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Sweet□s Syndrome:Retrospective Study of 42 Cases

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Sweet□s Syndrome:Retrospective Study of 42 Cases

Hyperbaric Oxygen Therapy in Acute Traumatic Peripheral Ischemic Diseases

The 10th china-Japan Joint Meeting of Dermatology 20th Anniversary

作者： Honghui Xu Ting Xiao Chundi He Xinghua Gao Long Geng Hongduo Chen Department of Dermatology first hospital of china medical university shenyang 110001 china

＜正＞Objective:To describe and evaluate clinical,histopathological and therapeutic features of Sweet’s syndrome（SS）.All the patients fulfilled Su’s diagnostic criteria.

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Hyperbaric Oxygen Therapy in Acute Traumatic Peripheral Isch...

A nude mouse model of endometriosis and its biological behaviors

第十六届国际高气压医学学术会议暨第十七届全国高压氧医学学术会议

作者： Wang Gang M.D.Ph.D. Emergency Dept & Hyperbaric Oxygen Dept.first affiliated hospital,china medical university,shenyang,china

HBO can be used as adjunctive therapy for trauma patients with crush injury,compartment syndrome,and other acute traumatic peripheral ischemia(ATPI).The rationale for HBOT is the need to counter the effects of tissue hypoxia arising as a direct consequence of vascular injury and as a secondary consequence of trauma and infection.

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中华医学杂志(英文版) 2005年第18期000卷 70-73页

作者： WANG Dan-bo, ZHANG Shu-lan,NIU Hui-yan and LU Jing-ming Department of Obstetrics and Gynecology, Second hospital of china medical university, shenyang 110004, china Department of Obstetrics and Gynecology Second Hospital of China Medical University Shenyang 110004 China

Endometriosis (EM) as a common and intractable gynecological disease is characterized by unknown etiology and complex pathologic changes. Many factors of the disease are uncertain at the molecular level and it is difficult to study clinically. In this study, we attempted to establish a nude mice model of EM for dynamical observation of the genesis and development of the disease, morphological changes in tissue, and biological behaviors. METHODS Tissue processing The endometrium of late secretory phase was obtained from 24 patients with endometriosis and 24 normal premenopausal women undergoing endometrial biopsy or hysterectomy. Some fresh endometrial tissues were kept at -70℃, and others were washed in phosphate buffer solution (PBS) and cut into 2-3 mm3 fragments under sterile conditions. The tissues were transported in a mixture of PBS, 200 U/ml penicillin, and 200 μg/ml streptomycin. The specimens of the human greater omentum were obtained from patients with benign gynecologic diseases, and processed as the endometrial tissues. All the above tissues were proved normal pathologically after operation.

关键词： endometriosis · models animal · mice nude

Efficacy of intraperitoneal thermochemotherapy and immunotherapy in intraperitoneal recurrence after gastrointestinal cancer resection

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World Journal of Gastroenterology 2002年第6期8卷 1019-1022页

作者： Qing-Guo Fu Fan-Dong Meng Xiao-Dong Shen Ren-Xuan Guo,The Second General Surgery Department of The first Clinical College,china medical university,shenyang 110001,Liaoning Province,china The Second General Surgery Department of The first Clinical College China Medical University Shenyang 110001 Liaoning Province China. qingguofu@***

AIM:To investigate the prophylactic and therapeutic efficacy of intraperitoneal IL-2 innunotherapy following intraperitoneal thermochemotheray int the metastasis and recurrence of gastric and colorectal cancer after o... 详细信息

关键词：胃肠癌切除术手术后腹膜内复发腹膜内化疗免疫疗法治疗效果

The expression of glucose regulated protein-94 in colorectal carcinoma cells treated by sodium butyrate

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Cell Research 2000年第2期10卷 115-125页

作者： WU YI DI JIN DAN SONG( Fax: (024)23256087 E-mail: jdsong@***)(Key Laboratory of Cell Biology, Ministry of Public Health of chinaInstitute of medical Molecular Biology, china medical university, 92 Beier Rd. Heping District, shenyang 110001, Key Laboratory of Cell Biology Ministry of Public Health of China Institute of Medical Molecular Biology China Medical University Heping District China

The expression of glucose regulated protein 94 (GRP94)during the treatment of human colorectal carcinoma cell lineClone A cells with sodium butyrate was studied. Sodium butyrate (SB) can cause functional and morphological effects on Clone A cells including growth arrest at Go/G1 stage and cell differentiation as observed by morphological changes, MTT and flow cytometry assays, as well as reduced Grp94 gene expression as shown by Northern blot and Western blot assays. The possible mechanism of the correlation between Grp94 gene expression and tumor growth inhibition and cell differentiation is briefly discussed.

