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Classification of breast microcalcifications: radiological-pathological correlation

中华医学杂志(英文版) 2005年第17期000卷 23-29页

作者： SUN Zhe,LIANG Hong-wei and XU Hui-mianDepartment of Oncological Surgery, first affiliated hospital of china medical university, shenyang 110001, china Department of Oncological Surgery First Affiliated Hospital of China Medical University Shenyang 110001 China

Background Microcalcifications play a very important role in detection of breast cancer, especially early stagebreast ***, ambiguity still exists in understanding the relationship between radiological andpathological characteristics of *** definitive indication of a biopsy has not been *** purpose of this study is to evaluate the relationship of classification of breast microcalcifications using full-field digital mammography to the pathological *** For all the women an open biopsy had been *** hundred and three mammographsshowing clustered microcalcifications from 98 consecutive patients were reviewed along with their *** investigate the value of each criterion for the detection of cancer, univariate and multivariate analyseswere performed on the entire sample and then on morphological *** Pathological examination showed 67 malignant lesions (65.05%) and 36 benign lesions (34.95%).In the univariate analysis, four radiological variables were significant: morphological type (P=0.001),complicated by a mass (P=0.002), number of microcalcifications per cluster (P=0.02) and linear ortriangular distribution of clusters (P=0.009).In the multivariate analysis, two criteria remained significant:morphological type (P<0.001) and complicated by a mass (P=0.001).The percentage of malignancy was37.0%, 60.0%, 78.8%, and 88.9%, respectively, for type 2 (regularly punctiform), type 3 (dusty), type4 ( irregularly punctiform) and type 5 ( vermicular) microcalcifications ( Le Gal’s classification).Themalignancy was78.6% for microcalcifications complicated by a mass and 48.9% without a *** differencewas significant (P<0.05).The relationship between morphological types of microcalcifications and thepathological characteristics was also *** subgroups, type 3 (dusty) microcalcifications complicated by amass (P=0.001) or with the number of microcalcifications more than 10 (P

关键词： calcinosis · breast neoplasms · mammography

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Decreased IgA+ plasma cells and IgA expression in acute liver necrosis mice

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World Journal of Gastroenterology 2010年第30期16卷 3827-3833页

作者： Jin-Long Fu, Zhao-Han Wang, Guo-Zhen Li, Yu-Rong Wang, Pei Liu, Department of Infectious Diseases, The first Aff iliated hospital, china medical university, shenyang 110001, Liaoning Province, china Department of Infectious Diseases The First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China.

AIM: To investigate the number of intestinal immunoglobulin A (IgA+) plasma cells and expression of intestinal IgA in mice with acute liver necrosis. METHODS: A model of acute liver necrosis was established by intraperitoneal injection of galactosamine (GalN) and lipopolysaccharide (LPS). Sixty mice were randomly divided into one of 4 equal groups: normal control, acute liver necrosis, LPS, or GalN. Hematoxylin and eosin staining, immunohistochemistry, and an enzyme-linked immunosorbent assay were employed to assess liver and intestinal injury, count intestinal IgA+ plasma cells, and measure the expression level of IgA and interferon γ (IFN-γ) in the small intestinal mucosa of mice. RESULTS: Injured intestinal mucosa was observed in the acute liver necrosis group but not in the normal, LPS or GalN groups. Compared with the normal group,intestinal IgA+ plasma cells were slightly decreased in the LPS and GalN groups [429 ± 20 per high power f ield (HPF), 406 ± 18/HPF, respectively], whereas they were markedly decreased in the acute liver necrosis group (282 ± 17/HPF vs 495 ± 26/HPF in normal group, P 0.05). CONCLUSION: Intestinal IgA+ plasma cells and IgA expression levels indicating that mucosal immune barrier dysfunction, does exist in acute liver necrosis.

关键词： Acute liver necrosis Intestinal mucosa Immunity Immunoglobulin A

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Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer's disease:a meta-analysis

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 401-405页

作者： Xue-Fei He 1,Yi-Ting Liu 2,Cheng Peng 1,Fan Zhang 1,Shi Zhuang 1,Jin-Song Zhang 1 1Key Laboratory of Lens Research Liaoning Province,Department of Ophthalmology,Eye hospital of china medical university,the Fourth affiliated hospital of china medical university shenyang 110005,Liaoning Province,china 2 Department of Clinical Epidemiology,the first affiliated hospital,china medical university,shenyang 110001,Liaoning Province,china Key Laboratory of Lens Research Liaoning Province Department of Ophthalmology Eye Hospital of China Medical University the Fourth Affiliated Hospital of China Medical University Shenyang 110005 Liaoning Province China.

