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Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging

Neural Regeneration Research 2023年第1期18卷 51-56页

作者： itzel ortiz flores Samuel Treviño Alfonso Díaz Department of Health Sciences School of MedicineUniversity of the Americas PueblaPueblaMexico Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico

Aging is a global phenomenon and a complex biological process of all living beings that introduces various *** this physiological process,the brain is the most affected organ due to changes in its structural and chemical functions,such as changes in plasticity and decrease in the number,diameter,length,and branching of dendrites and dendritic ***,it presents a great reduction in volume resulting from the contraction of the gray ***,aging can affect not only cognitive functions,including learning and memory,but also the quality of life of older *** a result of the phenomena,various molecules with notable neuroprotective capacity have been proposed,which provide a therapeutic alternative for people under conditions of aging or some neurodegenerative *** is important to indicate that in recent years the use of molecules with neurotrophic activity has shown interesting results when evaluated in in vivo *** review aims to describe the neurotrophic potential of molecules such as resveratrol(3,5,4′-trihydroxystilbene),neurotrophins(brain-derived neurotrophic factor),and neurotrophic-type compounds such as the terminal carboxyl domain of the heavy chain of tetanus toxin,cerebrolysin,neuropeptide-12,and *** of these molecules have been evaluated by our research *** suggest that these molecules exert an important therapeutic potential,restoring brain function in aging conditions or models of neurodegenerative ***,our interest is in describing the current scientific evidence that supports the therapeutic potential of these molecules with active neurotrophic.

关键词： Alzheimer’s disease brain cerebral cortex cognitive function dendritic spines HC-TeTx hippocampus neurodegeneration neuronal survival neurotrophins

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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Coxiella burnetii:living inside the host cell

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BIOCELL 2019年第1期43卷 1-6页

作者： Jesus Sebastian DISTEL Walter BERON Rodolfo Matias ortiz flores Instituto de Histologia y Embriologia de Mendoza(IHEM) ONICETUniversidad Nacional de CuyoMendozaArgentina Facultad de Odontologia Universidad Nacional de CuyoMendozaArgentina

Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q *** this brief review,we describe how recently described mechanisms help our understanding of *** invasion and its survival in the host cell by the formation of a replicative niche:the Coxiella-containing *** describe the actin-associated proteins involved in the internalization of ***,and we discuss the contribution of diverse degradation pathways of the cell during the formation and stabilization of the Coxiella-containing vacuole.

关键词： Actin Coxiellosis Phagocytic pathway Q fever

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Characterization by EBSD of Antimony-calcium Rich Phases Formed during Purification of Aluminum Scrap

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Journal of Wuhan University of Technology(Materials Science) 2013年第4期28卷 647-649页

作者： MUIZ Rodrigo flores Alfredo ortiz Juan RODRíGUEZ Nelly MARTíNEZ Fernando LUNA Jesús OROZCO Pilar Faculty of Engineering Autonomous University of Coahuila Camporedondo Unit CINVESTAV Saltillo Unit Department of Metal Mechanics Technological Institute of Saltillo Faculty of Engineering Autonomous University of Zacatecas

We studied the influence of antimony on the modification rate of the silicon eutectic with sodium and/or strontium for castiig of A1-Si alloys, and introduced controlled Ca and Sb to the system and studied the resulting compounds, which were determined to be CazSb and A1Sb. Scanning electron microscopy together with the complementary technique of electron backscatter diffraction （EBSD） were used to characterize the materials. The experimental results provided the basis for us to establish that antimony removal from AI occurs mainly through the reaction （Sb）A1 ＋ 2Ca = Ca^Sb ＋ A1.

关键词： aluminum alloys antimony contamination modification

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Ligand effects on the structure and vibrational properties of the thiolated Au18 cluster

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Progress in Natural Science:Materials International 2016年第5期26卷 510-515页

作者： Alfredo Tlahuice-flores CICFIM-Facultad de Ciencias Físico-Matemáticas Universidad Autónoma de Nuevo León

Most of the studies devoted to thiolated gold clusters suppose that their core and Au-S framework do not suffer from distortion independently of the protecting ligands（-SR） and it is assumed as correct to simplify the ligand as SCH3. In this work is delivered a systematic study of the structure and vibrational properties（IR and Raman）of the Au18（SR）14cluster. The pursued goal is to understand the dependency of the displayed vibrational properties of the thiolated Au18cluster with the ligands type. A set of six ligands was considered during calculations of the vibrational properties based on density functional theory（DFT） and in its dispersioncorrected approach（DFT-D）.

