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Microscopic colitis: A retrospective study of clinical presentation in 53 patients

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World Journal of Gastroenterology 2005年第9期11卷 1351-1355页

作者： Zsolt Barta Gabriella Mekkel istván csíp(o|") László Tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher Third Department of Medicine Department of pathology

AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and ***: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively ***: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation ***: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups.

关键词： Microscopic colitis Constipation Autoimmune

On non-normal Arc-Transitive 4-Valent Dihedrants

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1485-1498页

作者： istván KOVcs Botjan KUZMAn Aleksander MALnI FAMnIT University of Primorska peF University of Ljubljana IMFM University of Ljubljana

Let X be a connected non-normal 4-valent arc-transitive Cayley graph on a dihedral group Dn such that X is bipartite, with the two bipartition sets being the two orbits of the cyclic subgroup within Dn. It is shown that X is isomorphic either to the lexicographic product Cn[2K1] with n 〉 4 even, or to one of the five sporadic graphs on 10, 14, 26, 28 and 30 vertices, respectively.

关键词： Cayley graph arc transitivity dihedral group

Impacts of pI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(pI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the pI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/pI3K/AKT/connexin 43,and notch/pI3K/AKT *** targeting the inactivation of the pI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the pI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Isomorphisms of Cubic Cayley Graphs on Dihedral Groups and Sparse Circulant Matrices

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Acta Mathematica Sinica,English Series 2023年第4期39卷 618-632页

作者： istvan KOVAcs Up IAM&FAMnIT University of PrimorskaMuzejski trg 26000 KoperSlovenia

We show that,up to isomorphism,there is a unique non-CI connected cubic Cayley graph on the dihedral group of order 2n for each even number n≥*** answers in the negative the question of Li whether all connected cubic Cayley graphs are CI-graphs(Discrete Math.,256,301-334(2002)).As an application,a formula is derived for the number of isomorphism classes of connected cubic Cayley graphs on dihedral groups,which generalises the earlier formula of Huang et *** with the particular case when n is a prime(Acta ***.,***.,33,996-1011(2017)).As another application,a short proof is also given for a result on sparse circulant matrices obtained by Wiedemann and Zieve(arXiv preprint,(2007)).

关键词： Cayley graph graph isomorphism dihedral group circulant matrix

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen cs De Oliveira Luiz C Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy

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World Journal of Gastroenterology 2013年第6期19卷 889-896页

作者： istván Rácz Milán Szalai Valéria Kovács Henriett Regczi Gyngyi Kiss Zoltán Horváth Department of Gastroenterology Petz Aladár County and Teaching Hospital Department of Mathematics and Computational Sciences Széchenyi István University

AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the pillCam SB CE system with RApID 5 *** Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal *** patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were *** with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the *** this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d *** the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS *** primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine ***:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one *** patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS n five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two *** patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was *** comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,p=0.271).Moreover,a significant difference between pre-and post-t

关键词： nonsteroidal anti-inflammatory drug Small bowel enteropathy Mesalazine granules Mucosal healing Capsule endoscopy

Water in the upper mantle and deep crust of eastern China: concentration, distribution and implications

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national Science Review 2019年第1期6卷 125-144页

作者： Qun-Ke Xia Jia Liu istván Kovács Yan-Tao Hao pei Li Xiao-Zhi Yang Huan Chen Ying-Ming Sheng School of Earth Sciences Zhejiang University CAS Key Laboratory of Crust-Mantle Materials and Environments University of Science and Technology of China Hungarian Geological and Geophysical Institute 4. School of Earth Sciences and Engineering Nanjing University

Understanding the concentration and distribution of water in the Earth’s mantle plays a substantial role in studying its chemical, physical and dynamic processes. After a decade of research, a comprehensive dataset of water content in upper-mantle samples has been built for eastern China, which is now the only place with water-content data from such diverse types of natural samples, and provides an integrated picture of the water content and its distribution in the upper mantle at a continental scale. The main findings include the following:(i) the temporal heterogeneity of the water content in the lithospheric mantle from early Cretaceous(～120 Ma) to Cenozoic(nnected with the stability of the north China Craton(from its destruction to its consolidation);(ii) the heterogeneous water content in the Cenozoic lithospheric mantle beneath different blocks of eastern China was not only inherited from tectonic settings from which they came, but was also affected later by geological processes they experienced;(iii) the distinct water content between the lowermost crust and lithospheric mantle of eastern China and its induced rheological contrast at the base of the crust indicate that the continental crust–mantle boundary could behave either in a coupled or decoupled manner beneath different areas and/or at different stages;(iv) the alkali basalts of eastern China demonstrate a heterogeneous distribution of water content in the mantle;local and regional comparisons of the water content between the lithospheric mantle and basalts’ source indicate that the Cenozoic alkali basalts in eastern China were not sourced from the lithospheric ***, the inferred high water contents in the mantle sources suggest that the Cenozoic eastern China basalts were likely sourced from the mantle transition zone(MTZ); and(v) both oceanic and continental crusts may carry a certain amount of water back into the deep mantle of eastern China by plate *** re

关键词： water upper mantle and deep crust continental stability basalt genesis eastern China

Rendering algorithms for aberrated human vision simulation

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Visual Computing for Industry,Biomedicine,and Art 2023年第1期6卷 51-75页

作者： istván csoba Roland Kunkli Faculty of Informatics University of DebrecenDebrecen 4028Hungary Doctoral School of Informatics University of DebrecenDebrecen 4028Hungary

Vision-simulated imagery―the process of generating images that mimic the human visual system―is a valuable tool with a wide spectrum of possible applications, including visual acuity measurements, personalized planning of corrective lenses and surgeries, vision-correcting displays, vision-related hardware development, and extended reality discomfort reduction. A critical property of human vision is that it is imperfect because of the highly influential wavefront aberrations that vary from person to person. This study provides an overview of the existing computational image generation techniques that properly simulate human vision in the presence of wavefront aberrations. These algorithms typically apply ray tracing with a detailed description of the simulated eye or utilize the point-spread func-tion of the eye to perform convolution on the input image. Based on the description of the vision simulation tech-niques, several of their characteristic features have been evaluated and some potential application areas and research directions have been outlined.

关键词： Human vision Human visual system Vision simulation Wavefront aberrations Visual aberrations Vision-realistic rendering