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Seasonal change in sexual differences in nestling size and survival： a framework to evaluate sex-dependent environmental sensitivity in the wild

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Avian Research 2018年第2期9卷 136-143页

作者： Daisuke Nomi Teru Yuta itsuro koizumi Graduate School of Environmental Science Hokkaido University Sapporo Hokkaido Japan Center for Toki and Ecological Restoration Niigata University Sado Niigata Japan Faculty of Environmental Earth Science Hokkaido University Sapporo Hokkaido Japan

Background: Sexual size dimorphism(SSD) occurs in a wide range of species in birds and other animals, but the magnitude of SSD often varies with environmental conditions. In general, in the developmental stages, the larger sex is more vulnerable to adverse environmental conditions because the larger sex requires more energy than the smaller sex. However, this may not hold true for birds with large brood sizes; the larger sex can acquire more food by suppressing the smaller sex. In addition, most previous studies have been experimental, such as by manipulating clutch size and ectoparasites, which may not reflect natural ***: In the present study, we propose a general framework to assess sexual differences in environmental sensitivity in natural populations. Because environmental conditions change throughout the breeding season, seasonal changes of nestling SSD and sex ratio should reflect sexual differences in environmental sensitivity. We applied this approach to a large dataset(1555 nestlings over 5 years) of Japanese Tits(Parus minor). In this population, the male nestling is generally larger than the female(5% SSD in body weight).Results: We found that the magnitude of SSD(weight, tarsus, wing) and fledgling sex ratio increased both in the beginning and the end of the breeding ***: Our study suggested that female nestlings are more valuable to poor environmental conditions in the relatively fecund species. This study underscores the importance of brood size on sexual differences in environmental stochasticity and our framework encourages comparative analysis among different bird species.

关键词： Brood size Japanese tit Parus minor Seasonal change Sexual size dimorphism

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Greater than 200 Gb/s Transmission Using Direct-Detection Optical OFDM Superchannel

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ZTE Communications 2012年第1期10卷 10-17页

作者： itsuro Morita Hidenori Takahashi Takehiro Tsuritani KDDI R&D Laboratories Inc.

In this paper, we propose directdetection optical orthogonal frequency division multiplexing superchannel （DDOOFDMS） and optical multiband receiving method （OMBR） to support a greater than 200 Gb/s data rate and longer distance for direct-detection systems. For the new OMBR, we discuss the optimum carriertosideband power ratio （CSPR） in the cases of backtoback and post transmission. We derive the analytical form for CSPR and theoretically verify it. A low overhead training method for estimating I/Q imbalance is also introduced in order to improve performance and maintain high system throughput. The experiment results show that these proposals enable an unprecedented data rate of 214 Gb/s （190 Gb/s without overhead） per wavelength over an unprecedented distance of 720 km SSMF in greater than 100 Gb/s DDOFDM systems.

关键词： orthogonal frequency division multiplexing (OFDM) direct detection multiband transmission

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Rice Stomatal Closure Requires Guard Cell Plasma Membrane ATP-Binding Cassette Transporter RCN1/OsABCG5

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Molecular Plant 2016年第3期9卷 417-427页

作者： Shuichi Matsuda Sho Takano Moeko Sato Kaoru Furukawa Hidetaka Nagasawa Shoko Yoshikawa Jun Kasuga Yoshihiko Tokuji Kazufumi Yazaki Mikio Nakazono itsuro Takamure Kiyoaki Kato Department of Agro-environmental Science Obihiro University of Agricultural and Veterinary Medicine 2-11 Nishi Inada Obihiro Hokkaido 080-0834 Japan Department of Food Science Obihiro University of Agricultural and Veterinary Medicine 2-11 Nishi Inada Obihiro Hokkaido 080-0834 Japan Research Institute for Sustainable Humanosphere Kyoto University Gokasho Uji Kyoto 611-0011 Japan Graduate School of Bioagricultural Sciences Nagoya University Furo-cho Chikusa Nagoya Aichi 464-8601 Japan Graduate School of Agriculture Hokkaido University Kita 9 Nishi 9 Kita-ku Sapporo Hokkaido 060-8589 Japan