关键词： HSPs Grp94 sodium butyrate colorectal carcinoma cells

Expression of prostaglandin E_2 receptors in rat hippocampus

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Neural Regeneration Research 2006年第7期1卷 668-669页

作者： Fang Liu1,2, Weidong Xu1, Xijiu Fu1, Jie Li1, Yanrong Song1, Xiaolin Li1, Xiaoxin He1, Dong Han1, Qiuxia Li1, Yuhua Chen3 1Department of Neurology, Fengtian hospital, shenyang medical College, shenyang 110024, Liaoning Province, china 2university of South Carolina, USA 3Department of Development, china medical university, shenyang 110024, Liaoning Province, china Department of Neurology Fengtian Hospital Shenyang Medical College Shenyang 110024 Liaoning Province China university of South Carolina Columbia SC United States Department of Development China Medical University Shenyang 110024 Liaoning Province China

BACKGROUND: Prostaglandin E2 (PGE2) can directly regulate toxic injury of hippocampal neurons through participation by its receptor. Increase of excitability of hippocampal membrane and long-term synaptic elasticity are closely related to PGE2, PGD2 and PGF2A. This suggests that PGE2 may be a key molecule of neuronal signal passage and regulate the existence of neurons through its receptor. However, which isoforms of PGE2 receptor expressing in hippocampal neurons is still unclear. OBJECTIVE: To research the subtype expression of PGE2 receptor in hippocampus of rats through mRNA transcription and protein interpretation. DESIGN: Animal studies with random, control and operator and designer double-blind methods. SETTING: university of South Carolina, Animal Center. MATERIALS: Sprague-Dawley rats, aged 12 weeks, weighing 200 g, females 48 and males 48, were selected from Animal Center in South Carolina university. Tri ReagentTM kit was provided by Molecular Research Center, USA. METHODS: The experiment was carried out in Animal Center in South Carolina university from January to December 2005. The expression of the PGE2 receptors was profiled and compared in rat hippocampus using real-time RT-PCR and Western-blot techniques. MAIN OUTCOME MEASURES: Expression of PGE2 receptors in various isoforms of hippocampal neurons of rats. RESULTS: mRNAs of all four EP1-4 subtypes were detected in the hippocampus. Western-blot data showed consistently detectable bands at approximately Mr 50 000 of EP1, Mr 40 000 and Mr 52 000 of EP2, Mr 45 000, Mr 57 000 and Mr 105 000 of EP3, and Mr 46 000 of EP4. CONCLUSION: Identifying four subtypes of EPs heterogeneously expresses in the hippocampus.

关键词： PCR Expression of prostaglandin E2 receptors in rat hippocampus PGE

The Gamma Fuzzy Reliability Design of Vehicle parts

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The Gamma Fuzzy Reliability Design of Vehicle parts

2009中国控制与决策会议

作者： Tie Wang~1,Gaonan Wang~2,Jianyang Lin~3 1.School of Vehicle,shenyang Ligong university,shenyang 110168,china. 2.School of Mechanical Engineering,Tsinghua university,Beijing 100084,china. 3.The first affiliated hospital,china medical university,shenyang 110001,china

With considering lightening and safety of strength,integrations of both distribution’s density and function’s density,the normal fussy reliability formulas about vehicle parts that forces,strengths are gamma distribution and subordinate is parabola of exponential k was gotten;first integral change was achieved according to initial data and function imported and extent of integrated,second this number result with VB program in the computer was achieved by using middle-points integral calculus and romberg integration. This program can be used in design of vehicle parts for rising up level of design.

