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Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging

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World Journal of Gastroenterology 2021年第35期27卷 5978-5988页

作者： Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál n Kaposi Department of Radiology Medical Imaging CentreFaculty of MedicineSemmelweis UniversityBudapest 1083Hungary Department of Transplantation and Surgery Faculty of MedicineSemmelweis UniversityBudapest 1082Hungary MedInnoScan Research and Development Ltd. Budapest 1112Hungary

BACKGROUnD The nature of input data is an essential factor when training neural *** concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly ***,evidence to support the utilization of multi-dimensional and multi-parametric image data is *** to higher information content,three-dimensional input should presumably result in higher classification ***,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI *** To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(Densenet)for FLLs on multi-sequence *** We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FnH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FnH,69 HCC and 76 *** volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-Densenet264 *** bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-Densenet264 *** test set consisted of 10-10-10 *** performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(nPV),and f1 *** The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,nPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FnH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D ***

关键词： Artificial intelligence Multi-parametric magnetic resonance imaging Hepatocyte-specific contrast Densely connected convolutional network Hepatocellular carcinoma Focal nodular hyperplasia

Addition of ‘Chetoui’ olive leaf extract to reduce acrylamide in Californian-style black olive

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Food Bioscience 2022年第6期50卷 842-851页

作者： Dalel Mechi Antonio Fernández Bechir Baccouri Leila Abaza Daniel martín-Vertedor Laboratory of Olive Biotechnology Centre of Biotechnology of Borj-Cedria (CBBC)BP 9012050Hammam-lifTunisia The Faculty of Science of Bizerte University of CarthageTunisia Technological Institute of Food and Agriculture (CICYTEX-InTAEX) Junta of ExtremaduraAvda.Adolfo Suárez S/n06007BadajozSpain

To improve food quality, the use of olive leaf extracts has been an emergent strategy that needs to be study in different scenarios. Certain local olive varieties are waiting to be discovered as potential by-product sources, in which a Tunisian variety named ‘Chetoui’ can be pointed out. The use of this variety at different tree ages to elaborate olive leaf extracts (OLE) in different solvents has been the main procedure to study during this assay. Different OLE concentrations were prepared in order to evaluate its effect in contaminants such as acrylamide. Adult ‘Chetoui’ OLE presented a richer phenolic content that is younger homonym. Principal phenols like hydroxytyrosol, tyrosol, oleuropein and luteolin-7-O-gluvoside presented higher levels for both tree ages. In terms of extractants, the most effective was Methanol, having concentrations for oleuropein, hydroxytyrosol and Luteolin-7-O-glucoside of 175331, 32433 and 10688 mg 100 g−1 respectively. Hexane was the least successful solvent, having no concentration for plenty of the phenols. Acrylamide concentration was deeply affected for the OLE presence for every extract concentration, being OLE (1:10) and OLE (1:10 + HTy) the additions with a better performance followed by OLE (1:100). A sensory analysis was performed finding out that OLE (1:100) was the most appealing for the consumer when adding it to table olives. The current research attempts to discover new applications for local varieties, using by-products to enhance oxidized black table olives added value. Finally, market products would become healthier, safer and with better quality to be released in the food industry.

关键词： Tunisia Olive leaf extract Acrylamide Phenolic compounds Table olive

Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure

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World Journal of Gastroenterology 2015年第14期21卷 4126-4135页

作者： nicholas G Theodorakis Yining n Wang Vyacheslav A Korshunov mary A Maluccio nicholas J Skill Division of Transplant Surgery Department of SurgerySchool of MedicineIndiana University School of Medicine University of Rochester

