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Induction of Extracellular Lytic Enzymes by <i>Fusarium solani</i>

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Advances in Microbiology 2013年第8期3卷 24-30页

作者： María de Guadalupe Moctezuma-Zárate Juan Manuel Vargas-Morales Juan F. Cárdenas-González Víctor Manuel Martínez-Juárez ismael acosta-rodríguez área Académica de Medicina Veterinaria y Zootecnia Instituto de Ciencias Agropecuarias Universidad Autónoma del Estado de Hidalgo Tulancingo de Bravo Hidalgo México Laboratorio de Micología Experimental Centro de Investigación y de Estudios de Posgrado Facultad de Ciencias Químicas Universidad Autónoma de San Luis Potosí San Luis Potosí México

Fusarium solani is a necrotrophic parasitic fungus that causes wilt in some plants, causing severe economic losses in some areas of the country. The objective of this work was to analyze the induction of extracellular lytic enzymes produced by a strain of F. solani, isolated from a culture of tomato, in Villa de Arista, S.L.P. México. Polygalacturonase activity has a greater induction time at 10 days, and the xylanase has two times higher activity at 8 and 13 days of incubation at 28?C. Also, the xylanase activities A and B were very stable at 4?C. After 7 days of incubation, it has an activity of 100% and 96%, respectively, while polygalacturonase retains 61% of its initial activity. Both activities are better induced with glutamate and urea as nitrogen sources respectively, and both exhibit an initial pH optimum of 5.5. Finally, we didn’t find cellulase activity in the analyzing conditions.

关键词： Fusarium solani Necrotrophic Fungus Lytic Enzymes

Complexity of adaptive testing in scenarios defined extensionally

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Frontiers of Computer Science 2023年第3期17卷 11-28页

作者： ismael rodrÍguez David RUBIO Fernando RUBIO Dpto.Sistemas Informáticos y Computación Facultad de InformáticaUniversidad Complutense de MadridMadrid 28040Spain Instituto de Tecnologías del Conocimiento Universidad Complutense de MadridMadrid 28040Spain Instituto de Biomecánica de Valencia.Universitat Politècnica de València València 46022Spain

In this paper,we consider a testing setting where the set of possible definitions of the Implementation Under Test(IUT),as well as the behavior of each of these definitions in all possible interactions,are extensionally defined,i.e.,on an element-by-element and case-by-case *** this setting,the problem of finding the minimum testing strategy such that collected observations will necessarily let us decide whether the IUT is correct or not(i.e.,whether it necessarily belongs to the set of possible correct definitions or not)is studied in four possible problem variants:with or without non-determinism;and with or without more than one possible definition in the sets of possible correct and incorrect *** computational complexity of these variants is studied,and properties such as PSPACE-completeness and Log-APX-hardness are identified.

关键词： formal testing adaptive testing computational complexity PSPACE-completeness approximation hardness

The Limit Case of a Domination Property

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Acta Mathematica Sinica,English Series 2012年第3期28卷 463-468页

作者： Magdalena LEMANSKA Juan A. rodríguez-VELZQUEZ ismael G. YERO Department of Technical Physics and Applied Mathematics Gdańsk University of Technology Departament d’Enginyeria Informàtica i Matemàtiques Universitat Rovira i Virgili Departament d'Enginyeria Informàtica i Matemàtiques Universitat Rovira i Virgili

The domination number γ,（G） of a connected graph G of order n is bounded below by

关键词： Dominating set domination number

A new early Visean coral assemblage from Azrou-Khenifra Basin,central Morocco and palaeobiogeographic implications

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Journal of Palaeogeography 2020年第1期9卷 1-20页

