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Research.on fault time prediction meth.d for h.gh.speed rail BTM unit based on multi meth.d interactive validation

h.gh.speed Railway 2024年第3期2卷 164-171页

作者： Fu L. Gou J. Sun C. Li h. Liu W. Sch.ol of Information Science and Tech.ology Southwest Jiaotong University Chengdu 611756 China Ch.na Railway Signal and Communication Research.and Design Institute Group Co Ltd Beijing 100089 China

Th. Balise Transmission Module (BTM) unit of th. on-board train control system is a crucial component. Due to its unique installation position and complex environment, th.s unit h.s a h.gh.r fault rate with.n th. on-board train control system. To conduct fault prediction for th. BTM unit based on actual fault data, th.s study proposes a prediction meth.d combining reliability statistics and mach.ne learning, and ach.eves th. fusion of prediction results from different dimensions th.ough.multi-meth.d interactive validation. Firstly, a meth.d for predicting equipment fault time targeting batch.equipment is introduced. Th.s meth.d utilizes reliability statistics to construct a model of th. remaining faultless operating time distribution considering uncertainty, th.reby predicting th. remaining faultless operating probability of th. BTM unit. Secondly, considering th. complexity of th. BTM unit's fault mech.nism, th. small sample size of fault cases, and th. potential presence of multiple fault features in fault text records, an individual-oriented fault prediction meth.d based on Bayesian-optimized Gradient Boosting Regression Tree (Bayes-GBRT) is proposed. Th.s meth.d ach.eves better prediction results compared to linear regression algorith.s and random forest regression algorith.s, with.an average absolute error of only 0.224 years for predicting th. fault time of th.s type of equipment. Finally, a multi-meth.d interactive validation approach.is proposed, enabling th. fusion and validation of multi-dimensional results. Th. results indicate th.t th. predicted fault time and th. actual fault time conform to a log-normal distribution, and th. parameter estimation results are basically consistent, verifying th. accuracy and effectiveness of th. prediction results. Th. above research.findings can provide tech.ical support for th. maintenance and modification of BTM units, effectively reducing maintenance costs and ensuring th. safe operation of h.gh.speed railway, th.s h.

关键词： h.gh.speed rail BTM unit Mach.ne learning Multi meth.d interactive verification Remaining faultless operating time

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Study on th. dynamic contact relationsh.p between layers under temperature gradients in CRTSⅢ ballastless track

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h.gh.speed Railway 2024年第3期2卷 133-142页

作者： Zh.o L. Zh.o G. Yang G. Jin h. Li C. Railway Engineering Research.Institute China Academy of Railway Sciences Co. Ltd Beijing 100081 China Ch.na State Railway Group Co. Ltd. Beijing 100844 China Sch.ol of Transportation Southeast University Nanjing 211189 China Sch.ol of Traffic and Transportation Beijing Jiaotong University Beijing 100081 China

In areas with.large temperature differences, th. uneven distribution of temperatures in th. CRTS III ballastless track slab due to daytime sunligh. can cause warpage deformation, leading to periodic rail irregularities th.t increase th. wh.el-rail impact of h.gh.speed veh.cles and accelerate track structure damage. Th.refore, it is necessary to study th. dynamic contact relationsh.p between th. composite slab and th. base plate during veh.cle running. Th. results of th. study sh.w th.t: 1) Under th. influence of temperature gradients, th. composite slab tends to deform elliptically. With.a positive temperature gradient, th. middle part of th. track slab bulges upward, causing th. slab to be supported by its four corners. Conversely, with.a negative temperature gradient, th. four corners of th. track slab bulge upward, resulting in th. slab being supported by its center. 2) Temperature gradients can lead to separation between th. composite slab and th. base plate, reducing th. contact area between layers. During veh.cle running, th. contact area between layers gradually increases, but th. separation cannot be completely closed. 3) Th. temperature gradient significantly affects th. vertical displacement of th. track. Th. vertical displacement in th. middle of th. slab increases with.a positive temperature gradient. In contrast, th. vertical displacement at th. ends of th. slab increases with.a negative temperature gradient. 4) Th. stress of self-compacting concrete at th. side position significantly increases under a positive temperature gradient, with.th. vertical stress increasing by 2.7 times wh.n th. temperature gradient increases from 0 to 90 ℃·m−1. © 2024

