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Bioequivalence of Two Brands of Valsartan 80 mg Coated Breakable Tablets in 15 Healthy Algerian Volunteers： A Pilot Study

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Journal of Pharmacy and Pharmacology 2017年第9期5卷 661-667页

作者： mansouri. k.,Behloul. S. Cherait. I., Nekhoul. k. k., Hadjaz. I. m mansouri. m. B. Department of Bioequivalence National Control Laboratory for Pharmaceuticals Products Algiers 16000 Algeria

A randomized, two-way, crossover study was conducted in 15 fasting, healthy, Algerian volunteers to compare the bioavailability of two brands of Valsartan 80 mg coated breakable tablets. The present study aimed to evaluate the intra-subject variability of this active substance in the Algerian population. The test brand was compared to TAREG （Novartis） as the reference product. The study was performed at the bioequivalence center of the national control laboratory for pharmaceuticals products, in joint venture with University Hospital Center Ibn Badis, Constantine, Algeria. The drug was administered with 200 mL of water after a 10 h overnight fasting on two treatment days separated by one week washout period. After dosing, serial blood samples were collected for a period of 24 h. A reliable, simple, and robust liquid chromatography-tandem mass spectro-metric （LC-mS/mS） method has been developed and validated that employs protein precipitation （or denaturation） for the estimation of valsartan in human plasma using losartan as internal standard. The assay was found to be linear over the range of 50-5,000 ng/mL, with a lower limit of quantitation of 50ng/mL. Various pharnaacokinetic parameters including AUC0-t, AUC∞, Cmax, Tmax, and TI/2 were determined from plasma concentrations of both formulations and found to be in good agreement with reported values. The pharmacokinetical and statistical analysis was conducted with kinetica 4.4.1. AUC0.t, AUC0-∞ and Cmax were tested for bioequivalence after log-transformation of data. No significant difference was found based on ANOVA; 90% confidence interval （[85.82%, 118.76%] for AUC0.t [86.09%, 118.83%] for AUC0-∞） of test/reference ratio for these parameters were found within bioequivalence acceptance range of 80-125%. But for the Cmax, the 90% confidence interval of test/reference ratio wasn＇t in this acceptance range [90.18%, 131.07%] .The results of Pk analysis suggested that the reference and test formulations ofvalsartan 8

关键词： Valsartan bioequivalence LC-mS/mS pharmacokinetics.

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结合频域有限差分法分析二维柱体电磁散射

电子科技大学学报 2001年第5期30卷 445-448页

作者：朱汉清吴正德 k.m.Luk 电子科技大学应用物理所成都610054 香港城市大学电子工程系

引入多波前算法,提出了结合频域有限差分法分析二维柱体的电磁散射问题。数值计算过程中利用murs二阶吸收边界条件和场平均吸收条件截断网格;作为算例,分析了一无限长理想导体柱对平面电磁波的散射,由于使用了多波前算法求解差分矩阵方... 详细信息

引入多波前算法,提出了结合频域有限差分法分析二维柱体的电磁散射问题。数值计算过程中利用murs二阶吸收边界条件和场平均吸收条件截断网格;作为算例,分析了一无限长理想导体柱对平面电磁波的散射,由于使用了多波前算法求解差分矩阵方程,大大地减少了计算时间,数值结果表明了该方法的有效性。

关键词：频域有限差分法多波前算法吸收边界条件电磁散射二维柱体

Electrochemical synthesis of boron-containing coatings on mg alloy for thermal neutron shielding

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Journal of magnesium and Alloys 2023年第10期11卷 3779-3789页

作者： k.V.Nadaraia S.N.Suchkov N.S.markin I.m.Imshinetskiy S.I.Ivannikov D.V.mashtalyar A.Yu.Ustinov S.L.Sinebryukhov S.V.Gnedenkov Institute of Chemistry FEB RAS 159 Pr.100-Letiya VladivostokaVladivostok 690022Russia

The work provides the results of the one-step formation of boron-containing coatings on an mg–mn–Ce alloy by plasma electrolytic oxidation. The results of studies of the composition, structure and morphology of heteroxide coatings are presented. It was established that the boron is contained in the coating mainly in the form of B or B_(2)O_(3). The introduction of B changes the color of coatings, and also helps to increase their porosity. The method of determining the full cross section of the interaction of thermal neutron absorption efficiency by samples material using the installation of neutron-activation analysis based on ^(252)Cf was developed. It was shown that the introduction of boron into the formed coatings allows to increase the macroscopic cross-section of the interaction of samples with thermal neutrons by 3.8 times. This effect opens the potential for the use of synthesized material in the field of nuclear technologies and aerospace industry.

