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The Adverse Event Profile in Patients Treated with Transferon<sup>TM</sup>(Dialyzable Leukocyte Extracts): A Preliminary Report

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Pharmacology & Pharmacy 2015年第2期6卷 65-74页

作者： Toni Homberg Violeta Sáenz Jorge Galicia-Carreón iván lara Edgar Cervantes-Trujano Maria C. Andaluz Erika Vera Oscar Pineda Julio Ayala-Balboa Alejandro Estrada-García Sergio Estrada-Parra Mayra Pérez-Tapia Maria C. Jiménez-Martínez Clinical Trials Branch and Clinical Immunology Service Unit of External Services and Clinical Research (USEIC) National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Unit of Pharmacovigilance Unit of External Services and Clinical Research (USEIC) National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Department of Immunology National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Unit of R&D in Bioprocesses (UDIBI) National School of Biological Sciences National Poly-technic Institute Mexico City Mexico Department of Biochemistry Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico

Background: Dialyzable leukocyte extracts (DLE) are heterogeneous mixtures of peptides less than 10 kDa in size that are used as immunomodulatory adjuvants in immune-mediated diseases. TransferonTM is DLE manufactured by national Polytechnic Institute (IPn), and is registered by Mexican health-regulatory authorities as an immunomodulatory drug and commercialized nationally. The proposed mechanism of action of TransferonTM is induction of a Th1 immunoregulatory response. Despite that it is widely used, to date there are no reports of adverse events related to the clinical safety of human DLE or TransferonTM. Objective: To assess the safety of TransferonTM in a large group of patients exposed to DLE as adjuvant treatment. Methods: We included in this study 3844 patients from our Clinical Immunology Service at the Unit of External Services and Clinical Research (USEIC), IPn. Analysis was performed from January 2014 to november 2014, searching for clinical adverse events in patients with immune-mediated diseases and treated with TransferonTM as an adjuvant. Results: In this work we observed clinical nonserious adverse events (AE) in 1.9% of patients treated with TransferonTM (MD 1.9, IQR 1.7 - 2.0). AE were 2.8 times more frequently observed in female than in male patients. The most common AE were headache in 15.7%, followed by rash in 11.4%, increased disease-related symptomatology in 10%, rhinorrhea in 7.1%, cough in 5.7%, and fatigue in 5.7% of patients with AE. 63% of adverse event presentation occurred from day 1 to day 4 of treatment with TransferonTM, and mean time resolution of adverse events was 14 days. In 23 cases, the therapy was stopped because of adverse events and no serious adverse events were observed in this study. Conclusion: TransferonTM induced low frequency of nonserious adverse events during adjuvant treatment. Further monitoring is advisable for different age and disease groups of patients.

关键词： Dialyzable Leukocyte Extracts Adverse Events Monitoring Drug Safety Adjuvant Therapy Immunoregulation Guidelines Transfer Factor Pharmacovigilance

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Productive evaluation of slow-growing Mexican turkeys with different diets in confinement

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Open Journal of Animal Sciences 2013年第1期3卷 46-53页

作者： Elizabeth Pérez-lara Marco Antonio Camacho-Escobar narciso Ysac ávila-Serrano Jaime Arroyo-Ledezma Edgar iván Sánchez-Bernal Mabel Rodríguez-dela Torre Virginia Reyes-Borques Chila’s Bajos Mixtepec Oaxaca México Cuerpo Académico Ciencias Agropecuarias Universidad del Mar Campus Puerto Escondido Puerto Escondido México

Were assessed the effect of five traditional diets backyard turkeys in confinement. The experiment lasted 36 weeks, the turkeys were randomized to one of five diets: kitchen waste + fresh forage (T1), kitchen waste (T2), commercial feed + fresh forage (T3), cracked corn + fresh forage (T4) and commercial feed (T5). Food and water were provided ad libitum. Each treatment with birds of both sexes had two repetitions with four birds and each bird was considered as an experimental unit. Were evaluated daily weight gain, total weight gain, final live weight, total length peak-tail, monthly gain peak-tail, total length, total length of wings, monthly gain wings length, and feed cost. The data were analyzed in a completely randomized arrangement with adjusted means and Tukey’s mean comparison, then an evaluation of treatment groups by analyzing clusters for semi quantitative data. The biggest daily gain, total weight gain and final live weight was obtained with treatment T3, while the highest increase in peak-length tail and wings was obtained with treatment T1 (P nt turned out to be most economical, but the treatment that best scores obtained was T1. We conclude that the use of kitchen waste + fresh forage is a feasible strategy to feed slow-growing turkeys.

