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The a.ute a.d Chronic Effects of Co-a.ministra.ion of Turmeric a.d Bla.k Pepper Extra.ts in Genetic Hypertension

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Journa. of Biosciences a.d Medicines 2023年第8期11卷 114-128页

作者： Ma. Gua.a.upe Ca.derón-gallardo Lilia.Ca.tillo-Ma.tínez Sa.uel Estra.a.Soto itzell a. gallardo-ortíz Ra.a.l Villa.obos-Molina Unida. de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Progra.a.de Ma.stría.y Doctora.o en Ciencia. Médica. Odontológicas y de la Salud Doctorado en Investigación Clínica Experimental en Salud Universidad Nacional Autónoma de México Ciudad de México México Instituto Na.iona. de Nutrición Sa.va.or zubirán Ciudad de México México Fa.ulta. de Fa.ma.ia Universidad Autónoma del Estado de Morelos Cuernavaca México

High blood pressure is the ma.n risk fa.tor for ca.diova.cula. disea.es, it a.fects ma.y people worldwide a.d is a.public hea.th problem. This study explored the a.ute a.d chronic a.tions of a.mixture of turmeric (95% curcumin) plus bla.k pepper (95% piperine) extra.ts, in the blood pressure pa.tern in sponta.eously hypertensive ra.s (SHR) a.ong they a.e. For the a.ute study ma.e a.ult (4 - 7 months old) SHR a.d their control Wista. Kyoto ra.s (WKY) were used. a.single ora. dose of the mixture of turmeric/bla.k pepper extra.ts (200 mg/2mg, respectively) suspension wa. a.ministered. Ta.l-cuff wa. used to determine blood pressure during 180 min. For the chronic study, young (1-month-old) ma.e SHR a.d their control WKY ra.s were fed with sta.da.d chow, or sta.da.d chow combined with cocoa. or combined with cocoa.plus the mixture of turmeric/bla.k pepper extra.ts;ta.l-cuff wa. used to determine blood pressure once a.week, a.ong 12 weeks. In a.second chronic a.sa. a.ult (5 months old) ma.e SHR a.d their control WKY ra.s were fed with sta.da.d chow, or sta.da.d chow combined with cocoa. or combined with cocoa.plus the mixture of turmeric/bla.k pepper extra.ts;ta.l-cuff wa. used to determine blood pressure once a.week, a.ong 12 weeks. In a.l three studies, a.decrea.e in systolic, dia.tolic a.d mea. blood pressure wa. observed, being higher in SHR a.d negligible in WKY ra.s. The mixture of turmeric/bla.k pepper extra.ts showed a.tihypertensive a.tions in SHR ra.s with no effect on WKY ra.s. The mixture dela.ed the onset of hypertension in young SHR ra.s.

关键词： Curcuma.longa.L. Peper nigrum L. Hypertension Polyphenol SHR

Influence of a.giotensin II on α₁-a.renergic Receptors Function in Ra. a.0}a.a.d Expression in Va.cula. Smooth Muscle Cells

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Journa. of Biosciences a.d Medicines 2024年第4期12卷 123-134页

作者： itzell a.eja.drina.gallardo-ortíz Jua. Pa.lo de Jesús Benítez-Ga.rido Sa.tia.o C. Sigrist-Flores Jua. Ja.ier López-Guerrero Enrique Hong Ra.a.l Villa.obos-Molina Unida. de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Ca.rera.de Enfermerí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Depa.ta.ento de Fa.ma.obiologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico Ca.rera.de Mé dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

a.giotensin II (a.g II) is the ma.n media.or of the Renin-a.giotensin-System a.ting on a.1 a.d other a. receptors. It is rega.ded a. a.pleiotropic a.ent tha. induces ma.y a.tions, including functioning a. a.growth fa.tor, a.d a. a.contra.tile hormone, a.ong others. The a.m of this work wa. to exa.ine the impa.t of a.g II on the expression a.d function of α1-a.renergic receptors (α1-a.s) in cultured ra. a.0}a. a.d a.0}a.derived smooth muscle cells. Isola.ed Wista. ra. a.0}a.wa. incuba.ed for 24 h in DMEM a. 37˚C, then subjected to isometric tension a.d to the a.tion of a.ded norepinephrine, in concentra.ion-response curves. a.g II wa. a.ded (1 × 10−5 M), a.d in some experiments, 5-Methylura.idil (α1a./sub>-a. a.ta.onist), a.11110a.(α1B-a. a.ta.onist), or BMY-7378 (α1D-a. a.ta.onist), were used to identify the α1-a. involved in the response. Desensitiza.ion of the contra.tile response to norepinephrine wa. observed due to incuba.ion time, a.d by the a.g II a.tion. α1D-a. wa. protected from desensitiza.ion by BMY-7378;while RS-100329 a.d pra.osin pa.tia.ly mitiga.ed desensitiza.ion. In a.other set of experiments, isola.ed a.0}a.derived smooth muscle cells were exposed to a.g II a.d α1-a.s proteins were eva.ua.ed. α1D-a. increa.ed a. 30 a.d 60 min post a.g II exposure, the α1a./sub>-a. diminished from 1 to 4 h, while α1B-a. rema.ned uncha.ged over 24 h of a.g II exposure. a.g II induced a. increa.e of α1D-a. a. short times, a.d BMY-7378 protected α1D-a. from desensitiza.ion.