AIM:To investigate the difference of retinal nerve fiber layer(RNFL) thickness between Alzheimer's disease patients and normal people,so as to provide clue for the early diagnosis of Alzheimer's disease.· METHODS:The articles on the association of RNFL thickness and Alzheimer's disease were retrieved by searching international and national *** qualified articles were assessed by meta analysis with Stata11.0 *** results were pooled using weighted mean difference(WMD) with a corresponding 95% confidence interval(CI).· RESULTS:Totally 7 studies enrolled 324 eyes were included in the *** results of meta analysis showed that in AD patients,there was a significant average RNFL thickness reduction compared with the control group [WMD=-17.561,95%CI:(-23.971,-11.151)].There were significant differences in superior,inferior,nasal and temporal RNFL thickness between the two *** with a 95%CI were [-18.829,95%CI:(-25.915,-11.743);P<0.05],[-25.775,95%CI:(-34.304,-17.247);P <0.05],[-16.877,95%CI:(-29.141,-4.613);P<0.001] and [-14.565,95%CI:(-28.002,-1.128);P<0.001] ***'s test and Egger's test did not show significant difference,funnel plot was basically symmetrical,indicating that there was no publication bias existed.· CONCLUSION:There are significant differences in the RNFL thickness in all quadrants between the two *** thickness is reduced in AD patients compared with the control group.·

关键词： retinal nerve fiber layer thickness optical coherence tomography Alzheimer's disease meta analysis

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Detecting cancer cell-surface glycome profilings by lectin microarray

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生物物理学报 2009年第S1期25卷 203-204页

作者： Chun-Hui Li 1, Qun He 1, Yu-Jie Zhao1 1 Biochip Center, Key Laboratory of Cell Biology, Ministry of Public Health of china, china medical university, shenyang 110001, china 2 Department of Pathology, The first affiliated hospital and College of Basic medical Sciences, china medical university, shenyang 110001, china

Objective: Glycomics is an emerging field in the postgenome and postproteome era. Glycosylation changes of cell-surface have been observed in tumour cell progression

关键词： lectin microarray glycome profilings biomarker

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Protective effect of zinc: a potent heat shock protein inducer in cold preservation of rat liver

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Hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 258-261页

作者： Ying Cheng Yong-Feng Liu Jian Liang From the Organ Transplant Institute, first hospital,china medical university, shenyang 110001, china Organ Transplant Institute First Hospital China Medical University Shenyang 110001 China

Objective: To study the synthesis of heat shock pro- tein 70 (HSP70) by zinc ( ZnSO_4) and its protective effect during cold preservation in rat liver by estab- lishment of a simple cold preservation model. Methods: Wistar rats were divided into 5 groups (n =6): control group untreated before operation; Zn- 1, Zn-2, and Zn-3 groups treated before operation with zinc sulfate (Zn^(2+) 5 mg/kg, 10 mg/kg, 15 mg/ kg respectively); H group treated with heat shock (42.5 ℃×15 min). The livers of the rats were pre- served in UW solution for 6, 12, 24 hours. The re- sults of heat shock protein (HSP) synthesis were ana- lyzed with Western blot. The aspartate aminotrans- ferase (AST) and lactic dehydrogenase (LDH) values of perfusion and histological findings were evaluated. Results: A great amount of HSPs was synthesized af- ter pretreatment with zinc and heat shock. The AST and LDH values of the Zn-1, Zn-2 and H groups were significantly lower than those of the C group (P <0.05). But the value of the Zn-3 group was much higher. Histologically, mild injury was observed in the Zn-1, Zn-2 and H groups, but severe injury in the Zn-3 group. Conclusions: Zn^(2+), as a potent and feasible inducer of HSP expression, is able to protect the liver for cold preservation. Proper induction dosage of Zn^(2+) ranges from 5 mg/kg to 10 mg/kg, and Zn^(2+) 15 mg/ kg could not be a stress conditioning factor for its ad- verse effect on rat liver.

关键词： zinc heat shock protein rat liver

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5-Hydroxytryptamine-induced proliferation of pulmonary artery smooth muscle cells are extracellular signal-regulated kinase pathway dependent

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Acta Pharmacologica Sinica 2005年第5期26卷 563-567页

作者： Dan SONG,Huai-liang WANG~2,Shuang WANG,Xin-hua ZHANGDepartment of Clinical Pharmacology,china medical university,shenyang 110001,china Department of Clinical Pharmacology China Medical University Shenyang China