关键词： Gold cluster Ligand effects Structure Vibration Au18(SR)14 Density functional theory

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Curcuma longa L. extract improves the cortical neural connectivity during the aging process

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Neural Regeneration Research 2017年第6期12卷 875-880页

作者： Gonzalo flores Laboratorio de Neuropsiquiatría Instituto de Fisiología Benemérita Universidad Autónoma de Puebla

Turmeric or Curcuma is a natural product that has anti-inflammatory, antioxidant and anti-apoptotic pharmacological properties. It can be used in the control of the aging process that involves oxidative stress, inflammation, and apoptosis. Aging is a physiological process that affects higher cortical and cognitive functions with a reduction in learning and memory, limited judgment and deficits in emotional control and social behavior. Moreover, aging is a major risk factor for the appearance of several disorders such as cerebrovascular disease, diabetes mellitus, and hypertension. At the brain level, the aging process alters the synaptic intercommunication by a reduction in the dendritic arbor as well as the number of the dendritic spine in the pyramidal neurons of the prefrontal cortex, hippocampus and basolateral amygdala, consequently reducing the size of these regions. The present review discusses the synaptic changes caused by the aging process and the neuroprotective role the Curcuma has through its anti-inflammatory, antioxidant and anti-apoptotic actions.

关键词： Curcuma longa cortical curcumin hippocampus synaptic antioxidant spine connectivity cortex

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Application of antigenic biomarkers for Mycobacterium tuberculosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第11期21卷 856-870页

作者： Elba RODRIGUEZ-HERNANDEZ Laura itzel QUINTAS-GRANADOS Susana flores-VILLALVA Jorge Germinal CANTO-ALARCON Feliciano MILIAN-SUAZO Instituto Nacional de Investigaciones Forestales Agricolas y Pecuarias(INIFAP)Centro Nacional de Investigacion Disciplinaria en Fisiologia y Mejoramiento AnimalKm.1 Carretera a ColonAjuchitlan Colon76280ColonQueretaroMexico Universidad Mexiquense del Bicentenario Unidad de Estudios Superiores de TultitlanAvenida Ex-Hacienda de Portales s/nVilla EsmeraldaTultitlan Estado de Mexico54910TultitlanMexico Universidad Autonoma de Queretaro Facultadde Ciencias NaturalesAvenida de las Ciencias s/nJuriquillaDelegacion Santa Rosa Jauregui76230QueretaroMexico

The study and characterization of biomolecules involved in the interaction between mycobacteria and their hosts are crucial to determine their roles in the invasion process and provide basic knowledge about the biology and pathogenesis of *** new biomarkers for diagnosis and immunotherapy have emerged *** is an ancient pathogen that has developed complex strategies for its persistence in the host and environment,likely based on the complexity of the network of interactions between the molecules involved in *** biomarkers have received recent attention in the process of developing rapid and reliable detection techniques for *** the most widely investigated antigens are CFP-10(10-kDa culture filtrate protein),ESAT-6(6-kD a early secretory antigenic target),Ag85 A,Ag85 B,CFP-7,and *** of these antigens have been proposed as biomarkers to assess the key elements of the response to infection of both the pathogen and *** design of novel and accurate diagnostic methods is essential for the control of tuberculosis ***,the diagnostic methods are based on the identification of molecules in the humoral response in infected ***,these tests depend on the capacity of the host to develop an immune response,which usually is *** the last 20 years,special attention has been given to the design of multiantigenic diagnostic methods to improve the levels of sensitivity and *** this review,we summarize the state of the art in the study and use of mycobacterium biomolecules with the potential to support novel tuberculosis control strategies.