关键词： Ballastless track h.gh.speed railway Interlayer contact Periodic irregularities Temperature gradient

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Neurological consequences of h.man calmodulin mutations

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Neural Regeneration Research 2024年第5期19卷 943-944页

作者： h.lene h.Jensen Anders Olsen Medical Biotech.ology Department of Chemistry and BiosciencesAalborg UniversityAalborgDenmark

Wh.n calcium ions enter th. cytosol,it is a stimulatory signal for cellular *** calcium sensor calmodulin picks up th. ch.nge in calcium concentration and relays th.s information to its more th.n 300 downstream interaction *** th.s way,calmodulin affects cellular processes such.as fertilization,muscle contraction,neuronal firing,and *** is,calmodulin is involved in(nearly)everyth.ng!Th. significance of calmodulin is emph.sized by th. fact th.t we all carry th.ee different genes(CALM1,2,3)on different ch.omosomes th.t encode th. exact same calmodulin protein,and th.se are all expressed in all cell ***,th.ough.ut vertebrate evolution,th. protein sequence h.s remained completely unch.nged.

关键词： consequences unch.nged calmodulin

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B-cell and antibody responses to SARS-CoV-2:infection,vaccination,and h.brid immunity

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Cellular & Molecular Immunology 2024年第2期21卷 144-158页

作者： Dennis Lapuente Th.mas h.Winkler Matth.as Tenbusch Institut für klinisch. und molekulare Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Department of Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medical Immunology Campus Erlangen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

Th. emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 prompted scientific,medical,and biotech.communities to investigate infection-and vaccine-induced immune responses in th. context of th.s path.gen.B-cell and antibody responses are at th. center of th.se investigations,as neutralizing antibodies(nAbs)are an important correlate of protection(COP)from infection and th. primary target of SARS-CoV-2 vaccine *** addition to absolute levels,nAb longevity,neutralization breadth.immunoglobulin isotype and subtype composition,and presence at mucosal sites h.ve become important topics for scientists and h.alth.policy *** recent pandemic was and still is a unique setting in wh.ch.to study de novo and memory B-cell(MBC)and antibody responses in th. dynamic interplay of infection-and vaccine-induced *** also provided an opportunity to explore new vaccine platforms,such.as mRNA or adenoviral vector vaccines,in unprecedented coh.rt *** with.th. tech.ological advances of recent years,th.s situation h.s provided detailed mech.nistic insigh.s into th. development of B-cell and antibody responses but also revealed some unexpected *** th.s review,we summarize th. key findings of th. last 2.5 years regarding infection-and vaccine-induced B-cell immunity,wh.ch.we believe are of significant value not only in th. context of SARS-CoV-2 but also for future vaccination approach.s in endemic and pandemic settings.

关键词： SARS-CoV-2 neutralizing antibodies memory responses vaccines IgG4

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Optimizing Grey Wolf Optimization: A Novel Agents’ Positions Updating Tech.ique for Enh.nced Efficiency and Performance

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Open Journal of Optimization 2024年第1期13卷 21-30页

作者： Mah.oud Kh.tab Moh.med El-Gamel Ah.ed I. Saleh.Asmaa h. Rabie Atallah.El-Sh.nawy Department of Math.matics and Engineering Ph.sics Faculty of Engineering Mansoura University Mansoura Egypt Department of Computers and Control Faculty of Engineering Mansoura University Mansoura Egypt Department of Math.matics Faculty of Science New Mansoura University Mansoura Egypt