Water stress is one of the major environmental stresses that affect agricultural production worldwide. Water loss from plants occurs primarily through stomatal pores. Here, we report that an Oryza sativa half-size ATP-binding cassette （ABC） subfamily G protein, RCN 1/OsABCG5, is involved in stomatal closure mediated by phytohormone abscisic acid （ABA） accumulation in guard cells. We found that the GFP-RCN1/ OsABCG5-fusion protein was localized at the plasma membrane in guard cells. The percentage of guard cell pairs containing both ABA and GFP-RCN1/OsABCG5 increased after exogenous ABA treatment, whereas they were co-localized in guard cell pairs regardless of whether exogenous ABA was applied. ABA application resulted in a smaller increase in the percentage of guard cell pairs containing ABA in rcnl mutant （A684P） and RCN1-RNAi than in wild-type plants. Furthermore, polyethylene glycol （drought stress）-inducible ABA accumulation in guard cells did not occur in rcnl mutants. Stomata closure mediated by exogenous ABA application was strongly reduced in rcnl mutants. Finally, rcnl mutant plants had more rapid water loss from detached leaves than the wild-type plants. These results indicate that in response to drought stress, RCN1/OsABCG5 is involved in accumulation of ABA in guard cells, which is indispensable for stomatal closure.

关键词： stomatal closure abscisic acid ABC transporter rice drought stress

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Synchronous Changes of Nitrogen and Carbon Isotopic Ratios and Nannoplankton Assemblage in Marine Sediments off Peru at 250 ka: A Role of Phytoplankton in Primary Ocean Productivity

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Open Journal of Geology 2013年第2期3卷 113-120页

作者： Hidenao Hasegawa itsuro Kita Shingo Tsukamoto Shun Chiyonobu Yoshihiro Kuwahara Department of Environmental Changes Faculty of Social and Cultural Studies Kyushu University Fukuoka Japan

We report the mechanism controlling changes of δ15Norg and δ13Corg values of marine organic matter, based on the change of calcareous nannoplankton assemblage during the last 500,000 years in core samples from ODP Hole 846B off Peru in the equatorial Pacific Ocean. The δ15Norg values fluctuate in a range from 2.1‰ to 6.7‰, giving an abrupt increase since about 250 ka with the averages of 3.8‰ and 5.0‰ during the older and younger periods, respectively. The δ13Corg values change in a range from ?23.5‰ to ?20.1‰ in an inverse correlation with δ15Norg values, describing an increase of average values at 250 ka as well as those of δ15Norg values. The total organic carbon content also shows averages of 0.6% and 0.3% during the younger and older periods, respectively. The numerical increase of deep dwelling species (Florisphaera profunda) of calcareous nannoplankton during the younger period in comparison with the older period indicates that these chemical and isotopic jumps synchronized with nannoplankton assemblage changes in marine sediments are caused by activity of deep dwellers in photic zone more stratified by an abrupt decline of trade wind strength on this sea area since about 250 ka. A study coupling δ15Norg and δ13Corg values and nannoplankton assemblage can be a useful method for evaluating the extent of stratification of photic zone and the roles of surface and deep dwellers of phytoplankton in producing primary organic matter.

