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The Giant Radio Array for Neutrino Detection(GRAND):Science and design

Science China(Physics,Mechanics & Astronomy) 2020年第1期63卷 5-47页

作者： Jaime álvarez-Mu?iz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier isma?l cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley Stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra le Coz Jean-Philippe lenain Guo liang léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang li Qian Bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schr ?der Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian li Zhang Yi Zhang Qian Zheng Anne Zilles SUBATECH Institut Mines-Telecom Atlantique – CNRS/IN2P3 – Université de Nantes laboratoire de Physique et Chimie de l’Environnement et de l’Espace lPC2E CNRS-Université d’Orléans 12. Station de Radioastronomie de Nan?cay Observatoire de Paris Sorbonne Université UMR 7095 Institut d’Astrophysique de Paris Institute for Mathematics Astrophysics and Particle Physics (IMAPP) Radboud Universiteit Nationaal Instituut voor Kernfysica en Hoge Energie Fysica (NIKHEF) IIHE/ElEM Vrije Universiteit Brussel Institute for Nuclear Physics (IKP) Karlsruhe Institute of Technology (KIT) Einstein Fellow Stanford University Department of Astronomy University of Maryland Departamento de Física de Partículas & Instituto Galego de Física de Altas Enerxías Universidad de Santiago de Compostela Joint Space-Science Institute Oskar Klein Centre Stockholm University Department of Physics Stockholm University Astro Particule et Cosmologie (APC) Université Paris Diderot CNRS/IN2P3 CEA/Irfu Observatoire de Paris Institute of High Energy Physics Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences School of Physical Science and Technology Xinjiang University Center for Particle and Gravitational Astrophysics Pennsylvania State University Department of Physics Pennsylvania State University Department of Astronomy & Astrophysics Pennsylvania State University Instituto de Astronomia Geofísica e Ciências Atmosféricas Universidade de S?o Paulo lUTH Observatoire de Paris CNRS Université Paris Diderot PSL Research University Clermont Université Université Blaise Pascal CNRS/IN2P3 Lab. de Physique Corpusculaire European Southern Observatory Department of Mechanical and Electrical Engineering Shandong Management University Bartol Research Institute Department of Physics and Astronomy University of Delaware IRFU CEA Université Paris-Saclay GEPI Observatoire de Paris CNRS Université Paris Diderot Instituto de F′?sica la P

The Giant Radio Array for Neutrino Detection(GRAND) is a planned large-scale observatory of ultra-high-energy(UHE) cosmic particles, with energies exceeding 10~8 Ge V. Its goal is to solve the long-standing mystery of the origin of UHE cosmic rays. To do this, GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched sensitivity. GRAND will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the atmosphere. Its design is modular: 20 separate, independent sub-arrays, each of 10000 radio antennas deployed over 10000 km~2. A staged construction plan will validate key detection techniques while achieving important science goals early. Here we present the science goals, detection strategy, preliminary design, performance goals, and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation: sources galactic and extragalactic cosmic rays

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The Giant Radio Array for Neutrino Detection(GRAND):Science and design

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Science China(Physics,Mechanics & Astronomy) 2020年第1期63卷 1-43页

作者： Jaime Alvarez-Muniz Rafael Alves Batista Aswathi Balagopal V. Julien Bolmont Mauricio Bustamante Washington Carvalho Jr. Didier Charrier ismael cognard Valentin Decoene Peter B.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley Stefano Gabici Quan Bu Gou Jun Hua Gu Claire Guépin Hong Bo Hu Yan Huang Kumiko Kotera Sandra le Coz Jean-Philippe lenain Guo liang léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase Valentin Niess Foteini Oikonomou Tanguy Pierog Xiang li Qian Bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schroder Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech B.Theodore Zhang Jian li Zhang Yi Zhang Qian Zheng Anne Zilles Departamento de Fisica de Particulas&lnstituto Galego de Fisica de Altas Enerxias Universidad de Santiago de CompostelaSantiago de Compostela 15782Spain Instituto de Astronomia Geofisica e Ciencias AtmosfericasUniversidade de Sao PauloSao Paulo-SP 05508-090Brazil Department of Physics-Astrophysics University of OxfordDWBOxford 0X13RHUK Institute of Experimental Particle Physics(ETP) Karlsruhe Institute of Technology(KIT)Karlsru he D-76021Germany laboratoire de Physique Nucleeaire et de Hautes Energies(lPNHE) Sorbonne UniversiteUniversite Paris DiderotSorbonne Paris CiteCNRS place Jussieu F-75252Paris Cedex 5France Niels Bohr International Academy and DARK Niels Bohr InstituteCopenhagen 2100Denmark Discovery Center Niels Bohr InstituteCopenhagen 2100Denmark Center for Cosmology and AstroParticle Physics(CCA.PP)&Department of Physics Ohio State UniversityColumbus OH 43210USA Universidade de Santiago de Compostela Santiago de Compostela 15782Spain 0SUBATECH Institut Mines-Telecom Atlantique-CNRS/IN2P3-Universite de NantesNantes 44300France laboratoire de Physique et Chimie de KEnvironnement et de VEspace lPC2E CNRS-Universite d'Orleans Orleans F-45071France Station de Radioastronomie de Nancay Observatoire de ParisCNRS/INSU F-18330 NangayFrance Sorbonne Universite UMR 7095Institut d'Astrophysique de Paris98 bis bd AragoParis 75014France Institute for Mathematics Astrophysics and Particle Physics(IMAPP)Radboud UniversiteitNijmegen 6500Netherlands Nationaal Instituut voor Kemfysica en Hoge Energie Fysica(NIKHEF) Amsterdam NL-1009Netherlands IIHE/ElEM Vrije Universiteit BrusselPleinlaan 2Brussels 1050Belgium Institute for Nuclear Physics(IKP) Karlsruhe Institute of Technology(KIT)Karlsruhe D-76021Germany Einstein Fellow Stanford UniversityStanford CA 94305USA Department of Astronomy University of MarylandCollege Park MD 20742-2421USA Joint Space-Science Institute College Park MD 20742-2421USA Oskar Klein Centre Stockholm UniversityStockholm SE-10691Sweden Department of Phy