AIM: Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and *** reports have suggested that the compound thalidomide attenuates portal hypertension(PHT).However, the mechanism for this action is not fully *** hypothesis is that thalidomide destabilizes tumor necrosis factor α(TnFα) mR nA and therefore diminishes TnFα induction of nitric oxide synthase(nOS) and the production of nitric oxide(nO).To examine this hypothesis, we utilized the murine partial portal vein ligation(PVL) PHT model in combination with endothelial or inducible nOS isoform gene knockout ***: Wild type, inducible nitric oxide synthase(i nOS)-/- and endothelial nitric oxide synthase(e nOS)-/-mice received either PVL or sham surgery and were given either thalidomide or *** nitrate(total nitrate, nOx) was measured daily for 7 d as a surrogate of nO *** TnFα level was quantified by enzyme-linked immunosorbent ***α m RnA was quantified in liver and aorta tissue by reverse transcription-polymerase chain *** was determined by recording splenic pulp pressure(SPP) and abdominal aortic flow after 0-7 *** to thalidomide was determined by measurement of SPP and mean arterial pressure(MAP).RESULTS: SPP, abdominal aortic flow(Qao) and plasma nOx were increased in wild type and i nOS-/-PVL mice when compared to sham operated control *** contrast, SPP, Qao and plasma nOx were not increased in e nOS-/- PVL mice when compared to sham *** TnFα level in both sham and PVL mice was below the detection limit of the commercial ELISA ***, the effect of thalidomide on serum TnFα levels was undetermined in wild type, e nOS-/-or i nOS-/- *** acutely increased plasma nOx in wild type and e nOS-/- mice but not i nOS-/-***, thalidomide temporarily(0-90 min) decreased mean arterial pressure, SPP and Qao in wild type, e nOS-/- and i nOS-/- PVL mice, aft

关键词： Portal hypertension Thalidomide nitric oxide Knock

An alternative approach for sustainable sheep meat production:implications for food security

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Journal of Animal Science and Biotechnology 2021年第2期12卷 791-805页

作者： Eric n.Ponnampalam Matthew I.Knight Peter J.Moate Joe L.Jacobs Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsBundooraVIC 3083Australia Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsHamiltonVIC 3300Australia Animal Production Sciences Agriculture Victoria ResearchDepartment of JobsPrecincts and RegionsEllinbankVictoria 3821Australia Centre for Agricultural Innovation School of Agriculture and FoodFaculty of Veterinary and Agricultural SciencesThe University of MelbourneMelbourneVictoria 3010Australia

Background:A pelleted diet containing camelina hay(CAMH)or camelina meal(CAMM)as a supplement along with a control pellet(COnT)diet formulated with commonly available feeds during summer was used to investigate an alternative pathway for sustainable meat *** meat production was based on a simple estimation of income from meat produced versus feed costs if animals were fed for an extended period over summer compared to early slaughter at the beginning of *** maternal composite wether lambs(Composite)based on Coopworth genetics and 80 pure Merino wether yearlings were divided into 10 groups within breed(n=8)using stratified randomisation based on *** 1 week of adaptation to experimental diets,animals were fed experimental diets for up to10 ***:Animals were slaughtered after either 8,9 or 10 weeks of full feeding when the average liveweight of diet/genetic combination reached a weight appropriate for either‘heavy lamb’or‘heavy hogget’production,which occurred between 8 and 10 weeks of full *** was no diet×breed interactions except for dressing percentage(DP),where Composite lambs fed the CAMH diet had the greatest DP(48.1±0.35)and the Merino yearlings fed the CAMM diet the lowest DP(45.8±0.33).Composite lambs gained 17.6–20.3 kg and Merino yearlings gained 10.7–12.9 kg *** on their DP,this resulted in the production of approximately 8.3–9.5 kg additional carcass weight in Composites and 4.9–5.7 kg in Merinos,which in turn produced greater profit per Composite lamb and a small profit per Merino ***:Composite lambs fed CAMM and CAMH had 5%greater carcass weights at slaughter compared to the COnT group,but dietary treatments did not change carcass weight of Merino yearlings at *** extended feeding approach offered the producer an estimated economic gain of AUD$20.00 to$25.00 when yearly average prices were used(Method 1)and AUD$40.00 to$47.70 when pre-and post-summer

关键词： Animal welfare Environmental sustainability Global demand Livestock Sheep meat Summer feeding

Optical coherence tomography angiography at the acute phase of optic disc edema

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Eye and Vision 2018年第1期5卷 144-150页

作者： marie-Bénédicte Rougier Mélanie Le Goff Jean-François Korobelnik Service d’Ophtalmologie CHU de BordeauxBordeauxFrance Bordeaux Population Health Research Center Team LEHAUniversity BordeauxINSERMUMR 1219F-33000 BordeauxFrance

