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Digital Intubation without Stylet: Myth or Reality? Case Report

Open Journal of Anesthesiology 2021年第5期11卷 156-163页

作者： Maya Christiam Mauricio Jesús Alberto Melendez Ordoñez ismael bernardo viveros peralta Villanueva Verónica Juan José Dosta Herrera Andrea Carolina Jimenez Palacios Jimmy Andersson Delgado Criollo Monserrat Escalante Rodríguez Dalia Fernanda Farrera Rámirez Maribel Méndez Suarez Pedro Sánchez Mata Residente de Anestesiología Hospital Juárez de México Ciudad de México México Médico adjunto al Servicio de Anestesiología Unidad Médica de Alta Especialidad (UMAE) Hospital General Doctor Gaudencio Jefe del Servicio de Anestesiología Unidad Médica de Alta Especialidad (UMAE) Hospital General Doctor Gaudencio González Garza (LA RAZA) Ciudad de México México

Digital intubation was discovered as one of the first methods to face a difficult airway without direct laryngoscopy. From the very beginning, this technique has been surrounded by much controversy, mainly because it required to be performed by an expert. Nowadays, it remains a useful technique when treating patients with difficult airways, so it is of utmost importance all personnel involved with airway management must know and perfect this technique when scenarios where conventional laryngoscopy or rescue devices for difficult airway are not available or contraindicated. The present work’s main objective is to suggest digital intubation as a safe and effective technique for the management of patients with difficult airways when there are no other devices available. The authors present a successful case of digital intubation on a patient with a difficult airway, demonstrating this technique is useful when performed by expert practitioners and when there is no other equipment available.

关键词： Intubation Intratracheal Oxygenation Anesthesia Airway Management

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Gene Expression Analysis of Extracellular Matrix and Cytokines after Uterine Artery Embolization

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Open Journal of Obstetrics and Gynecology 2014年第15期4卷 935-943页

作者： André bernardo Tatiana Carvalho de Souza Bonetti ismael Dale Cotrim Guerreiro da Silva Mariano Tamura Vieira Gomes Rodrigo Aquino Castro Manoel Joao Batista Castello Girao Claudio Emilio Bonduki Gynecology Department Paulista School of MedicineFederal University of Sao Paulo(EPM-UNIFESP)Sao PauloBrazil

Arterial embolization of myomas (AEM) is an established option for the conservative treatment of uterine leio-myomas;it treats all present uterine nodules at once, is less invasive than other procedures and effective in controlling symptoms, and does not require long term hospitalizations. Nevertheless, the potential impact on endometrial morphological and functional outcomes after the procedure is still controversial based on reports of endometritis or eventual transient ischemia. This study evaluated endometrial reorganization in uterine leiomyoma patients, before and after AEM, through gene expression analyses of extracellular matrix and cytokines genes in theendometrial tissue. Eight patients with leiomyomas were evaluated before AEM and 6 months after. The examinations included transvaginal pelvic ultrasonography, dosing of the follicle-stimulating hormone, and endometrial biopsy during the second phase of the menstrual cycle. RNA was extracted from endometrial samples, cDNA was synthesized, and applied on PCR arrayTM plates to evaluate the expression of extracellular matrix (ECM) genes and cytokines and their receptors’ genes (CYT). The ECM overexpressed genes were MMP (1, 3, 10, 11, and 14), CTGF1, ICAM1, TBHS1, ITGA2, ITGA3, ITGB3, COL7A1, COL12A, SPP1, and TNC;ADAMTS8 was underexpressed. The CYT overexpressed genes were SPP1, BCL6, CXCL12, IL-8, and CEBPB;CXCL13 and CCL21 were underexpressed. The ECM results showed overexpression of proteases that are responsible for dysfunctions in the ECM, and of genes responsible for adhesion and membrane components. The CYT results showed overexpression of chemokines responsible for endometrial repair, and underexpression of cytokines involved in inflammatory processes in the endometrial tissue. AEM treatment did not negatively affect the endometrial function at 6 months after embolization. This study broadens the knowledge about using a procedure that is relevant to the treatment of leiomyomas and contributes to the es

关键词： Component Myoma Arterial Embolization of Myomas Extracellular Matrix Cytokines

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Effects on Cell Viability and on Apoptosis in Tumoral(MCF-7)and in Normal(MCF10A)Epithelial Breast Cells after Human Chorionic Gonadotropin and Derivated-Angiotensin Peptides Treatments

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Journal of Cancer Therapy 2013年第7期4卷 65-69页

作者： Silvana Aparecida Alves Correa de Noronha Werica bernardo Alexandre Jesus Barros Clovis Ryuichi Nakaie Suma Imura Shimuta ismael Dale Cotrim Guerreiro da Silva Samuel Marcos Ribeiro de Noronha Laboratorio de Cirurgia Translacional Departamento de CirurgiaUniversidade Federal De Sao Paulo/Escola Paulista De MedicinaSao PauloBrazil Laboratorio de Ginecologia Molecular Universidade Federal de Sao PauloSao PauloBrazil Departamento de Biofísica Universidade Federal de Sao PauloSao PauloBrazil

Angiotensin-(1 - 7) [Ang-(1 - 7)] is an endogenous heptapeptide hormone of the renin-angiotensin system that has antiproliferative properties. The aim of this work was to evaluate the anti-proliferative and pro-apoptotic properties of Ang-(1 - 7) and of Ang-(1 - 7)-substituents 9-fluorenylmethyloxycarbonyl (Fmoc) e Ang II-derivatives containing the TOAC (2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid) in normal (MCF10A) and in tumoral (MCF7) epithelial mammary cell lines. Both cell lines received an hCG and angiotensin peptides 24-hour treatment, in combination or alone followed by cell viability, apoptosis and cell cycle assays performed by flow cytometer (GUAVA). After hCG, Ang-(1 - 7), hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments, MCF7 displayed cell viability decrease and mid-apoptosis increase. We also observed cell viability decrease in MCF10A after Ang-(1 - 7), Ang-(1 - 7) Fmoc and hCG + AngII Toac treatments. These cells had an increase in late apoptosis and necrosis after AngII Toac, hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments. Regarding the cell cycle analysis, we did not observed any changes in cell cycle phases. In summary, cell viability was decreased and apoptosis (initial, mid and late) was increased after hCG and/or Ang-(1 - 7) peptides treatments. These results point out hCG and Ang-(1 - 7) as effective compounds to inhibit cell proliferation, since they decrease cell viability and increase apoptosis in both normal and in tumoral breast cells, being the effect more pronounced in the tumoral cell line. Our results support the idea of investigating more closely the putative use of these compounds as novel therapeutic agents for breast cancer.

关键词： Angiotensin II Angiotensin 1-7 Angiotensin II Type 1 Receptor(AT1R) Breast Cancer Apoptosis Human Chorionic Gonadotropin

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Gene Expression Analysis of Extracellular Matrix and Cytokines after Uterine Artery Embolization

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2014年第15期

作者： André bernardo Tatiana Carvalho de Souza Bonetti ismael Dale Cotrim Guerreiro da Silva Mariano Tamura Vieira Gomes Rodrigo Aquino Castro Manoel João Batista Castello Girão Claudio Emilio Bonduki

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