关键词： Creole Turkey Cost of Feed Fresh Forage Guajolote Meleagris Gallopavo Traditional Diets

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Metastatic colorectal cancer-past,progress and future

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World Journal of Gastroenterology 2007年第28期13卷 3806-3815页

作者： Kathryn Field lara Lipton Department of Medical Oncology and Clinical Haematology Western HospitalFootscray 3011VictoriaAustralia

The clinical management of metastatic (stage Ⅳ) colorectal cancer (CRC) is a common challenge faced by surgeons and physicians. The last decade has seen exciting developments in the management of CRC, with significant improvements in prognosis for patients diagnosed with stage Ⅳ disease. Treatment options have expanded from 5-fluorouracil alone to a range of pharmaceutical and interventional therapies, improving survival, and providing a cure in selected cases. Enhanced understanding of the biologic pathways most important in colorectal carcinogenesis has led to a new generation of drugs showing promise in advanced disease. It is hoped that in the near future the treatment paradigm of metastatic CRC will be analogous to that of a chronic illness, rather than a rapidly terminal condition. This overview discusses the epidemiology of advanced CRC and currently available therapeutic options including medical, surgical, ablative and novel modalities in the management of metastatic colorectal cancer.

关键词：结肠癌直肠癌肿瘤转移化学疗法肿瘤学生物治疗

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Correlations between corneal and optic nerve head variables in healthy subjects and patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1156-1161页

作者： Federico Saenz-Frances Luis Janez lara Borrego-Sanz Clara Berrozpe-Villabona Jose Maria Martinez-de-la-Casa Laura Morales-Fernandez Julian Garcia-Sanchez Enrique Santos-Bueso Julian Garcia-Feijoo Department of Ophthalmology Clinico San Carlos HospitalComplutense University of Madrid Technology of Knowledge Institute Complutense University of Madrid

AIMTo correlate corneal variables (determined using the Pentacam) with optic nerve head (OnH) variables determined using the Heidelberg retina tomograph (HRT) in healthy subjects and patients diagnosed with primary open angle glaucoma (POAG).METHODSMeasurements were made in 75 healthy eyes and 73 eyes with POAG and correlations examined through Pearson correlation coefficients between the two sets of variables in the two subject groups. The corneal variables determined were corneal volume (CVol), central corneal thickness (CCT), overall corneal thickness (OvCT), the mean thickness of a circular zone centered at the corneal apex of 1 mm radius (zone I) and the mean thickness of several concentric rings, also centered at the apex until the limbus, each of 1 mm width (zones II to VI respectively). The OnH variables were determined using the *** following pairs of variables were correlated in the control group: CCT-disc area (DAr) (-0.48; Pne I-DAr (-0.503; Pnd Zone II-DAr (-0.443; Pnd in the POAG group: CCT-cup-to-disc area ratio (CDRa) (-0.402; Pne I-CDRa (-0.418; Pne II-CDRa (-0.405; P=0.006), Zone I-cup shape measure (CSM) (-0.415; P=0.002), Zone II-CSM (-0.405; P=0.001), Zone iv-height variation contour (HVC) (0.378; P=0.002); Zone V-HVC (0.388, PnCLUSIOnSIn the healthy subjects, significant negative correlation was detected between central and paracentral corneal thickness and optic disc area. In contrast, the POAG patients showed significant negative correlation between central and paracentral corneal thickness and the cup-disc ratio and CSM, and positive correlation between peripheral corneal thickness and HVC.

关键词： glaucoma optic nerve head corneal thickness

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