Aim:To investigate the effect of 5-hydroxytryptamine transporter(5-HTT)inhibi-tor fluoxetine and antisense oligodeoxynucleotide(ODN)to extracelluar signal-regulated kinases(ERKs)on pulmonary arterial smooth muscle cells(PASMCs)proliferation induced by ***:Liposomal transfection was used tointroduce ODNs to ERK1/2 into cultured rat PASMCs and the transfection effi-ciency was measured by observing the uptake of the fluorecein isothiocynate(FITC)-labeled antisense ODN in *** effects of 5-HTT selective inhibi-tor fluoxetine and ODNs on the proliferation of PASMCs were evaluated by cellnumber counting and cell cycle analysis,and measured by microculture tetrazo-lium(MTT)assay and flow cytometry(FCM),***:Liposomesmediated the transfection of ODNs into PASMCs with high *** showed fluoxetine(10μmol/L,1 μmol/L,and 100 nmol/L)concentrationdependently inhibited the proliferation of PASMCs induced by 5-HT(1 μmol/L)*** proliferation rate of PASMCs by 5-HT was significantly inhibited bypretreatment with ERK1/2 antisense ODN(0.2μmol/L)from 251%±18% to 86%±5%(P<0.01).Flow cytometric analysis of cell cycle distribution showed that theincrease of 5-HT induced S phase fraction(SPF)and proliferation index(PI)weresignificantly inhibited by fluoxetine(1μmol/L)or antisense ODN with SPF from36%±4% to 26%±3% and 24%±4%,and PI from 34%±2% to 29%±2% and 24%±2%,***:5-HTT mediates the mitogenic effect of 5-HT onPASMCs and the proliferation of PASMCs induced by 5-HT is dependent onERKs signal pathway.

关键词： antisense oligodeoxyribonucleotides serotonin membrane transport proteins pulmonary hypertension vascular smooth muscle fluxetine mitogen-activated protein kinases

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Hepatic blood inflow occlusion without hemihepatic artery control in treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第46期16卷 5895-5900页

作者： Shan Jin,Department of General Surgery,affiliated hospital of Inner Mongolia medical College,Hohhot 010050,Inner Mongolia Autonomous Region,china Chao-Liu Dai,Department of Hepatobiliary Surgery,Shengjing hospital,china medical university,shenyang,Liaoning Province,china Department of General Surgery Affiliated Hospital of Inner Mongolia Medical College Hohhot 010050 Inner Mongolia Autonomous Region China. jinshangood@***

AIM:To investigate the clinical significance of hepatic blood inflow occlusion without hemihepatic artery control (BIOwHAC) in the treatment of hepatocellular carcinoma (HCC).METHODS:Fifty-nine patients with HCC were divided into 3 groups based on the technique used for achieving hepatic vascular occlusion:group 1,vascular occlusion was achieved by the Pringle maneuver (n=20);group 2,by hemihepatic vascular occlusion (HVO) (n=20);and group 3,by BIOwHAC (n=19).We compared the procedures among the three groups in term of operation time,intraoperative bleeding,postoperative liver function,postoperative complications,and length of hospital ***:There were no statistically significant differences (P > 0.05) in age,sex,pathological diagnosis,preoperative Child's disease grade,hepatic function,and tumor size among the three *** intraoperative complications or deaths occurrred,and there were no significant intergroup differences (P > 0.05) in intraoperative bleeding,hepatic function change 3 and 7 d after operation,the incidence of complications,and length of hospital *** and Pringle maneuver required a significantly shorter operation time than HVO;the difference in the serum alanine aminotransferase or aspartate aminotransferase levels before and 1 d after operation was more significant in the BIOwHAC and HVO groups than in the Pringle maneuver group (P < 0.05).CONCLUSION:BIOwHAC is convenient and safe;this technique causes slight hepatic ischemia-reperfusion injury similar to HVO.

关键词： Hepatic blood inflow occlusion without hemihepatic artery control Hepatocellular carcinoma Intraoperative bleeding Ischemia-reperfusion injury

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Hepatobiliary membrane transporters involving in the formation of cholesterol calculus

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 286-289页

作者： Fan-Min Kong, Chun-Yang Sui, Yu-Ji Li, Ke-Jian Guo and Ren-Xuan Guo Department of General Surgery, first affiliated hospital, china medical university, shenyang 110001, china Department of General Surgery First Affiliated Hospital China Medical University Shenyang 110001 China. kong_fanmin@***

BACKGROUND: Cholecyst cholesterol lithiasis is a common disease of the digestive system; however, the cause of lithogenesis is still unclear. Although bile salt export pump (BSEP), multidrug resistance protein 2 (MRP2), and multiple drug resistance 3 (MDR3 ) are 3 well-known transporting proteins, their effect on lithogenesis has not been elucidated. This study was undertaken to examine the relationship between BSEP, MRP2, MDR3, and cholesterol calculus formation. METHODS: Liver tissue specimens were taken from 20 patients with cholesterol calculus and from 10 patients with normal liver. mRNA and protein expressions of BSEP, MRP2, and MDR3 were determined by reverse tran-scriptase-polymerase chain reaction (RT-PCR) and Western blot, respectively. This study was approved by the ethics committee of china medical university and informed consent was obtained from all patients. RESULTS: mRNA and protein expressions of BSEP, MRP2, and MDR3 were significantly down-regulated in the liver tissue of the patients with cholesterol calculus compared with normal liver tissue of the controls. CONCLUSION: The down-regulation of BSEP, MRP2, and MDR3 may be correlated with the formation of cholesterol calculus.