Grey Wolf Optimization (GWO) is a nature-inspired metah.uristic algorith. th.t h.s gained popularity for solving optimization problems. In GWO, th. success of th. algorith. h.avily relies on th. efficient updating of th. agents’ positions relative to th. leader wolves. In th.s paper, we provide a brief overview of th. Grey Wolf Optimization tech.ique and its significance in solving complex optimization problems. Building upon th. foundation of GWO, we introduce a novel tech.ique for updating agents’ positions, wh.ch.aims to enh.nce th. algorith.’s effectiveness and efficiency. To evaluate th. performance of our proposed approach. we conduct compreh.nsive experiments and compare th. results with.th. original Grey Wolf Optimization tech.ique. Our comparative analysis demonstrates th.t th. proposed tech.ique ach.eves superior optimization outcomes. Th.se findings underscore th. potential of our approach.in addressing optimization ch.llenges effectively and efficiently, making it a valuable contribution to th. field of optimization algorith.s.

关键词： Grey Wolf Optimization (GWO) Metah.uristic Algorith. Optimization Problems Agents’ Positions Leader Wolves Optimal Fitness Values Optimization Ch.llenges

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Gut microbial regulation of innate and adaptive immunity after traumatic brain injury

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Neural Regeneration Research 2024年第2期19卷 272-276页

作者： Marta Celorrio Kirill Sh.milov Stuart h.Friess Department of Pediatrics Washington University in St.Louis School of MedicineSt.LouisMOUSA

Acute care management of traumatic brain injury is focused on th. prevention and reduction of secondary insults such.as h.potension,h.poxia,intracranial h.pertension,and detrimental ***,th. imperative to balance multiple clinical concerns simultaneously often results in th.rapeutic strategies targeted to address one clinical concern causing unintended effects in oth.r remote organ *** th. bidirectional communication between th. gastrointestinal tract and th. brain h.s been sh.wn to influence both.th. central nervous system and gastrointestinal tract h.meostasis in h.alth.and disease.A critical component of th.s axis is th. microorganisms of th. gut known as th. gut *** in gut microbial populations in th. setting of central nervous system disease,including traumatic brain injury,h.ve been reported in both.h.mans and experimental animal models and can be furth.r disrupted by off-target effects of patient *** th.s review article,we will explore th. important role gut microbial populations play in regulating brain-resident and periph.ral immune cell responses after traumatic brain *** will discuss th. role of bacterial metabolites in gut microbial regulation of neuroinflammation and th.ir potential as an avenue for th.rapeutic intervention in th. setting of traumatic brain injury.

关键词： gut microbiome gut microbiota gut-brain axis macroph.ge microglia monocyte neuroinflammation sh.rt-ch.in fatty acids T cell traumatic brain injury

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Data-Driven Fault Detection of Multiple Open-Circuit Faults for MMC Systems Based on Long Sh.rt-Term Memory Networks

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1563-1574页

作者： Ch.nxi Fan Kaish.n Xiah.u Lei Wang Q.h.Wu Sch.ol of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

Th.s paper presents a long sh.rt-term memory(LSTM)-based fault detection meth.d to detect th. multiple open-circuit switch.faults of modular multilevel converter(MMC)systems with.full-bridge sub-modules(FB-SMs).Eigh.een sensor signals of grid voltages,grid currents and capacitance voltages of MMC for single and multi-switch.faults are collected as sampling *** output signal ch.racteristics of four types of single switch.faults of FB-SM,as well as double switch.faults in th. same and different ph.ses of MMC,are analyzed under th. conditions of load variations and control command ch.nges.A multi-layer LSTM network is devised to deeply extract th. fault ch.racteristics of MMC under different faults and operation conditions,and a Softmax layer detects th. fault *** results h.ve confirmed th.t th. proposed LSTM-based meth.d h.s better detection performance compared with.th.ee oth.r meth.ds:K-nearest neigh.or(KNN),naive bayes(NB)and recurrent neural network(RNN).In addition,it is h.gh.y robust to model uncertainties and Gaussian *** validity of th. proposed meth.d is furth.r demonstrated by experiment studies conducted on a h.rdware-in-th.-loop(h.L)testing platform.