关键词： Nannoplankton Assemblage Nitrogen and Carbon Isotopes Organic Matter Biological Productivity Se-diment off Peru

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Achieving the Goals of Healthy China 2030 Depends on Increasing Smoking Cessation in China:Comparative Findings from the ITC Project in China,Japan,and the Republic of Korea

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China CDC weekly 2021年第22期3卷 463-467页

作者： Geoffrey T.Fong Jiang Yuan Lorraine V.Craig Steve Shaowei Xu Gang Meng Anne C.K.Quah Hong-Gwan Seo Sungkyu Lee itsuro Yoshimi Kota Katanoda Takahiro Tabuchi University of Waterloo WaterlooOntarioCanada Ontario Institute for Cancer Research TorontoOntarioCanada Tobacco Control Office China CDCBeijingChina Korea National Cancer Center SeoulRepublic of Korea Korea Center for Tobacco Research and Education SeoulRepublic of Korea Japan National Cancer Center TokyoJapan Osaka International Cancer Institute OsakaJapan.

Summary Tobacco smoking is the number one preventable cause of disease and death in China as it is ***,the toll of smoking in China is much greater than its status as the world’s most populous *** is a persistent and continuing need for China to implement the measures specified in the global tobacco control treaty,the World Health Organization(WHO)Framework Convention on Tobacco Control(FCTC),which China ratified in 2005.

关键词： globally ITC specified

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硒蛋白-P在线粒体疾病患者不整红边纤维中的特异表达及相关作用

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中华神经科杂志 2005年第5期38卷 317-321页

作者：胡静樋口逸郎白石匡史中川正法日本鹿児岛大学大学院医歯学總合研究科神經内科.老年病学第三内科

目的研究硒蛋白P与琥珀酸脱氢酶、细胞色素C氧化酶的关系及它们在线粒体疾病患者不整红边纤维(raggedredfiber,RRF)中的表现和作用。方法(1)研究对象:线粒体疾病患者14例,其中Kearns Sayre综合征患者1例,线粒体脑肌病、乳酸酸中毒伴卒... 详细信息

目的研究硒蛋白P与琥珀酸脱氢酶、细胞色素C氧化酶的关系及它们在线粒体疾病患者不整红边纤维(raggedredfiber,RRF)中的表现和作用。方法(1)研究对象:线粒体疾病患者14例,其中Kearns Sayre综合征患者1例,线粒体脑肌病、乳酸酸中毒伴卒中样症状者4例,肌阵挛癫伴RRF1例,慢性进行性眼外肌麻痹6例,肢带型线粒体病2例;5例对照,其中多发性肌炎2例,其他神经肌病3例。全部患者均经临床、病理、分子生物学DNA分析确诊。(2)开放式肌肉活检。(3)连续切片,经组织化学、免疫组织化学染色分析。结果患者RRF的肌浆中硒蛋白-P显著表达,琥珀酸脱氢酶活性增强,细胞色素C氧化酶活性增强、减弱或缺陷。结论硒蛋白-P在对抗线粒体氧化损伤、保护线粒体机能方面可能充当了重要角色,可以作为病理学评价线粒体机能和诊断RRF的指标。

关键词：不整红边纤维疾病患者硒蛋白相关作用慢性进行性眼外肌麻痹表达及细胞色素C氧化酶琥珀酸脱氢酶活性线粒体氧化损伤特异线粒体脑肌病免疫组织化学乳酸酸中毒肌阵挛癫痫多发性肌炎分子生物学 DNA分析病理学评价

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Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies

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中国口腔颌面外科杂志 2008年第B5期6卷 79-80页

作者： itsuro Kato Yusei Fujita Akitoshi Kamida Akira Maruhashi Yoshinofi Sakurai Hiroaki Kumada Masatoshi Ohmae Mitsunori Kifihata Yoshio Imahori Tetsuro Sumi Souichi Iwai Mitsuhiro Nakazawa Koji Ono Department of Oral and Maxillofacial Surgery 11 Osaka University Graduate School of Dentistry Suita Osaka 5650871 Japan Radiation Oncology Osaka 590-494 Japan Research Reactor Institute Research Reactor Institute School of Medicine Sapporo Medical University Hokkaido 060-8556 Japan JapanAtomic Energy Agency Tokai Research and Development Center lbaraki Japan Department of Oral and Maxillofacial Surgery Izumisano Municipal Hospital Rinku General Hospital lzumisao Osaka 598-0048 Japan Graduate School of Agriculture and Life Sciences Osaka Prefecture University Osaka 599-8531 Japan CEO of Cancer Intelligence Care System Inc. Tokyo 135-0063 Japan