关键词： Plasma electrolytic oxidation Boron Neutron capture Neutron shielding Protective coatings

超高电流增益多晶硅发射极BICFET的研制与特性

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Journal of Semiconductors 1997年第4期18卷 286-291页

作者：郭维廉宋玉兴 m.A.Green m.k.morvvej-Farshi 天津大学电子工程系天津300072 澳大利亚新南威尔士大学电机系

研制并测量了poly－Si（n+）／UTI／n－Si隧道结发射极双极反型沟道场效应晶体管（BICFET）．发现在极低电流下，此器件的小信号电流增益（G）超过106．本文对此作出了新的解释．

关键词： BICFET 增益场效应晶体管多晶硅发射极

An assessment of the concentrations of particulate polycyclic aromatic hydrocarbons (PAHs) in the aftermath of a chemical store fire incident

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Journal of Environmental Sciences 2004年第5期16卷 751-754页

作者： m. Radzi Bin Abas Nasr Yousef m. J. Omar m. Jamil maah Department of Chemistry University of Malaya 50603 Kuala Lumpur MalaysiaDepartment of Chemistry University of Malaya 50603 Kuala Lumpur MalaysiaDepartment of Chemistry University of Malaya 50603 Kuala Lumpur Malaysia

Pm 10 airborne particles and soot deposit collected after a fire incident at a chemical store were analyzed in order to determine the concentrations of polycyclic aromatic hydrocarbons(PAHs). The samples were extracted with 1∶1 hexane-dichloromethane by ultrasonic agitation. The extracts were then subjected to gas chromatography-mass spectrometric(GC-mS) analysis. The total PAHs concentrations in airborne particles and soot deposit were found to be 3.27±1.55 ng/m 3 and 12.81±24.37 μg/g, respectively. Based on the molecular distributions of PAHs and the interpretation of their diagnostic ratios such as PHEN/(PHEN + ANTH), FLT/(FLT + PYR) and BeP/(BeP + BaP), PAHs in both airborne particles and soot deposit may be inferred to be from the same source. The difference in the value of IP/(IP + BgP) for these samples indicated that benzo[g,h,i]perylene and coronene tend to be attached to finer particles and reside in the air for longer periods. Comparison between the molecular distributions of PAHs and their diagnostic ratios observed in the current study with those reported for urban atmospheric and roadside soil particles revealed that they are of different sources.

关键词： airborne particles soot deposit PAHs

microstructures and Hardness Properties for β-Phase Ti-24Nb-4Zr-7.9Sn Alloy Fabricated by Electron Beam melting

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Journal of materials Science & Technology 2013年第11期29卷 1011-1017页

作者： J.Hernandez S.J.Li E.martinez L.E.murr X.m.Pan k.N.Amato X.Y.Cheng F.Yang C.A.Terrazas S.m.Gaytan Y.L.Hao R.Yang F.medina R.B.Wicker Department of metallurgical and materials Engineering The University of Texas at El Paso Shenyang National Laboratory for materials Science Institute of Metal ResearchChinese Academy of Sciences School of materials Science and Engineering Dalian University of Technology W.m.keck Center for 3D Innovation The University of Texas at E1 Paso

Atomized, pre-alloyed Ti-24Nb-4Zr-7.9Sn （wt%） powder was used to fabricate solid, prototype components by electron beam melting （EBm）. Vickers microindentation hardness values were observed to average 2 GPa for the precursor powder and 2.5 GPa for the solid, EBm-fabricated products. The powder and solid product microstructures were examined by optical and electron microscopy. X-ray diffraction analyses showed that they had bcc β-phase microstructure. However, it was found by transmission electron microscopy that the EBm-fabricated product had plate morphology with space -100-200 nm. Although the corresponding selected area diffraction patterns can be indexed by β-phase plus α＂-martensite with orthorhombic crystal structure, the dark-field analyses failed to observe the α＂-martensite. Such phenomenon was also found in deformed gum metals and explained by stress-induced diffusion scattering due to phonon softening.

