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Molecular regulation of the key specialized metabolism pathways in medicinal plants

Journal of Integrative Plant Biology 2024年第3期66卷 510-531页

作者： Min Shi Siwei Zhang Zizhen Zheng itay maoz Lei Zhang Guoyin Kai Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and TransformationSchool of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhou 310053China Department of Postharvest Science Agricultural Research OrganizationVolcani CenterRishonLeZion 7505101Israel Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

The basis of modern pharmacology is the human ability to exploit the production of specialized metabolites from medical plants,for example,terpenoids,alkaloids,and phenolic ***,in most cases,the availability of these valuable compounds is limited by cellular or organelle barriers or spatio-temporal accumulation patterns within different plant *** factors(TFs)regulate biosynthesis of these specialized metabolites by tightly controlling the expression of biosynthetic ***-edge technologies and/or combining multiple strategies and approaches have been applied to elucidate the role of *** this review,we focus on recent progress in the transcription regulation mechanism of representative high-value products and describe the transcriptional regulatory network,and future perspectives are discussed,which will help develop high-yield plant resources.

关键词： biosynthesis medicinal plants omics secondary metabolism transcription factors

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Jasmonic acid regulates the biosynthesis of medicinal metabolites via the JAZ9-MYB76 complex in Salvia miltiorrhiza

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Horticulture Research 2023年第3期10卷 110-123页

作者： Shucan Liu Xiankui Gao Min Shi Meihong Sun Kunlun Li Yan Cai Chengan Chen Can Wang itay maoz Xinhong Guo Guoyin Kai Laboratory of Medicinal Plant Biotechnology School of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhouZhejiang 310053China College of Biology Hunan UniversityChangshaHunan 410082China Institute of Plant Biotechnology School of Life SciencesShanghai Normal UniversityShanghai 200234China Department of Postharvest Science AROThe Volcani CenterHaMaccabim Rd 68POB 15159Rishon LeZion7528809Israel

Jasmonic acid(JA)signaling pathway plays an important role in tanshinone and phenolic acid biosynthesis in Salvia ***,the specific regulatory mechanism remains largely *** work showed that a JASMONATE ZIM-domain(JAZ)protein,SmJAZ9,acted as a repressor of tanshinone production in *** this study,we revealed that SmJAZ9 reduced both phenolic acid accumulation and related biosynthetic gene expression,confirming that SmJAZ9 also negatively affected phenolic acid ***,we identified a novel MYB transcription factor,SmMYB76,which interacted with ***76 repressed phenolic acid biosynthesis by directly downregulating SmPAL1,Sm4CL2,and *** investigation demonstrated that JA mediated phenolic acids biosynthesis via SmJAZ9-SmMYB76 *** together,these findings state the molecular mechanism that SmJAZ9-SmMYB76 regulated phenolic acid biosynthesis at the transcriptional and protein levels,which provided new insights into JA signaling pathway regulating plant metabolism.

关键词： complex phenolic insight

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OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O-methyltransferase in Ophiorrhiza pumila

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Journal of Integrative Plant Biology 2023年第1期65卷 133-149页

作者： Xiaolong Hao Can Wang Wei Zhou Qingyan Ruan Chenhong Xie Yinkai Yang Chengyu Xiao Yan Cai Jingyi Wang Yao Wang Xuebin Zhang itay maoz Guoyin Kai Laboratory of Medicinal Plant Biotechnology School of Pharmaceutical SciencesAcademy of Chinese Medical Science Zhejiang Chinese Medical UniversityHangzhou 310053 China State Key Laboratory of Crop Stress Adaptation and Improvement Henan Joint International Laboratory for Crop Multi-Omics ResearchSchool of Life Sciences Henan UniversityKaifeng 475001 China Department of Postharvest Science ARO The Volcani Center HaMaccabim Rd 68POB 15159Rishon LeZion 7528809 Israel

Camptothecin(CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation of camptothecin are largely unknown. Ophiorrhiza pumila, the herbaceous plant from the Rubiaceae family, has emerged as a model plant for studying camptothecin biosynthesis and regulation. In this study, a high-quality reference genome of O. pumila with estimated size of ~456.90Mb was reported, and the accumulation level of camptothecin in roots was higher than that in stems and leaves. Based on its spatial distribution in the plant, we examined gene functions and expression by combining genomics with transcriptomic *** loganic acid O-methyltransferase(OpLAMTs)were identified in strictosidine-producing plant ***, and enzyme catalysis assays showed that OpLAMT1 and not OpLAMT2 could convert loganic acid into loganin. Further knock-out of OpL AMT1expression led to the elimination of loganin and camptothecin accumulation in O. pumila hairy *** key residues were identified in OpLAMT1 protein crucial for the catalytic activity of loganic acid to loganin. By co-expression network, we identified a NAC transcription factor, OpNAC1, as a candidate gene for regulating camptothecin *** hairy roots and biochemical assays demonstrated that OpNAC1 suppressed OpLAMT1 expression. Here, we reported on two camptothecin metabolic engineering strategies paving the road for industrial-scale production of camptothecin in CPT-producing plants.

关键词： camptothecin biosynthesis metabolic engineering strategies Ophiorrhiza pumila plant secondary metabolism transcriptional regulation

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Cytokinin but not gibberellin application had major impact on the phenylpropanoid pathway in grape

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Horticulture Research 2021年第1期8卷 599-613页

作者： Kamal Tyagi itay maoz Bettina Kochanek Noa Sela Larry Lerno Susan EEbeler Amnon Lichter Department of Postharvest Science Agricultural Research OrganizationThe Volcani CenterRishon LeZionIsrael Department of Viticulture and Enology University of CaliforniaDavisCA 95616USA Department of Plant Pathology Agricultural Research OrganizationThe Volcani CenterRishon LeZionIsrael Food Safety and Measurement Facility University of CaliforniaDavisCA 95616USA

Cytokinin and gibberellic acid(GA)are growth regulators used to increase berry size in seedless grapes and it is of interest to understand their effects on the phenylpropanoid pathway and on ripening *** 3 and synthetic cytokinin forchlorfenuron(N-(2-chloro-4-pyridyl)-N′-phenylurea,CPPU)and their combination were applied to 6 mm diameter fruitlets of‘Sable Seedless’,and berries were sampled 51 and 70 days(d)following *** treatments increased berry size and delayed sugar accumulation and acid degradation with a stronger effect of ***,but not GA,reduced berry color and the levels of *** CPPU reduced the levels of anthocyanins by more than 50%,the combined treatment of GA+CPPU reduced the levels by about 25%at 51 *** treatment had minor effects on flavonols content but increased the levels of monomeric flavan-3-ols by more than *** analysis using HPLC showed that proanthocyanidin content was significantly increased by CPPU,whereas mean degree of polymerization was reduced from 26 to *** analysis by GC-MS showed changes in composition with CPPU or GA treatment with potential impact on ***-seq analysis showed that GA had a minor overall effect on the transcriptome whereas CPPU had pronounced effects on gene expression at both 51 and 70 *** the control and CPPU at similar Brix of ca.19.7°,a reduced expression of stilbene synthases(STSs)including their regulators MYB14 and MYB15,and other phenylpropanoid-related genes was observed in CPPU-treated ***,our study shows that CPPU had a major influence on the phenylpropanoid pathway and affected multiple ripening-related processes.

关键词： CPPU impact treatment

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