Background:The differential diagnosis of optic disc edema at the acute phase can be *** angiography(OCTA)is a new technology allowing the visualization of the peripapillary vascular network and optic disc *** peripapillary network alterations of glaucoma and chronic non-arteritic anterior ischemic optic neuropathy(nAIOn)were ***,no OCTA studies on acute optic disc edema from various *** aim of this project was to use OCTA to demonstrate the vascular changes the optic nerve head of various types of optic disc edema at the acute ***:In this retrospective study,patients with non-arteritic anterior ischemic optic neuropathy(nAIOn),papillitis or papilledema were *** patient was imaged using the AngioPlex^(TM)CIRRUS^(TM)HD-OCT device(model 5000,Carl Zeiss Meditec,Inc.,Dublin,USA)with a scanning area of 6×6 mm^(2) centered on the optic disc.A morphological analysis of the peripapillary network was *** some patients with unilateral optic disc edema,a quantitative analysis was performed using a swept-source OCT-A system(PLEX®Elite 9000,Carl Zeiss Meditec,Inc.,Dublin,USA).Vessel perfusion density and flux index of the peripapillary area were ***:Eight eyes with nAIOn(4 patients),12 eyes with papillitis(6 patients)and 25 eyes with papilledema(13 patients)were *** apparent disappearance or moderate pattern alteration of the peripapillary capillary vessels were observed in patients with nAIOn or papillitis,*** papilledema,the capillaries at the surface of the optic disc were dilated and tortuous,but no peripapillary network pattern changes were *** quantitative analysis did not show any difference of peripapillary network between nAIOn and healthy *** papillitis,the flux index was higher in inflammatory eyes compared to the healthy eyes in average(p=0.03).Conclusion:At the acute phase,the morphological analysis of OCT-A appeared to be more useful than the q

关键词： Optical coherence tomography angiography Optic nerve head Edema nAIOn Microvascular network And morphology

Design of internal model control based fractional order PID controller

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控制理论与应用（英文版） 2012年第3期10卷 297-302页

作者： T.VInOPRABA n.SIVAKUmarAn S.nARAYAnAn T.K.RADHAKRISHnAn Department of Instrumentation and Control Engineering National Institute of TechnologyTiruchirappalli 620015India Department of Chemical Engineering National Institute of TechnologyTiruchirappalli 620015India

This article presents a design of the internal model control （IMC） based single degree of freedom （SDF） fractional order （FO） PID controller with a desired bandwidth specification for a class of fractional order system （FOS）. The drawbacks of the SDF FO-IMC are eliminated with the help of the two-degree of freedom （TDF） FO PID controller. The robust stability and robust performance of the designed controller are analyzed using an example.

关键词： Fractional order PID controller Fractional order systems Model based control Robust control

Metabolic reprogramming in tumors:Contributions of the tumor microenvironment

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Genes & Diseases 2020年第2期7卷 185-198页

作者： Andrew n.Lane Richard M.Higashi Teresa W-M.Fan Center for Environmental and Systems Biochemistry Markey Cancer CenterDepartment of Toxicology and Cancer BiologyUniversity of KentuckyUSA

The genetic alterations associated with cell transformation are in large measure expressed in the metabolic phenotype as cancer cells proliferate and change their local environment,and prepare for ***,the fundamental biochemistry of cancer cells is generally the same as in the untransformed cells,but the cancer cells produce a local environment,the TME,that is hostile to the stromal cells,and compete for *** order to proliferate,cells need sufficient nutrients,either those that cannot be made by the cells themselves,or must be made from simpler ***,in solid tumors,the nutrient supply is often limiting given the potential for rapid proliferation,and the poor quality of the ***,cancer cells may employ a variety of strategies to obtain nutrients for survival,growth and *** much has been learned using established cell lines in standard culture conditions,it is becoming clear from in vivo metabolic studies that this can also be misleading,and which nutrients are used for energy production versus building blocks for synthesis of macromolecules can vary greatly from tumor to tumor,and even within the same *** we review the operation of metabolic networks,and how recent understanding of nutrient supply in the TME and utilization are being revealed using stable isotope tracers in vivo as well as in vitro.