The Giant Radio Array for Neutrino Detection(GRAND)is a planned large-scale observatory of ultra-high-energy(UHE)cosmic particles,with energies exceeding 10~8 Ge V.Its goal is to solve the long-standing mystery of the origin of UHE cosmic rays.To do this,GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched sensitivity.GRAND will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the atmosphere.Its design is modular:20 separate,independent sub-arrays,each of 10000 radio antennas deployed over 10000 km^2.A staged construction plan will validate key detection techniques while achieving important science goals early.Here we present the science goals,detection strategy,preliminary design,performance goals,and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation:sources galactic and extragalactic cosmic rays:galactic and extragalactic

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Effects of two medicinal plants Psidium guajava l. (Myrtaceae) and Diospyros mespiliformis l. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第1期7卷 56-63页

作者： BElEMTOUGRI R.G. CONSTANTIN B. cognard C. RAYMOND G. SAWADOGO l. laboratory of Physiological Animal University of Ouagadougou BP 7021 Burkina Faso Institute of Physiology & Biology Cell University of Poitiers France

Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespili- formis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explaine their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.

关键词：动物钙代谢房间，有教养比较学习剂量反应关系，药 Ebenaceae 化学肌肉纤维药效果新陈代谢 PlantExtracts 管理 & 剂量种叶子化学植物，药用的化学 Psidiumchemistry 老鼠

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Periodic interstellar scintillation variations of PSRs J0613-0200 and J0636+5128 associated with the local Bubble shell

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中国科学:物理学、力学、天文学英文版 2023年第11期66卷 221-232页

作者： Yulan liu Robert A.Main Joris P.W.Verbiest Ziwei Wu Krishnakumar M.Ambalappat Jiguang lu David J.Champion ismael cognard lucas Guillemot Kuo liu James W.Mc Kee Nataliya Porayko Golam.M.Shaifullah Gilles Theureau National Astronomical Observatories Chinese Academy of SciencesBeijing100101China Fakultät für Physik Universität BielefeldBielefeld33501Germany Max-Planck-Institut für Radioastronomie Bonn53121Germany Florida Space Institute University of Central FloridaOrlandoFL32826USA Station de radioastronomie de Nançay Observatoire de ParisNançay18330France laboratoire de Physique et Chimie de l’Environnement et de l’Espace Universitéd’OrléansOrléans45071France E.A.Milne Centre for Astrophysics University of HullHullHU67RXUK Centre of Excellence for Data Science Artificial Intelligence and ModellingUniversity of HullHullHU67RXUK Dipartimento di Fisica“G.Occhialini” Universitàdi Milano-BicoccaMilano20126Italy INAF-Osservatorio Astronomico di Cagliari Selargius(CA)09047Italy INFN Sezione di Milano-BicoccaMilano20126Italy

Annual variations of interstellar scintillation can be modelled to constrain parameters of the ionized interstellar medium.If a pulsar is in a binary system,then investigating the orbital parameters is possible through analysis of the orbital variation of scintillation.In observations carried out from 2011 to 2020 by the European Pulsar Timing Array radio telescopes,PSRs J0613-0200and J0636+5128 show strong annual variations in their scintillation velocity,while the former additionally exhibits an orbital fluctuation.Bayesian theory and Markov-chain-Monte-Carlo methods are used to interpret these periodic variations.We assume a thin and anisotropic scattering screen model,and discuss the mildly and extremely anisotropic scattering cases.PSR J0613-0200is best described by mildly anisotropic scattering,while PSR J0636+5128 exhibits extremely anisotropic scattering.We measure the distance,velocity,and degree of anisotropy of the scattering screen for our two pulsars,finding that scattering screen distances from Earth for PSRs J0613-0200 and J0636+5128 are 316_(-20)^(+28)pc and 262_(-38)^(+96)pc,respectively.The positions of these scattering screens are coincident with the shell of the local Bubble towards both pulsars.These associations add to the growing evidence of the local Bubble shell as a dominant region of scattering along many sightlines.