关键词： Mycobacterium tuberculosis Recombinant antigen Diagnostics Biomarker

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Effect of pesticides on phosphorylation of tau protein,and its influence on Alzheimer’s disease

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World Journal of Clinical Cases 2023年第24期11卷 5628-5642页

作者： Erandis D Torres-Sánchez Genaro G ortiz Emmanuel Reyes-Uribe Juan H Torres-Jasso Joel Salazar-flores Department of Medical and Life Sciences University Center of la CienegaUniversity of GuadalajaraOcotlan 47820JaliscoMexico Department of Philosophical and Methodological Disciplines and Service of Molecular Biology in Medicine Hospital Civil University of GuadalajaraGuadalajara 44340JaliscoMexico Department of Biological Sciences CUCOSTAUniversity of GuadalajaraPuerto Vallarta 48280JaliscoMexico

Alzheimer’s disease(AD)is a progressive and neurodegenerative illness which results in alterations in cognitive *** is characterized by loss/dysfunction of cholinergic neurons,and formation of amyloid plaques,and formation of neurofibrillary tangles,among other changes,due to hyperphosphorylation of *** to pesticides in humans occurs frequently due to contact with contaminated food,water,or ***,organophosphates,carbamates,pyrethroids and neonicotinoids are associated with the most diagnosed incidents of severe cognitive *** aim of this study was to determine the effects of these pesticides on the phosphorylation of tau protein,and its cognitive implications in the development of *** was found that exposure to pesticides increased the phosphorylation of tau protein at sites Ser198,Ser199,Ser202,Thr205,Ser396 and *** with these chemicals altered the enzymatic activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta,and protein ***,it altered the expression of the microtubule associated protein tau gene,and changed levels of intracellular *** changes affected tau protein phosphorylation and neuroinflammation,and also increased oxidative *** addition,the exposed subjects had poor level of performance in tests that involved evaluation of novelty,as test on verbal,non-verbal,spatial memory,attention,and problem-solving skills.

关键词： Organochlorines Organophosphates Carbamates Pyrethroids Neonicotinoids Tau protein

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A transition from a large open pit into a novel “macroblock variant” block caving geometry at Chuquicamata mine, Codelco Chile

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 549-561页

作者： German flores Alex Catalan Newcrest Mining Ltd. Melbourne3004Australia Codelco Chile Santiago8320000Chile

With a history of more than 100 years, Chuquicamata has become one of the largest open pits in the world. Its current depth of 1100 m, length of 4500 m and width of 3000 m, resulting in haulage distances of over 11,000 m from pit bottom to the processing plant or waste dumps, with waste/ore ratio greater than 4 and much lower grades, are effectively determining its profitable limit by the end of this decade. Currently, there are over 4300 Mt of geological resources containing 0.7% of copper and 340 ppm (1 ppm = 1 g/t) of molybdenum below the final pit shell. The corresponding orebody geometry is 3000 m northsouth, 300-800 m eastwest and the drilling campaign suggested the existence of more than 900 m of mineable ore from the final pit bottom. This is in spite of the fact that the Chuquicamata orebody is still open at depth. The business case to continue with the mining of the Chuquicamata orebody is to change from the current large open pit to a novel macroblock variant block caving geometry. This requires a production rate of 140,000 t/d (50 Mt per annum), with a continuous material handling system to achieve the 7-year ramp-up to full production. The resolution of a number of known technical, operational and logistical challenges outside current industry practises which Chuquicamata will face over its projected 40-year mine life is therefore essential. These challenges include simultaneous operations of open pit and underground macroblocks and from the initial lift to the second lift, rapid ramp-up and optimum sequencing of the planned macroblocks, early dilution from the west fault and late dilution from potential slope failures, and the potential for major operational hazards. An equally important issue to be addressed is cultural given that the mining history in the northern region of Chile, which includes Chuquicamata, is predominantly open pit. This paper presents a synopsis of the main challenges that the Chuquicamata underground project will face in order t

关键词： Macroblock variant Block caving Cave propagation Early and late dilutions Intensive preconditioning Rib pillar West fault Ore buffer

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