作者： Sergio rodríguez Ian D.Somerville Pedro Cózar Javier Sanz-López ismael Coronado Felipe González Ismail Said Mohamed El Houicha GEODESPAL Universidad Complutense de Madridc/Jose Antonio Novais.1228040 MadridSpain Instituto de Geociencias(CSIC UCM)c/Jose Antonio Novais 1228040 MadridSpain UCD School of Earth Sciences University College DublinBelfieldDublin 4Ireland Departmento de Geología Universidad de OviedoArias de Velasco s/n33005 OviedoSpain Institute of Paleobiology WarsawPoland Dpto.de Ciencias de la Tierra Universidad de HuelvaAvda.Fuerzas Armadas s/nCampus de El Carmen21071 HuelvaSpain Laboratoire de Géodynamique et Géomatique Facultédes SciencesUniversite Chouaib DoukkaliBP.2024000 El JadidaMorocco

A new early Visean coral assemblage has been recorded from turbidite facies in the southern part of the AzrouKhenifra Basin,northwest of Khenifra,central *** newly discovered Ba Moussa West(BMW)coral fauna includes Siphonophyllia khenifrense ***.,Sychnoelasma urbanowitschi,Cravenia lamellata,Cravenia tela,Cravenia rhytoides,Turnacipora megastoma and Pleurosiphonella *** early Visean age of the coral assemblage is supported by foraminiferal and conodont data,with the recognition of the basal Visean MFZ9 *** confirms that the first transgression in the Azrou-Khenifra Basin was during the earliest *** allochthonous coral assemblage was recovered from coarse-grained proximal limestone debris flow and turbidite beds within a faultbounded unit,lying to the west of a thrust syncline containing upper Visean *** evidence exists of the former early Visean shallow-water platform from which the corals were *** other in situ platform carbonate rocks around the southern margin of the Azrou-Khenifra Basin are probably of late Visean(Asbian–Brigantian)*** early Visean Ba Moussa West coral fauna can be compared with that at Tafilalt in eastern Morocco,as well as in other Saharian basins of *** of the genera and species in the Ba Moussa West assemblage are identical to those in NW Europe,with which it must have had marine *** new rugose species described,Siphonophyllia khenifrense,is probably endemic to North *** ecological niche in NW Europe was occupied by *** or ***.

关键词： Mississippian Visean Corals Foraminifers Conodonts Palaeobiogeography Morocco

Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez Mónica G Mendoza-rodríguez Omar R Alemán Fernando A Candanedo-González Miriam rodríguez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

Mixed structures as a new strategy to develop outstanding oxides-based cathode materials for sodium ion batteries: A review

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Journal of Energy Chemistry 2021年第10期30卷 47-60,I0002页

作者： Charifa Hakim Noha Sabi ismael Saadoune Cadi Ayyad University(UCA) IMED-LabAv.A.El KhattabiP.B.549MarrakeshMorocco Mohammed VI Polytechnic University(UM6P) Lot 660 Hay Moulay RachidBen GuerirMorocco Institute for Applied Materials-Energy Storage Systems(IAM-ESS) Karlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Sodium ion batteries(SIBs)are an exciting alternative for post-lithium energy *** can be regarded as a promising and cost-efficient solution for grid applications as they exhibit similar’rocking chair’mechanism as lithium ion batteries,in addition to the abundance and low cost of sodium ***,electrode materials,electrolytes,separators and smart design strategies are under spot and researchers are competing to come up with the ideal *** oxides with mixed structures are regarded as new concept that can offer a set of desired structural and energetic properties and are an attractive choice for next generation sodium ion ***,unlocking this system chemistry,kinetics and reliable understanding of the intercalation/deintercalation mechanism upon electrochemical cycling is quite *** review,through the examination of literature,gives a brief summary of the research progress and recent advances in the investigation of electrode materials based on layered oxides with mixed structures for sodium ion *** new strategy leads in fact to positive electrodes with enhanced energetic performance as they consist of a combination of the energetic or/and structural properties of the existing structures.

