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Hepatoprotective effect of acetone semicarbazone on Ehrlich ascites carcinoma induced carcinogenesis in experimental mice

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Asian Pacific Journal of Tropical Biomedicine 2013年第2期3卷 105-110页

作者： Farhadul Islam Shaikh Mohummad Mohsin Ali Jahan ara khanam Department of Biochemistry and Molecular Biology Rajshahi University Applied Chemistry and Chemical Technology Rajshahi University

Objective:To determine the hepatoprotective effect of acetone semicarbazone(ASC)in vivo in normal and Ehrlich ascites carcinoma(EAC)bearing male Swiss albino ***:Druginduced changes in biochemical and behavioral parameters at dose of 2.0 mg/kg body weight for14 d and nullifying the toxicity induced by EAC cells were *** histopathology studies of the protective effects of ASC on vital organs were also ***:The administration of ASC made insignificant changes in body weight and behavioral(salivation,diarrhea,muscular numbness)changes during treatment period due to minor toxicity were minimized after the treatment in normal *** biochemical parameters,including serum glutamate pyruvate transaminase,glutamate oxaloactate transaminase,alkaline phosphatase,serum glucose,cholesterol,urea,triglyceride and billirubin changed modestly in normal mice receiving *** the treatment continued,these values gradually decreased to normal level after the *** EAC bearing mice,the toxic effects due to EAC cells in all cases were nullified by treatment with the *** abnormalities were not detected in histology of the various organs of the normal mice treated with ***:ASC can,therefore,be considered safe in formulating novel anticancer drug,as it exhibits strong protective effect against EAC cell bearing mice.

关键词： EAC cell Host toxicity Acetone semicarbazone Schiff bases Histopathology Subacute toxicity

Morphology and Molecular Identification of Dry Fish Fungus Cunninghamella blakesleeana from Small Indigenous Fish “Kachki” Corica soborna (Hamilton 1822) in Bangladesh

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American Journal of Plant Sciences 2023年第11期14卷 1316-1326页

作者： Abdullah Al Masud ismot ara Nuhu Alam Department of Zoology Jagannath University Dhaka Bangladesh Department of Zoology Jahangirnagar University Savar Bangladesh Department of Botany Jahangirnagar University Savar Bangladesh

The present experiment was conducted to investigate a dry fish fungus, Cunnighamella blakesleeana, which was identified from the infected part of the Corica soborna, locally named as Kachki fish. Mycelium was hyaline, often with granular content, and conidiophores were erected, with verticillate or solitary branches. Zygospores were globose, tuberculate, suspensors equal, smooth, hyaline and heterothallic. Using ITS4 and ITS5 primers, the 740 bp-long ITS region was amplified and sequenced. The ITS region sequences had reciprocal homologies of 98% to 100%. The findings showed that several species of C. blakesleeana fall into the same cluster. It has been determined by molecular data that the fungus we had studied was C. blakesleeana. The maximum mycelial growth (95.33 mm) was observed in the PDA medium, followed by the PSA medium, and the lowest growth (65.50 mm) was measured in the HPA medium in the study of the impact of culture media on the mycelial growth of C. blakesleeana. The influence of temperature on the radial mycelial growth of C. blakesleeana on PDA medium was investigated through five different temperatures. Although pH is a crucial factor in understanding the ecology of spoilage fungus, the highest mycelial growth of C. blakesleeana (88.25 mm) was seen at pH 7, followed by pH 8 and pH 6, while pH 9 was revealed to have the lowest mycelial growth. The outcome suggested that C. blakesleeana thrived in neutral environments.

关键词： Culture Media Molecular Identification Temperature pH Vegetative Growth

In vivo Anticancer Activities of Benzophenone Semicarbazone against Ehrlich Ascites Carcinoma Cells in Swiss Albino Mice

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Clinical oncology and cancer researeh 2012年第4期9卷 242-247页

作者： Khairul Islam Shaikh M Mohsin Ali Mele Jesmin Jahan ara khanam Department of Applied Chemistry and Chemical Engineering University of RajshahiRajshahi 6205Bangladesh Department of Biochemistry and Molecular Biology University of RajshahiRajshahi 6205Bangladesh

Objective Benzophenone semicarbazone(BSC) was synthesized and characterized to identify compounds with anticancer activities. Methods Anticancer activities were studied against Ehrlich Ascites Carcinoma(EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement,survival time of tumor bearing mice,tumor cell growth inhibition,and so *** hematological parameters,such as red blood cells,white blood cells,and hemoglobin content,were also measured. Results The results showed that BSC has a positive effect against EAC *** assessment was conducted by comparing these results with those obtained using the standard drug bleomycin. Conclusions The BSC compound can be considered as a potent anticancer agent.

关键词： anticancer activities EAC cell benzophenone semicarbazone

In vivo anticancer activity of vanillin semicarbazone

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Asian Pacific Journal of Tropical Biomedicine 2012年第6期2卷 438-442页

作者： Shaikh M Mohsin Ali M Abul Kalam Azad Mele Jesmin Shamim Ahsan M Mijanur Rahman Jahan ara khanam M Nazrul Islam Sha M Shahan Shahriar Department of Applied Chemistry and Chemical Engineering University of Rajshahi Department of Biochemistry and Molecular Biology University of Rajshahi Department of Chemistry University of Chittagong Department of Food Science & Technology Chittagong Veterinary and Animal Science University

Objective:To evaluate the anticancer activity of vanillin semicarbazone(VSC) against Ehrlich ascites carcinoma(EAC) cells in Swiss albino ***:The compound VSC at three doses(5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight,enhancement of survival time as well as the changes in depleted hematological parameters. Allsuch parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg(i.p.).Results:Among the doses studied, 10 mg/kg(i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg(i.p.). The host toxic effects of VSC was found to be ***:It can be concluded that VSC can therefore be considered as potent anticancer agent.

关键词： Anticancer activity Ehrlich ascites carcinoma Schiffbase