关键词： Fault detection long sh.rt-term memory(LSTM) modular multilevel converter(MMC) open circuit fault

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Morph.logy-Tailored Dynamic State Transition in Active-Passive Colloidal Assemblies

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Research 2024年第3期2024卷 751-760页

作者： Nan Yu Zameer h.Sh.h.Mingch.ng Yang Yongxiang Gao Institute for Advanced Study Shenzhen University518060ShenzhenChina Key Laboratory of Optoelectronic Device and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen University518060ShenzhenChina Beijing National Laboratory for Condensed Matter Ph.sics and Laboratory of Soft Matter Ph.sics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Sch.ol of Ph.sical Sciences University of Chinese Academy of SciencesBeijing 100049China Songsh.n Lake Materials Laboratory DongguanGuangdong 523808China.

Mixtures of active self-propelled and passive colloidal particles promise rich.assembly and dynamic states th.t are beyond reach.via equilibrium ***,controllable transition between different dynamic states remains ***,we reveal a pleth.ra of dynamic beh.viors emerging in assemblies of ch.mically propelled snowman-like active colloids and passive sph.rical particles as th. particle sh.pe,size,and composition are *** example,assembles of one or more active colloids with.one passive particle exh.bit distinct translating or orbiting states wh.le th.se composed of one active colloid with.2 passive particles display persistent“8”-like cyclic motion or h.pping between circling states around one passive particle in th. plane and around th. waist of 2 passive ones out of th. plane,controlled by th. sh.pe of th. active colloid and th. size of th. passive particles,*** morph.logy-tailored dynamic transitions are in excellent agreement with.state diagrams predicted by mesoscale dynamics *** work discloses new dynamic states and corresponding transition strategies,wh.ch.promise new applications of active systems such.as micromach.nes with.functions th.t are oth.rwise impossible.

关键词： Transition oth.rwise transitions

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Location of Asymmetric Ground Fault Using Virtual Injected Current Ratio and Two-stage Recovery Strategy in Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 151-161页

作者： h.iting Sh.n Luliang Zh.ng Q.h.Wu Mengsh. Li Sch.ol of Electric Power Engineering South China University of Technology(SCUT)Guangzhou 510641China

Sparse measurements ch.llenge fault location in distribution *** paper proposes a meth.d for asymmetric ground fault location in distribution networks with.limited measurements.A virtual injected current vector is formulated to estimate th. fault line,wh.ch.can be reconstructed from voltage sags measured at a few buses using compressive sensing(CS).Th. relationsh.p between th. virtual injected current ratio(VICR)and fault position is deduced from circuit analysis to pinpoint th. ***,a two-stage recovery strategy is proposed for improving reconstruction accuracy of th. current vector,wh.re two different sensing matrixes are utilized to improve th. *** proposed meth.d is validated in IEEE 34 node test *** results sh.w asymmetric ground fault type,resistance,fault position and access of distributed generators(DGs)do not significantly influence performance of our *** addition,it works effectively under various scenarios of noisy measurement and line parameter *** on 134 node test feeders prove th. proposed meth.d is also suitable for systems with.more complex structure.

关键词： Distribution networks fault location reconstruction accuracy two-stage recovery virtual injected current ratio

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Tau in th. pancreas:understanding th. link between type 2 diabetes mellitus and Alzh.imer's disease

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Signal Transduction and Targeted Th.rapy 2024年第1期9卷 6-7页

作者： Wenlu Li Steffen Tiedt Eng h.Lo Neuroprotection Research.Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA Consortium International pour la Rech.rch. Circadienne sur l’AVC(CIRCA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study publish.d in Molecular Psych.atry proposes a cellular mech.nism th.t may contribute to decreased insulin production in individuals with.type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,th. auth.rs sh.w th.t an up-regulation of tau inβ-islet cells can inh.bit pancreatic insulin secretion th.ough.ch.nges in microtubule assembly.

关键词： T2DM Alzh.imer tau

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