关键词： SIBs Layered oxides Cathode Mixedstructures Phase transition

Verapamil,a possible repurposed therapeutic candidate for stroke under hyperglycemia

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Neural Regeneration Research 2022年第11期17卷 2418-2419页

作者： Saifudeen ismael Tauheed Ishrat Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA Pharmaceutical Sciences Neuroscience InstituteUniversity of Tennessee Health Science CenterMemphisTNUSA

Admission hyperglycemia is an independent predictor,that contributes to hemorrhagic transformation (HT),and worsened functional outcome following reperfusion therapy with tissue plasminogen activator (tPA) in ischemic *** studies have revealed a strong association between hyperglycemia and incidence of HT independent of prior diabetes diagnosis (Alvarez-Sabin et al.

关键词： diagnosis Clinical

An ACO-RFD hybrid method to solve NP-complete problems

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Frontiers of Computer Science 2013年第5期7卷 729-744页

作者： Pablo RABANAL ismael rodrIguez Fernando RUBIO Dept. Sistemas Inforrnaiticos y Computacion Facultad de Informatica Universidad Complutense de Madrid Madrid 28040 Spain

In this paper we hybridize ant colony optimiza- tion （ACt） and river formation dynamics （RFD）, two related swarm intelligence methods. In ACt, ants form paths （prob- lem solutions） by following each other＇s pheromone trails and reinforcing trails at best paths until eventually a single path is followed. On the other hand, RFD is based on copy- ing how drops form rivers by eroding the ground and de- positing sediments. In a rough sense, RFD can be seen as a gradient-oriented version of ACt. Several previous experi- ments have shown that the gradient orientation of RFD makes this method solve problems in a different way as ACt. In particular, RFD typically performs deeper searches, which in turn makes it find worse solutions than ACt in the first exe- cution steps in general, though RFD solutions surpass ACt solutions after some more time passes. In this paper we try to get the best features of both worlds by hybridizing RFD and ACt. We use a kind of ant-drop hybrid and consider both pheromone trails and altitudes in the environment. We apply the hybrid method, as well as ACt and RFD, to solve two NP-hard problems where ACt and RFD fit in a different manner： the traveling salesman problem （TSP） and the prob- lem of the minimum distances tree in a variable-cost graph （MDV）. We compare the results of each method and we an- alyze the advantages of using the hybrid approach in each case.

关键词： river formation dynamics ant colony optimization heuristic algorithms NP-hard problems

Extension of pilot tests of cyanide elimination by ozone from blast furnace gas washing water through Aspen Plus based model

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Frontiers of Chemical Science and Engineering 2018年第4期12卷 718-730页

作者： ismael Matino Valentina CoHa Teresa A.Branca Scuola Superiore Sant' Anna TeCIP Institute-ICT-COISP56124 PisaItaly

For improving wastewater quality, one of the dare of steelworks is reducing cyanide in wastewater of gas washing treatment of blast furnaces. Costs of existing treatments, stringent environmental regulations and changeable composition of water from gas treatment, have led to study how available treatments can be modified and to examine new ones. Ozonation is one of cyanide treatments, tested within a European project. A process model was set up with Aspen Plus (R), to assess operating conditions and wastewater distinctive characteristics and to demonstrate treatment robustness. Process was modeled by theoretical reactors, taking into account all more affecting reactions. A genetic algorithm was exploited to find kinetic parameters of these reactions. After validation, the model was used to analyse scenarios, by considering also real contexts. Pilot tests were extended, process knowledge was enhanced and suggestions were obtained. To promote cyanide removal with ozone, temperature and pH values were 30 degrees C and 10, respectively. With an ozone (mg/h)/ water (L/h) ratio of 100 mg/L, batch mode ensure reaching cyanide regulation limit (0.2 mg/L) after maximum 4.5 h, if initial amount was less than 20 mg/L. Higher removal was obtained than in continuous mode due to constraints related to this last run. Higher wastewater contamination needed further time and more ozone.

关键词： blast furnace cyanide removal gas washing water modeling and simulation ozonation