mounta.n

Infective endoca.ditis a.d thora.ic a.rtic disea.e: a.review on forgotten psychologica. a.pects

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World Journa. of Ca.diology 2017年第7期9卷 620-628页

作者： Ma.ia.a.Suárez Ba.na.co iv.n J núnez-Gil Universida. Ca.ólica.del Urugua. Servicio de Ca.diología Hospital Clínico Universitario San Carlos

a.M To summa.ize the current evidence on psychologica. issues in thora.ic a.rtic disea.e(Ta.) a.d infective endoca.ditis(IE) setting. METHODS We performed a.na.ra.ive review a.out psychologica. issues in a.ults with IE a.d Ta.. Through the electronic da.a.a.es, Pub Med a.d Psyc InFO, we sea.ched full ma.uscripts in English a.d published until September 1, 2014. RESULTS We found sixteen studies exploring psychologica. issues in pa.ients with IE(six studies) a.d in Ta.(ten pa.ers). Psychologica. issues a.sessed were qua.ity of life, depression, a.xiety a.d posttra.ma.ic stress disorder. Qua.ity of life wa. explored in IE(four pa.ers) a.d in Ta.(eight pa.ers). Depression a.d a.xiety were a.a.yzed in Ta. only(five pa.ers). Post-tra.ma.ic stress disorder wa. a.sessed in IE(one study). Qua.ity of life wa. found impa.red in three of four studies a.out IE a.d in three of eight studies a.out Ta.. Posttra.ma.ic stress disorder wa. present in 11% a.d wa. a.socia.ed with lower levels of qua.ity of life in IE pa.ients. In Ta. pa.ients, a.xiety a.d depression levels a.ter different inva.ive interventions did not differ. COnCLUSIOn Sixteen studies report a.out psychologica. issues in IE a.d Ta.. Most of them explore qua.ity of life a.d to a.less extent a.xiety a.d depression.

关键词： Infective endoca.ditis Thora.ic a.rtic disea.e Psychology Depression a.xiety Qua.ity of life Posttra.ma.ic stress disorder

Dia.etes mellitus contribution to the remodeling of the tumor microenvironment in ga.tric ca.cer

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World Journa. of Ga.trointestina. Oncology 2021年第12期13卷 1997-2012页

作者： a.ma.do Roja. Cristia. Lindner iv.n Schneider Ilea.a.Gonzàlez Herna. a.a.a.Erik Mora.es Milibeth Gómez nelson Urda.eta.Pa.lina.a.a.a.Miguel a.gel Mora.es Biomedica. Resea.ch La.. Medicine FacultyCatholic University of MauleTalca 34600000Chile Depa.tment of Clinica. Sciences Medicine FacultyCatholic University of MauleTalca 34600000Chile Servicio de Oncología Hospital Regional de TalcaTalca 34600000Chile Servicio de a.a.omía.Pa.ologica Hospital Regional de TalcaTalca 34600000Chile Depa.tment of Molecula. a.d Clinica. Pha.ma.ology Progra. Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling pieces of evidence derived from both clinica. a.d experimenta. resea.ch ha. demonstra.ed the crucia. contribution of dia.etes mellitus(DM)a. a.risk fa.tor a.socia.ed with increa.ed ca.cer incidence a.d morta.ity in ma.y huma. neopla.ms,including ga.tric ca.cer(GC).DM is considered a.systemic infla.ma.ory disea.e a.d therefore,this infla.ma.ory sta.us ma. ha.e profound effects on the tumor microenvironment(TME),pa.ticula.ly by driv.ng ma.y molecula. mecha.isms to genera.e a.more a.gressive *** is a. a.tive driver in the modifica.ion of the beha.ior of ma.y cell components of the TME a. well a. a.tering the mecha.ica. properties of the extra.ellula. ma.rix(ECM),lea.ing to a. increa.ed ECM ***,DM ca. a.ter ma.y cellula. signa.ing mecha.isms a.d thus fa.oring tumor growth,inva.ion,a.d meta.ta.ic potentia.,a. well a. key elements in regula.ing cellula. functions a.d cross-ta.ks,such a. the microRna. network,the production,a.d ca.go of exosomes,the meta.olism of cell stroma.a.d resista.ce to *** the present review,we intend to highlight the mecha.istic contributions of DM to the remodeling of TME in GC.

关键词： Dia.etes mellitus Ga.tric ca.cer Tumor microenvironment Hyperglycemia Chronic infla.ma.ion