关键词： cholecyst cholesterol lithiasis bile salt export pump multidrug resistance protein 2 multiple drug resistance 3

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Prognostic Factors for Patients after Curative Resection for Proximal Gastric Cancer

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Journal of Huazhong university of Science and Technology(medical Sciences) 2010年第4期30卷 530-535页

作者：赵东晖徐惠绵李凯孙哲 Department of Surgical Oncology Research Unit of General Surgery Department of Gastrointestinal Oncosurgery First Affiliated Hospital of China Medical University

The factors influencing the long-term survival of patients with proximal gastric cancer (PGC) after curative resection were investigated. Data from 171 patients who underwent curative resection for PGC were retrospectively analyzed. The patients were grouped according to the clinicopathological factors and operative procedures. The tumor depth (T stage) and lymph node metastasis (pN stage) were graded according to the fifth edition of TNM Staging System published by UICC in 1997. The metastatic lymph node ratio (MLR) was divided into four levels: 0%, 30%. The data of survival rate were analyzed by Kaplan-Meier method (log-rank test) and Cox regression model. The 5-year overall survival rate of 171 patients was 37.32%. The univariate analysis demonstrated that the survival time of the postoperative patients with PGC was related to tumor size (χ2=4.57, P=0.0325), gross type (χ2=21.38, P30% (χ2=13.34, P=0.0003), TNM Ⅲ (χ2=14.05, P=0.0002) or TNM Ⅳ stage (χ2=4.37, P=0.0366); and combining splenectomy was beneficial to the cases of T3 (χ2=5.68, P=0.0171) or MLR >30% (χ2=6.11, P=0.0134). It was concluded that MLR, pN stage, TNM stage, T stage, and gross type had advantages in providing a precise prognostic evaluation for patients undergoing curative resection for PGC, in which MLR was the most valuable index. TG and combining splenectomy were useful to improve the prognosis to patients with PGC of TNM Ⅲ/Ⅲ stage, serosa invasion, or extensive regional lymph node metastasis.

关键词： stomach neoplasms proximal gastric cancer curative resection prognosis.

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Protective effects of L-arginine on reperfusion injury after pancreaticoduodenal transplantation in rats

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 349-354页

作者： Chun-Hui Yuan, Yong-Feng Liu, Ying Cheng, Ning Zhao, Gui-Chen Li,Jing Liang and San-Guang He Department of Organ Transplantation, first affiliated hospital of china medical university, shenyang 110001 , china Department of Organ Transplantation First Affiliated Hospital of China Medical University Shenyang 110001 China. ychdoctor@***

BACKGROUND: Post-transplantation pancreatitis andgraft thrombosis are two major complications of pancreastrans-plantation that contribute to morbidity, mortality, andgraft loss. Nitric oxide (NO) is a potent vasodilator agentformed when L-arginine ( L-Arg) is converted to L-citrul-line by the action of NO synthase (NOS), and plays a ma-jor role in microcirculatory changes. We therefore investi-gated the effect of L-Arg on reperfusion injury followingpancreaticoduodenal transplantation in ***: The homologous male Wistar rat model ofheterotopic total pancreaticoduodenal transplantation wasused. The L-Arg-treated rats received the intravenous in-jection of L-Arg 5 minutes before and after reperfusion at adose of 200 mg/kg while the N-Nitro-L-arginine methyl es-ter (L-NAME) -treated rats at a dose of 10 mg/kg. Theamount of NO in the pancreas graft was measured. Serumconcentration of cytokine-induced neutrophil chemoattrac-tant ( CINC) was determined by enzyme-linked immu-nosorbant assay, the expression of CINC mRNA was detect-ed by Northern blot assay in the pancreas graft, and the ac-tivity of myeloperoxidase (MPO) was measured. Histolo-gical examination was ***: The amount of NO was higher in the L-Arggroup than in the control group, while it was lower in theL-NAME group than in the control group (P <0.05). Thepeak of serum CINC concentration occurred 3 hours afterreperfusion with the difference among the groups being sig-nificant. The expression peak of CINC mRNA in the pan-creas graft occurred 3 hours after reperfusion. The expres-sion level in the L-Arg group (7.66 ± 1.53 μg/L) was lowerthan in the control group (26.31±2.01 μg/L), while in theL-NAME group (34.18 ±3.12 μg/L) it was higher than thatin the control group (P <0. 05). The activity of MPO inthe L-Arg group was obviously decreasd as compared within the other groups. The pancreas inflammation was ame-liorated when L-Arg was administered, whereas the panc-reas damage was aggravated whe

关键词： pancreas transplantation reperfusion L-arginine

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