关键词： Vehicle parts Reliability design Gamma distribution Fussy mathematics

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人胃癌细胞腹膜粘附影响因素的实验研究

中华肿瘤杂志 1999年第5期21卷 336-338页

作者：刘庆华陈峻青中国医科大学附属第一医院肿瘤科沈阳110001

目的　探讨影响人胃癌细胞在腹膜粘附的因素，为临床上采取有效措施，减少腹膜转移的发生提供依据。方法　用人胃癌细胞株在小鼠腹膜上培养，以ＭＴＴ法检测粘附细胞数的体外实验模型，观察腹膜损伤、血液成分和癌胚抗原（ＣＥＡ）对胃... 详细信息

目的　探讨影响人胃癌细胞在腹膜粘附的因素，为临床上采取有效措施，减少腹膜转移的发生提供依据。方法　用人胃癌细胞株在小鼠腹膜上培养，以ＭＴＴ法检测粘附细胞数的体外实验模型，观察腹膜损伤、血液成分和癌胚抗原（ＣＥＡ）对胃癌细胞在腹膜粘附的影响。结果　腹膜损伤组的粘附细胞数（ＡＤ）较对照组明显增高（Ｐ＜０－０１）。血液中的白细胞、血小板组ＡＤ值较对照组明显增高（Ｐ＜０－０１），血浆组ＡＤ值亦较对照组增高（Ｐ＜０－０５）。ＣＥＡ组ＡＤ值明显高于对照组（Ｐ＜０－０５）。结论　腹膜损伤、血液成分中的白细胞、血小板、血浆以及ＣＥＡ，均可增加癌细胞在腹膜的粘附。减少腹膜损伤，减少血液中的粘附因子及ＣＥＡ在腹腔滞留机会。

关键词：胃肿瘤腹膜瘤腹膜粘附影响因素实验研究

Effect of Xiaofenghuoxue decotion on Th1 and Th2 cytokine production in BALF in allergen-induced asthma guinea pigs

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沈阳药科大学学报 2008年第S1期25卷 108-109页

作者： LI Hong1,XIA Ming-yu2,CHEN Li1,ZHOU Lian-di3,WANG Zhi-hui2,HUANG Jia-nan4,ZHANG Qi-hui5(1.Department of Respiratory Medicine,Kunshan hospital of Traditional Chinese 215300 2.School of Life Science and Biopharmaceutics,shenyang Pharmaceutical university,shenyang 110016 china 3.Department of Immunology,china medical university,shenyang 110016 4.Department of Respiratory Medicine,first affiliated hospital of Soochow university 215006 5.School of Traditional Chinese Material Medica shenyang Pharmaceutical university,shenyang 110016 china)

Objective To investigate the effect of Xiaofenghuoxue decotion(XFHX)on the production of Th1 and Th2 cytokine in bronchoalveolar lavage fluid(BALF)in asthma guinea pigs sensitized and challenged with *** The animals were randomly divided into 5 groups:the normal control group,the asthma group,the XFHX high dose group,the XFHX low dose group and the budesonide group.2 weeks after sensitization with a mixture of 10% OVA and 10% Al(OH)3,the drugs were given to the animals for 7 days,and then the animals were challenged with aerosol of 1% ovalbumin,the latency time for the onset of respiratory abnormalities was examined,BALF was collected 16 h *** in BALF was *** level of IFN-γ reduced by Th1 cells and IL-4 and IL-5 produced by Th2 cells were determined by *** contents were also *** The latency time for the onset of respiratory abnormalities and leukocyte infiltration in both XFHX high dose group and low dose group significantly decreased compared with the asthma *** level of IFN-γ in both XFHX high dose group and low dose group significantly increased compared with the asthma group,the level of IL-4 and IL-5 in both XFHX high dose group and low dose group significantly decreased compared with the asthma *** production of NO was inhibited in both XFHX high dose group and low dose group compared with the asthma *** These results suggest that the anti-asthma effect of Xiaofenghuoxue decotion is associated with NO regulated reversal of Th1/Th2 cytokine balance in allergen-induced asthma guinea pigs.

关键词： Xiaofenghuoxue asthma IFN-γ IL-4 IL-5 NO