关键词： pulsar interstellar scintillation ionized interstellar medium

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破裂的颅内动脉瘤:782例病人血管内治疗后并发症的发生率和严重程度的影响因素(ClARITY研究)

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国际医学放射学杂志 2010年第6期 567-568页

作者： l.Pierot C.cognard R.Anxionnat F.Ricolfi 曹伟 Department of Radiology Hpital Maison-Blanche45 rue Cognacq-Jay51092 ReimsFrance

目的在一个大样本的多中心研究中,分析影响破裂颅内动脉瘤的血管内治疗并发症(血栓栓子和术中破裂)发生率和严重程度的临床与解剖因素。材料与方法本研究

关键词：血管内 ClARITY 发生率颅内动脉瘤并发症并发病疾病病人

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未破裂颅内动脉瘤的血管腔内治疗:成形术与标准弹簧圈治疗安全性的比较

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国际医学放射学杂志 2009年第4期32卷 395-396页

作者： l.Pierot l.Spelle X.leclerc C.cognard A.Bonafeé J.Moret 关祥祯 Department of Neuroradiology Reims UniversityHopital Maison-Blanche

目的作为血管腔内治疗未破裂动脉瘤分析（ATENA）研究的一部分，对比分析了一多中心大样本血管腔内治疗未破裂颅内动脉瘤的成形术与标准弹簧圈治疗的安全性。方法医学伦理委员会批准了ATENA研究，所有参与该研究的病人均知情同意。该研... 详细信息

目的作为血管腔内治疗未破裂动脉瘤分析（ATENA）研究的一部分，对比分析了一多中心大样本血管腔内治疗未破裂颅内动脉瘤的成形术与标准弹簧圈治疗的安全性。方法医学伦理委员会批准了ATENA研究，所有参与该研究的病人均知情同意。该研究在27个机构进行。记录了每组病例的动脉瘤特征、治疗相关不良事件的发生率以及治疗效果。结果547例病人[383例女性，164例男性；平均年龄（51．0±11．11岁；年龄范围22～83岁1572个动脉瘤纳入本研究。325例仅应用弹簧圈进行治疗，222例行成形术。

关键词：未破裂颅内动脉瘤血管腔内治疗弹簧圈成形术安全性标准医学伦理委员会未破裂动脉瘤

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液体栓塞剂对脑动静脉畸形的血管内治疗:前瞻性、多中心研究(BRAVO)

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国际医学放射学杂志 2013年第6期 610-611页

作者： l.Pierot C.cognard D.Herbreteau H.Fransen W.J.van Rooij E.Boccardi 何亚娜程悦 Service de Radiologie Hpital Maison-Blanche 45 rue Cognacq-Jay51092 REIMS cedex France

摘要目的评价一种新型液体栓塞剂(Onyx)在脑动静脉畸形(bAVM)栓塞术中的安全性及疗效。方法在欧洲的11个介入治疗中心行前瞻性、多中心研究评价一种新型液体栓

关键词：脑动静脉畸形栓塞术血管内治疗 Onyx 放射外科学外科治疗

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le Śenat [Ressource ́electronique]

Le Śenat [Ressource ́electronique]

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1997年

作者： B́eatrice Schneider concepteur chef de projet Fraņcoise Moinet Th́er̀ese de Cherisey auteur des textes Pierre Avril ́editeur Index+ ŕealisation Olivier Pryszlak musique Bruno Carna Fraņcois cognard Michel Papineschi... [et al.] voix.

Titre provenant de l'?ecran-titre.,1 disque optique num?erique (CD-ROM) : coul., son. ; 12 cm.

ISBN: (纸本)225902484X;9782259024846

Titre provenant de l'?ecran-titre.,1 disque optique num?erique (CD-ROM) : coul., son. ; 12 cm.

关键词： France. S?enat

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重塑技术用于颅内动脉瘤破裂的血管内治疗的术后充分栓堵率高于常规弹簧圈栓堵且同等安全

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国际医学放射学杂志 2011年第2期 184-184页

作者： l.Pierot C.cognard R.Anxionnat F.Ricolfi 唐光健 Department of Neuroradiology Reims UniversityHpital Maison-Blanche

目的比较大型多中心系列ClARITY(破裂的颅动脉瘤治疗临床与解剖学结果)研究中重塑技术与常规弹簧圈栓堵血管内治疗破裂的颅内动脉瘤的安全性与有效性。材料

关键词：弹簧圈栓堵血管内常规

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