关键词： Biomedical titanium alloy β-martensite Electron beam melting Hardness Optical and electron microscopy

Formation and Decay of Electron-Hole Plasma Clusters in a Direct-Gap Semiconductor CuCl

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Chinese Physics Letters 2003年第10期20卷 1833-1835页

作者：姜磊吴明卫 m.Nagai m.kuwata-Gonokami StructureResearchLaboratory UniversityofScienceandTechnologyofChinaHefei230026 DepartmentofPhysics UniversityofScienceandTeclmologyofChinaHefe230026 DepartmentofPhysics KyotoUniversityKyoto606-8502Japan DepartmentofAppliedPhysics UniversityofTokyoHongoBunkyo-kuTokyo113-8656Japan

The master equation for the cluster-size distribution function is solved numerically to investigate the electron-hole droplet formation claimed to be discovered in the direct-gap CuCl excited by picosecond laser pulses [Nagai et al. Phys. Rev. Lett. 86 (2001) 5795; J. Lumin. 100 (2002) 233]. Our result shows that for the excitation in the experiment, the average number of pairs per cluster (ANPC) is only around 5.2, much smaller than that (10~6 typically for Ge) of the well studied electron-hole droplet in indirect-gap semiconductors such as Ge and Si. These results indicate that what measured in CuCl by Nagai et al. may not come from the EHD formed from exciton gas, instead possibly come from some bubbles of excitons in metallic liquid.

关键词： Exciton Electrohydrodynamics bubbles Semiconductor materials decay lumin Excitation Clusters Distribution function aluminium Decay Electron-hole plasma master equation Picosecond pulsed laser device digitally

Fragmentation Cross Sections of 158 AGeV Pb Projectiles

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Chinese Physics Letters 2007年第10期24卷 2800-2803页

作者： G. Sher m.I. Shahzad m. Hussain Physics Division PINSTECH Islamabad Pakistan Department of Physics University of the Punjab Lahore Pakistan

We investigate the fragmentation cross sections of 158 AGeV ^207Pb projectile interacting with different targets using CR39 nuclear track detectors. The exposure is made at SPS beam facility of CERN. The detectors are chemically etched to obtain data in the form of etched cone length. The nuclear and electromagnetic contributions to the measured total charge-changing cross sections are investigated. The estimated results are compared with those found in the literature for similar research work.

关键词： coated conductor buffer layer self-epitaxy CeO2

Experimental study of electro-optical-switched pulsed Nd:YAG laser

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Chinese Physics B 2016年第3期25卷 210-214页

作者： A maleki m kavosh Tehrani H Saghafifar m H moghtader Dindarlu Optic & Laser Science & Technoltogy Research Center Malek-Ashtar University of Technology Isfahan Iran

We report the specification of a compact and stable side diode-pumped Q-switched pulsed Nd：YAG laser. We ex- perimentally study and compare the performance of the pulsed Nd：YAG laser in the free-running and Q-switched modes at different pulse repetition rates from 1 Hz to 100 Hz. The laser output energy is stabilized by using a special configu- ration of the optical resonator. In this laser, an unsymmetrical concave-concave resonator is used and this structure helps the mode volume to be nearly fixed when the pulse repetition rate is increased. According to the experimental results in the Q-switched operation, the laser output energy is nearly constant around 70 mJ with an FWHm pulse width of 7 ns at 100 Hz. The optical-to-optical conversion efficiency in the Q-switched regime is 17.5%.

关键词： side diode-pumped Nd:YAG laser concave-concave resonator electro-optical Q-switched laser