关键词： Cancer metabolism nutrient supply Stable isotope resolved metabolomics Tumor microenvironment Metabolic flux

Prevalence of celiac disease in an urban area of Brazil with predominantly European ancestry

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World Journal of Gastroenterology 2006年第40期12卷 6546-6550页

作者： maria Angélica G Pereira Carmen L Ortiz-Agostinho Iêda nishitokukado maria n Sato Adérson OMC Damio marília L Alencar Clarice P Abrantes-Lemos Eduardo LR Canado Thales de Brito Sérgio O Ioshii Sandra BM Valarini Aytan M Sipahi Department of Gastroenterology Medical Investigation Laboratories (LIM 07) University of So Paulo School of Medicine So Paulo SP Brazil Medical Investigation Laboratories (LIM 56) University of So Paulo School of Medicine So Paulo SP Brazil Institute of Tropical Medicine (LIM 06) University of So Paulo School of Medicine So Paulo SP Brazil Department of Histopathology Federal University of Paraná Brazil Department of Internal Medicine Catholic University of Paraná Brazil

AIM： To determine the prevalence of celiac disease in a group of volunteer blood donors at a blood bank in the city of Curitiba, Brazil through detection of the serum marker immunoglobulin A （IgA） antitransglutaminase antibody. METHODS： Blood samples collected from 2086 healthy subjects at the Paraná State Center for Hematology and Hemotherapy in Curitiba were submitted to ELISA testing for the IgA antitransglutaminase antibody. Positive samples received IgA antiendomysium antibody test through indirect immunofluorescence using human umbilical cord as substrate. Subsequently, patients who were positive on both tests underwent small bowel （distal duodenum） biopsy. RESULTS： Six subjects, four males and two females, tested positive for the two serum markers. Five of the six were submitted to intestinal biopsy （one declined the procedure）. Biopsy results revealed changes in the distal duodenum mucosa （three classified as marsh mb lesions and two as marsh Ⅱ lesions）. Most donors diagnosed having celiac disease presented multiple symptoms （gastrointestinal tract complaints）. One donor reported having a family history of celiac disease （in a niece）. COnCLUSIOn： Among apparently healthy blood donors,the prevalence of biopsy-confirmed celiac disease was approximately 1：417, similar to that seen in European countries.

关键词： Celiac disease Epidemiology Malabsorption Prevalence Small bowel disease

Morphological and molecular evidence supports the first occurrence of two fishes, Siganus sutor(Valenciennes, 1835)and Seriolina nigrofasciata(Rüppell, 1829)(Actinopterygii:Perciformes), from marine waters of Odisha coast, Bay of Bengal, India

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Acta Oceanologica Sinica 2020年第6期39卷 26-35页

作者： Tapan K.Barik Surya n.Swain Bijayalaxmi Sahu Bibarani Tripathy Usha R.Acharya Post Graduate Department of Zoology Berhampur UniversityBerhampur 760007OdishaIndia

marine ecosystems provide a wide variety of diverse habitats that frequently promote migration and ecological *** extent to which the geographic distribution of marine organism has reshaped by human activities remains *** limitations intrinsic to morphology-based identification systems have engendered an urgent need for reliable genetic methods that enable the unequivocal recognition of fish species,particularly those that are prone to overexploitation and/or market *** the present study,however,an attempt has been taken to identify two locally adapted fish species,Siganus sutor(Valenciennes,1835)and Seriolina nigrofasciata(Rüppell,1829)of order Perciformes,which happens to be the first record in Odisha coast,Bay of *** diagnostic characteristics of Siganus sutor are:dorsal fin XIII-10,anal fin VII-9,pectoral fin 15,pelvic fin II-3,while that of Seriolina nigrofasciata dorsal fin VI-I-35,anal fin I-17,pectoral fin 16,pelvic fin *** COI barcodes generated in this study were matched with reference sequences of expected species,according to morphological *** and likelihood phylogenetic trees were drawn based on DnA barcodes and all the specimens clustered in agreement with their taxonomic classification at the species *** phylogeographic studies based on haplotype network and migration rates suggest that both the species were not panmitic and the high-frequency population distribution indicates successful *** result of this study provides an important validation of the use of DnA barcode sequences for monitoring species diversity and changes within a complex marine ecosystem.

关键词： Siganus sutor Seriolina nigrofasciata morphological characteristics DnA Barcoding