Background: Recurrent head & neck malignancies (HNM) are often radio-/chemo-resistant and show extensive growth, necessitating a wide resection including surrounding tissues。To avoid severe impairment of oro-facial structures and functions, it is necessary to explore new treatments for HNM。Boron neutron capture therapy (BNCT) is tumor-cell targeted radiotherapy that has significant superiority over conventional radiotherapies in principle。When 10B absorbs thermal neutrons, the alpha and 7Li particles generated by the 10B(n, alpha)7Li reaction are high LET particles, and carry high kinetic energy (2.34MeV), and have short ranges (4-9 micron-meters) of approximately one-cell diameter, resulting in a large relative biological effectiveness and selective destruction of tumor cells containing 10B。We have, first in the world treated with BNCT for a patient with parotid gland carcinoma in 2001。Purpose: To evaluate the effect of BNCT on Recurrent head & neck malignancies。Methods: So far for 6 years, we have treated with 42 times of BNCT for 26 patients with a recurrent HNM who were composed of 19 squamous cell carcinomas (SCC), 4 salivary gland carcinomas and 3 sarcomas。Results: (1) 10B concentration of tumor/normal tissue ratios (T/N ratio) of PET studies wereSCC: 1.8-5.7, sarcoma: 2.5-4.0, parotidtumor: 2.5-3.7。(2)Regression rateswere CR: 12cases (46%), PR: 10cases (39%), PD: 3cases (12%), NE (not evaluated):lcase。

关键词：中子俘获治疗法头颈部恶性肿瘤治疗方法

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Selective inta-arterial infusion achieved by coil embolization of Non-concerning artery in patient with oral cancer

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中国口腔颌面外科杂志 2008年第B5期6卷 145-145页

作者： Masatoshi Ohmae Junko Yamamoto itsuro Kato Kosuke Sakurai Mitsuhiro Nakazawa Department of Oral and Maxillofacial Surgery Izimisano Municipal Hospital Rinku General Hospital lzumisano Osaka 598-0048 Japan Department of Radiology lzimisano Municipal Hospital Rinku General Hospital lzumisano Osaka 598-0048 Department of Oral and MaxiUofacial Surgery 11 Osaka University Graduate School of Dentistry Suita Osaka 565- 0871 Japan

Inta-arterial chemotherapy has been widely used for cancer treatment。A mandibular squamous cell cancer patient, T2N1M0 with severe heart complication should be treated with less invasive method of high-dose intra-arterial infusion chemotherapy。We tried the selective intra-arterial infusion by embolization of uninterested artery and report the case and problems。We estimated that the tumor feeding arteries were the lingual artery(LA), the facial artery(FA) and the inferior alveolar artery (IAA), which was a very small branch of the maxillary artery (MA)。To make an effective drug delivery to IAA, we planned the coil embolization of the main trunk of the MA just disal of the IAA branching。The catheter was introduced into the external carotid artery in a retrograde manner via the superficial temporal artery (STA), and coil embolization was performed at the intended area。We assured the location of catheter and the perfusion distribution by digital subtraction angiography (DSA) or Indigo Carmin staining。The catheter was positioned at the lowest area of external carotid artery and per-cutaneously fixed。Then we performed high-dose intra-arterial chemotherapy with CDDP under intravenous infusion of Sodium thiosulfate (STS), cisplatin neutralizer。Following angiogram and Indigo Carmine staining showed the intended selectiveness。We performed the selective intra-arterial infusion chemotherapy using a arterial embolization technique。It was otherwise very difficult to infuse super-selectively to the too small artery to insert a microcatheter。This method is very useful for patients of poor performance status。

关键词：口腔癌治疗方法化学疗法临床分析

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