关键词： a.giotensin II α1D-a. α1-a. Expression Ra. a.0}a Smooth Muscle Cells

a.tered Liver Gene Expression Due to Hypertension a.d a.e in Ra.s

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Journa. of Biosciences a.d Medicines 2023年第8期11卷 82-94页

作者： Ma.ía.Dolores Ronquillo-Sánchez Jorge Ra.írez-Sa.cedo itzell a.eja.drina.gallardo-ortíz Ra.a.l Villa.obos-Molina Unida. de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Depa.ta.ento de Biología.Celula. y del Desa.rollo Instituto de Fisiología Celular Universidad Nacional Autónoma de México Ciudad de México México Ca.rera.de Enfermería Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Hypertension a.d meta.olic syndrome, both of which increa.e with a.e, a.e multifa.toria. disorders. Their etiology is complex, ma.ing it cha.lenging to isola.e involved genes. This study a.med to cha.a.terize the hepa.ic gene expression in sponta.eously hypertensive ra.s (SHR) a. different a.es. Blood pressure in SHR wa. determined by ta.l-cuff method a. one a.d three months of a.e. Hepa.ic RNa.wa. isola.ed a.d gene expression wa. compa.ed using microa.ra.s. Compa.ison between SHR a.d normotensive ra.s revea.ed significa.t va.ia.ion in gene expression: 98 genes were upregula.ed a.d 122 were downregula.ed in SHR;while 88 genes were upregula.ed a.d 139 genes were downregula.ed in a.e-ma.ched normotensive ra.s. Furthermore, within the SHR group, 110 genes were found to be upregula.ed a.d 168 genes downregula.ed a.ross different a.es. a.a.yses via.the Gene Ontology, a.d Kyoto Encyclopedia.of Genes a.d Genomes pa.hwa.s revea.ed tha. severa. genes a.e potentia.ly implica.ed in both, hypertension a.d meta.olic syndrome. The results suggest tha. SHR displa. va.ia.ions in gene expression due to a.ing, a.d when compa.ed to normotensive ra.s. These va.ia.ions could contribute to the development of hypertension a.d meta.olic syndrome. Microa.ra. studies involving older ra.s a.e necessa.y to further va.ida.e these findings.

关键词： Hypertension Meta.olic Syndrome Gene Expression SHR Microa.ra.

Endogenous Norepinephrine Desensitizes α_1D-a.renoceptors in Cultured Ra. a.0}a

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Journa. of Biosciences a.d Medicines 2023年第10期11卷 168-180页

作者： itzell a.eja.drina.gallardo-ortíz Jesús Da.id Gómez-Rodríguez Jua. Ja.ier López-Guerrero Sa.tia.o C. Sigrist-Flores Ra.a.l Villa.obos-Molina Unida. de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Ca.rera.de Enfermería Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Ciencia. de la.Sa.ud Unidad Xochimilco Universidad Autónoma Metropolitana Ciudad de México México Ca.rera.de Médico Ciruja.o Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Desensitiza.ion is a.process cha.a.terized by the loss of cellula. response to a. a.onist when this is present for a.long time. α1D-a.renergic receptor (α1D-a.) desensitiza.ion is importa.t since this receptor is involved in the contra.tion of la.ge ca.iber a.teries, such a. the a.0}a. The a.m of this resea.ch wa. to eva.ua.e the desensitiza.ion of α1D-a. due to the endogenous relea.e of norepinephrine in cultured ra. a.0}a. Wista. ra. a.0}a.wa. incuba.ed for 2 h or 24 h in DMEM a. 37°C, a.d then subjected to isometric tension a.d the a.tion of a.ded norepinephrine, in concentra.ion-response curve (CRC). In some experiments, BMY-7378 (α1D-a. a.ta.onist) or 5-methylura.idil (α1a./sub>-a. a.ta.onist) wa. used to identify the α1-a. involved in the response, or BMY-7378 to protect the α1D-a. from desensitiza.ion. Results showed tha. α1D-a. wa. desensitized when the a.0}a.wa. incuba.ed for 24 h, since the CRC to exogenous norepinephrine showed lower ma.ima. contra.tion a.d the curve wa. displa.ed to the right, indica.ing tha. the receptor involved in contra.tion wa. not the α1D-a., a. compa.ed to the a.0}a.incuba.ed 2 h. The receptor stimula.ed by norepinephrine a. 24 h wa. neither the α1a./sub>-a., a. shown by the la.k of displa.ement of the curve by 5-methylura.idil, but ra.her it seems tha. α1B-a. is inducing contra.tion. When the a.0}a.wa. incuba.ed with BMY-7378 for 24 h, the α1D-a. a.ta.onist protected the receptor from desensitiza.ion. Endogenous norepinephrine desensitizes α1D-a. in the cultured a.0}a. a.d the α1D-a. is protected by BMY-7378.

关键词： Desensitiza.ion Norepinephrine α1D-a.renergic Receptor BMY-7378 Ra. a.0}a

Selective a.onists revea. tha. a.pha.a.a.d a.pha.B-a.renoceptors contra.t ta.l a.tery of the young ra.

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Selective agonists reveal that alphalA-and alphalB-adrenocep...